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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX57
Full Name:
Putative ATP-dependent RNA helicase DHX57
Alias:
DDX57; DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57; DEAH box protein 57
Type:
RNA binding protein; EC 3.6.1.-; Helicase
Mass (Da):
155604
Number AA:
1386
UniProt ID:
Q6P158
International Prot ID:
IPI00168885
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
G
K
G
G
G
K
G
S
S
R
G
G
R
G
G
Site 2
S20
K
G
G
G
K
G
S
S
R
G
G
R
G
G
R
Site 3
S28
R
G
G
R
G
G
R
S
H
A
S
K
S
H
G
Site 4
S31
R
G
G
R
S
H
A
S
K
S
H
G
S
G
G
Site 5
S33
G
R
S
H
A
S
K
S
H
G
S
G
G
G
G
Site 6
S54
G
G
G
N
R
K
A
S
S
R
I
W
D
D
G
Site 7
S55
G
G
N
R
K
A
S
S
R
I
W
D
D
G
D
Site 8
S68
G
D
D
F
C
I
F
S
E
S
R
R
P
S
R
Site 9
S70
D
F
C
I
F
S
E
S
R
R
P
S
R
P
S
Site 10
S74
F
S
E
S
R
R
P
S
R
P
S
N
S
N
I
Site 11
S77
S
R
R
P
S
R
P
S
N
S
N
I
S
K
G
Site 12
S79
R
P
S
R
P
S
N
S
N
I
S
K
G
E
S
Site 13
S82
R
P
S
N
S
N
I
S
K
G
E
S
R
P
K
Site 14
S86
S
N
I
S
K
G
E
S
R
P
K
W
K
P
K
Site 15
S127
E
Q
D
A
D
A
G
S
E
R
G
L
S
G
E
Site 16
S132
A
G
S
E
R
G
L
S
G
E
E
E
D
D
E
Site 17
S156
W
P
A
G
Q
E
P
S
L
V
P
D
L
D
P
Site 18
S190
P
F
A
V
Q
K
L
S
R
Y
G
F
N
T
E
Site 19
T196
L
S
R
Y
G
F
N
T
E
R
C
Q
A
V
L
Site 20
S213
C
D
G
D
V
G
A
S
L
E
H
L
L
T
Q
Site 21
T225
L
T
Q
C
F
S
E
T
F
G
E
R
M
K
I
Site 22
S240
S
E
A
V
N
Q
I
S
L
D
E
C
M
E
Q
Site 23
T273
R
I
Q
N
R
V
W
T
I
G
L
E
L
E
Y
Site 24
Y280
T
I
G
L
E
L
E
Y
L
T
S
R
F
R
K
Site 25
T282
G
L
E
L
E
Y
L
T
S
R
F
R
K
S
K
Site 26
S283
L
E
L
E
Y
L
T
S
R
F
R
K
S
K
P
Site 27
S288
L
T
S
R
F
R
K
S
K
P
K
E
S
T
K
Site 28
S337
I
V
G
R
I
E
R
S
V
D
D
S
H
L
N
Site 29
S341
I
E
R
S
V
D
D
S
H
L
N
A
I
E
D
Site 30
Y365
R
F
S
K
D
H
K
Y
P
Y
Q
A
P
L
V
Site 31
Y367
S
K
D
H
K
Y
P
Y
Q
A
P
L
V
A
F
Site 32
T377
P
L
V
A
F
Y
S
T
N
E
N
L
P
L
A
Site 33
T399
F
L
Y
D
K
A
L
T
F
A
E
T
S
E
P
Site 34
T426
S
E
I
V
K
L
L
T
N
T
H
H
K
Y
S
Site 35
Y432
L
T
N
T
H
H
K
Y
S
D
P
P
V
N
F
Site 36
S444
V
N
F
L
P
V
P
S
R
T
R
I
N
N
P
Site 37
S462
K
T
V
I
P
N
N
S
F
V
S
N
Q
I
P
Site 38
S475
I
P
E
V
E
K
A
S
E
S
E
E
S
D
E
Site 39
S477
E
V
E
K
A
S
E
S
E
E
S
D
E
D
D
Site 40
S480
K
A
S
E
S
E
E
S
D
E
D
D
G
P
A
Site 41
Y496
V
I
V
E
N
E
S
Y
V
N
L
K
K
K
I
Site 42
S531
Q
F
R
M
K
Q
A
S
R
Q
F
Q
S
I
L
Site 43
S543
S
I
L
Q
E
R
Q
S
L
P
A
W
E
E
R
Site 44
T552
P
A
W
E
E
R
E
T
I
L
N
L
L
R
K
Site 45
S585
P
Q
F
I
L
D
D
S
L
N
G
P
P
E
K
Site 46
T599
K
V
A
N
I
I
C
T
Q
P
R
R
I
S
A
Site 47
S605
C
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
Site 48
S608
P
R
R
I
S
A
I
S
V
A
E
R
V
A
K
Site 49
T624
R
A
E
R
V
G
L
T
V
G
Y
Q
I
R
L
Site 50
S633
G
Y
Q
I
R
L
E
S
V
K
S
S
A
T
R
Site 51
S636
I
R
L
E
S
V
K
S
S
A
T
R
L
L
Y
Site 52
S637
R
L
E
S
V
K
S
S
A
T
R
L
L
Y
C
Site 53
T639
E
S
V
K
S
S
A
T
R
L
L
Y
C
T
T
Site 54
T657
L
R
R
L
E
G
D
T
A
L
Q
G
V
S
H
Site 55
Y741
D
A
I
A
V
T
R
Y
V
L
Q
D
G
S
P
Site 56
S747
R
Y
V
L
Q
D
G
S
P
Y
M
R
S
M
K
Site 57
Y749
V
L
Q
D
G
S
P
Y
M
R
S
M
K
Q
I
Site 58
S752
D
G
S
P
Y
M
R
S
M
K
Q
I
S
K
E
Site 59
T768
L
K
A
R
R
N
R
T
A
F
E
E
V
E
E
Site 60
S780
V
E
E
D
L
R
L
S
L
H
L
Q
D
Q
D
Site 61
S788
L
H
L
Q
D
Q
D
S
V
K
D
A
V
P
D
Site 62
Y807
F
K
Q
L
L
A
R
Y
K
G
V
S
K
S
V
Site 63
S811
L
A
R
Y
K
G
V
S
K
S
V
I
K
T
M
Site 64
S813
R
Y
K
G
V
S
K
S
V
I
K
T
M
S
I
Site 65
S844
W
I
V
D
G
K
H
S
Y
P
P
G
A
I
L
Site 66
Y864
L
A
E
I
K
M
L
Y
E
Q
L
Q
S
N
S
Site 67
S869
M
L
Y
E
Q
L
Q
S
N
S
L
F
N
N
R
Site 68
S871
Y
E
Q
L
Q
S
N
S
L
F
N
N
R
R
S
Site 69
S888
C
V
I
H
P
L
H
S
S
L
S
S
E
E
Q
Site 70
S889
V
I
H
P
L
H
S
S
L
S
S
E
E
Q
Q
Site 71
S891
H
P
L
H
S
S
L
S
S
E
E
Q
Q
A
V
Site 72
S892
P
L
H
S
S
L
S
S
E
E
Q
Q
A
V
F
Site 73
Y939
G
K
M
K
E
K
R
Y
D
A
S
K
G
M
E
Site 74
S942
K
E
K
R
Y
D
A
S
K
G
M
E
S
L
E
Site 75
S947
D
A
S
K
G
M
E
S
L
E
D
T
F
V
S
Site 76
T951
G
M
E
S
L
E
D
T
F
V
S
Q
A
N
A
Site 77
S954
S
L
E
D
T
F
V
S
Q
A
N
A
L
Q
R
Site 78
T1030
R
L
I
E
P
P
H
T
D
S
L
R
A
S
K
Site 79
S1032
I
E
P
P
H
T
D
S
L
R
A
S
K
I
R
Site 80
S1036
H
T
D
S
L
R
A
S
K
I
R
L
R
D
L
Site 81
T1047
L
R
D
L
G
A
L
T
P
D
E
R
L
T
P
Site 82
T1053
L
T
P
D
E
R
L
T
P
L
G
Y
H
L
A
Site 83
S1099
A
F
K
S
P
F
V
S
P
W
D
K
K
E
E
Site 84
S1134
A
Y
K
G
W
Q
L
S
T
K
E
G
V
R
A
Site 85
S1142
T
K
E
G
V
R
A
S
Y
N
Y
C
R
Q
N
Site 86
Y1143
K
E
G
V
R
A
S
Y
N
Y
C
R
Q
N
F
Site 87
Y1145
G
V
R
A
S
Y
N
Y
C
R
Q
N
F
L
S
Site 88
S1161
R
V
L
Q
E
M
A
S
L
K
R
Q
F
T
E
Site 89
T1167
A
S
L
K
R
Q
F
T
E
L
L
S
D
I
G
Site 90
S1171
R
Q
F
T
E
L
L
S
D
I
G
F
A
R
E
Site 91
T1199
G
D
G
V
L
D
A
T
G
E
E
A
N
S
N
Site 92
S1205
A
T
G
E
E
A
N
S
N
A
E
N
P
K
L
Site 93
S1230
P
N
V
V
Q
V
K
S
P
E
G
K
F
Q
K
Site 94
S1249
A
V
R
M
Q
P
K
S
A
E
L
K
F
V
T
Site 95
Y1261
F
V
T
K
N
D
G
Y
V
H
I
H
P
S
S
Site 96
S1267
G
Y
V
H
I
H
P
S
S
V
N
Y
Q
V
R
Site 97
Y1271
I
H
P
S
S
V
N
Y
Q
V
R
H
F
D
S
Site 98
S1278
Y
Q
V
R
H
F
D
S
P
Y
L
L
Y
H
E
Site 99
Y1280
V
R
H
F
D
S
P
Y
L
L
Y
H
E
K
I
Site 100
Y1283
F
D
S
P
Y
L
L
Y
H
E
K
I
K
T
S
Site 101
T1289
L
Y
H
E
K
I
K
T
S
R
V
F
I
R
D
Site 102
S1325
Q
R
G
E
F
V
V
S
L
D
D
G
W
I
R
Site 103
T1368
N
P
S
I
D
L
C
T
C
P
R
G
S
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation