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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPF8
Full Name:
Pre-mRNA-processing-splicing factor 8
Alias:
220 kDa U5 snRNP-specific protein; PRP8 homologue; PRPC8; Splicing factor Prp8
Type:
RNA binding protein
Mass (Da):
273600
Number AA:
2335
UniProt ID:
Q6P2Q9
International Prot ID:
IPI00007928
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0005682
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
A
G
V
F
P
Y
R
G
P
G
N
P
V
Site 2
Y24
P
L
A
P
L
P
D
Y
M
S
E
E
K
L
Q
Site 3
S26
A
P
L
P
D
Y
M
S
E
E
K
L
Q
E
K
Site 4
Y88
F
R
H
D
K
R
V
Y
L
G
A
L
K
Y
M
Site 5
Y178
D
E
E
P
P
L
D
Y
A
D
N
I
L
D
V
Site 6
Y208
A
P
V
L
D
W
F
Y
D
H
Q
P
L
R
D
Site 7
S216
D
H
Q
P
L
R
D
S
R
K
Y
V
N
G
S
Site 8
Y219
P
L
R
D
S
R
K
Y
V
N
G
S
T
Y
Q
Site 9
Y225
K
Y
V
N
G
S
T
Y
Q
R
W
Q
F
T
L
Site 10
S236
Q
F
T
L
P
M
M
S
T
L
Y
R
L
A
N
Site 11
T237
F
T
L
P
M
M
S
T
L
Y
R
L
A
N
Q
Site 12
Y239
L
P
M
M
S
T
L
Y
R
L
A
N
Q
L
L
Site 13
T247
R
L
A
N
Q
L
L
T
D
L
V
D
D
N
Y
Site 14
Y254
T
D
L
V
D
D
N
Y
F
Y
L
F
D
L
K
Site 15
T310
I
I
R
Q
P
I
R
T
E
Y
K
I
A
F
P
Site 16
Y312
R
Q
P
I
R
T
E
Y
K
I
A
F
P
Y
L
Site 17
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Site 18
Y320
K
I
A
F
P
Y
L
Y
N
N
L
P
H
H
V
Site 19
T342
P
N
V
V
F
I
K
T
E
D
P
D
L
P
A
Site 20
Y351
D
P
D
L
P
A
F
Y
F
D
P
L
I
N
P
Site 21
S360
D
P
L
I
N
P
I
S
H
R
H
S
V
K
S
Site 22
S364
N
P
I
S
H
R
H
S
V
K
S
Q
E
P
L
Site 23
S367
S
H
R
H
S
V
K
S
Q
E
P
L
P
D
D
Site 24
T391
V
E
P
F
L
K
D
T
P
L
Y
T
D
N
T
Site 25
Y394
F
L
K
D
T
P
L
Y
T
D
N
T
A
N
G
Site 26
S415
P
R
P
F
N
L
R
S
G
R
T
R
R
A
L
Site 27
Y431
I
P
L
V
K
N
W
Y
R
E
H
C
P
A
G
Site 28
S446
Q
P
V
K
V
R
V
S
Y
Q
K
L
L
K
Y
Site 29
Y447
P
V
K
V
R
V
S
Y
Q
K
L
L
K
Y
Y
Site 30
Y453
S
Y
Q
K
L
L
K
Y
Y
V
L
N
A
L
K
Site 31
Y454
Y
Q
K
L
L
K
Y
Y
V
L
N
A
L
K
H
Site 32
Y471
P
K
A
Q
K
K
R
Y
L
F
R
S
F
K
A
Site 33
S475
K
K
R
Y
L
F
R
S
F
K
A
T
K
F
F
Site 34
T479
L
F
R
S
F
K
A
T
K
F
F
Q
S
T
K
Site 35
Y515
I
H
R
K
N
L
N
Y
L
H
L
D
Y
N
F
Site 36
Y520
L
N
Y
L
H
L
D
Y
N
F
N
L
K
P
V
Site 37
T529
F
N
L
K
P
V
K
T
L
T
T
K
E
R
K
Site 38
S538
T
T
K
E
R
K
K
S
R
F
G
N
A
F
H
Site 39
Y592
V
G
Q
L
T
G
M
Y
R
Y
K
Y
K
L
M
Site 40
Y596
T
G
M
Y
R
Y
K
Y
K
L
M
R
Q
I
R
Site 41
Y613
K
D
L
K
H
L
I
Y
Y
R
F
N
T
G
P
Site 42
Y614
D
L
K
H
L
I
Y
Y
R
F
N
T
G
P
V
Site 43
T618
L
I
Y
Y
R
F
N
T
G
P
V
G
K
G
P
Site 44
T645
L
F
F
M
R
G
I
T
P
L
L
E
R
W
L
Site 45
S665
R
Q
F
E
G
R
H
S
K
G
V
A
K
T
V
Site 46
T671
H
S
K
G
V
A
K
T
V
T
K
Q
R
V
E
Site 47
T673
K
G
V
A
K
T
V
T
K
Q
R
V
E
S
H
Site 48
S679
V
T
K
Q
R
V
E
S
H
F
D
L
E
L
R
Site 49
T733
W
K
V
P
G
L
P
T
P
I
E
N
M
I
L
Site 50
Y742
I
E
N
M
I
L
R
Y
V
K
A
K
A
D
W
Site 51
T766
E
R
I
R
R
G
A
T
V
D
K
T
V
C
K
Site 52
T770
R
G
A
T
V
D
K
T
V
C
K
K
N
L
G
Site 53
T780
K
K
N
L
G
R
L
T
R
L
Y
L
K
A
E
Site 54
Y783
L
G
R
L
T
R
L
Y
L
K
A
E
Q
E
R
Site 55
Y794
E
Q
E
R
Q
H
N
Y
L
K
D
G
P
Y
I
Site 56
Y800
N
Y
L
K
D
G
P
Y
I
T
A
E
E
A
V
Site 57
S819
T
T
V
H
W
L
E
S
R
R
F
S
P
I
P
Site 58
S823
W
L
E
S
R
R
F
S
P
I
P
F
P
P
L
Site 59
S831
P
I
P
F
P
P
L
S
Y
K
H
D
T
K
L
Site 60
Y850
L
E
R
L
K
E
A
Y
S
V
K
S
R
L
N
Site 61
S851
E
R
L
K
E
A
Y
S
V
K
S
R
L
N
Q
Site 62
S854
K
E
A
Y
S
V
K
S
R
L
N
Q
S
Q
R
Site 63
S859
V
K
S
R
L
N
Q
S
Q
R
E
E
L
G
L
Site 64
Y871
L
G
L
I
E
Q
A
Y
D
N
P
H
E
A
L
Site 65
T887
R
I
K
R
H
L
L
T
Q
R
A
F
K
E
V
Site 66
Y909
Y
S
H
L
V
P
V
Y
D
V
E
P
L
E
K
Site 67
Y921
L
E
K
I
T
D
A
Y
L
D
Q
Y
L
W
Y
Site 68
Y925
T
D
A
Y
L
D
Q
Y
L
W
Y
E
A
D
K
Site 69
Y928
Y
L
D
Q
Y
L
W
Y
E
A
D
K
R
R
L
Site 70
T945
P
W
I
K
P
A
D
T
E
P
P
P
L
L
V
Site 71
Y953
E
P
P
P
L
L
V
Y
K
W
C
Q
G
I
N
Site 72
Y985
E
S
R
F
E
K
M
Y
E
K
I
D
L
T
L
Site 73
T991
M
Y
E
K
I
D
L
T
L
L
N
R
L
L
R
Site 74
Y1008
V
D
H
N
I
A
D
Y
M
T
A
K
N
N
V
Site 75
S1027
K
D
M
N
H
T
N
S
Y
G
I
I
R
G
L
Site 76
Y1028
D
M
N
H
T
N
S
Y
G
I
I
R
G
L
Q
Site 77
S1059
V
L
G
L
H
R
A
S
E
M
A
G
P
P
Q
Site 78
S1073
Q
M
P
N
D
F
L
S
F
Q
D
I
A
T
E
Site 79
T1079
L
S
F
Q
D
I
A
T
E
A
A
H
P
I
R
Site 80
Y1091
P
I
R
L
F
C
R
Y
I
D
R
I
H
I
F
Site 81
Y1113
A
R
D
L
I
Q
R
Y
L
T
E
H
P
D
P
Site 82
T1115
D
L
I
Q
R
Y
L
T
E
H
P
D
P
N
N
Site 83
Y1128
N
N
E
N
I
V
G
Y
N
N
K
K
C
W
P
Site 84
S1164
I
K
N
R
L
P
R
S
V
T
T
V
Q
W
E
Site 85
T1166
N
R
L
P
R
S
V
T
T
V
Q
W
E
N
S
Site 86
S1173
T
T
V
Q
W
E
N
S
F
V
S
V
Y
S
K
Site 87
S1176
Q
W
E
N
S
F
V
S
V
Y
S
K
D
N
P
Site 88
Y1178
E
N
S
F
V
S
V
Y
S
K
D
N
P
N
L
Site 89
S1203
I
L
P
K
C
R
T
S
Y
E
E
F
T
H
K
Site 90
Y1204
L
P
K
C
R
T
S
Y
E
E
F
T
H
K
D
Site 91
T1257
A
S
G
S
T
T
F
T
K
I
V
N
K
W
N
Site 92
S1305
R
I
K
I
G
L
N
S
K
M
P
S
R
F
P
Site 93
S1309
G
L
N
S
K
M
P
S
R
F
P
P
V
V
F
Site 94
Y1317
R
F
P
P
V
V
F
Y
T
P
K
E
L
G
G
Site 95
T1318
F
P
P
V
V
F
Y
T
P
K
E
L
G
G
L
Site 96
S1338
G
H
V
L
I
P
Q
S
D
L
R
W
S
K
Q
Site 97
S1343
P
Q
S
D
L
R
W
S
K
Q
T
D
V
G
I
Site 98
T1346
D
L
R
W
S
K
Q
T
D
V
G
I
T
H
F
Site 99
T1351
K
Q
T
D
V
G
I
T
H
F
R
S
G
M
S
Site 100
S1355
V
G
I
T
H
F
R
S
G
M
S
H
E
E
D
Site 101
Y1369
D
Q
L
I
P
N
L
Y
R
Y
I
Q
P
W
E
Site 102
Y1371
L
I
P
N
L
Y
R
Y
I
Q
P
W
E
S
E
Site 103
Y1389
S
Q
R
V
W
A
E
Y
A
L
K
R
Q
E
A
Site 104
T1404
I
A
Q
N
R
R
L
T
L
E
D
L
E
D
S
Site 105
S1411
T
L
E
D
L
E
D
S
W
D
R
G
I
P
R
Site 106
T1421
R
G
I
P
R
I
N
T
L
F
Q
K
D
R
H
Site 107
T1429
L
F
Q
K
D
R
H
T
L
A
Y
D
K
G
W
Site 108
Y1432
K
D
R
H
T
L
A
Y
D
K
G
W
R
V
R
Site 109
T1440
D
K
G
W
R
V
R
T
D
F
K
Q
Y
Q
V
Site 110
Y1470
K
L
W
N
L
N
N
Y
R
T
D
M
I
Q
A
Site 111
Y1494
H
T
L
F
K
G
T
Y
F
P
T
W
E
G
L
Site 112
S1507
G
L
F
W
E
K
A
S
G
F
E
E
S
M
K
Site 113
T1519
S
M
K
W
K
K
L
T
N
A
Q
R
S
G
L
Site 114
S1539
R
R
F
T
L
W
W
S
P
T
I
N
R
A
N
Site 115
T1608
L
D
A
L
E
I
E
T
V
Q
K
E
T
I
H
Site 116
S1619
E
T
I
H
P
R
K
S
Y
K
M
N
S
S
C
Site 117
Y1620
T
I
H
P
R
K
S
Y
K
M
N
S
S
C
A
Site 118
S1625
K
S
Y
K
M
N
S
S
C
A
D
I
L
L
F
Site 119
S1640
A
S
Y
K
W
N
V
S
R
P
S
L
L
A
D
Site 120
S1643
K
W
N
V
S
R
P
S
L
L
A
D
S
K
D
Site 121
S1648
R
P
S
L
L
A
D
S
K
D
V
M
D
S
T
Site 122
T1655
S
K
D
V
M
D
S
T
T
T
Q
K
Y
W
I
Site 123
Y1660
D
S
T
T
T
Q
K
Y
W
I
D
I
Q
L
R
Site 124
Y1671
I
Q
L
R
W
G
D
Y
D
S
H
D
I
E
R
Site 125
Y1679
D
S
H
D
I
E
R
Y
A
R
A
K
F
L
D
Site 126
Y1687
A
R
A
K
F
L
D
Y
T
T
D
N
M
S
I
Site 127
T1688
R
A
K
F
L
D
Y
T
T
D
N
M
S
I
Y
Site 128
S1693
D
Y
T
T
D
N
M
S
I
Y
P
S
P
T
G
Site 129
Y1695
T
T
D
N
M
S
I
Y
P
S
P
T
G
V
L
Site 130
Y1715
A
Y
N
L
H
S
A
Y
G
N
W
F
P
G
S
Site 131
Y1741
M
K
A
N
P
A
L
Y
V
L
R
E
R
I
R
Site 132
S1755
R
K
G
L
Q
L
Y
S
S
E
P
T
E
P
Y
Site 133
S1756
K
G
L
Q
L
Y
S
S
E
P
T
E
P
Y
L
Site 134
T1759
Q
L
Y
S
S
E
P
T
E
P
Y
L
S
S
Q
Site 135
Y1762
S
S
E
P
T
E
P
Y
L
S
S
Q
N
Y
G
Site 136
S1764
E
P
T
E
P
Y
L
S
S
Q
N
Y
G
E
L
Site 137
S1765
P
T
E
P
Y
L
S
S
Q
N
Y
G
E
L
F
Site 138
Y1768
P
Y
L
S
S
Q
N
Y
G
E
L
F
S
N
Q
Site 139
T1789
D
T
N
V
Y
R
V
T
I
H
K
T
F
E
G
Site 140
T1793
Y
R
V
T
I
H
K
T
F
E
G
N
L
T
T
Site 141
T1799
K
T
F
E
G
N
L
T
T
K
P
I
N
G
A
Site 142
T1841
G
Q
L
A
K
W
K
T
A
E
E
V
A
A
L
Site 143
S1851
E
V
A
A
L
I
R
S
L
P
V
E
E
Q
P
Site 144
T1926
L
Y
D
D
W
L
K
T
I
S
S
Y
T
A
F
Site 145
S1929
D
W
L
K
T
I
S
S
Y
T
A
F
S
R
L
Site 146
T1959
V
I
L
K
P
D
K
T
T
I
T
E
P
H
H
Site 147
Y1991
K
D
L
I
L
A
D
Y
G
K
K
N
N
V
N
Site 148
S2001
K
N
N
V
N
V
A
S
L
T
Q
S
E
I
R
Site 149
S2017
I
I
L
G
M
E
I
S
A
P
S
Q
Q
R
Q
Site 150
S2020
G
M
E
I
S
A
P
S
Q
Q
R
Q
Q
I
A
Site 151
S2037
E
K
Q
T
K
E
Q
S
Q
L
T
A
T
Q
T
Site 152
T2042
E
Q
S
Q
L
T
A
T
Q
T
R
T
V
N
K
Site 153
T2044
S
Q
L
T
A
T
Q
T
R
T
V
N
K
H
G
Site 154
T2046
L
T
A
T
Q
T
R
T
V
N
K
H
G
D
E
Site 155
S2057
H
G
D
E
I
I
T
S
T
T
S
N
Y
E
T
Site 156
Y2062
I
T
S
T
T
S
N
Y
E
T
Q
T
F
S
S
Site 157
T2064
S
T
T
S
N
Y
E
T
Q
T
F
S
S
K
T
Site 158
T2066
T
S
N
Y
E
T
Q
T
F
S
S
K
T
E
W
Site 159
T2071
T
Q
T
F
S
S
K
T
E
W
R
V
R
A
I
Site 160
S2079
E
W
R
V
R
A
I
S
A
A
N
L
H
L
R
Site 161
T2087
A
A
N
L
H
L
R
T
N
H
I
Y
V
S
S
Site 162
Y2091
H
L
R
T
N
H
I
Y
V
S
S
D
D
I
K
Site 163
S2093
R
T
N
H
I
Y
V
S
S
D
D
I
K
E
T
Site 164
S2094
T
N
H
I
Y
V
S
S
D
D
I
K
E
T
G
Site 165
Y2102
D
D
I
K
E
T
G
Y
T
Y
I
L
P
K
N
Site 166
T2103
D
I
K
E
T
G
Y
T
Y
I
L
P
K
N
V
Site 167
Y2104
I
K
E
T
G
Y
T
Y
I
L
P
K
N
V
L
Site 168
Y2129
A
Q
I
A
G
Y
L
Y
G
V
S
P
P
D
N
Site 169
S2132
A
G
Y
L
Y
G
V
S
P
P
D
N
P
Q
V
Site 170
T2156
P
Q
W
G
T
H
Q
T
V
H
L
P
G
Q
L
Site 171
Y2168
G
Q
L
P
Q
H
E
Y
L
K
E
M
E
P
L
Site 172
T2180
E
P
L
G
W
I
H
T
Q
P
N
E
S
P
Q
Site 173
S2185
I
H
T
Q
P
N
E
S
P
Q
L
S
P
Q
D
Site 174
S2189
P
N
E
S
P
Q
L
S
P
Q
D
V
T
T
H
Site 175
T2195
L
S
P
Q
D
V
T
T
H
A
K
I
M
A
D
Site 176
S2205
K
I
M
A
D
N
P
S
W
D
G
E
K
T
I
Site 177
S2222
T
C
S
F
T
P
G
S
C
T
L
T
A
Y
K
Site 178
T2226
T
P
G
S
C
T
L
T
A
Y
K
L
T
P
S
Site 179
Y2228
G
S
C
T
L
T
A
Y
K
L
T
P
S
G
Y
Site 180
T2231
T
L
T
A
Y
K
L
T
P
S
G
Y
E
W
G
Site 181
T2242
Y
E
W
G
R
Q
N
T
D
K
G
N
N
P
K
Site 182
Y2251
K
G
N
N
P
K
G
Y
L
P
S
H
Y
E
R
Site 183
S2254
N
P
K
G
Y
L
P
S
H
Y
E
R
V
Q
M
Site 184
Y2256
K
G
Y
L
P
S
H
Y
E
R
V
Q
M
L
L
Site 185
Y2294
R
H
D
P
N
M
K
Y
E
L
Q
L
A
N
P
Site 186
Y2326
L
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Site 187
S2327
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation