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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CaMK1-beta
Full Name:
Calcium/calmodulin-dependent protein kinase type 1B
Alias:
CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; EC 2.7.11.17; KCC1B; PNCK; Pregnancy up-regulated non-ubiquitously expressed CaM kinase
Type:
Cytoplasm, Nucleus protein
Mass (Da):
38500
Number AA:
343
UniProt ID:
Q6P2M8
International Prot ID:
IPI00550491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Autocamtide-2 peptide - Autocamtide 2 CaMK2-derived peptide substrate - Powder PE-01ACM95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACM95#CREB1 (123-135) KinSub - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95#CREB1 (123-135) KinSub, biotinyl. - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-03AAF90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAF90#CREB1 (123-135) KinSub, biotinyl. - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-03AAF90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAF90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
L
L
L
K
K
H
T
E
D
I
S
S
V
Y
Site 2
S12
K
K
H
T
E
D
I
S
S
V
Y
E
I
R
E
Site 3
S13
K
H
T
E
D
I
S
S
V
Y
E
I
R
E
R
Site 4
Y15
T
E
D
I
S
S
V
Y
E
I
R
E
R
L
G
Site 5
S23
E
I
R
E
R
L
G
S
G
A
F
S
E
V
V
Site 6
S82
A
L
E
D
V
H
E
S
P
S
H
L
Y
L
A
Site 7
Y87
H
E
S
P
S
H
L
Y
L
A
M
E
L
V
T
Site 8
S107
D
R
I
M
E
R
G
S
Y
T
E
K
D
A
S
Site 9
Y108
R
I
M
E
R
G
S
Y
T
E
K
D
A
S
H
Site 10
T109
I
M
E
R
G
S
Y
T
E
K
D
A
S
H
L
Site 11
S114
S
Y
T
E
K
D
A
S
H
L
V
G
Q
V
L
Site 12
Y126
Q
V
L
G
A
V
S
Y
L
H
S
L
G
I
V
Site 13
Y144
L
K
P
E
N
L
L
Y
A
T
P
F
E
D
S
Site 14
T146
P
E
N
L
L
Y
A
T
P
F
E
D
S
K
I
Site 15
S156
E
D
S
K
I
M
V
S
D
F
G
L
S
K
I
Site 16
T171
Q
A
G
N
M
L
G
T
A
C
G
T
P
G
Y
Site 17
T175
M
L
G
T
A
C
G
T
P
G
Y
V
A
P
E
Site 18
Y189
E
L
L
E
Q
K
P
Y
G
K
A
V
D
V
W
Site 19
Y209
S
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
S
Site 20
Y213
L
C
G
Y
P
P
F
Y
D
E
S
D
P
E
L
Site 21
S216
Y
P
P
F
Y
D
E
S
D
P
E
L
F
S
Q
Site 22
S222
E
S
D
P
E
L
F
S
Q
I
L
R
A
S
Y
Site 23
S228
F
S
Q
I
L
R
A
S
Y
E
F
D
S
P
F
Site 24
Y229
S
Q
I
L
R
A
S
Y
E
F
D
S
P
F
W
Site 25
S233
R
A
S
Y
E
F
D
S
P
F
W
D
D
I
S
Site 26
S240
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
Site 27
T260
R
D
P
Q
K
R
F
T
C
Q
Q
A
L
R
H
Site 28
S271
A
L
R
H
L
W
I
S
G
D
T
A
F
D
R
Site 29
S283
F
D
R
D
I
L
G
S
V
S
E
Q
I
R
K
Site 30
S285
R
D
I
L
G
S
V
S
E
Q
I
R
K
N
F
Site 31
T304
W
K
R
A
F
N
A
T
S
F
L
R
H
I
R
Site 32
S305
K
R
A
F
N
A
T
S
F
L
R
H
I
R
K
Site 33
S331
E
Q
G
M
A
R
H
S
H
S
G
L
R
A
G
Site 34
S333
G
M
A
R
H
S
H
S
G
L
R
A
G
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation