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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DARS2
Full Name:
Aspartyl-tRNA synthetase, mitochondrial
Alias:
Aspartate--tRNA ligase
Type:
Mass (Da):
73545
Number AA:
645
UniProt ID:
Q6PI48
International Prot ID:
IPI00100460
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005739
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006139
GO:0006399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
Y
F
P
S
W
L
S
Q
L
Y
R
G
L
S
Site 2
Y11
P
S
W
L
S
Q
L
Y
R
G
L
S
R
P
I
Site 3
S15
S
Q
L
Y
R
G
L
S
R
P
I
R
R
T
T
Site 4
T21
L
S
R
P
I
R
R
T
T
Q
P
I
W
G
S
Site 5
T22
S
R
P
I
R
R
T
T
Q
P
I
W
G
S
L
Site 6
S28
T
T
Q
P
I
W
G
S
L
Y
R
S
L
L
Q
Site 7
Y30
Q
P
I
W
G
S
L
Y
R
S
L
L
Q
S
S
Site 8
S32
I
W
G
S
L
Y
R
S
L
L
Q
S
S
Q
R
Site 9
S36
L
Y
R
S
L
L
Q
S
S
Q
R
R
I
P
E
Site 10
S37
Y
R
S
L
L
Q
S
S
Q
R
R
I
P
E
F
Site 11
S45
Q
R
R
I
P
E
F
S
S
F
V
V
R
T
N
Site 12
S46
R
R
I
P
E
F
S
S
F
V
V
R
T
N
T
Site 13
T53
S
F
V
V
R
T
N
T
C
G
E
L
R
S
S
Site 14
S60
T
C
G
E
L
R
S
S
H
L
G
Q
E
V
T
Site 15
T79
I
Q
Y
R
R
Q
N
T
F
L
V
L
R
D
F
Site 16
S102
P
Q
D
E
S
A
A
S
V
K
K
I
L
C
E
Site 17
T166
I
K
N
F
V
K
K
T
E
A
L
R
L
Q
Y
Site 18
Y173
T
E
A
L
R
L
Q
Y
R
Y
L
D
L
R
S
Site 19
Y175
A
L
R
L
Q
Y
R
Y
L
D
L
R
S
F
Q
Site 20
Y185
L
R
S
F
Q
M
Q
Y
N
L
R
L
R
S
Q
Site 21
T212
H
G
F
V
D
I
E
T
P
T
L
F
K
R
T
Site 22
T219
T
P
T
L
F
K
R
T
P
G
G
A
K
E
F
Site 23
S230
A
K
E
F
L
V
P
S
R
E
P
G
K
F
Y
Site 24
Y237
S
R
E
P
G
K
F
Y
S
L
P
Q
S
P
Q
Site 25
S238
R
E
P
G
K
F
Y
S
L
P
Q
S
P
Q
Q
Site 26
S242
K
F
Y
S
L
P
Q
S
P
Q
Q
F
K
Q
L
Site 27
Y265
Y
F
Q
V
A
R
C
Y
R
D
E
G
S
R
P
Site 28
T279
P
D
R
Q
P
E
F
T
Q
I
D
I
E
M
S
Site 29
T291
E
M
S
F
V
D
Q
T
G
I
Q
S
L
I
E
Site 30
Y303
L
I
E
G
L
L
Q
Y
S
W
P
N
D
K
D
Site 31
T330
E
V
L
A
T
Y
G
T
D
K
P
D
T
R
F
Site 32
T335
Y
G
T
D
K
P
D
T
R
F
G
M
K
I
I
Site 33
S345
G
M
K
I
I
D
I
S
D
V
F
R
N
T
E
Site 34
T351
I
S
D
V
F
R
N
T
E
I
G
F
L
Q
D
Site 35
S361
G
F
L
Q
D
A
L
S
K
P
H
G
T
V
K
Site 36
Y378
C
I
P
E
G
A
K
Y
L
K
R
K
D
I
E
Site 37
S386
L
K
R
K
D
I
E
S
I
R
N
F
A
A
D
Site 38
S450
G
E
H
N
K
A
C
S
L
L
G
K
L
R
L
Site 39
T505
E
S
A
H
H
P
F
T
A
P
H
P
S
D
I
Site 40
S510
P
F
T
A
P
H
P
S
D
I
H
L
L
Y
T
Site 41
Y516
P
S
D
I
H
L
L
Y
T
E
P
K
K
A
R
Site 42
T517
S
D
I
H
L
L
Y
T
E
P
K
K
A
R
S
Site 43
S524
T
E
P
K
K
A
R
S
Q
H
Y
D
L
V
L
Site 44
S540
G
N
E
I
G
G
G
S
I
R
I
H
N
A
E
Site 45
Y551
H
N
A
E
L
Q
R
Y
I
L
A
T
L
L
K
Site 46
Y573
H
L
L
Q
A
L
D
Y
G
A
P
P
H
G
G
Site 47
S607
D
V
I
A
F
P
K
S
F
R
G
H
D
L
M
Site 48
S615
F
R
G
H
D
L
M
S
N
T
P
D
S
V
P
Site 49
T617
G
H
D
L
M
S
N
T
P
D
S
V
P
P
E
Site 50
S620
L
M
S
N
T
P
D
S
V
P
P
E
E
L
K
Site 51
Y629
P
P
E
E
L
K
P
Y
H
I
R
V
S
K
P
Site 52
S634
K
P
Y
H
I
R
V
S
K
P
T
D
S
K
A
Site 53
T637
H
I
R
V
S
K
P
T
D
S
K
A
E
R
A
Site 54
S639
R
V
S
K
P
T
D
S
K
A
E
R
A
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation