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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Shc4
Full Name:
SHC-transforming protein 4
Alias:
rai-like protein; RaLP; SHC (Src homology 2 domain containing) family, member 4; SHC (Srcy 2 domain containing) family, member 4
Type:
Adaptor/scaffold
Mass (Da):
68785
Number AA:
630
UniProt ID:
Q6S5L8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
E
R
G
Q
D
S
L
A
G
L
V
L
Y
Site 2
Y30
G
M
L
H
R
A
K
Y
S
R
F
R
N
E
S
Site 3
S37
Y
S
R
F
R
N
E
S
I
T
S
L
D
E
G
Site 4
T39
R
F
R
N
E
S
I
T
S
L
D
E
G
S
S
Site 5
S40
F
R
N
E
S
I
T
S
L
D
E
G
S
S
G
Site 6
S45
I
T
S
L
D
E
G
S
S
G
G
S
V
G
N
Site 7
S46
T
S
L
D
E
G
S
S
G
G
S
V
G
N
K
Site 8
S49
D
E
G
S
S
G
G
S
V
G
N
K
G
S
P
Site 9
S55
G
S
V
G
N
K
G
S
P
Q
P
P
H
P
A
Site 10
T73
H
L
P
T
E
D
A
T
L
P
S
Q
E
S
P
Site 11
S76
T
E
D
A
T
L
P
S
Q
E
S
P
T
P
L
Site 12
S79
A
T
L
P
S
Q
E
S
P
T
P
L
C
T
L
Site 13
T81
L
P
S
Q
E
S
P
T
P
L
C
T
L
I
P
Site 14
S122
P
R
L
K
L
Q
E
S
R
D
P
G
S
S
G
Site 15
S127
Q
E
S
R
D
P
G
S
S
G
P
S
S
P
E
Site 16
S128
E
S
R
D
P
G
S
S
G
P
S
S
P
E
T
Site 17
S131
D
P
G
S
S
G
P
S
S
P
E
T
S
L
S
Site 18
S132
P
G
S
S
G
P
S
S
P
E
T
S
L
S
R
Site 19
T135
S
G
P
S
S
P
E
T
S
L
S
R
S
G
T
Site 20
S136
G
P
S
S
P
E
T
S
L
S
R
S
G
T
A
Site 21
S138
S
S
P
E
T
S
L
S
R
S
G
T
A
P
P
Site 22
S140
P
E
T
S
L
S
R
S
G
T
A
P
P
P
Q
Site 23
T142
T
S
L
S
R
S
G
T
A
P
P
P
Q
Q
D
Site 24
T156
D
L
V
G
H
R
A
T
A
L
T
P
D
S
C
Site 25
T159
G
H
R
A
T
A
L
T
P
D
S
C
P
L
P
Site 26
S162
A
T
A
L
T
P
D
S
C
P
L
P
G
P
G
Site 27
T172
L
P
G
P
G
E
P
T
L
R
S
R
Q
D
R
Site 28
S208
E
V
L
Q
S
M
R
S
L
D
F
G
M
R
T
Site 29
S247
K
P
P
V
K
F
L
S
T
V
L
G
K
S
N
Site 30
S258
G
K
S
N
L
Q
F
S
G
M
N
I
K
L
T
Site 31
S289
I
A
N
H
H
M
Q
S
I
S
F
A
S
G
G
Site 32
S291
N
H
H
M
Q
S
I
S
F
A
S
G
G
D
P
Site 33
S294
M
Q
S
I
S
F
A
S
G
G
D
P
D
T
T
Site 34
T300
A
S
G
G
D
P
D
T
T
D
Y
V
A
Y
V
Site 35
T301
S
G
G
D
P
D
T
T
D
Y
V
A
Y
V
A
Site 36
Y303
G
D
P
D
T
T
D
Y
V
A
Y
V
A
K
D
Site 37
Y306
D
T
T
D
Y
V
A
Y
V
A
K
D
P
V
N
Site 38
Y345
F
E
L
R
F
K
Q
Y
L
K
N
P
S
L
N
Site 39
S350
K
Q
Y
L
K
N
P
S
L
N
T
S
C
E
S
Site 40
S354
K
N
P
S
L
N
T
S
C
E
S
E
E
V
H
Site 41
S364
S
E
E
V
H
I
D
S
H
A
E
E
R
E
D
Site 42
Y374
E
E
R
E
D
H
E
Y
Y
N
E
I
P
G
K
Site 43
Y375
E
R
E
D
H
E
Y
Y
N
E
I
P
G
K
Q
Site 44
Y403
Q
A
T
E
Q
M
A
Y
C
P
I
Q
C
E
K
Site 45
Y413
I
Q
C
E
K
L
C
Y
L
P
G
N
S
K
C
Site 46
S418
L
C
Y
L
P
G
N
S
K
C
S
S
V
Y
E
Site 47
S422
P
G
N
S
K
C
S
S
V
Y
E
N
C
L
E
Site 48
Y424
N
S
K
C
S
S
V
Y
E
N
C
L
E
Q
S
Site 49
S444
V
H
P
R
G
V
Q
S
Q
R
D
T
S
L
L
Site 50
T448
G
V
Q
S
Q
R
D
T
S
L
L
K
H
T
C
Site 51
S449
V
Q
S
Q
R
D
T
S
L
L
K
H
T
C
R
Site 52
T454
D
T
S
L
L
K
H
T
C
R
V
D
L
F
D
Site 53
Y465
D
L
F
D
D
P
C
Y
I
N
T
Q
A
L
Q
Site 54
S473
I
N
T
Q
A
L
Q
S
T
P
G
S
A
G
N
Site 55
T474
N
T
Q
A
L
Q
S
T
P
G
S
A
G
N
Q
Site 56
S477
A
L
Q
S
T
P
G
S
A
G
N
Q
R
S
A
Site 57
S483
G
S
A
G
N
Q
R
S
A
Q
P
L
G
S
P
Site 58
S489
R
S
A
Q
P
L
G
S
P
W
H
C
G
K
A
Site 59
T499
H
C
G
K
A
P
E
T
V
Q
P
G
A
T
A
Site 60
T505
E
T
V
Q
P
G
A
T
A
Q
P
A
S
S
H
Site 61
S510
G
A
T
A
Q
P
A
S
S
H
S
L
P
H
I
Site 62
S511
A
T
A
Q
P
A
S
S
H
S
L
P
H
I
K
Site 63
S513
A
Q
P
A
S
S
H
S
L
P
H
I
K
Q
Q
Site 64
Y527
Q
L
W
S
E
E
C
Y
H
G
K
L
S
R
K
Site 65
S532
E
C
Y
H
G
K
L
S
R
K
A
A
E
S
L
Site 66
S538
L
S
R
K
A
A
E
S
L
L
V
K
D
G
D
Site 67
S551
G
D
F
L
V
R
E
S
A
T
S
P
G
Q
Y
Site 68
S554
L
V
R
E
S
A
T
S
P
G
Q
Y
V
L
S
Site 69
Y558
S
A
T
S
P
G
Q
Y
V
L
S
G
L
Q
G
Site 70
S561
S
P
G
Q
Y
V
L
S
G
L
Q
G
G
Q
A
Site 71
Y596
N
V
G
H
L
I
R
Y
H
M
D
N
S
L
P
Site 72
S601
I
R
Y
H
M
D
N
S
L
P
I
I
S
S
G
Site 73
S606
D
N
S
L
P
I
I
S
S
G
S
E
V
S
L
Site 74
S607
N
S
L
P
I
I
S
S
G
S
E
V
S
L
K
Site 75
S609
L
P
I
I
S
S
G
S
E
V
S
L
K
Q
P
Site 76
S612
I
S
S
G
S
E
V
S
L
K
Q
P
V
R
K
Site 77
S628
N
N
P
A
L
L
H
S
N
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation