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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXO46
Full Name:
F-box only protein 46
Alias:
20D7-FC4; F-box only protein 34-like; F-box protein 46; Fbx46; FBXO34L; FX46
Type:
Ubiquitin conjugating system
Mass (Da):
69031
Number AA:
646
UniProt ID:
Q6PJ61
International Prot ID:
IPI00419450
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
C
P
R
P
F
G
T
Y
S
Q
N
Q
P
R
P
Site 2
S21
P
R
P
F
G
T
Y
S
Q
N
Q
P
R
P
P
Site 3
S29
Q
N
Q
P
R
P
P
S
A
A
L
K
P
S
A
Site 4
S35
P
S
A
A
L
K
P
S
A
C
P
E
P
G
G
Site 5
S53
P
D
H
G
P
A
H
S
E
N
T
P
P
A
L
Site 6
T56
G
P
A
H
S
E
N
T
P
P
A
L
A
T
E
Site 7
T62
N
T
P
P
A
L
A
T
E
V
P
A
S
Q
P
Site 8
S74
S
Q
P
A
P
L
L
S
A
A
A
A
G
D
E
Site 9
T88
E
G
R
V
L
L
D
T
W
Y
V
I
K
P
G
Site 10
Y90
R
V
L
L
D
T
W
Y
V
I
K
P
G
N
T
Site 11
S113
A
H
Q
C
G
G
G
S
R
A
S
S
M
K
V
Site 12
S116
C
G
G
G
S
R
A
S
S
M
K
V
K
G
H
Site 13
S117
G
G
G
S
R
A
S
S
M
K
V
K
G
H
W
Site 14
S126
K
V
K
G
H
W
G
S
D
S
S
K
A
K
R
Site 15
S128
K
G
H
W
G
S
D
S
S
K
A
K
R
R
R
Site 16
S129
G
H
W
G
S
D
S
S
K
A
K
R
R
R
R
Site 17
T141
R
R
R
C
L
D
P
T
K
A
P
P
D
P
G
Site 18
S162
A
A
E
E
G
P
A
S
A
G
E
D
V
D
L
Site 19
S189
R
A
A
L
A
L
Q
S
Y
P
R
P
T
T
P
Site 20
Y190
A
A
L
A
L
Q
S
Y
P
R
P
T
T
P
A
Site 21
T194
L
Q
S
Y
P
R
P
T
T
P
A
P
V
V
F
Site 22
T195
Q
S
Y
P
R
P
T
T
P
A
P
V
V
F
V
Site 23
S215
G
P
A
K
G
V
G
S
E
R
R
S
G
G
G
Site 24
S219
G
V
G
S
E
R
R
S
G
G
G
D
C
S
R
Site 25
S225
R
S
G
G
G
D
C
S
R
V
A
E
A
V
A
Site 26
S240
H
F
E
A
Q
R
D
S
P
P
T
K
G
L
R
Site 27
S266
V
R
I
A
F
R
I
S
N
G
R
E
P
R
A
Site 28
S276
R
E
P
R
A
P
D
S
G
L
P
S
G
G
G
Site 29
S280
A
P
D
S
G
L
P
S
G
G
G
G
R
P
G
Site 30
Y290
G
G
R
P
G
C
A
Y
P
G
S
P
G
P
G
Site 31
S293
P
G
C
A
Y
P
G
S
P
G
P
G
A
R
A
Site 32
Y309
D
K
I
T
C
D
L
Y
Q
L
I
S
P
S
R
Site 33
S313
C
D
L
Y
Q
L
I
S
P
S
R
D
A
L
P
Site 34
S315
L
Y
Q
L
I
S
P
S
R
D
A
L
P
S
N
Site 35
S334
L
A
R
A
D
E
A
S
E
G
D
S
P
A
P
Site 36
S338
D
E
A
S
E
G
D
S
P
A
P
A
R
P
E
Site 37
T347
A
P
A
R
P
E
D
T
P
P
A
P
P
P
P
Site 38
T385
I
F
F
G
K
D
G
T
K
N
V
K
E
E
T
Site 39
T392
T
K
N
V
K
E
E
T
V
C
L
T
V
S
P
Site 40
T396
K
E
E
T
V
C
L
T
V
S
P
E
E
P
P
Site 41
S398
E
T
V
C
L
T
V
S
P
E
E
P
P
P
P
Site 42
S427
P
E
P
P
P
A
D
S
P
A
T
A
P
G
P
Site 43
T440
G
P
D
D
A
E
G
T
A
D
T
S
L
C
R
Site 44
S444
A
E
G
T
A
D
T
S
L
C
R
L
Y
R
H
Site 45
Y449
D
T
S
L
C
R
L
Y
R
H
V
S
H
D
F
Site 46
S453
C
R
L
Y
R
H
V
S
H
D
F
L
E
I
R
Site 47
Y472
R
L
L
E
P
R
Q
Y
M
L
L
L
P
E
H
Site 48
T515
E
A
F
G
V
R
A
T
D
S
R
W
S
R
D
Site 49
S517
F
G
V
R
A
T
D
S
R
W
S
R
D
P
L
Site 50
S520
R
A
T
D
S
R
W
S
R
D
P
L
Y
R
D
Site 51
Y525
R
W
S
R
D
P
L
Y
R
D
D
P
C
K
Q
Site 52
Y537
C
K
Q
C
R
K
R
Y
E
K
G
D
V
S
L
Site 53
T573
C
R
R
A
D
R
E
T
P
G
C
R
L
G
L
Site 54
S604
A
G
R
E
E
G
R
S
T
R
G
R
G
G
E
Site 55
T605
G
R
E
E
G
R
S
T
R
G
R
G
G
E
S
Site 56
S612
T
R
G
R
G
G
E
S
P
P
R
P
P
L
P
Site 57
S620
P
P
R
P
P
L
P
S
P
P
G
S
R
G
S
Site 58
S624
P
L
P
S
P
P
G
S
R
G
S
G
L
G
R
Site 59
S627
S
P
P
G
S
R
G
S
G
L
G
R
L
P
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation