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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOK6
Full Name:
Docking protein 6
Alias:
Downstream of tyrosine kinase 6
Type:
Mass (Da):
38318
Number AA:
331
UniProt ID:
Q6PKX4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
N
D
I
V
K
Q
G
Y
V
K
I
R
S
R
K
Site 2
S18
Q
G
Y
V
K
I
R
S
R
K
L
G
I
F
R
Site 3
Y52
F
P
D
E
K
A
A
Y
F
R
N
F
H
K
V
Site 4
T75
I
T
R
L
P
R
E
T
K
K
H
A
V
A
I
Site 5
T88
A
I
I
F
H
D
E
T
S
K
T
F
A
C
E
Site 6
T91
F
H
D
E
T
S
K
T
F
A
C
E
S
E
L
Site 7
S96
S
K
T
F
A
C
E
S
E
L
E
A
E
E
W
Site 8
S120
G
T
R
L
N
D
I
S
L
G
E
P
D
L
L
Site 9
Y142
Q
N
E
R
F
N
V
Y
L
M
P
T
P
N
L
Site 10
Y152
P
T
P
N
L
D
I
Y
G
E
C
T
M
Q
I
Site 11
S182
K
L
V
M
W
P
L
S
S
L
R
R
Y
G
R
Site 12
S183
L
V
M
W
P
L
S
S
L
R
R
Y
G
R
D
Site 13
Y187
P
L
S
S
L
R
R
Y
G
R
D
S
T
W
F
Site 14
S191
L
R
R
Y
G
R
D
S
T
W
F
T
F
E
S
Site 15
T192
R
R
Y
G
R
D
S
T
W
F
T
F
E
S
G
Site 16
T195
G
R
D
S
T
W
F
T
F
E
S
G
R
M
C
Site 17
T204
E
S
G
R
M
C
D
T
G
E
G
L
F
T
F
Site 18
T210
D
T
G
E
G
L
F
T
F
Q
T
R
E
G
E
Site 19
T213
E
G
L
F
T
F
Q
T
R
E
G
E
M
I
Y
Site 20
Y220
T
R
E
G
E
M
I
Y
Q
K
V
H
S
A
T
Site 21
T249
E
Q
K
A
R
L
Q
T
S
L
T
E
P
M
T
Site 22
S250
Q
K
A
R
L
Q
T
S
L
T
E
P
M
T
L
Site 23
T252
A
R
L
Q
T
S
L
T
E
P
M
T
L
S
K
Site 24
T256
T
S
L
T
E
P
M
T
L
S
K
S
I
S
L
Site 25
S258
L
T
E
P
M
T
L
S
K
S
I
S
L
P
R
Site 26
S260
E
P
M
T
L
S
K
S
I
S
L
P
R
S
A
Site 27
S262
M
T
L
S
K
S
I
S
L
P
R
S
A
Y
W
Site 28
S266
K
S
I
S
L
P
R
S
A
Y
W
H
H
I
T
Site 29
Y268
I
S
L
P
R
S
A
Y
W
H
H
I
T
R
Q
Site 30
S277
H
H
I
T
R
Q
N
S
V
G
E
I
Y
S
L
Site 31
Y282
Q
N
S
V
G
E
I
Y
S
L
Q
G
H
G
F
Site 32
S283
N
S
V
G
E
I
Y
S
L
Q
G
H
G
F
G
Site 33
S291
L
Q
G
H
G
F
G
S
S
K
M
S
R
A
Q
Site 34
S292
Q
G
H
G
F
G
S
S
K
M
S
R
A
Q
T
Site 35
S295
G
F
G
S
S
K
M
S
R
A
Q
T
F
P
S
Site 36
T299
S
K
M
S
R
A
Q
T
F
P
S
Y
A
P
E
Site 37
S302
S
R
A
Q
T
F
P
S
Y
A
P
E
Q
S
E
Site 38
Y303
R
A
Q
T
F
P
S
Y
A
P
E
Q
S
E
E
Site 39
S316
E
E
A
Q
Q
P
L
S
R
S
S
S
Y
G
F
Site 40
S318
A
Q
Q
P
L
S
R
S
S
S
Y
G
F
S
Y
Site 41
S319
Q
Q
P
L
S
R
S
S
S
Y
G
F
S
Y
S
Site 42
S320
Q
P
L
S
R
S
S
S
Y
G
F
S
Y
S
S
Site 43
S324
R
S
S
S
Y
G
F
S
Y
S
S
S
L
I
Q
Site 44
Y325
S
S
S
Y
G
F
S
Y
S
S
S
L
I
Q
_
Site 45
S326
S
S
Y
G
F
S
Y
S
S
S
L
I
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation