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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0372
Full Name:
Tetratricopeptide repeat protein 37
Alias:
Tetratricopeptide repeat domain 37; TPR repeat protein 37; TTC37
Type:
Unknown function
Mass (Da):
175486
Number AA:
1564
UniProt ID:
Q6PGP7
International Prot ID:
IPI00005634
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
S
K
E
V
K
T
A
L
K
S
A
R
D
Site 2
S12
E
V
K
T
A
L
K
S
A
R
D
A
I
R
N
Site 3
T31
E
A
L
K
H
C
K
T
V
L
K
Q
E
K
N
Site 4
Y40
L
K
Q
E
K
N
N
Y
N
A
W
V
F
I
G
Site 5
Y84
W
Q
G
L
A
N
L
Y
E
K
Y
N
H
I
N
Site 6
Y107
Y
Q
K
L
L
D
L
Y
E
S
V
D
K
Q
K
Site 7
S109
K
L
L
D
L
Y
E
S
V
D
K
Q
K
W
C
Site 8
Y126
C
K
K
L
V
D
L
Y
Y
Q
E
K
K
H
L
Site 9
Y127
K
K
L
V
D
L
Y
Y
Q
E
K
K
H
L
E
Site 10
T138
K
H
L
E
V
A
R
T
W
H
K
L
I
K
T
Site 11
T164
H
Q
L
W
R
K
L
T
Q
F
L
A
E
S
T
Site 12
S193
F
E
N
A
L
G
L
S
D
K
I
P
S
E
D
Site 13
Y205
S
E
D
H
Q
V
L
Y
R
H
F
I
Q
S
L
Site 14
S211
L
Y
R
H
F
I
Q
S
L
S
K
F
P
H
E
Site 15
S213
R
H
F
I
Q
S
L
S
K
F
P
H
E
S
A
Site 16
S219
L
S
K
F
P
H
E
S
A
R
L
K
K
A
C
Site 17
T254
L
I
E
S
G
N
L
T
D
E
G
Q
Q
Y
C
Site 18
Y260
L
T
D
E
G
Q
Q
Y
C
C
R
L
V
E
M
Site 19
S269
C
R
L
V
E
M
D
S
K
S
G
P
G
L
I
Site 20
Y288
K
A
L
Q
D
K
K
Y
E
D
A
V
R
N
L
Site 21
T296
E
D
A
V
R
N
L
T
E
G
L
K
E
S
P
Site 22
S302
L
T
E
G
L
K
E
S
P
V
C
T
S
G
W
Site 23
S328
R
P
K
E
A
V
L
S
C
S
Q
A
L
K
I
Site 24
Y347
G
A
S
G
N
S
L
Y
Q
R
N
L
C
L
H
Site 25
S364
A
E
A
L
I
K
L
S
D
Y
D
S
S
E
E
Site 26
Y366
A
L
I
K
L
S
D
Y
D
S
S
E
E
A
I
Site 27
S368
I
K
L
S
D
Y
D
S
S
E
E
A
I
R
T
Site 28
S369
K
L
S
D
Y
D
S
S
E
E
A
I
R
T
L
Site 29
T375
S
S
E
E
A
I
R
T
L
D
Q
I
S
D
A
Site 30
S380
I
R
T
L
D
Q
I
S
D
A
D
N
I
P
G
Site 31
S393
P
G
L
L
V
L
K
S
L
A
Y
R
N
K
G
Site 32
Y396
L
V
L
K
S
L
A
Y
R
N
K
G
S
F
D
Site 33
S401
L
A
Y
R
N
K
G
S
F
D
E
A
A
K
I
Site 34
S414
K
I
M
E
D
L
L
S
S
Y
P
D
L
A
E
Site 35
Y416
M
E
D
L
L
S
S
Y
P
D
L
A
E
V
H
Site 36
Y436
I
H
F
T
K
K
D
Y
L
Q
A
E
K
C
F
Site 37
T451
Q
R
A
L
E
K
D
T
E
V
A
E
Y
H
Y
Site 38
Y456
K
D
T
E
V
A
E
Y
H
Y
Q
L
G
L
T
Site 39
Y458
T
E
V
A
E
Y
H
Y
Q
L
G
L
T
Y
W
Site 40
Y464
H
Y
Q
L
G
L
T
Y
W
F
M
G
E
E
T
Site 41
T476
E
E
T
R
K
D
K
T
K
A
L
T
H
F
L
Site 42
Y491
K
A
A
R
L
D
T
Y
M
G
K
V
F
C
Y
Site 43
Y503
F
C
Y
L
G
H
Y
Y
R
D
V
V
G
D
K
Site 44
Y517
K
N
R
A
R
G
C
Y
R
K
A
F
E
L
D
Site 45
T526
K
A
F
E
L
D
D
T
D
A
E
S
G
A
A
Site 46
Y573
A
W
L
R
R
G
L
Y
Y
L
K
A
G
Q
H
Site 47
Y574
W
L
R
R
G
L
Y
Y
L
K
A
G
Q
H
S
Site 48
Y608
W
E
S
L
G
E
A
Y
L
S
R
G
G
Y
T
Site 49
S610
S
L
G
E
A
Y
L
S
R
G
G
Y
T
T
A
Site 50
Y614
A
Y
L
S
R
G
G
Y
T
T
A
L
K
S
F
Site 51
T616
L
S
R
G
G
Y
T
T
A
L
K
S
F
T
K
Site 52
S620
G
Y
T
T
A
L
K
S
F
T
K
A
S
E
L
Site 53
S631
A
S
E
L
N
P
E
S
I
Y
S
V
F
K
V
Site 54
Y648
I
Q
Q
I
L
G
K
Y
K
E
A
V
A
Q
Y
Site 55
Y665
I
I
K
K
K
E
D
Y
V
P
A
L
K
G
L
Site 56
Y695
L
D
G
K
A
V
D
Y
I
E
K
A
L
E
Y
Site 57
Y702
Y
I
E
K
A
L
E
Y
F
T
C
A
L
Q
H
Site 58
S714
L
Q
H
R
A
D
V
S
C
L
W
K
L
A
G
Site 59
S798
Q
H
L
A
E
T
G
S
N
M
N
D
L
K
E
Site 60
S810
L
K
E
L
L
E
K
S
L
H
C
L
K
K
A
Site 61
Y827
L
D
S
N
N
H
L
Y
W
N
A
L
G
V
V
Site 62
Y871
W
T
N
L
G
V
L
Y
L
T
N
E
N
I
E
Site 63
S889
E
A
F
K
M
A
Q
S
L
D
P
S
Y
L
M
Site 64
Y894
A
Q
S
L
D
P
S
Y
L
M
C
W
I
G
Q
Site 65
T920
T
M
D
L
F
R
H
T
T
E
L
N
M
H
T
Site 66
S945
C
T
T
L
Q
D
K
S
N
R
E
T
E
L
Y
Site 67
T949
Q
D
K
S
N
R
E
T
E
L
Y
Q
Y
N
I
Site 68
Y952
S
N
R
E
T
E
L
Y
Q
Y
N
I
L
Q
M
Site 69
Y954
R
E
T
E
L
Y
Q
Y
N
I
L
Q
M
N
A
Site 70
Y972
A
Q
V
I
L
N
K
Y
V
E
R
I
Q
N
Y
Site 71
Y979
Y
V
E
R
I
Q
N
Y
A
P
A
F
T
M
L
Site 72
Y988
P
A
F
T
M
L
G
Y
L
N
E
H
L
Q
L
Site 73
Y1003
K
K
E
A
A
N
A
Y
Q
R
A
I
L
L
L
Site 74
T1018
Q
T
A
E
D
Q
D
T
Y
N
V
A
I
R
N
Site 75
Y1019
T
A
E
D
Q
D
T
Y
N
V
A
I
R
N
Y
Site 76
Y1026
Y
N
V
A
I
R
N
Y
G
R
L
L
C
S
T
Site 77
T1033
Y
G
R
L
L
C
S
T
G
E
Y
D
K
A
I
Site 78
S1045
K
A
I
Q
A
F
K
S
T
P
L
E
V
L
E
Site 79
Y1067
A
L
F
M
K
G
L
Y
K
E
S
S
K
A
Y
Site 80
S1071
K
G
L
Y
K
E
S
S
K
A
Y
E
R
A
L
Site 81
Y1074
Y
K
E
S
S
K
A
Y
E
R
A
L
S
I
V
Site 82
S1079
K
A
Y
E
R
A
L
S
I
V
E
S
E
Q
D
Site 83
S1083
R
A
L
S
I
V
E
S
E
Q
D
K
A
H
I
Site 84
T1104
T
E
Y
K
Q
G
K
T
D
V
A
K
T
L
L
Site 85
T1122
S
I
L
K
E
P
T
T
E
S
L
Q
A
L
C
Site 86
T1139
G
L
A
M
Q
D
A
T
L
S
K
A
A
L
N
Site 87
S1141
A
M
Q
D
A
T
L
S
K
A
A
L
N
E
L
Site 88
Y1159
I
K
H
K
D
S
N
Y
Q
R
C
L
L
T
S
Site 89
Y1169
C
L
L
T
S
A
I
Y
A
L
Q
G
R
S
V
Site 90
S1188
Q
I
S
K
A
V
H
S
N
P
G
D
P
A
L
Site 91
Y1206
L
S
R
V
V
A
Q
Y
A
Q
R
N
A
K
G
Site 92
S1226
N
V
A
H
I
L
D
S
N
H
G
K
K
A
L
Site 93
Y1235
H
G
K
K
A
L
L
Y
T
A
V
N
Q
L
A
Site 94
T1254
S
A
E
D
E
K
N
T
A
L
K
T
I
Q
K
Site 95
Y1320
D
E
K
F
F
E
N
Y
N
Q
S
L
E
K
W
Site 96
S1323
F
F
E
N
Y
N
Q
S
L
E
K
W
S
L
S
Site 97
S1328
N
Q
S
L
E
K
W
S
L
S
Q
A
V
T
G
Site 98
T1334
W
S
L
S
Q
A
V
T
G
L
I
D
T
G
R
Site 99
T1347
G
R
I
S
E
A
E
T
L
C
T
K
N
L
K
Site 100
T1350
S
E
A
E
T
L
C
T
K
N
L
K
S
N
P
Site 101
S1355
L
C
T
K
N
L
K
S
N
P
D
Q
P
A
V
Site 102
S1377
Q
C
K
P
L
L
E
S
Q
K
P
L
P
D
A
Site 103
T1392
V
L
E
E
L
Q
K
T
V
M
S
N
S
T
S
Site 104
S1395
E
L
Q
K
T
V
M
S
N
S
T
S
V
P
A
Site 105
S1426
A
E
M
C
Y
R
K
S
L
Q
L
A
S
Q
R
Site 106
S1431
R
K
S
L
Q
L
A
S
Q
R
G
S
W
S
G
Site 107
S1435
Q
L
A
S
Q
R
G
S
W
S
G
K
L
S
S
Site 108
S1437
A
S
Q
R
G
S
W
S
G
K
L
S
S
L
L
Site 109
S1465
I
S
N
D
H
W
P
S
L
V
Q
E
A
T
T
Site 110
T1501
R
K
M
G
A
R
E
T
R
R
L
L
E
R
V
Site 111
Y1510
R
L
L
E
R
V
V
Y
Q
P
G
Y
P
K
S
Site 112
Y1514
R
V
V
Y
Q
P
G
Y
P
K
S
I
A
S
T
Site 113
S1517
Y
Q
P
G
Y
P
K
S
I
A
S
T
A
R
W
Site 114
S1520
G
Y
P
K
S
I
A
S
T
A
R
W
Y
L
L
Site 115
T1521
Y
P
K
S
I
A
S
T
A
R
W
Y
L
L
R
Site 116
Y1531
W
Y
L
L
R
H
L
Y
A
K
D
D
Y
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation