KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KLHL24
Full Name:
Kelch-like protein 24
Alias:
Kainate receptor-interacting protein for GluR6;Protein DRE1
Type:
Mass (Da):
68361
Number AA:
600
UniProt ID:
Q6TFL4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
E
D
L
G
V
R
D
S
P
A
T
K
R
K
V
Site 2
T22
G
V
R
D
S
P
A
T
K
R
K
V
F
E
M
Site 3
S33
V
F
E
M
D
P
K
S
L
T
G
H
E
F
F
Site 4
T35
E
M
D
P
K
S
L
T
G
H
E
F
F
D
F
Site 5
S43
G
H
E
F
F
D
F
S
S
G
S
S
H
A
E
Site 6
S44
H
E
F
F
D
F
S
S
G
S
S
H
A
E
N
Site 7
S47
F
D
F
S
S
G
S
S
H
A
E
N
I
L
Q
Site 8
S62
I
F
N
E
F
R
D
S
R
L
F
T
D
V
I
Site 9
S85
P
C
H
R
A
V
L
S
A
C
S
S
Y
F
R
Site 10
Y138
I
T
T
E
N
V
Q
Y
L
F
E
T
S
S
L
Site 11
T177
G
I
Q
R
F
A
D
T
H
S
L
K
T
L
F
Site 12
S179
Q
R
F
A
D
T
H
S
L
K
T
L
F
T
K
Site 13
T185
H
S
L
K
T
L
F
T
K
C
K
N
F
A
L
Site 14
T194
C
K
N
F
A
L
Q
T
F
E
D
V
S
Q
H
Site 15
S199
L
Q
T
F
E
D
V
S
Q
H
E
E
F
L
E
Site 16
Y215
D
K
D
E
L
I
D
Y
I
C
S
D
E
L
V
Site 17
Y238
E
A
V
M
R
W
V
Y
R
A
V
D
L
R
R
Site 18
T268
H
P
N
Y
F
V
Q
T
V
E
V
D
Q
L
I
Site 19
S278
V
D
Q
L
I
Q
N
S
P
E
C
Y
Q
L
L
Site 20
Y282
I
Q
N
S
P
E
C
Y
Q
L
L
H
E
A
R
Site 21
Y291
L
L
H
E
A
R
R
Y
H
I
L
G
N
E
M
Site 22
S300
I
L
G
N
E
M
M
S
P
R
T
R
P
R
R
Site 23
T303
N
E
M
M
S
P
R
T
R
P
R
R
S
T
G
Site 24
S308
P
R
T
R
P
R
R
S
T
G
Y
S
E
V
I
Site 25
T309
R
T
R
P
R
R
S
T
G
Y
S
E
V
I
V
Site 26
Y311
R
P
R
R
S
T
G
Y
S
E
V
I
V
V
V
Site 27
Y331
V
G
G
F
N
L
P
Y
T
E
C
Y
D
P
V
Site 28
T332
G
G
F
N
L
P
Y
T
E
C
Y
D
P
V
T
Site 29
Y335
N
L
P
Y
T
E
C
Y
D
P
V
T
G
E
W
Site 30
T339
T
E
C
Y
D
P
V
T
G
E
W
K
S
L
A
Site 31
S344
P
V
T
G
E
W
K
S
L
A
K
L
P
E
F
Site 32
Y356
P
E
F
T
K
S
E
Y
A
V
C
A
L
R
N
Site 33
S374
V
S
G
G
R
I
N
S
R
D
V
W
I
Y
N
Site 34
S422
Y
D
G
Q
N
R
L
S
S
V
E
C
Y
D
S
Site 35
S423
D
G
Q
N
R
L
S
S
V
E
C
Y
D
S
F
Site 36
Y427
R
L
S
S
V
E
C
Y
D
S
F
S
N
R
W
Site 37
S429
S
S
V
E
C
Y
D
S
F
S
N
R
W
T
E
Site 38
T435
D
S
F
S
N
R
W
T
E
V
A
P
L
K
E
Site 39
T467
G
G
G
P
D
D
N
T
C
S
D
K
V
Q
S
Site 40
S469
G
P
D
D
N
T
C
S
D
K
V
Q
S
Y
D
Site 41
Y475
C
S
D
K
V
Q
S
Y
D
P
E
T
N
S
W
Site 42
T479
V
Q
S
Y
D
P
E
T
N
S
W
L
L
R
A
Site 43
S481
S
Y
D
P
E
T
N
S
W
L
L
R
A
A
I
Site 44
Y515
G
G
L
T
K
A
I
Y
C
Y
D
P
V
E
D
Site 45
Y517
L
T
K
A
I
Y
C
Y
D
P
V
E
D
Y
W
Site 46
Y547
S
V
C
N
G
K
I
Y
I
L
G
G
R
R
E
Site 47
T561
E
N
G
E
A
T
D
T
I
L
C
Y
D
P
A
Site 48
Y593
G
C
V
T
I
H
R
Y
N
E
K
C
F
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation