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Updated November 2019
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Protein Info
Short Name:
NFRKB
Full Name:
Nuclear factor related to kappa-B-binding protein
Alias:
DNA-binding protein R kappa-B;INO80 complex subunit G
Type:
Mass (Da):
141860
Number AA:
1324
UniProt ID:
Q6P4R8
International Prot ID:
IPI00006171
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003704
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
S
L
D
H
M
L
T
D
P
L
E
L
G
P
Site 2
S63
S
T
W
Q
E
V
L
S
D
S
Q
R
E
H
L
Site 3
S65
W
Q
E
V
L
S
D
S
Q
R
E
H
L
Q
Q
Site 4
S81
L
P
Q
F
P
E
D
S
A
E
Q
Q
N
E
L
Site 5
Y123
F
N
P
E
V
V
K
Y
R
Q
L
C
F
K
S
Site 6
Y132
Q
L
C
F
K
S
Q
Y
K
R
Y
L
N
S
Q
Site 7
Y135
F
K
S
Q
Y
K
R
Y
L
N
S
Q
Q
Q
Y
Site 8
Y142
Y
L
N
S
Q
Q
Q
Y
F
H
R
L
L
K
Q
Site 9
S155
K
Q
I
L
A
S
R
S
D
L
L
E
M
A
R
Site 10
S164
L
L
E
M
A
R
R
S
G
P
A
L
P
F
R
Site 11
S176
P
F
R
Q
K
R
P
S
P
S
R
T
P
E
E
Site 12
S178
R
Q
K
R
P
S
P
S
R
T
P
E
E
R
E
Site 13
T180
K
R
P
S
P
S
R
T
P
E
E
R
E
W
R
Site 14
Y192
E
W
R
T
Q
Q
R
Y
L
K
V
L
R
E
V
Site 15
T206
V
K
E
E
C
G
D
T
A
L
S
S
D
E
E
Site 16
S209
E
C
G
D
T
A
L
S
S
D
E
E
D
L
S
Site 17
S210
C
G
D
T
A
L
S
S
D
E
E
D
L
S
S
Site 18
S216
S
S
D
E
E
D
L
S
S
W
L
P
S
S
P
Site 19
S217
S
D
E
E
D
L
S
S
W
L
P
S
S
P
A
Site 20
S221
D
L
S
S
W
L
P
S
S
P
A
R
S
P
S
Site 21
S222
L
S
S
W
L
P
S
S
P
A
R
S
P
S
P
Site 22
S226
L
P
S
S
P
A
R
S
P
S
P
A
V
P
L
Site 23
S228
S
S
P
A
R
S
P
S
P
A
V
P
L
R
V
Site 24
T246
L
S
T
T
D
M
K
T
A
D
K
V
E
L
G
Site 25
S255
D
K
V
E
L
G
D
S
D
L
K
I
M
L
K
Site 26
T279
P
D
H
P
D
L
L
T
G
D
L
T
L
N
D
Site 27
T289
L
T
L
N
D
I
M
T
R
V
N
A
G
R
K
Site 28
S298
V
N
A
G
R
K
G
S
L
A
A
L
Y
D
L
Site 29
T325
K
K
K
K
K
I
K
T
I
K
S
E
A
E
D
Site 30
S328
K
K
I
K
T
I
K
S
E
A
E
D
L
A
E
Site 31
S338
E
D
L
A
E
P
L
S
S
T
E
G
V
A
P
Site 32
S351
A
P
L
S
Q
A
P
S
P
L
A
I
P
A
I
Site 33
S376
C
L
G
I
N
E
I
S
S
S
F
F
S
L
L
Site 34
S394
L
L
L
E
S
Q
A
S
L
P
M
L
E
E
R
Site 35
S407
E
R
V
L
D
W
Q
S
S
P
A
S
S
L
N
Site 36
S408
R
V
L
D
W
Q
S
S
P
A
S
S
L
N
S
Site 37
S411
D
W
Q
S
S
P
A
S
S
L
N
S
W
F
S
Site 38
S412
W
Q
S
S
P
A
S
S
L
N
S
W
F
S
A
Site 39
S415
S
P
A
S
S
L
N
S
W
F
S
A
A
P
N
Site 40
S418
S
S
L
N
S
W
F
S
A
A
P
N
W
A
E
Site 41
S444
E
S
R
A
V
P
S
S
F
S
P
F
V
E
F
Site 42
S446
R
A
V
P
S
S
F
S
P
F
V
E
F
K
E
Site 43
T455
F
V
E
F
K
E
K
T
Q
Q
W
K
L
L
G
Site 44
S494
C
K
Q
E
N
E
D
S
S
D
A
T
T
P
V
Site 45
S495
K
Q
E
N
E
D
S
S
D
A
T
T
P
V
P
Site 46
T498
N
E
D
S
S
D
A
T
T
P
V
P
R
V
R
Site 47
T499
E
D
S
S
D
A
T
T
P
V
P
R
V
R
T
Site 48
T506
T
P
V
P
R
V
R
T
D
Y
V
V
R
P
S
Site 49
Y508
V
P
R
V
R
T
D
Y
V
V
R
P
S
T
G
Site 50
S513
T
D
Y
V
V
R
P
S
T
G
E
E
K
R
V
Site 51
T514
D
Y
V
V
R
P
S
T
G
E
E
K
R
V
F
Site 52
Y527
V
F
Q
E
Q
E
R
Y
R
Y
S
Q
P
H
K
Site 53
Y529
Q
E
Q
E
R
Y
R
Y
S
Q
P
H
K
A
F
Site 54
S530
E
Q
E
R
Y
R
Y
S
Q
P
H
K
A
F
T
Site 55
S559
G
V
F
D
K
E
T
S
L
N
K
A
R
E
H
Site 56
S567
L
N
K
A
R
E
H
S
L
L
R
S
D
R
P
Site 57
S571
R
E
H
S
L
L
R
S
D
R
P
A
Y
V
T
Site 58
T578
S
D
R
P
A
Y
V
T
I
L
S
L
V
R
D
Site 59
Y632
G
A
L
D
R
L
H
Y
E
K
D
P
C
V
K
Site 60
Y640
E
K
D
P
C
V
K
Y
D
I
G
R
K
L
W
Site 61
Y649
I
G
R
K
L
W
I
Y
L
H
R
D
R
S
E
Site 62
S655
I
Y
L
H
R
D
R
S
E
E
E
F
E
R
I
Site 63
S684
Q
Q
K
P
K
P
P
S
K
V
K
S
S
S
K
Site 64
S688
K
P
P
S
K
V
K
S
S
S
K
E
S
S
I
Site 65
S689
P
P
S
K
V
K
S
S
S
K
E
S
S
I
K
Site 66
S690
P
S
K
V
K
S
S
S
K
E
S
S
I
K
V
Site 67
S693
V
K
S
S
S
K
E
S
S
I
K
V
L
S
S
Site 68
S694
K
S
S
S
K
E
S
S
I
K
V
L
S
S
G
Site 69
S699
E
S
S
I
K
V
L
S
S
G
P
S
E
Q
S
Site 70
S700
S
S
I
K
V
L
S
S
G
P
S
E
Q
S
Q
Site 71
S703
K
V
L
S
S
G
P
S
E
Q
S
Q
M
S
L
Site 72
S706
S
S
G
P
S
E
Q
S
Q
M
S
L
S
D
S
Site 73
S709
P
S
E
Q
S
Q
M
S
L
S
D
S
S
M
P
Site 74
S711
E
Q
S
Q
M
S
L
S
D
S
S
M
P
P
T
Site 75
S713
S
Q
M
S
L
S
D
S
S
M
P
P
T
P
V
Site 76
S714
Q
M
S
L
S
D
S
S
M
P
P
T
P
V
T
Site 77
T718
S
D
S
S
M
P
P
T
P
V
T
P
V
T
P
Site 78
T721
S
M
P
P
T
P
V
T
P
V
T
P
T
T
P
Site 79
S741
P
I
S
P
P
P
V
S
A
V
N
K
S
G
P
Site 80
S746
P
V
S
A
V
N
K
S
G
P
S
T
V
S
E
Site 81
S749
A
V
N
K
S
G
P
S
T
V
S
E
P
A
K
Site 82
T750
V
N
K
S
G
P
S
T
V
S
E
P
A
K
S
Site 83
S752
K
S
G
P
S
T
V
S
E
P
A
K
S
S
S
Site 84
S759
S
E
P
A
K
S
S
S
G
V
L
L
V
S
S
Site 85
T768
V
L
L
V
S
S
P
T
M
P
H
L
G
T
M
Site 86
S777
P
H
L
G
T
M
L
S
P
A
S
S
Q
T
A
Site 87
S780
G
T
M
L
S
P
A
S
S
Q
T
A
P
S
S
Site 88
S781
T
M
L
S
P
A
S
S
Q
T
A
P
S
S
Q
Site 89
T783
L
S
P
A
S
S
Q
T
A
P
S
S
Q
A
A
Site 90
S787
S
S
Q
T
A
P
S
S
Q
A
A
A
R
V
V
Site 91
S797
A
A
R
V
V
S
H
S
G
S
A
G
L
S
Q
Site 92
S799
R
V
V
S
H
S
G
S
A
G
L
S
Q
V
R
Site 93
S803
H
S
G
S
A
G
L
S
Q
V
R
V
V
A
Q
Site 94
T826
Q
S
G
G
P
A
Q
T
L
P
Q
M
P
A
G
Site 95
T866
K
A
Q
T
T
A
A
T
V
Q
R
P
G
P
G
Site 96
T885
T
V
T
S
L
P
A
T
A
S
P
V
S
K
P
Site 97
S887
T
S
L
P
A
T
A
S
P
V
S
K
P
A
T
Site 98
S890
P
A
T
A
S
P
V
S
K
P
A
T
S
S
P
Site 99
T894
S
P
V
S
K
P
A
T
S
S
P
G
T
S
A
Site 100
S895
P
V
S
K
P
A
T
S
S
P
G
T
S
A
P
Site 101
S896
V
S
K
P
A
T
S
S
P
G
T
S
A
P
S
Site 102
T899
P
A
T
S
S
P
G
T
S
A
P
S
A
S
T
Site 103
S900
A
T
S
S
P
G
T
S
A
P
S
A
S
T
A
Site 104
T934
Q
L
G
V
K
P
Q
T
G
N
S
I
P
L
T
Site 105
T941
T
G
N
S
I
P
L
T
A
T
N
F
R
I
Q
Site 106
S958
D
V
L
R
L
P
P
S
S
I
T
T
D
A
K
Site 107
S959
V
L
R
L
P
P
S
S
I
T
T
D
A
K
G
Site 108
T962
L
P
P
S
S
I
T
T
D
A
K
G
Q
T
V
Site 109
T987
L
A
K
S
Q
V
T
T
V
K
L
T
Q
D
L
Site 110
T1009
T
G
K
G
I
S
A
T
L
H
V
T
S
N
P
Site 111
S1022
N
P
V
H
A
A
D
S
P
A
K
A
S
S
A
Site 112
S1027
A
D
S
P
A
K
A
S
S
A
S
A
P
S
S
Site 113
S1028
D
S
P
A
K
A
S
S
A
S
A
P
S
S
T
Site 114
S1030
P
A
K
A
S
S
A
S
A
P
S
S
T
P
T
Site 115
S1033
A
S
S
A
S
A
P
S
S
T
P
T
G
T
T
Site 116
S1034
S
S
A
S
A
P
S
S
T
P
T
G
T
T
V
Site 117
T1035
S
A
S
A
P
S
S
T
P
T
G
T
T
V
V
Site 118
T1037
S
A
P
S
S
T
P
T
G
T
T
V
V
K
V
Site 119
T1039
P
S
S
T
P
T
G
T
T
V
V
K
V
T
P
Site 120
T1040
S
S
T
P
T
G
T
T
V
V
K
V
T
P
D
Site 121
T1045
G
T
T
V
V
K
V
T
P
D
L
K
P
T
E
Site 122
T1051
V
T
P
D
L
K
P
T
E
A
S
S
S
A
F
Site 123
S1055
L
K
P
T
E
A
S
S
S
A
F
R
L
M
P
Site 124
S1056
K
P
T
E
A
S
S
S
A
F
R
L
M
P
A
Site 125
S1075
V
A
D
Q
K
G
K
S
T
V
A
S
S
E
A
Site 126
T1076
A
D
Q
K
G
K
S
T
V
A
S
S
E
A
K
Site 127
S1079
K
G
K
S
T
V
A
S
S
E
A
K
P
A
A
Site 128
T1106
P
K
A
G
Q
T
I
T
V
A
T
H
A
K
Q
Site 129
S1116
T
H
A
K
Q
G
A
S
V
A
S
G
S
G
T
Site 130
S1119
K
Q
G
A
S
V
A
S
G
S
G
T
V
H
T
Site 131
T1126
S
G
S
G
T
V
H
T
S
A
V
S
L
P
S
Site 132
T1170
R
Q
V
P
V
S
T
T
V
V
S
T
S
Q
A
Site 133
S1175
S
T
T
V
V
S
T
S
Q
A
G
K
L
P
T
Site 134
S1192
T
V
P
L
S
V
I
S
Q
P
M
K
G
K
S
Site 135
T1230
L
T
T
M
P
A
G
T
K
L
I
A
G
N
K
Site 136
T1263
A
T
Q
V
R
I
Q
T
V
P
A
S
H
L
Q
Site 137
S1267
R
I
Q
T
V
P
A
S
H
L
Q
Q
G
T
A
Site 138
T1273
A
S
H
L
Q
Q
G
T
A
S
G
S
S
K
A
Site 139
S1275
H
L
Q
Q
G
T
A
S
G
S
S
K
A
V
S
Site 140
S1277
Q
Q
G
T
A
S
G
S
S
K
A
V
S
T
V
Site 141
S1278
Q
G
T
A
S
G
S
S
K
A
V
S
T
V
V
Site 142
S1291
V
V
V
T
T
A
P
S
P
K
Q
A
P
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation