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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GNN
Full Name:
Tetratricopeptide repeat protein GNN
Alias:
Grp94-neighboring nucleotidase
Type:
Mass (Da):
151684
Number AA:
1318
UniProt ID:
Q6P2S7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
N
E
N
V
E
R
Y
T
Q
F
L
Q
K
P
Q
Site 2
Y26
P
Q
K
P
I
Q
P
Y
I
C
S
T
L
N
D
Site 3
T30
I
Q
P
Y
I
C
S
T
L
N
D
F
Q
E
E
Site 4
S75
S
A
L
K
A
P
K
S
L
P
T
H
L
F
R
Site 5
Y84
P
T
H
L
F
R
Q
Y
S
C
L
R
S
Q
R
Site 6
S85
T
H
L
F
R
Q
Y
S
C
L
R
S
Q
R
L
Site 7
S89
R
Q
Y
S
C
L
R
S
Q
R
L
K
L
C
L
Site 8
Y121
Y
G
D
F
L
P
D
Y
S
H
F
M
T
S
K
Site 9
T126
P
D
Y
S
H
F
M
T
S
K
V
T
R
L
S
Site 10
S127
D
Y
S
H
F
M
T
S
K
V
T
R
L
S
S
Site 11
S133
T
S
K
V
T
R
L
S
S
L
S
K
V
E
N
Site 12
S134
S
K
V
T
R
L
S
S
L
S
K
V
E
N
L
Site 13
Y142
L
S
K
V
E
N
L
Y
V
A
A
K
N
G
Y
Site 14
Y149
Y
V
A
A
K
N
G
Y
P
W
V
L
E
N
P
Site 15
T161
E
N
P
S
C
S
L
T
E
F
E
I
I
Q
A
Site 16
Y178
L
N
E
S
Q
F
Q
Y
F
Y
F
R
T
G
T
Site 17
Y180
E
S
Q
F
Q
Y
F
Y
F
R
T
G
T
T
L
Site 18
S202
K
K
G
E
R
L
P
S
S
S
S
T
N
E
E
Site 19
S203
K
G
E
R
L
P
S
S
S
S
T
N
E
E
E
Site 20
S204
G
E
R
L
P
S
S
S
S
T
N
E
E
E
T
Site 21
S205
E
R
L
P
S
S
S
S
T
N
E
E
E
T
L
Site 22
T206
R
L
P
S
S
S
S
T
N
E
E
E
T
L
R
Site 23
T211
S
S
T
N
E
E
E
T
L
R
I
G
K
L
K
Site 24
Y231
K
G
L
P
V
R
F
Y
S
D
L
H
E
L
G
Site 25
S232
G
L
P
V
R
F
Y
S
D
L
H
E
L
G
E
Site 26
Y264
L
M
I
E
N
I
D
Y
K
H
S
F
E
R
F
Site 27
Y272
K
H
S
F
E
R
F
Y
H
E
E
F
T
E
K
Site 28
T293
I
S
K
E
S
D
R
T
F
E
I
L
E
K
F
Site 29
S316
F
N
N
V
A
A
D
S
S
L
D
S
V
P
R
Site 30
S317
N
N
V
A
A
D
S
S
L
D
S
V
P
R
F
Site 31
S320
A
A
D
S
S
L
D
S
V
P
R
F
F
R
I
Site 32
T330
R
F
F
R
I
N
P
T
P
T
Y
K
S
I
L
Site 33
Y333
R
I
N
P
T
P
T
Y
K
S
I
L
L
L
S
Site 34
S335
N
P
T
P
T
Y
K
S
I
L
L
L
S
R
E
Site 35
S340
Y
K
S
I
L
L
L
S
R
E
H
G
C
G
K
Site 36
Y357
L
I
A
N
W
V
N
Y
F
K
K
K
H
P
S
Site 37
Y397
T
E
L
Q
Y
R
N
Y
G
T
Q
L
E
T
D
Site 38
S410
T
D
I
L
N
E
D
S
D
G
L
V
F
S
F
Site 39
S456
G
Q
K
V
K
D
F
S
W
L
P
H
S
L
S
Site 40
S474
K
F
I
M
S
T
V
S
S
S
L
S
Y
K
S
Site 41
S478
S
T
V
S
S
S
L
S
Y
K
S
L
C
A
R
Site 42
Y479
T
V
S
S
S
L
S
Y
K
S
L
C
A
R
P
Site 43
S481
S
S
S
L
S
Y
K
S
L
C
A
R
P
D
V
Site 44
T490
C
A
R
P
D
V
R
T
V
E
L
I
S
T
G
Site 45
T496
R
T
V
E
L
I
S
T
G
D
E
E
T
K
L
Site 46
S532
L
R
K
K
P
D
L
S
P
L
K
L
T
I
L
Site 47
Y546
L
A
N
E
L
K
E
Y
R
I
N
H
N
E
F
Site 48
Y559
E
F
Q
C
M
K
E
Y
L
E
A
V
S
V
Q
Site 49
S564
K
E
Y
L
E
A
V
S
V
Q
E
L
W
E
L
Site 50
Y580
L
K
R
W
I
E
D
Y
S
W
T
F
Q
P
K
Site 51
S591
F
Q
P
K
R
A
N
S
D
T
V
A
S
G
E
Site 52
T593
P
K
R
A
N
S
D
T
V
A
S
G
E
G
L
Site 53
S596
A
N
S
D
T
V
A
S
G
E
G
L
D
S
W
Site 54
Y636
M
L
G
Y
R
N
H
Y
K
V
T
A
L
H
W
Site 55
Y663
E
K
P
N
G
L
L
Y
F
W
H
Q
S
L
S
Site 56
S686
V
I
T
P
V
E
S
S
P
C
S
F
Q
T
P
Site 57
S689
P
V
E
S
S
P
C
S
F
Q
T
P
M
N
H
Site 58
T692
S
S
P
C
S
F
Q
T
P
M
N
H
K
K
T
Site 59
Y708
F
H
Q
V
L
I
R
Y
F
Q
R
Q
T
S
F
Site 60
T794
I
K
A
D
Q
C
H
T
M
R
K
S
G
T
L
Site 61
S798
Q
C
H
T
M
R
K
S
G
T
L
S
V
L
Q
Site 62
T800
H
T
M
R
K
S
G
T
L
S
V
L
Q
C
R
Site 63
S850
V
E
D
M
L
V
Q
S
Q
S
M
T
D
M
L
Site 64
S852
D
M
L
V
Q
S
Q
S
M
T
D
M
L
L
K
Site 65
Y868
Q
N
A
I
G
E
L
Y
L
E
T
G
M
T
Q
Site 66
T874
L
Y
L
E
T
G
M
T
Q
E
G
F
Q
Y
F
Site 67
Y880
M
T
Q
E
G
F
Q
Y
F
Q
K
A
W
S
S
Site 68
S887
Y
F
Q
K
A
W
S
S
M
L
R
L
S
L
S
Site 69
S892
W
S
S
M
L
R
L
S
L
S
D
L
E
D
S
Site 70
S894
S
M
L
R
L
S
L
S
D
L
E
D
S
R
D
Site 71
S899
S
L
S
D
L
E
D
S
R
D
L
V
K
Q
K
Site 72
S916
V
L
D
N
L
A
K
S
A
S
E
E
Y
L
K
Site 73
S918
D
N
L
A
K
S
A
S
E
E
Y
L
K
E
N
Site 74
Y950
R
D
Q
A
T
M
K
Y
I
E
G
V
L
M
F
Site 75
S978
E
C
L
N
I
R
K
S
L
F
G
K
K
N
M
Site 76
S1005
L
F
F
P
Q
R
D
S
K
K
S
Q
R
K
Q
Site 77
S1008
P
Q
R
D
S
K
K
S
Q
R
K
Q
V
L
K
Site 78
Y1016
Q
R
K
Q
V
L
K
Y
Y
K
Q
V
I
K
I
Site 79
Y1017
R
K
Q
V
L
K
Y
Y
K
Q
V
I
K
I
K
Site 80
T1029
K
I
K
E
N
A
E
T
L
A
K
S
S
L
L
Site 81
S1034
A
E
T
L
A
K
S
S
L
L
R
K
Q
L
S
Site 82
S1043
L
R
K
Q
L
S
I
S
L
S
D
T
L
C
K
Site 83
S1085
L
R
V
I
H
L
G
S
S
H
S
S
I
H
G
Site 84
S1086
R
V
I
H
L
G
S
S
H
S
S
I
H
G
I
Site 85
S1088
I
H
L
G
S
S
H
S
S
I
H
G
I
H
G
Site 86
S1089
H
L
G
S
S
H
S
S
I
H
G
I
H
G
I
Site 87
S1117
R
Y
W
P
Q
G
M
S
Q
Q
H
S
E
G
S
Site 88
S1121
Q
G
M
S
Q
Q
H
S
E
G
S
R
N
G
F
Site 89
S1129
E
G
S
R
N
G
F
S
L
W
E
H
L
V
K
Site 90
Y1139
E
H
L
V
K
L
N
Y
H
S
A
Q
S
S
N
Site 91
S1141
L
V
K
L
N
Y
H
S
A
Q
S
S
N
T
V
Site 92
S1144
L
N
Y
H
S
A
Q
S
S
N
T
V
S
S
A
Site 93
S1145
N
Y
H
S
A
Q
S
S
N
T
V
S
S
A
M
Site 94
T1147
H
S
A
Q
S
S
N
T
V
S
S
A
M
C
M
Site 95
S1149
A
Q
S
S
N
T
V
S
S
A
M
C
M
N
A
Site 96
T1171
R
M
D
L
A
P
Q
T
I
S
D
K
S
K
C
Site 97
S1173
D
L
A
P
Q
T
I
S
D
K
S
K
C
A
P
Site 98
S1176
P
Q
T
I
S
D
K
S
K
C
A
P
G
K
G
Site 99
S1192
K
K
P
I
I
C
I
S
A
E
E
K
I
Q
R
Site 100
T1201
E
E
K
I
Q
R
K
T
Q
N
N
A
E
I
W
Site 101
S1216
N
G
S
G
K
E
A
S
K
K
K
T
D
Y
S
Site 102
T1220
K
E
A
S
K
K
K
T
D
Y
S
S
N
I
L
Site 103
Y1222
A
S
K
K
K
T
D
Y
S
S
N
I
L
S
L
Site 104
S1223
S
K
K
K
T
D
Y
S
S
N
I
L
S
L
G
Site 105
S1224
K
K
K
T
D
Y
S
S
N
I
L
S
L
G
K
Site 106
S1228
D
Y
S
S
N
I
L
S
L
G
K
M
N
G
L
Site 107
S1248
Q
R
I
L
L
A
K
S
E
S
G
E
G
E
I
Site 108
S1250
I
L
L
A
K
S
E
S
G
E
G
E
I
T
T
Site 109
T1256
E
S
G
E
G
E
I
T
T
I
Y
H
H
P
L
Site 110
T1257
S
G
E
G
E
I
T
T
I
Y
H
H
P
L
P
Site 111
Y1259
E
G
E
I
T
T
I
Y
H
H
P
L
P
W
P
Site 112
S1268
H
P
L
P
W
P
V
S
T
K
N
P
G
E
S
Site 113
T1269
P
L
P
W
P
V
S
T
K
N
P
G
E
S
E
Site 114
S1275
S
T
K
N
P
G
E
S
E
F
I
S
E
K
W
Site 115
S1279
P
G
E
S
E
F
I
S
E
K
W
L
F
H
S
Site 116
S1286
S
E
K
W
L
F
H
S
P
D
Y
I
S
I
S
Site 117
Y1289
W
L
F
H
S
P
D
Y
I
S
I
S
Q
K
S
Site 118
S1291
F
H
S
P
D
Y
I
S
I
S
Q
K
S
F
L
Site 119
S1293
S
P
D
Y
I
S
I
S
Q
K
S
F
L
Q
R
Site 120
S1296
Y
I
S
I
S
Q
K
S
F
L
Q
R
R
L
H
Site 121
T1306
Q
R
R
L
H
I
E
T
K
L
L
K
T
S
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation