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Updated November 2019
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Protein Info
Short Name:
EDC4
Full Name:
Enhancer of mRNA-decapping protein 4
Alias:
autoantigen Ge-1; autoantigen RCD-8; enhancer of mRNA decapping 4; Ge-1; hedls; human enhancer of decapping large subunit; RCD-8
Type:
RNA processing
Mass (Da):
151661
Number AA:
1401
UniProt ID:
Q6P2E9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
S
I
D
I
E
D
A
T
Q
H
L
R
D
I
L
Site 2
S30
D
R
P
A
G
G
P
S
A
E
S
P
R
P
S
Site 3
S33
A
G
G
P
S
A
E
S
P
R
P
S
S
A
Y
Site 4
S37
S
A
E
S
P
R
P
S
S
A
Y
N
G
D
L
Site 5
S38
A
E
S
P
R
P
S
S
A
Y
N
G
D
L
N
Site 6
Y40
S
P
R
P
S
S
A
Y
N
G
D
L
N
G
L
Site 7
S55
L
V
P
D
P
L
C
S
G
D
S
T
S
A
N
Site 8
S58
D
P
L
C
S
G
D
S
T
S
A
N
K
T
G
Site 9
T59
P
L
C
S
G
D
S
T
S
A
N
K
T
G
L
Site 10
S60
L
C
S
G
D
S
T
S
A
N
K
T
G
L
R
Site 11
T64
D
S
T
S
A
N
K
T
G
L
R
T
M
P
P
Site 12
S83
E
K
Q
V
I
C
L
S
G
D
D
S
S
T
C
Site 13
S103
K
E
V
E
I
V
A
S
S
D
S
S
I
S
S
Site 14
S104
E
V
E
I
V
A
S
S
D
S
S
I
S
S
K
Site 15
S106
E
I
V
A
S
S
D
S
S
I
S
S
K
A
R
Site 16
S107
I
V
A
S
S
D
S
S
I
S
S
K
A
R
G
Site 17
S109
A
S
S
D
S
S
I
S
S
K
A
R
G
S
N
Site 18
S110
S
S
D
S
S
I
S
S
K
A
R
G
S
N
K
Site 19
S115
I
S
S
K
A
R
G
S
N
K
V
K
I
Q
P
Site 20
Y126
K
I
Q
P
V
A
K
Y
D
W
E
Q
K
Y
Y
Site 21
Y132
K
Y
D
W
E
Q
K
Y
Y
Y
G
N
L
I
A
Site 22
Y133
Y
D
W
E
Q
K
Y
Y
Y
G
N
L
I
A
V
Site 23
Y147
V
S
N
S
F
L
A
Y
A
I
R
A
A
N
N
Site 24
S163
S
A
M
V
R
V
I
S
V
S
T
S
E
R
T
Site 25
S167
R
V
I
S
V
S
T
S
E
R
T
L
L
K
G
Site 26
T227
H
I
R
Q
P
E
G
T
P
L
N
H
F
R
R
Site 27
S252
S
E
D
C
C
E
E
S
S
P
T
V
A
L
L
Site 28
S253
E
D
C
C
E
E
S
S
P
T
V
A
L
L
H
Site 29
T255
C
C
E
E
S
S
P
T
V
A
L
L
H
E
D
Site 30
S275
D
L
D
M
L
R
S
S
H
S
T
W
P
V
D
Site 31
S277
D
M
L
R
S
S
H
S
T
W
P
V
D
V
S
Site 32
T278
M
L
R
S
S
H
S
T
W
P
V
D
V
S
Q
Site 33
S284
S
T
W
P
V
D
V
S
Q
I
K
Q
G
F
I
Site 34
S301
K
G
H
S
T
C
L
S
E
G
A
L
S
P
D
Site 35
Y320
A
T
A
S
H
D
G
Y
V
K
F
W
Q
I
Y
Site 36
S349
P
H
D
G
R
P
L
S
C
L
L
F
C
D
N
Site 37
S402
R
F
S
P
D
I
F
S
S
V
S
V
P
P
S
Site 38
Y432
D
V
Q
R
K
V
L
Y
V
M
E
L
L
Q
N
Site 39
S468
S
F
G
I
Q
V
V
S
R
C
R
L
R
H
T
Site 40
T475
S
R
C
R
L
R
H
T
E
V
L
P
A
E
E
Site 41
S486
P
A
E
E
E
N
D
S
L
G
A
D
G
T
H
Site 42
T492
D
S
L
G
A
D
G
T
H
G
A
G
A
M
E
Site 43
T545
H
T
A
H
E
D
F
T
F
G
E
S
R
P
E
Site 44
S555
E
S
R
P
E
L
G
S
E
G
L
G
S
A
A
Site 45
S560
L
G
S
E
G
L
G
S
A
A
H
G
S
Q
P
Site 46
S565
L
G
S
A
A
H
G
S
Q
P
D
L
R
R
I
Site 47
S583
P
A
P
A
D
F
L
S
L
S
S
E
T
K
P
Site 48
S585
P
A
D
F
L
S
L
S
S
E
T
K
P
K
L
Site 49
T588
F
L
S
L
S
S
E
T
K
P
K
L
M
T
P
Site 50
T594
E
T
K
P
K
L
M
T
P
D
A
F
M
T
P
Site 51
T600
M
T
P
D
A
F
M
T
P
S
A
S
L
Q
Q
Site 52
S602
P
D
A
F
M
T
P
S
A
S
L
Q
Q
I
T
Site 53
T609
S
A
S
L
Q
Q
I
T
A
S
P
S
S
S
S
Site 54
S611
S
L
Q
Q
I
T
A
S
P
S
S
S
S
S
G
Site 55
S613
Q
Q
I
T
A
S
P
S
S
S
S
S
G
S
S
Site 56
S614
Q
I
T
A
S
P
S
S
S
S
S
G
S
S
S
Site 57
S615
I
T
A
S
P
S
S
S
S
S
G
S
S
S
S
Site 58
S616
T
A
S
P
S
S
S
S
S
G
S
S
S
S
S
Site 59
S617
A
S
P
S
S
S
S
S
G
S
S
S
S
S
S
Site 60
S619
P
S
S
S
S
S
G
S
S
S
S
S
S
S
S
Site 61
S620
S
S
S
S
S
G
S
S
S
S
S
S
S
S
S
Site 62
S621
S
S
S
S
G
S
S
S
S
S
S
S
S
S
S
Site 63
S622
S
S
S
G
S
S
S
S
S
S
S
S
S
S
S
Site 64
S623
S
S
G
S
S
S
S
S
S
S
S
S
S
S
L
Site 65
S624
S
G
S
S
S
S
S
S
S
S
S
S
S
L
T
Site 66
S625
G
S
S
S
S
S
S
S
S
S
S
S
L
T
A
Site 67
S626
S
S
S
S
S
S
S
S
S
S
S
L
T
A
V
Site 68
S627
S
S
S
S
S
S
S
S
S
S
L
T
A
V
S
Site 69
S628
S
S
S
S
S
S
S
S
S
L
T
A
V
S
A
Site 70
S629
S
S
S
S
S
S
S
S
L
T
A
V
S
A
M
Site 71
T631
S
S
S
S
S
S
L
T
A
V
S
A
M
S
S
Site 72
S645
S
T
S
A
V
D
P
S
L
T
R
P
P
E
E
Site 73
T647
S
A
V
D
P
S
L
T
R
P
P
E
E
L
T
Site 74
T654
T
R
P
P
E
E
L
T
L
S
P
K
L
Q
L
Site 75
S656
P
P
E
E
L
T
L
S
P
K
L
Q
L
D
G
Site 76
S664
P
K
L
Q
L
D
G
S
L
T
M
S
S
S
G
Site 77
S668
L
D
G
S
L
T
M
S
S
S
G
S
L
Q
A
Site 78
S670
G
S
L
T
M
S
S
S
G
S
L
Q
A
S
P
Site 79
S672
L
T
M
S
S
S
G
S
L
Q
A
S
P
R
G
Site 80
S676
S
S
G
S
L
Q
A
S
P
R
G
L
L
P
G
Site 81
T693
P
A
P
A
D
K
L
T
P
K
G
P
G
Q
V
Site 82
T702
K
G
P
G
Q
V
P
T
A
T
S
A
L
S
L
Site 83
T704
P
G
Q
V
P
T
A
T
S
A
L
S
L
E
L
Site 84
S705
G
Q
V
P
T
A
T
S
A
L
S
L
E
L
Q
Site 85
S708
P
T
A
T
S
A
L
S
L
E
L
Q
E
V
E
Site 86
S723
P
L
G
L
P
Q
A
S
P
S
R
T
R
S
P
Site 87
S725
G
L
P
Q
A
S
P
S
R
T
R
S
P
D
V
Site 88
T727
P
Q
A
S
P
S
R
T
R
S
P
D
V
I
S
Site 89
S729
A
S
P
S
R
T
R
S
P
D
V
I
S
S
A
Site 90
S734
T
R
S
P
D
V
I
S
S
A
S
T
A
L
S
Site 91
S735
R
S
P
D
V
I
S
S
A
S
T
A
L
S
Q
Site 92
S737
P
D
V
I
S
S
A
S
T
A
L
S
Q
D
I
Site 93
T738
D
V
I
S
S
A
S
T
A
L
S
Q
D
I
P
Site 94
S741
S
S
A
S
T
A
L
S
Q
D
I
P
E
I
A
Site 95
S749
Q
D
I
P
E
I
A
S
E
A
L
S
R
G
F
Site 96
S753
E
I
A
S
E
A
L
S
R
G
F
G
S
S
A
Site 97
S758
A
L
S
R
G
F
G
S
S
A
P
E
G
L
E
Site 98
S759
L
S
R
G
F
G
S
S
A
P
E
G
L
E
P
Site 99
S768
P
E
G
L
E
P
D
S
M
A
S
A
A
S
A
Site 100
S774
D
S
M
A
S
A
A
S
A
L
H
L
L
S
P
Site 101
S780
A
S
A
L
H
L
L
S
P
R
P
R
P
G
P
Site 102
T807
G
D
G
D
R
H
N
T
P
S
L
L
E
A
A
Site 103
S809
G
D
R
H
N
T
P
S
L
L
E
A
A
L
T
Site 104
T816
S
L
L
E
A
A
L
T
Q
E
A
S
T
P
D
Site 105
S820
A
A
L
T
Q
E
A
S
T
P
D
S
Q
V
W
Site 106
T821
A
L
T
Q
E
A
S
T
P
D
S
Q
V
W
P
Site 107
S824
Q
E
A
S
T
P
D
S
Q
V
W
P
T
A
P
Site 108
T837
A
P
D
I
T
R
E
T
C
S
T
L
A
E
S
Site 109
S839
D
I
T
R
E
T
C
S
T
L
A
E
S
P
R
Site 110
T840
I
T
R
E
T
C
S
T
L
A
E
S
P
R
N
Site 111
S844
T
C
S
T
L
A
E
S
P
R
N
G
L
Q
E
Site 112
S855
G
L
Q
E
K
H
K
S
L
A
F
H
R
P
P
Site 113
Y863
L
A
F
H
R
P
P
Y
H
L
L
Q
Q
R
D
Site 114
S871
H
L
L
Q
Q
R
D
S
Q
D
A
S
A
E
Q
Site 115
S875
Q
R
D
S
Q
D
A
S
A
E
Q
S
D
H
D
Site 116
S879
Q
D
A
S
A
E
Q
S
D
H
D
D
E
V
A
Site 117
S887
D
H
D
D
E
V
A
S
L
A
S
A
S
G
G
Site 118
S890
D
E
V
A
S
L
A
S
A
S
G
G
F
G
T
Site 119
S892
V
A
S
L
A
S
A
S
G
G
F
G
T
K
V
Site 120
T897
S
A
S
G
G
F
G
T
K
V
P
A
P
R
L
Site 121
T911
L
P
A
K
D
W
K
T
K
G
S
P
R
T
S
Site 122
S914
K
D
W
K
T
K
G
S
P
R
T
S
P
K
L
Site 123
S918
T
K
G
S
P
R
T
S
P
K
L
K
R
K
S
Site 124
S925
S
P
K
L
K
R
K
S
K
K
D
D
G
D
A
Site 125
T939
A
A
M
G
S
R
L
T
E
H
Q
V
A
E
P
Site 126
S967
E
L
A
E
L
R
H
S
Q
E
E
L
L
Q
R
Site 127
T977
E
L
L
Q
R
L
C
T
Q
L
E
G
L
Q
S
Site 128
S984
T
Q
L
E
G
L
Q
S
T
V
T
G
H
V
E
Site 129
T1024
G
Q
L
Q
E
Q
L
T
Q
Q
L
S
Q
A
L
Site 130
S1028
E
Q
L
T
Q
Q
L
S
Q
A
L
S
S
A
V
Site 131
S1042
V
A
G
R
L
E
R
S
I
R
D
E
I
K
K
Site 132
T1050
I
R
D
E
I
K
K
T
V
P
P
C
V
S
R
Site 133
S1056
K
T
V
P
P
C
V
S
R
S
L
E
P
M
A
Site 134
S1058
V
P
P
C
V
S
R
S
L
E
P
M
A
G
Q
Site 135
S1067
E
P
M
A
G
Q
L
S
N
S
V
A
T
K
L
Site 136
T1072
Q
L
S
N
S
V
A
T
K
L
T
A
V
E
G
Site 137
S1086
G
S
M
K
E
N
I
S
K
L
L
K
S
K
N
Site 138
S1091
N
I
S
K
L
L
K
S
K
N
L
T
D
A
I
Site 139
Y1114
Q
G
P
M
Q
A
A
Y
R
E
A
F
Q
S
V
Site 140
S1140
M
F
Q
Q
I
N
D
S
F
R
L
G
T
Q
E
Site 141
T1145
N
D
S
F
R
L
G
T
Q
E
Y
L
Q
Q
L
Site 142
Y1148
F
R
L
G
T
Q
E
Y
L
Q
Q
L
E
S
H
Site 143
S1154
E
Y
L
Q
Q
L
E
S
H
M
K
S
R
K
A
Site 144
S1158
Q
L
E
S
H
M
K
S
R
K
A
R
E
Q
E
Site 145
S1179
A
Q
L
R
G
L
V
S
T
L
Q
S
A
T
E
Site 146
T1180
Q
L
R
G
L
V
S
T
L
Q
S
A
T
E
Q
Site 147
T1331
Q
L
A
S
D
L
G
T
R
T
D
L
K
L
S
Site 148
T1333
A
S
D
L
G
T
R
T
D
L
K
L
S
Y
L
Site 149
Y1339
R
T
D
L
K
L
S
Y
L
E
E
A
V
M
H
Site 150
S1350
A
V
M
H
L
D
H
S
D
P
I
T
R
D
H
Site 151
T1354
L
D
H
S
D
P
I
T
R
D
H
M
G
S
V
Site 152
S1360
I
T
R
D
H
M
G
S
V
M
A
Q
V
R
Q
Site 153
S1380
L
Q
A
E
P
H
N
S
L
G
K
A
A
R
R
Site 154
S1389
G
K
A
A
R
R
L
S
L
M
L
H
G
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation