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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC73
Full Name:
Parafibromin
Alias:
C1orf28; Cell division cycle 73; Cell division cycle 73, Paf1/RNA polymerase II complex component,; Cell division cycle protein 73 homologue; HRPT2; Hyperparathyroidism 2 protein
Type:
Cell cycle regulation
Mass (Da):
60577
Number AA:
531
UniProt ID:
Q6P1J9
International Prot ID:
IPI00300659
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
D
V
L
S
V
L
R
Q
Y
N
I
Site 2
Y11
V
L
S
V
L
R
Q
Y
N
I
Q
K
K
E
I
Site 3
Y40
P
K
N
V
K
T
N
Y
V
V
W
G
T
G
K
Site 4
Y54
K
E
G
Q
P
R
E
Y
Y
T
L
D
S
I
L
Site 5
Y55
E
G
Q
P
R
E
Y
Y
T
L
D
S
I
L
F
Site 6
T56
G
Q
P
R
E
Y
Y
T
L
D
S
I
L
F
L
Site 7
S59
R
E
Y
Y
T
L
D
S
I
L
F
L
L
N
N
Site 8
S70
L
L
N
N
V
H
L
S
H
P
V
Y
V
R
R
Site 9
Y74
V
H
L
S
H
P
V
Y
V
R
R
A
A
T
E
Site 10
Y97
D
R
K
D
L
L
G
Y
L
N
G
E
A
S
T
Site 11
S103
G
Y
L
N
G
E
A
S
T
S
A
S
I
D
R
Site 12
T104
Y
L
N
G
E
A
S
T
S
A
S
I
D
R
S
Site 13
S105
L
N
G
E
A
S
T
S
A
S
I
D
R
S
A
Site 14
S107
G
E
A
S
T
S
A
S
I
D
R
S
A
P
L
Site 15
S121
L
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
Site 16
T122
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
D
Site 17
S172
V
Q
T
E
Q
I
R
S
L
S
E
A
M
S
V
Site 18
S174
T
E
Q
I
R
S
L
S
E
A
M
S
V
E
K
Site 19
S195
K
I
M
A
K
K
R
S
T
I
K
T
D
L
D
Site 20
T196
I
M
A
K
K
R
S
T
I
K
T
D
L
D
D
Site 21
T199
K
K
R
S
T
I
K
T
D
L
D
D
D
I
T
Site 22
T206
T
D
L
D
D
D
I
T
A
L
K
Q
R
S
F
Site 23
S212
I
T
A
L
K
Q
R
S
F
V
D
A
E
V
D
Site 24
T221
V
D
A
E
V
D
V
T
R
D
I
V
S
R
E
Site 25
S226
D
V
T
R
D
I
V
S
R
E
R
V
W
R
T
Site 26
T235
E
R
V
W
R
T
R
T
T
I
L
Q
S
T
G
Site 27
T236
R
V
W
R
T
R
T
T
I
L
Q
S
T
G
K
Site 28
S240
T
R
T
T
I
L
Q
S
T
G
K
N
F
S
K
Site 29
T241
R
T
T
I
L
Q
S
T
G
K
N
F
S
K
N
Site 30
S246
Q
S
T
G
K
N
F
S
K
N
I
F
A
I
L
Site 31
T282
P
V
D
P
T
L
R
T
K
Q
P
I
P
A
A
Site 32
Y290
K
Q
P
I
P
A
A
Y
N
R
Y
D
Q
E
R
Site 33
Y293
I
P
A
A
Y
N
R
Y
D
Q
E
R
F
K
G
Site 34
Y315
K
I
D
T
M
G
T
Y
H
G
M
T
L
K
S
Site 35
T319
M
G
T
Y
H
G
M
T
L
K
S
V
T
E
G
Site 36
S322
Y
H
G
M
T
L
K
S
V
T
E
G
A
S
A
Site 37
S328
K
S
V
T
E
G
A
S
A
R
K
T
Q
T
P
Site 38
T332
E
G
A
S
A
R
K
T
Q
T
P
A
A
Q
P
Site 39
T334
A
S
A
R
K
T
Q
T
P
A
A
Q
P
V
P
Site 40
S345
Q
P
V
P
R
P
V
S
Q
A
R
P
P
P
N
Site 41
T359
N
Q
K
K
G
S
R
T
P
I
I
I
I
P
A
Site 42
S389
Q
D
L
K
F
V
P
S
D
E
K
K
K
Q
G
Site 43
Y480
I
K
A
F
H
L
K
Y
D
E
V
R
L
D
P
Site 44
T495
N
V
Q
K
W
D
V
T
V
L
E
L
S
Y
H
Site 45
S500
D
V
T
V
L
E
L
S
Y
H
K
R
H
L
D
Site 46
Y521
F
W
E
T
L
D
R
Y
M
V
K
H
K
S
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation