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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RHBDL6
Full Name:
Rhomboid family member 2
Alias:
FLJ22341; RHBDL5; Rhomboid 5 2; Rhomboid 5 homolog 2; Rhomboid veinlet-like protein 5; Rhomboid veinlet-like protein 6
Type:
Membrane protein, integral
Mass (Da):
96668
Number AA:
856
UniProt ID:
Q6PJF5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0016020
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
A
D
K
N
G
G
S
V
S
S
V
S
S
S
Site 2
S12
D
K
N
G
G
S
V
S
S
V
S
S
S
R
L
Site 3
S13
K
N
G
G
S
V
S
S
V
S
S
S
R
L
Q
Site 4
S15
G
G
S
V
S
S
V
S
S
S
R
L
Q
S
R
Site 5
S16
G
S
V
S
S
V
S
S
S
R
L
Q
S
R
K
Site 6
S17
S
V
S
S
V
S
S
S
R
L
Q
S
R
K
P
Site 7
S21
V
S
S
S
R
L
Q
S
R
K
P
P
N
L
S
Site 8
S28
S
R
K
P
P
N
L
S
I
T
I
P
P
P
E
Site 9
T30
K
P
P
N
L
S
I
T
I
P
P
P
E
K
E
Site 10
T38
I
P
P
P
E
K
E
T
Q
A
P
G
E
Q
D
Site 11
S46
Q
A
P
G
E
Q
D
S
M
L
P
E
G
F
Q
Site 12
S60
Q
N
R
R
L
K
K
S
Q
P
R
T
W
A
A
Site 13
T64
L
K
K
S
Q
P
R
T
W
A
A
H
T
T
A
Site 14
T69
P
R
T
W
A
A
H
T
T
A
C
P
P
S
F
Site 15
T70
R
T
W
A
A
H
T
T
A
C
P
P
S
F
L
Site 16
S75
H
T
T
A
C
P
P
S
F
L
P
K
R
K
N
Site 17
Y85
P
K
R
K
N
P
A
Y
L
K
S
V
S
L
Q
Site 18
S88
K
N
P
A
Y
L
K
S
V
S
L
Q
E
P
R
Site 19
S90
P
A
Y
L
K
S
V
S
L
Q
E
P
R
S
R
Site 20
S96
V
S
L
Q
E
P
R
S
R
W
Q
E
S
S
E
Site 21
S101
P
R
S
R
W
Q
E
S
S
E
K
R
P
G
F
Site 22
S102
R
S
R
W
Q
E
S
S
E
K
R
P
G
F
R
Site 23
S113
P
G
F
R
R
Q
A
S
L
S
Q
S
I
R
K
Site 24
S115
F
R
R
Q
A
S
L
S
Q
S
I
R
K
G
A
Site 25
S117
R
Q
A
S
L
S
Q
S
I
R
K
G
A
A
Q
Site 26
S129
A
A
Q
W
F
G
V
S
G
D
W
E
G
Q
R
Site 27
S148
R
R
S
L
H
H
C
S
M
R
Y
G
R
L
K
Site 28
Y151
L
H
H
C
S
M
R
Y
G
R
L
K
A
S
C
Site 29
S157
R
Y
G
R
L
K
A
S
C
Q
R
D
L
E
L
Site 30
S166
Q
R
D
L
E
L
P
S
Q
E
A
P
S
F
Q
Site 31
S171
L
P
S
Q
E
A
P
S
F
Q
G
T
E
S
P
Site 32
T175
E
A
P
S
F
Q
G
T
E
S
P
K
P
C
K
Site 33
S177
P
S
F
Q
G
T
E
S
P
K
P
C
K
M
P
Site 34
S224
L
S
L
T
S
F
T
S
V
R
S
G
Y
S
H
Site 35
S227
T
S
F
T
S
V
R
S
G
Y
S
H
L
P
R
Site 36
Y229
F
T
S
V
R
S
G
Y
S
H
L
P
R
R
K
Site 37
S239
L
P
R
R
K
R
M
S
V
A
H
M
S
L
Q
Site 38
S276
K
R
S
F
A
F
P
S
F
L
E
E
D
V
V
Site 39
T288
D
V
V
D
G
A
D
T
F
D
S
S
F
F
S
Site 40
S291
D
G
A
D
T
F
D
S
S
F
F
S
K
E
E
Site 41
S292
G
A
D
T
F
D
S
S
F
F
S
K
E
E
M
Site 42
S295
T
F
D
S
S
F
F
S
K
E
E
M
S
S
M
Site 43
S300
F
F
S
K
E
E
M
S
S
M
P
D
D
V
F
Site 44
S301
F
S
K
E
E
M
S
S
M
P
D
D
V
F
E
Site 45
S309
M
P
D
D
V
F
E
S
P
P
L
S
A
S
Y
Site 46
S315
E
S
P
P
L
S
A
S
Y
F
R
G
I
P
H
Site 47
Y316
S
P
P
L
S
A
S
Y
F
R
G
I
P
H
S
Site 48
S323
Y
F
R
G
I
P
H
S
A
S
P
V
S
P
D
Site 49
S325
R
G
I
P
H
S
A
S
P
V
S
P
D
G
V
Site 50
S328
P
H
S
A
S
P
V
S
P
D
G
V
Q
I
P
Site 51
S355
R
R
G
K
R
I
A
S
K
V
K
H
F
A
F
Site 52
Y369
F
D
R
K
K
R
H
Y
G
L
G
V
V
G
N
Site 53
S381
V
G
N
W
L
N
R
S
Y
R
R
S
I
S
S
Site 54
Y382
G
N
W
L
N
R
S
Y
R
R
S
I
S
S
T
Site 55
S385
L
N
R
S
Y
R
R
S
I
S
S
T
V
Q
R
Site 56
S387
R
S
Y
R
R
S
I
S
S
T
V
Q
R
Q
L
Site 57
S388
S
Y
R
R
S
I
S
S
T
V
Q
R
Q
L
E
Site 58
T389
Y
R
R
S
I
S
S
T
V
Q
R
Q
L
E
S
Site 59
S396
T
V
Q
R
Q
L
E
S
F
D
S
H
R
P
Y
Site 60
S399
R
Q
L
E
S
F
D
S
H
R
P
Y
F
T
Y
Site 61
Y403
S
F
D
S
H
R
P
Y
F
T
Y
W
L
T
F
Site 62
Y446
V
L
R
N
K
G
V
Y
E
S
V
K
Y
I
Q
Site 63
S448
R
N
K
G
V
Y
E
S
V
K
Y
I
Q
Q
E
Site 64
Y451
G
V
Y
E
S
V
K
Y
I
Q
Q
E
N
F
W
Site 65
S474
I
H
L
G
A
K
F
S
P
C
I
R
K
D
G
Site 66
S497
E
R
D
L
E
R
D
S
G
C
C
V
Q
N
D
Site 67
T511
D
H
S
G
C
I
Q
T
Q
R
K
D
C
S
E
Site 68
T522
D
C
S
E
T
L
A
T
F
V
K
W
Q
D
D
Site 69
T530
F
V
K
W
Q
D
D
T
G
P
P
M
D
K
S
Site 70
S537
T
G
P
P
M
D
K
S
D
L
G
Q
K
R
T
Site 71
S545
D
L
G
Q
K
R
T
S
G
A
V
C
H
Q
D
Site 72
T555
V
C
H
Q
D
P
R
T
C
E
E
P
A
S
S
Site 73
S561
R
T
C
E
E
P
A
S
S
G
A
H
I
W
P
Site 74
S562
T
C
E
E
P
A
S
S
G
A
H
I
W
P
D
Site 75
S607
C
C
I
G
T
K
G
S
C
E
I
T
T
R
E
Site 76
T611
T
K
G
S
C
E
I
T
T
R
E
Y
C
E
F
Site 77
Y655
P
E
V
P
D
Q
F
Y
R
L
W
L
S
L
F
Site 78
S700
I
A
I
I
F
I
L
S
G
I
T
G
N
L
A
Site 79
T703
I
F
I
L
S
G
I
T
G
N
L
A
S
A
I
Site 80
S708
G
I
T
G
N
L
A
S
A
I
F
L
P
Y
R
Site 81
Y799
T
F
G
T
S
D
K
Y
R
K
R
A
L
I
L
Site 82
Y849
T
S
R
F
C
E
K
Y
E
L
D
Q
V
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation