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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PADI6
Full Name:
Protein-arginine deiminase type-6
Alias:
Peptidylarginine deiminase VI;Protein-arginine deiminase type VI
Type:
Mass (Da):
76897
Number AA:
686
UniProt ID:
Q6TGC4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T64
I
S
E
K
E
D
A
T
I
W
W
P
L
S
D
Site 2
Y74
W
P
L
S
D
P
T
Y
A
T
V
K
M
T
S
Site 3
T76
L
S
D
P
T
Y
A
T
V
K
M
T
S
P
S
Site 4
S81
Y
A
T
V
K
M
T
S
P
S
P
S
V
D
A
Site 5
S83
T
V
K
M
T
S
P
S
P
S
V
D
A
D
K
Site 6
S85
K
M
T
S
P
S
P
S
V
D
A
D
K
V
S
Site 7
S92
S
V
D
A
D
K
V
S
V
T
Y
Y
G
P
N
Site 8
Y95
A
D
K
V
S
V
T
Y
Y
G
P
N
E
D
A
Site 9
Y96
D
K
V
S
V
T
Y
Y
G
P
N
E
D
A
P
Site 10
Y123
V
S
L
E
V
D
I
Y
R
N
G
Q
V
E
M
Site 11
T169
Q
Q
L
E
D
K
K
T
K
K
V
I
F
S
E
Site 12
S182
S
E
E
I
T
N
L
S
Q
M
T
L
N
V
Q
Site 13
Y198
P
S
C
I
L
K
K
Y
R
L
V
L
H
T
S
Site 14
T204
K
Y
R
L
V
L
H
T
S
K
E
E
S
K
K
Site 15
S205
Y
R
L
V
L
H
T
S
K
E
E
S
K
K
A
Site 16
S209
L
H
T
S
K
E
E
S
K
K
A
R
V
Y
W
Site 17
Y215
E
S
K
K
A
R
V
Y
W
P
Q
K
D
N
S
Site 18
S222
Y
W
P
Q
K
D
N
S
S
T
F
E
L
V
L
Site 19
T224
P
Q
K
D
N
S
S
T
F
E
L
V
L
G
P
Site 20
T237
G
P
D
Q
H
A
Y
T
L
A
L
L
G
N
H
Site 21
Y250
N
H
L
K
E
T
F
Y
V
E
A
I
A
F
P
Site 22
S270
G
L
I
S
Y
S
V
S
L
V
E
E
S
Q
D
Site 23
S275
S
V
S
L
V
E
E
S
Q
D
P
S
I
P
E
Site 24
S279
V
E
E
S
Q
D
P
S
I
P
E
T
V
L
Y
Site 25
T283
Q
D
P
S
I
P
E
T
V
L
Y
K
D
T
V
Site 26
T323
Q
L
Q
G
F
V
D
T
V
T
K
L
S
E
K
Site 27
T325
Q
G
F
V
D
T
V
T
K
L
S
E
K
S
N
Site 28
S328
V
D
T
V
T
K
L
S
E
K
S
N
S
Q
V
Site 29
S331
V
T
K
L
S
E
K
S
N
S
Q
V
A
S
V
Site 30
S333
K
L
S
E
K
S
N
S
Q
V
A
S
V
Y
E
Site 31
S337
K
S
N
S
Q
V
A
S
V
Y
E
D
P
N
R
Site 32
Y339
N
S
Q
V
A
S
V
Y
E
D
P
N
R
L
G
Site 33
S366
Q
A
P
H
K
T
T
S
L
I
L
D
T
P
Q
Site 34
T371
T
T
S
L
I
L
D
T
P
Q
A
A
D
L
D
Site 35
Y384
L
D
E
F
P
M
K
Y
S
L
S
P
G
I
G
Site 36
S385
D
E
F
P
M
K
Y
S
L
S
P
G
I
G
Y
Site 37
T397
I
G
Y
M
I
Q
D
T
E
D
H
K
V
A
S
Site 38
S434
G
R
V
L
I
G
S
S
F
Y
P
S
A
E
G
Site 39
S438
I
G
S
S
F
Y
P
S
A
E
G
R
A
M
S
Site 40
S445
S
A
E
G
R
A
M
S
K
T
L
R
D
F
L
Site 41
T447
E
G
R
A
M
S
K
T
L
R
D
F
L
Y
A
Site 42
Y453
K
T
L
R
D
F
L
Y
A
Q
Q
V
Q
A
P
Site 43
S530
L
R
A
D
Q
L
L
S
N
G
R
E
A
K
T
Site 44
T537
S
N
G
R
E
A
K
T
I
D
Q
L
L
A
D
Site 45
S546
D
Q
L
L
A
D
E
S
L
K
K
Q
N
E
Y
Site 46
Y553
S
L
K
K
Q
N
E
Y
V
E
K
C
I
H
L
Site 47
T567
L
N
R
D
I
L
K
T
E
L
G
L
V
E
Q
Site 48
T589
L
F
C
L
E
K
L
T
N
I
P
S
D
Q
Q
Site 49
S593
E
K
L
T
N
I
P
S
D
Q
Q
P
K
R
S
Site 50
S600
S
D
Q
Q
P
K
R
S
F
A
R
P
Y
F
P
Site 51
Y605
K
R
S
F
A
R
P
Y
F
P
D
L
L
R
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation