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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TYW1B
Full Name:
tRNA wybutosine-synthesizing protein 1 homolog B
Alias:
Radical S-adenosyl methionine and flavodoxin domain-containing protein 2
Type:
Mass (Da):
76946
Number AA:
668
UniProt ID:
Q6NUM6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
P
S
A
D
T
W
D
L
S
S
P
L
Site 2
S11
S
A
D
T
W
D
L
S
S
P
L
I
S
L
W
Site 3
Y70
A
I
I
N
L
K
E
Y
D
P
D
D
H
L
I
Site 4
Y122
D
F
R
F
G
K
T
Y
L
K
G
M
R
D
A
Site 5
S136
A
V
F
G
L
G
N
S
A
Y
A
S
H
F
N
Site 6
Y138
F
G
L
G
N
S
A
Y
A
S
H
F
N
K
V
Site 7
S140
L
G
N
S
A
Y
A
S
H
F
N
K
V
G
K
Site 8
S163
L
G
V
H
R
V
M
S
R
G
E
G
D
C
D
Site 9
S174
G
D
C
D
V
V
K
S
K
H
G
S
I
E
A
Site 10
S178
V
V
K
S
K
H
G
S
I
E
A
N
F
R
A
Site 11
S192
A
W
K
T
K
F
I
S
Q
L
Q
A
L
Q
K
Site 12
S205
Q
K
G
E
R
K
K
S
C
G
G
H
C
K
K
Site 13
S217
C
K
K
G
K
C
E
S
H
Q
H
G
S
E
E
Site 14
S222
C
E
S
H
Q
H
G
S
E
E
R
E
E
G
S
Site 15
T240
D
E
L
H
H
R
D
T
K
E
E
E
P
F
E
Site 16
S248
K
E
E
E
P
F
E
S
S
S
E
E
E
F
G
Site 17
S250
E
E
P
F
E
S
S
S
E
E
E
F
G
G
E
Site 18
S261
F
G
G
E
D
H
Q
S
L
N
S
I
V
D
V
Site 19
S292
K
E
Q
Q
E
E
K
S
G
L
F
R
N
M
G
Site 20
T311
G
E
R
R
A
M
I
T
P
A
L
R
E
A
L
Site 21
S329
V
D
A
P
R
E
R
S
L
L
Q
T
H
I
L
Site 22
T333
R
E
R
S
L
L
Q
T
H
I
L
W
N
E
S
Site 23
T347
S
H
R
C
M
E
T
T
P
S
L
A
C
A
N
Site 24
T412
E
R
F
E
E
G
M
T
V
K
H
C
A
L
S
Site 25
S468
P
V
T
Q
L
Y
V
S
V
D
A
S
T
K
D
Site 26
S472
L
Y
V
S
V
D
A
S
T
K
D
S
L
K
K
Site 27
S476
V
D
A
S
T
K
D
S
L
K
K
I
D
R
P
Site 28
Y508
V
K
Q
Q
R
T
V
Y
R
L
M
L
V
K
A
Site 29
T542
F
I
E
V
K
G
V
T
Y
C
R
E
S
S
A
Site 30
Y543
I
E
V
K
G
V
T
Y
C
R
E
S
S
A
S
Site 31
S547
G
V
T
Y
C
R
E
S
S
A
S
S
L
T
M
Site 32
S548
V
T
Y
C
R
E
S
S
A
S
S
L
T
M
A
Site 33
S550
Y
C
R
E
S
S
A
S
S
L
T
M
A
H
V
Site 34
S551
C
R
E
S
S
A
S
S
L
T
M
A
H
V
P
Site 35
T553
E
S
S
A
S
S
L
T
M
A
H
V
P
W
H
Site 36
Y618
F
Q
E
L
I
Q
E
Y
E
D
S
G
G
S
K
Site 37
S621
L
I
Q
E
Y
E
D
S
G
G
S
K
T
F
S
Site 38
S624
E
Y
E
D
S
G
G
S
K
T
F
S
A
K
D
Site 39
T626
E
D
S
G
G
S
K
T
F
S
A
K
D
Y
M
Site 40
S628
S
G
G
S
K
T
F
S
A
K
D
Y
M
A
R
Site 41
Y632
K
T
F
S
A
K
D
Y
M
A
R
T
P
H
W
Site 42
T636
A
K
D
Y
M
A
R
T
P
H
W
A
L
F
G
Site 43
S648
L
F
G
A
N
E
R
S
F
D
P
K
D
T
R
Site 44
S662
R
H
Q
R
K
N
K
S
K
A
I
S
G
C
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation