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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM117B
Full Name:
Protein FAM117B
Alias:
AL2SC; ALS2CR13; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, 13; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein; Family with sequence similarity 117, member B; FLJ38771
Type:
Mass (Da):
61968
Number AA:
589
UniProt ID:
Q6P1L5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
Q
R
V
R
R
N
G
S
P
T
P
A
G
S
L
Site 2
T12
V
R
R
N
G
S
P
T
P
A
G
S
L
G
G
Site 3
S30
A
T
A
G
G
P
G
S
R
L
Q
P
M
R
A
Site 4
T38
R
L
Q
P
M
R
A
T
V
P
F
Q
L
K
Q
Site 5
S53
Q
Q
Q
Q
Q
H
G
S
P
T
R
S
G
G
G
Site 6
S57
Q
H
G
S
P
T
R
S
G
G
G
G
G
G
N
Site 7
T87
G
G
G
G
G
P
R
T
A
S
R
S
T
S
P
Site 8
S89
G
G
G
P
R
T
A
S
R
S
T
S
P
T
R
Site 9
S91
G
P
R
T
A
S
R
S
T
S
P
T
R
G
G
Site 10
T92
P
R
T
A
S
R
S
T
S
P
T
R
G
G
G
Site 11
S93
R
T
A
S
R
S
T
S
P
T
R
G
G
G
N
Site 12
T95
A
S
R
S
T
S
P
T
R
G
G
G
N
A
A
Site 13
T105
G
G
N
A
A
A
R
T
S
P
T
V
A
T
Q
Site 14
S106
G
N
A
A
A
R
T
S
P
T
V
A
T
Q
T
Site 15
T108
A
A
A
R
T
S
P
T
V
A
T
Q
T
G
A
Site 16
T113
S
P
T
V
A
T
Q
T
G
A
S
A
T
S
T
Site 17
S119
Q
T
G
A
S
A
T
S
T
R
G
T
S
P
T
Site 18
T120
T
G
A
S
A
T
S
T
R
G
T
S
P
T
R
Site 19
T123
S
A
T
S
T
R
G
T
S
P
T
R
S
A
A
Site 20
S124
A
T
S
T
R
G
T
S
P
T
R
S
A
A
P
Site 21
T126
S
T
R
G
T
S
P
T
R
S
A
A
P
G
A
Site 22
S128
R
G
T
S
P
T
R
S
A
A
P
G
A
R
G
Site 23
S136
A
A
P
G
A
R
G
S
P
P
R
P
P
P
P
Site 24
T149
P
P
P
P
L
L
G
T
V
S
S
P
S
S
S
Site 25
S151
P
P
L
L
G
T
V
S
S
P
S
S
S
P
T
Site 26
S152
P
L
L
G
T
V
S
S
P
S
S
S
P
T
H
Site 27
S154
L
G
T
V
S
S
P
S
S
S
P
T
H
L
W
Site 28
S155
G
T
V
S
S
P
S
S
S
P
T
H
L
W
T
Site 29
S156
T
V
S
S
P
S
S
S
P
T
H
L
W
T
G
Site 30
T158
S
S
P
S
S
S
P
T
H
L
W
T
G
E
V
Site 31
T162
S
S
P
T
H
L
W
T
G
E
V
S
A
A
P
Site 32
S166
H
L
W
T
G
E
V
S
A
A
P
P
P
A
R
Site 33
S180
R
V
R
H
R
R
R
S
P
E
Q
S
R
S
S
Site 34
S184
R
R
R
S
P
E
Q
S
R
S
S
P
E
K
R
Site 35
S186
R
S
P
E
Q
S
R
S
S
P
E
K
R
S
P
Site 36
S187
S
P
E
Q
S
R
S
S
P
E
K
R
S
P
S
Site 37
S192
R
S
S
P
E
K
R
S
P
S
A
P
V
C
K
Site 38
S194
S
P
E
K
R
S
P
S
A
P
V
C
K
A
G
Site 39
T204
V
C
K
A
G
D
K
T
R
Q
P
S
S
S
P
Site 40
S208
G
D
K
T
R
Q
P
S
S
S
P
S
S
I
I
Site 41
S209
D
K
T
R
Q
P
S
S
S
P
S
S
I
I
R
Site 42
S210
K
T
R
Q
P
S
S
S
P
S
S
I
I
R
R
Site 43
S212
R
Q
P
S
S
S
P
S
S
I
I
R
R
T
S
Site 44
S213
Q
P
S
S
S
P
S
S
I
I
R
R
T
S
S
Site 45
T218
P
S
S
I
I
R
R
T
S
S
L
D
T
L
A
Site 46
S219
S
S
I
I
R
R
T
S
S
L
D
T
L
A
A
Site 47
S220
S
I
I
R
R
T
S
S
L
D
T
L
A
A
P
Site 48
T223
R
R
T
S
S
L
D
T
L
A
A
P
Y
L
A
Site 49
Y228
L
D
T
L
A
A
P
Y
L
A
G
H
W
P
R
Site 50
T250
P
C
M
R
D
K
A
T
Q
T
E
S
A
W
A
Site 51
S254
D
K
A
T
Q
T
E
S
A
W
A
E
E
Y
S
Site 52
S261
S
A
W
A
E
E
Y
S
E
K
K
K
G
S
H
Site 53
S267
Y
S
E
K
K
K
G
S
H
K
R
S
A
S
W
Site 54
S271
K
K
G
S
H
K
R
S
A
S
W
G
S
T
D
Site 55
S273
G
S
H
K
R
S
A
S
W
G
S
T
D
Q
L
Site 56
T277
R
S
A
S
W
G
S
T
D
Q
L
K
E
I
A
Site 57
S293
L
R
Q
Q
L
Q
R
S
K
H
S
S
R
H
H
Site 58
S296
Q
L
Q
R
S
K
H
S
S
R
H
H
R
D
K
Site 59
S297
L
Q
R
S
K
H
S
S
R
H
H
R
D
K
E
Site 60
S307
H
R
D
K
E
R
Q
S
P
F
H
G
N
H
A
Site 61
S337
P
V
I
P
I
T
K
S
T
G
S
R
F
R
N
Site 62
T338
V
I
P
I
T
K
S
T
G
S
R
F
R
N
S
Site 63
S340
P
I
T
K
S
T
G
S
R
F
R
N
S
V
E
Site 64
S345
T
G
S
R
F
R
N
S
V
E
G
L
N
Q
E
Site 65
S386
P
P
P
L
V
Q
R
S
S
S
T
R
S
I
D
Site 66
S387
P
P
L
V
Q
R
S
S
S
T
R
S
I
D
T
Site 67
S388
P
L
V
Q
R
S
S
S
T
R
S
I
D
T
Q
Site 68
T389
L
V
Q
R
S
S
S
T
R
S
I
D
T
Q
T
Site 69
S391
Q
R
S
S
S
T
R
S
I
D
T
Q
T
P
G
Site 70
T394
S
S
T
R
S
I
D
T
Q
T
P
G
G
A
D
Site 71
T396
T
R
S
I
D
T
Q
T
P
G
G
A
D
R
G
Site 72
S404
P
G
G
A
D
R
G
S
N
N
S
S
R
S
Q
Site 73
S407
A
D
R
G
S
N
N
S
S
R
S
Q
S
V
S
Site 74
S408
D
R
G
S
N
N
S
S
R
S
Q
S
V
S
P
Site 75
S410
G
S
N
N
S
S
R
S
Q
S
V
S
P
T
S
Site 76
S412
N
N
S
S
R
S
Q
S
V
S
P
T
S
F
L
Site 77
S414
S
S
R
S
Q
S
V
S
P
T
S
F
L
T
I
Site 78
T416
R
S
Q
S
V
S
P
T
S
F
L
T
I
S
N
Site 79
S417
S
Q
S
V
S
P
T
S
F
L
T
I
S
N
E
Site 80
T420
V
S
P
T
S
F
L
T
I
S
N
E
G
S
E
Site 81
S422
P
T
S
F
L
T
I
S
N
E
G
S
E
E
S
Site 82
S426
L
T
I
S
N
E
G
S
E
E
S
P
C
S
A
Site 83
S429
S
N
E
G
S
E
E
S
P
C
S
A
D
D
L
Site 84
S432
G
S
E
E
S
P
C
S
A
D
D
L
L
V
D
Site 85
S449
D
K
E
N
G
N
N
S
P
L
P
K
Y
A
T
Site 86
Y454
N
N
S
P
L
P
K
Y
A
T
S
P
K
P
N
Site 87
T456
S
P
L
P
K
Y
A
T
S
P
K
P
N
N
S
Site 88
S457
P
L
P
K
Y
A
T
S
P
K
P
N
N
S
Y
Site 89
S463
T
S
P
K
P
N
N
S
Y
M
F
K
R
E
P
Site 90
Y464
S
P
K
P
N
N
S
Y
M
F
K
R
E
P
P
Site 91
S484
V
K
V
F
E
E
C
S
P
K
Q
L
H
E
I
Site 92
T528
L
L
P
T
P
D
L
T
L
K
G
S
G
H
S
Site 93
S532
P
D
L
T
L
K
G
S
G
H
S
L
T
V
T
Site 94
S535
T
L
K
G
S
G
H
S
L
T
V
T
T
G
M
Site 95
T537
K
G
S
G
H
S
L
T
V
T
T
G
M
T
T
Site 96
S554
L
Q
P
I
A
V
A
S
L
S
T
N
T
E
Q
Site 97
S556
P
I
A
V
A
S
L
S
T
N
T
E
Q
D
R
Site 98
S565
N
T
E
Q
D
R
V
S
R
G
T
S
T
V
M
Site 99
T568
Q
D
R
V
S
R
G
T
S
T
V
M
P
S
A
Site 100
S569
D
R
V
S
R
G
T
S
T
V
M
P
S
A
S
Site 101
T570
R
V
S
R
G
T
S
T
V
M
P
S
A
S
L
Site 102
S574
G
T
S
T
V
M
P
S
A
S
L
L
P
P
P
Site 103
S576
S
T
V
M
P
S
A
S
L
L
P
P
P
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation