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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC21
Full Name:
Coiled-coil domain-containing protein 21
Alias:
CCD21; coiled-coil domain containing 21; coiled-coil domain-containing 21; DKFZP434L0117
Type:
Unknown function
Mass (Da):
85639
Number AA:
762
UniProt ID:
Q6P2H3
International Prot ID:
IPI00550977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
M
Q
E
K
Y
P
T
E
G
I
S
H
V
T
Site 2
S13
K
Y
P
T
E
G
I
S
H
V
T
S
P
S
S
Site 3
T16
T
E
G
I
S
H
V
T
S
P
S
S
D
V
I
Site 4
S17
E
G
I
S
H
V
T
S
P
S
S
D
V
I
Q
Site 5
S20
S
H
V
T
S
P
S
S
D
V
I
Q
K
G
S
Site 6
S28
D
V
I
Q
K
G
S
S
L
G
T
E
W
Q
T
Site 7
T31
Q
K
G
S
S
L
G
T
E
W
Q
T
P
V
I
Site 8
T35
S
L
G
T
E
W
Q
T
P
V
I
S
E
P
F
Site 9
S39
E
W
Q
T
P
V
I
S
E
P
F
R
S
R
F
Site 10
S44
V
I
S
E
P
F
R
S
R
F
S
R
C
S
S
Site 11
S47
E
P
F
R
S
R
F
S
R
C
S
S
V
A
D
Site 12
S50
R
S
R
F
S
R
C
S
S
V
A
D
S
G
D
Site 13
S51
S
R
F
S
R
C
S
S
V
A
D
S
G
D
T
Site 14
S55
R
C
S
S
V
A
D
S
G
D
T
A
I
G
T
Site 15
T58
S
V
A
D
S
G
D
T
A
I
G
T
S
C
S
Site 16
T62
S
G
D
T
A
I
G
T
S
C
S
D
I
A
E
Site 17
S73
D
I
A
E
D
F
C
S
S
S
G
S
P
P
F
Site 18
S74
I
A
E
D
F
C
S
S
S
G
S
P
P
F
Q
Site 19
S75
A
E
D
F
C
S
S
S
G
S
P
P
F
Q
P
Site 20
S77
D
F
C
S
S
S
G
S
P
P
F
Q
P
I
K
Site 21
S85
P
P
F
Q
P
I
K
S
H
V
T
I
P
T
A
Site 22
T91
K
S
H
V
T
I
P
T
A
H
V
M
P
S
T
Site 23
S97
P
T
A
H
V
M
P
S
T
L
G
T
S
P
A
Site 24
T98
T
A
H
V
M
P
S
T
L
G
T
S
P
A
K
Site 25
T101
V
M
P
S
T
L
G
T
S
P
A
K
P
N
S
Site 26
S102
M
P
S
T
L
G
T
S
P
A
K
P
N
S
T
Site 27
S108
T
S
P
A
K
P
N
S
T
P
V
G
P
S
S
Site 28
T109
S
P
A
K
P
N
S
T
P
V
G
P
S
S
S
Site 29
S114
N
S
T
P
V
G
P
S
S
S
K
L
P
L
S
Site 30
S115
S
T
P
V
G
P
S
S
S
K
L
P
L
S
G
Site 31
S116
T
P
V
G
P
S
S
S
K
L
P
L
S
G
L
Site 32
S121
S
S
S
K
L
P
L
S
G
L
A
E
S
V
G
Site 33
S126
P
L
S
G
L
A
E
S
V
G
M
T
R
N
G
Site 34
S141
D
L
G
A
M
K
H
S
P
G
L
S
R
D
L
Site 35
S145
M
K
H
S
P
G
L
S
R
D
L
M
Y
F
S
Site 36
Y150
G
L
S
R
D
L
M
Y
F
S
G
A
T
G
E
Site 37
S152
S
R
D
L
M
Y
F
S
G
A
T
G
E
N
G
Site 38
S183
A
R
K
F
D
I
P
S
M
E
S
T
L
N
Q
Site 39
S186
F
D
I
P
S
M
E
S
T
L
N
Q
S
A
M
Site 40
T187
D
I
P
S
M
E
S
T
L
N
Q
S
A
M
M
Site 41
S191
M
E
S
T
L
N
Q
S
A
M
M
E
T
L
Y
Site 42
T196
N
Q
S
A
M
M
E
T
L
Y
S
D
P
H
H
Site 43
Y198
S
A
M
M
E
T
L
Y
S
D
P
H
H
R
V
Site 44
S199
A
M
M
E
T
L
Y
S
D
P
H
H
R
V
R
Site 45
T212
V
R
F
H
N
P
R
T
S
T
S
K
E
L
Y
Site 46
S213
R
F
H
N
P
R
T
S
T
S
K
E
L
Y
R
Site 47
T214
F
H
N
P
R
T
S
T
S
K
E
L
Y
R
V
Site 48
Y219
T
S
T
S
K
E
L
Y
R
V
L
P
E
A
K
Site 49
S231
E
A
K
K
A
P
G
S
G
A
V
F
E
R
N
Site 50
S242
F
E
R
N
G
P
H
S
N
S
S
G
V
L
P
Site 51
S244
R
N
G
P
H
S
N
S
S
G
V
L
P
L
G
Site 52
S245
N
G
P
H
S
N
S
S
G
V
L
P
L
G
L
Site 53
S259
L
Q
P
A
P
G
L
S
K
P
L
P
S
Q
V
Site 54
S264
G
L
S
K
P
L
P
S
Q
V
W
Q
P
S
P
Site 55
S270
P
S
Q
V
W
Q
P
S
P
D
T
W
H
P
R
Site 56
T273
V
W
Q
P
S
P
D
T
W
H
P
R
E
Q
S
Site 57
S284
R
E
Q
S
C
E
L
S
T
C
R
Q
Q
L
E
Site 58
S332
Q
W
I
S
I
L
N
S
N
E
H
L
L
K
E
Site 59
S352
D
K
Q
R
K
H
I
S
Q
L
E
Q
K
V
R
Site 60
S361
L
E
Q
K
V
R
E
S
E
L
Q
V
H
S
A
Site 61
T392
Q
E
L
Q
R
E
N
T
F
L
R
A
Q
F
A
Site 62
T402
R
A
Q
F
A
Q
K
T
E
A
L
S
R
E
K
Site 63
S417
I
D
L
E
K
K
L
S
A
S
E
V
E
V
Q
Site 64
S429
E
V
Q
L
I
R
E
S
L
K
V
A
L
Q
K
Site 65
T478
E
K
Q
Q
R
I
E
T
L
E
R
Y
L
A
D
Site 66
Y482
R
I
E
T
L
E
R
Y
L
A
D
L
P
T
L
Site 67
T488
R
Y
L
A
D
L
P
T
L
E
D
H
Q
K
Q
Site 68
S502
Q
S
Q
Q
L
K
D
S
E
L
K
S
T
E
L
Site 69
S506
L
K
D
S
E
L
K
S
T
E
L
Q
E
K
V
Site 70
T507
K
D
S
E
L
K
S
T
E
L
Q
E
K
V
T
Site 71
S518
E
K
V
T
E
L
E
S
L
L
E
E
T
Q
A
Site 72
S536
E
K
E
I
Q
L
E
S
L
R
Q
R
E
A
E
Site 73
S545
R
Q
R
E
A
E
F
S
S
A
G
H
S
L
Q
Site 74
S546
Q
R
E
A
E
F
S
S
A
G
H
S
L
Q
D
Site 75
S550
E
F
S
S
A
G
H
S
L
Q
D
K
Q
S
V
Site 76
S556
H
S
L
Q
D
K
Q
S
V
E
E
T
S
G
E
Site 77
T560
D
K
Q
S
V
E
E
T
S
G
E
G
P
E
V
Site 78
Y576
M
E
S
W
Q
K
R
Y
D
S
L
Q
K
I
V
Site 79
S578
S
W
Q
K
R
Y
D
S
L
Q
K
I
V
E
K
Site 80
S595
Q
K
M
D
Q
L
R
S
Q
V
Q
S
L
E
Q
Site 81
S599
Q
L
R
S
Q
V
Q
S
L
E
Q
E
V
A
Q
Site 82
S611
V
A
Q
E
E
G
T
S
Q
A
L
R
E
E
A
Site 83
S623
E
E
A
Q
R
R
D
S
A
L
Q
Q
L
R
T
Site 84
S636
R
T
A
V
K
E
L
S
V
Q
N
Q
D
L
I
Site 85
T648
D
L
I
E
K
N
L
T
L
Q
E
H
L
R
Q
Site 86
S660
L
R
Q
A
Q
P
G
S
P
P
S
P
D
T
A
Site 87
S663
A
Q
P
G
S
P
P
S
P
D
T
A
Q
L
A
Site 88
T666
G
S
P
P
S
P
D
T
A
Q
L
A
L
E
L
Site 89
S689
Q
D
L
Q
A
V
C
S
I
V
T
Q
R
A
Q
Site 90
T692
Q
A
V
C
S
I
V
T
Q
R
A
Q
G
H
D
Site 91
S703
Q
G
H
D
P
N
L
S
L
L
L
G
I
H
S
Site 92
S710
S
L
L
L
G
I
H
S
A
Q
H
P
E
T
Q
Site 93
T745
R
D
I
E
D
L
R
T
T
M
S
D
R
Y
A
Site 94
T746
D
I
E
D
L
R
T
T
M
S
D
R
Y
A
Q
Site 95
S748
E
D
L
R
T
T
M
S
D
R
Y
A
Q
D
M
Site 96
Y751
R
T
T
M
S
D
R
Y
A
Q
D
M
G
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation