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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DCLRE1A
Full Name:
DNA cross-link repair 1A protein
Alias:
DCR1A; DNA cross-link repair 1A; HSNM1A; KIAA0086; PSO2; SNM1; SNM1 homolog A
Type:
Mass (Da):
116422
Number AA:
1040
UniProt ID:
Q6PJP8
International Prot ID:
IPI00478916
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
S
E
E
D
I
W
E
Y
K
S
K
R
K
P
K
Site 2
S15
E
D
I
W
E
Y
K
S
K
R
K
P
K
R
V
Site 3
S34
G
S
K
N
I
L
K
S
V
E
K
A
T
D
G
Site 4
T39
L
K
S
V
E
K
A
T
D
G
K
Y
Q
S
K
Site 5
Y43
E
K
A
T
D
G
K
Y
Q
S
K
R
S
R
N
Site 6
S45
A
T
D
G
K
Y
Q
S
K
R
S
R
N
R
K
Site 7
S48
G
K
Y
Q
S
K
R
S
R
N
R
K
R
A
A
Site 8
T74
L
G
N
A
G
C
Q
T
S
V
A
S
S
Q
N
Site 9
S75
G
N
A
G
C
Q
T
S
V
A
S
S
Q
N
S
Site 10
S78
G
C
Q
T
S
V
A
S
S
Q
N
S
S
C
G
Site 11
S79
C
Q
T
S
V
A
S
S
Q
N
S
S
C
G
D
Site 12
S82
S
V
A
S
S
Q
N
S
S
C
G
D
G
I
Q
Site 13
S83
V
A
S
S
Q
N
S
S
C
G
D
G
I
Q
Q
Site 14
T96
Q
Q
T
Q
D
K
E
T
T
P
G
K
L
C
R
Site 15
T97
Q
T
Q
D
K
E
T
T
P
G
K
L
C
R
T
Site 16
S107
K
L
C
R
T
Q
K
S
Q
H
V
S
P
K
I
Site 17
S111
T
Q
K
S
Q
H
V
S
P
K
I
R
P
V
Y
Site 18
Y118
S
P
K
I
R
P
V
Y
D
G
Y
C
P
N
C
Site 19
Y121
I
R
P
V
Y
D
G
Y
C
P
N
C
Q
M
P
Site 20
S130
P
N
C
Q
M
P
F
S
S
L
I
G
Q
T
P
Site 21
S131
N
C
Q
M
P
F
S
S
L
I
G
Q
T
P
R
Site 22
T136
F
S
S
L
I
G
Q
T
P
R
W
H
V
F
E
Site 23
S147
H
V
F
E
C
L
D
S
P
P
R
S
E
T
E
Site 24
S151
C
L
D
S
P
P
R
S
E
T
E
C
P
D
G
Site 25
T153
D
S
P
P
R
S
E
T
E
C
P
D
G
L
L
Site 26
Y169
T
S
T
I
P
F
H
Y
K
R
Y
T
H
F
L
Site 27
T173
P
F
H
Y
K
R
Y
T
H
F
L
L
A
Q
S
Site 28
S188
R
A
G
D
H
P
F
S
S
P
S
P
A
S
G
Site 29
S189
A
G
D
H
P
F
S
S
P
S
P
A
S
G
G
Site 30
S191
D
H
P
F
S
S
P
S
P
A
S
G
G
S
F
Site 31
S194
F
S
S
P
S
P
A
S
G
G
S
F
S
E
T
Site 32
S197
P
S
P
A
S
G
G
S
F
S
E
T
K
S
G
Site 33
S199
P
A
S
G
G
S
F
S
E
T
K
S
G
V
L
Site 34
T201
S
G
G
S
F
S
E
T
K
S
G
V
L
C
S
Site 35
S203
G
S
F
S
E
T
K
S
G
V
L
C
S
L
E
Site 36
S208
T
K
S
G
V
L
C
S
L
E
E
R
W
S
S
Site 37
S214
C
S
L
E
E
R
W
S
S
Y
Q
N
Q
T
D
Site 38
S215
S
L
E
E
R
W
S
S
Y
Q
N
Q
T
D
N
Site 39
S223
Y
Q
N
Q
T
D
N
S
V
S
N
D
P
L
L
Site 40
S225
N
Q
T
D
N
S
V
S
N
D
P
L
L
M
T
Site 41
T232
S
N
D
P
L
L
M
T
Q
Y
F
K
K
S
P
Site 42
Y234
D
P
L
L
M
T
Q
Y
F
K
K
S
P
S
L
Site 43
S238
M
T
Q
Y
F
K
K
S
P
S
L
T
E
A
S
Site 44
S240
Q
Y
F
K
K
S
P
S
L
T
E
A
S
E
K
Site 45
T242
F
K
K
S
P
S
L
T
E
A
S
E
K
I
S
Site 46
S245
S
P
S
L
T
E
A
S
E
K
I
S
T
H
I
Site 47
S249
T
E
A
S
E
K
I
S
T
H
I
Q
T
S
Q
Site 48
T250
E
A
S
E
K
I
S
T
H
I
Q
T
S
Q
Q
Site 49
S255
I
S
T
H
I
Q
T
S
Q
Q
A
L
Q
F
T
Site 50
S281
A
L
R
L
A
N
N
S
E
H
I
N
L
P
L
Site 51
S294
P
L
P
E
N
D
F
S
D
C
E
I
S
Y
S
Site 52
S299
D
F
S
D
C
E
I
S
Y
S
P
L
Q
S
D
Site 53
S301
S
D
C
E
I
S
Y
S
P
L
Q
S
D
E
D
Site 54
S305
I
S
Y
S
P
L
Q
S
D
E
D
T
H
D
I
Site 55
T309
P
L
Q
S
D
E
D
T
H
D
I
D
E
K
P
Site 56
S319
I
D
E
K
P
H
D
S
Q
E
Q
L
F
F
T
Site 57
T326
S
Q
E
Q
L
F
F
T
E
S
S
K
D
G
S
Site 58
S328
E
Q
L
F
F
T
E
S
S
K
D
G
S
L
E
Site 59
S329
Q
L
F
F
T
E
S
S
K
D
G
S
L
E
E
Site 60
S333
T
E
S
S
K
D
G
S
L
E
E
D
D
D
S
Site 61
S340
S
L
E
E
D
D
D
S
C
G
F
F
K
K
R
Site 62
S364
E
S
C
P
K
V
N
S
F
L
T
R
D
K
Y
Site 63
Y371
S
F
L
T
R
D
K
Y
D
E
G
L
Y
R
F
Site 64
Y376
D
K
Y
D
E
G
L
Y
R
F
N
S
L
N
D
Site 65
S380
E
G
L
Y
R
F
N
S
L
N
D
L
S
Q
P
Site 66
S385
F
N
S
L
N
D
L
S
Q
P
I
S
Q
N
N
Site 67
S389
N
D
L
S
Q
P
I
S
Q
N
N
E
S
T
L
Site 68
Y398
N
N
E
S
T
L
P
Y
D
L
A
C
T
G
G
Site 69
S457
S
S
V
Y
N
Q
V
S
L
P
L
V
K
S
L
Site 70
S471
L
M
L
K
P
F
E
S
Q
V
E
G
Y
L
S
Site 71
Y476
F
E
S
Q
V
E
G
Y
L
S
S
Q
P
T
Q
Site 72
S478
S
Q
V
E
G
Y
L
S
S
Q
P
T
Q
N
T
Site 73
S479
Q
V
E
G
Y
L
S
S
Q
P
T
Q
N
T
I
Site 74
T482
G
Y
L
S
S
Q
P
T
Q
N
T
I
R
K
L
Site 75
T485
S
S
Q
P
T
Q
N
T
I
R
K
L
S
S
E
Site 76
S490
Q
N
T
I
R
K
L
S
S
E
N
L
N
A
K
Site 77
T523
G
K
A
T
I
L
N
T
E
N
L
S
S
T
P
Site 78
S527
I
L
N
T
E
N
L
S
S
T
P
A
P
K
Y
Site 79
S528
L
N
T
E
N
L
S
S
T
P
A
P
K
Y
L
Site 80
T529
N
T
E
N
L
S
S
T
P
A
P
K
Y
L
K
Site 81
Y534
S
S
T
P
A
P
K
Y
L
K
I
L
P
S
G
Site 82
S540
K
Y
L
K
I
L
P
S
G
L
K
Y
N
A
R
Site 83
Y544
I
L
P
S
G
L
K
Y
N
A
R
H
P
S
T
Site 84
Y562
K
Q
M
D
I
G
V
Y
F
G
L
P
P
K
R
Site 85
S590
I
N
L
N
P
V
P
S
P
N
Q
K
R
S
S
Site 86
S597
S
P
N
Q
K
R
S
S
Q
C
K
R
K
A
E
Site 87
S606
C
K
R
K
A
E
K
S
L
S
D
L
E
F
D
Site 88
S608
R
K
A
E
K
S
L
S
D
L
E
F
D
A
S
Site 89
S615
S
D
L
E
F
D
A
S
T
L
H
E
S
Q
L
Site 90
T616
D
L
E
F
D
A
S
T
L
H
E
S
Q
L
S
Site 91
S620
D
A
S
T
L
H
E
S
Q
L
S
V
E
L
S
Site 92
S623
T
L
H
E
S
Q
L
S
V
E
L
S
S
E
R
Site 93
S627
S
Q
L
S
V
E
L
S
S
E
R
S
Q
R
Q
Site 94
S628
Q
L
S
V
E
L
S
S
E
R
S
Q
R
Q
K
Site 95
S631
V
E
L
S
S
E
R
S
Q
R
Q
K
K
R
C
Site 96
S641
Q
K
K
R
C
R
K
S
N
S
L
Q
E
G
A
Site 97
S643
K
R
C
R
K
S
N
S
L
Q
E
G
A
C
Q
Site 98
S653
E
G
A
C
Q
K
R
S
D
H
L
I
N
T
E
Site 99
T659
R
S
D
H
L
I
N
T
E
S
E
A
V
N
L
Site 100
S661
D
H
L
I
N
T
E
S
E
A
V
N
L
S
K
Site 101
S667
E
S
E
A
V
N
L
S
K
V
K
V
F
T
K
Site 102
S675
K
V
K
V
F
T
K
S
A
H
G
G
L
Q
R
Site 103
S690
G
N
K
K
I
P
E
S
S
N
V
G
G
S
R
Site 104
S691
N
K
K
I
P
E
S
S
N
V
G
G
S
R
K
Site 105
T700
V
G
G
S
R
K
K
T
C
P
F
Y
K
K
I
Site 106
Y704
R
K
K
T
C
P
F
Y
K
K
I
P
G
T
G
Site 107
T713
K
I
P
G
T
G
F
T
V
D
A
F
Q
Y
G
Site 108
Y738
T
H
F
H
S
D
H
Y
A
G
L
S
K
H
F
Site 109
S742
S
D
H
Y
A
G
L
S
K
H
F
T
F
P
V
Site 110
T746
A
G
L
S
K
H
F
T
F
P
V
Y
C
S
E
Site 111
Y750
K
H
F
T
F
P
V
Y
C
S
E
I
T
G
N
Site 112
Y769
K
L
H
V
Q
E
Q
Y
I
H
P
L
P
L
D
Site 113
S821
G
D
F
R
A
D
P
S
M
E
R
S
L
L
A
Site 114
S825
A
D
P
S
M
E
R
S
L
L
A
D
Q
K
V
Site 115
Y836
D
Q
K
V
H
M
L
Y
L
D
T
T
Y
C
S
Site 116
Y841
M
L
Y
L
D
T
T
Y
C
S
P
E
Y
T
F
Site 117
S843
Y
L
D
T
T
Y
C
S
P
E
Y
T
F
P
S
Site 118
Y846
T
T
Y
C
S
P
E
Y
T
F
P
S
Q
Q
E
Site 119
T847
T
Y
C
S
P
E
Y
T
F
P
S
Q
Q
E
V
Site 120
S850
S
P
E
Y
T
F
P
S
Q
Q
E
V
I
R
F
Site 121
S901
L
G
S
K
V
G
M
S
Q
E
K
Y
K
T
L
Site 122
Y905
V
G
M
S
Q
E
K
Y
K
T
L
Q
C
L
N
Site 123
T907
M
S
Q
E
K
Y
K
T
L
Q
C
L
N
I
P
Site 124
S944
I
N
F
K
G
L
Q
S
H
L
K
K
C
G
G
Site 125
Y953
L
K
K
C
G
G
K
Y
N
Q
I
L
A
F
R
Site 126
T962
Q
I
L
A
F
R
P
T
G
W
T
H
S
N
K
Site 127
T965
A
F
R
P
T
G
W
T
H
S
N
K
F
T
R
Site 128
S985
P
Q
T
K
G
N
I
S
I
Y
G
I
P
Y
S
Site 129
Y987
T
K
G
N
I
S
I
Y
G
I
P
Y
S
E
H
Site 130
Y991
I
S
I
Y
G
I
P
Y
S
E
H
S
S
Y
L
Site 131
S992
S
I
Y
G
I
P
Y
S
E
H
S
S
Y
L
E
Site 132
S996
I
P
Y
S
E
H
S
S
Y
L
E
M
K
R
F
Site 133
Y997
P
Y
S
E
H
S
S
Y
L
E
M
K
R
F
V
Site 134
T1015
K
P
Q
K
I
I
P
T
V
N
V
G
T
W
K
Site 135
S1023
V
N
V
G
T
W
K
S
R
S
T
M
E
K
Y
Site 136
S1025
V
G
T
W
K
S
R
S
T
M
E
K
Y
F
R
Site 137
T1026
G
T
W
K
S
R
S
T
M
E
K
Y
F
R
E
Site 138
Y1030
S
R
S
T
M
E
K
Y
F
R
E
W
K
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation