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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERAP2
Full Name:
Endoplasmic reticulum aminopeptidase 2
Alias:
Leukocyte-derived arginine aminopeptidase
Type:
Mass (Da):
110462
Number AA:
960
UniProt ID:
Q6P179
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
S
Q
F
S
V
P
S
S
Y
H
F
T
E
D
P
Site 2
T47
V
P
S
S
Y
H
F
T
E
D
P
G
A
F
P
Site 3
S124
I
T
N
A
T
L
Q
S
E
E
D
S
R
Y
M
Site 4
S128
T
L
Q
S
E
E
D
S
R
Y
M
K
P
G
K
Site 5
Y130
Q
S
E
E
D
S
R
Y
M
K
P
G
K
E
L
Site 6
S141
G
K
E
L
K
V
L
S
Y
P
A
H
E
Q
I
Site 7
Y142
K
E
L
K
V
L
S
Y
P
A
H
E
Q
I
A
Site 8
Y162
K
L
T
P
H
L
K
Y
Y
V
A
M
D
F
Q
Site 9
S182
G
F
E
G
F
Y
K
S
T
Y
R
T
L
G
G
Site 10
T183
F
E
G
F
Y
K
S
T
Y
R
T
L
G
G
E
Site 11
Y184
E
G
F
Y
K
S
T
Y
R
T
L
G
G
E
T
Site 12
T186
F
Y
K
S
T
Y
R
T
L
G
G
E
T
R
I
Site 13
T197
E
T
R
I
L
A
V
T
D
F
E
P
T
Q
A
Site 14
S228
S
I
K
I
R
R
E
S
R
H
I
A
L
S
N
Site 15
S234
E
S
R
H
I
A
L
S
N
M
P
K
V
K
T
Site 16
T241
S
N
M
P
K
V
K
T
I
E
L
E
G
G
L
Site 17
T256
L
E
D
H
F
E
T
T
V
K
M
S
T
Y
L
Site 18
S285
T
S
S
G
V
K
V
S
I
Y
A
S
P
D
K
Site 19
Y287
S
G
V
K
V
S
I
Y
A
S
P
D
K
R
N
Site 20
S289
V
K
V
S
I
Y
A
S
P
D
K
R
N
Q
T
Site 21
T296
S
P
D
K
R
N
Q
T
H
Y
A
L
Q
A
S
Site 22
Y298
D
K
R
N
Q
T
H
Y
A
L
Q
A
S
L
K
Site 23
Y310
S
L
K
L
L
D
F
Y
E
K
Y
F
D
I
Y
Site 24
Y313
L
L
D
F
Y
E
K
Y
F
D
I
Y
Y
P
L
Site 25
Y317
Y
E
K
Y
F
D
I
Y
Y
P
L
S
K
L
D
Site 26
Y318
E
K
Y
F
D
I
Y
Y
P
L
S
K
L
D
L
Site 27
T343
M
E
N
W
G
L
I
T
Y
R
E
T
S
L
L
Site 28
Y344
E
N
W
G
L
I
T
Y
R
E
T
S
L
L
F
Site 29
T347
G
L
I
T
Y
R
E
T
S
L
L
F
D
P
K
Site 30
S348
L
I
T
Y
R
E
T
S
L
L
F
D
P
K
T
Site 31
T355
S
L
L
F
D
P
K
T
S
S
A
S
D
K
L
Site 32
S357
L
F
D
P
K
T
S
S
A
S
D
K
L
W
V
Site 33
Y416
P
E
L
Q
F
D
D
Y
F
L
N
V
C
F
E
Site 34
S429
F
E
V
I
T
K
D
S
L
N
S
S
R
P
I
Site 35
S432
I
T
K
D
S
L
N
S
S
R
P
I
S
K
P
Site 36
S433
T
K
D
S
L
N
S
S
R
P
I
S
K
P
A
Site 37
S437
L
N
S
S
R
P
I
S
K
P
A
E
T
P
T
Site 38
T442
P
I
S
K
P
A
E
T
P
T
Q
I
Q
E
M
Site 39
Y481
F
Q
K
G
I
I
Q
Y
L
K
K
F
S
Y
R
Site 40
S497
A
K
N
D
D
L
W
S
S
L
S
N
S
C
L
Site 41
S498
K
N
D
D
L
W
S
S
L
S
N
S
C
L
E
Site 42
S500
D
D
L
W
S
S
L
S
N
S
C
L
E
S
D
Site 43
S502
L
W
S
S
L
S
N
S
C
L
E
S
D
F
T
Site 44
S506
L
S
N
S
C
L
E
S
D
F
T
S
G
G
V
Site 45
T509
S
C
L
E
S
D
F
T
S
G
G
V
C
H
S
Site 46
S510
C
L
E
S
D
F
T
S
G
G
V
C
H
S
D
Site 47
S516
T
S
G
G
V
C
H
S
D
P
K
M
T
S
N
Site 48
S522
H
S
D
P
K
M
T
S
N
M
L
A
F
L
G
Site 49
T540
E
V
K
E
M
M
T
T
W
T
L
Q
K
G
I
Site 50
S558
V
V
K
Q
D
G
C
S
L
R
L
Q
Q
E
R
Site 51
Y584
W
R
A
L
Q
E
R
Y
L
W
H
I
P
L
T
Site 52
T591
Y
L
W
H
I
P
L
T
Y
S
T
S
S
S
N
Site 53
Y592
L
W
H
I
P
L
T
Y
S
T
S
S
S
N
V
Site 54
S593
W
H
I
P
L
T
Y
S
T
S
S
S
N
V
I
Site 55
S595
I
P
L
T
Y
S
T
S
S
S
N
V
I
H
R
Site 56
S597
L
T
Y
S
T
S
S
S
N
V
I
H
R
H
I
Site 57
S607
I
H
R
H
I
L
K
S
K
T
D
T
L
D
L
Site 58
T609
R
H
I
L
K
S
K
T
D
T
L
D
L
P
E
Site 59
T611
I
L
K
S
K
T
D
T
L
D
L
P
E
K
T
Site 60
S619
L
D
L
P
E
K
T
S
W
V
K
F
N
V
D
Site 61
Y631
N
V
D
S
N
G
Y
Y
I
V
H
Y
E
G
H
Site 62
T652
T
Q
L
N
Q
N
H
T
L
L
R
P
K
D
R
Site 63
T684
L
D
K
A
L
D
M
T
Y
Y
L
Q
H
E
T
Site 64
Y685
D
K
A
L
D
M
T
Y
Y
L
Q
H
E
T
S
Site 65
Y686
K
A
L
D
M
T
Y
Y
L
Q
H
E
T
S
S
Site 66
S692
Y
Y
L
Q
H
E
T
S
S
P
A
L
L
E
G
Site 67
S693
Y
L
Q
H
E
T
S
S
P
A
L
L
E
G
L
Site 68
S716
M
M
D
R
R
N
I
S
D
I
S
E
N
L
K
Site 69
S719
R
R
N
I
S
D
I
S
E
N
L
K
R
Y
L
Site 70
Y729
L
K
R
Y
L
L
Q
Y
F
K
P
V
I
D
R
Site 71
S738
K
P
V
I
D
R
Q
S
W
S
D
K
G
S
V
Site 72
S740
V
I
D
R
Q
S
W
S
D
K
G
S
V
W
D
Site 73
S744
Q
S
W
S
D
K
G
S
V
W
D
R
M
L
R
Site 74
S775
Q
K
A
A
E
L
F
S
Q
W
M
E
S
S
G
Site 75
S780
L
F
S
Q
W
M
E
S
S
G
K
L
N
I
P
Site 76
S815
L
L
E
Q
Y
E
L
S
M
S
S
A
E
Q
N
Site 77
S817
E
Q
Y
E
L
S
M
S
S
A
E
Q
N
K
I
Site 78
Y826
A
E
Q
N
K
I
L
Y
A
L
S
T
S
K
H
Site 79
S829
N
K
I
L
Y
A
L
S
T
S
K
H
Q
E
K
Site 80
Y892
K
K
F
D
L
G
S
Y
D
I
R
M
I
I
S
Site 81
S899
Y
D
I
R
M
I
I
S
G
T
T
A
H
F
S
Site 82
S906
S
G
T
T
A
H
F
S
S
K
D
K
L
Q
E
Site 83
S920
E
V
K
L
F
F
E
S
L
E
A
Q
G
S
H
Site 84
S926
E
S
L
E
A
Q
G
S
H
L
D
I
F
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation