PhosphoNET

           
Protein Info 
   
Short Name:  CASC4
Full Name:  Protein CASC4
Alias:  Cancer susceptibility candidate 4; DKFZp459F1927; H63; MGC74708; UNQ2573/PRO6308
Type: 
Mass (Da):  48864
Number AA:  433
UniProt ID:  Q6P4E1
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021  GO:0016021  GO:0031224 Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S68GRLEKRNSDLLLLVD
Site 2T76DLLLLVDTHKKQIDQ
Site 3Y88IDQKEADYGRLSSRL
Site 4S92EADYGRLSSRLQARE
Site 5S93ADYGRLSSRLQAREG
Site 6Y147QEDQLQDYRKNNTYL
Site 7Y153DYRKNNTYLVKRLEY
Site 8Y160YLVKRLEYESFQCGQ
Site 9S233DKNEEPSSNHIPHGK
Site 10S275ALRKPPISVSQHESH
Site 11S277RKPPISVSQHESHQA
Site 12S281ISVSQHESHQAISHL
Site 13T290QAISHLPTGQPLSPN
Site 14S295LPTGQPLSPNMPPDS
Site 15S313HNGNPGTSKQNPSSP
Site 16S319TSKQNPSSPLQRLIP
Site 17S328LQRLIPGSNLDSEPR
Site 18S332IPGSNLDSEPRIQTD
Site 19T338DSEPRIQTDILKQAT
Site 20S350QATKDRVSDFHKLKQ
Site 21S366RFFDENESPVDPQHG
Site 22S374PVDPQHGSKLADYNG
Site 23Y379HGSKLADYNGDDGNV
Site 24Y389DDGNVGEYEADKQAE
Site 25T424GPGLHAITMKPTSKF
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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