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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PWWP2B
Full Name:
PWWP domain-containing protein 2B
Alias:
bA432J24.1; FLJ46823; PWP2B; PWWP domain containing 2B; PWWP domain-containing protein 2; PWWP2
Type:
Uncharacterized protein
Mass (Da):
63967
Number AA:
590
UniProt ID:
Q6NUJ5
International Prot ID:
IPI00103812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
L
L
D
C
T
K
K
S
G
L
F
G
L
P
P
Site 2
S60
P
L
P
Q
V
D
E
S
P
V
N
D
S
H
G
Site 3
S65
D
E
S
P
V
N
D
S
H
G
R
A
P
E
E
Site 4
S82
A
E
V
M
Q
L
G
S
S
S
P
P
P
A
R
Site 5
S84
V
M
Q
L
G
S
S
S
P
P
P
A
R
G
V
Site 6
T96
R
G
V
Q
P
P
E
T
T
R
P
E
P
P
P
Site 7
S113
V
P
P
L
P
A
G
S
L
P
P
Y
P
P
Y
Site 8
Y117
P
A
G
S
L
P
P
Y
P
P
Y
F
E
G
A
Site 9
Y120
S
L
P
P
Y
P
P
Y
F
E
G
A
P
F
P
Site 10
Y136
P
L
W
L
R
D
T
Y
K
L
W
V
P
Q
P
Site 11
T147
V
P
Q
P
P
P
R
T
I
K
R
T
R
R
R
Site 12
T151
P
P
R
T
I
K
R
T
R
R
R
L
S
R
N
Site 13
S156
K
R
T
R
R
R
L
S
R
N
R
D
P
G
R
Site 14
S167
D
P
G
R
L
I
L
S
T
I
R
L
R
P
R
Site 15
T168
P
G
R
L
I
L
S
T
I
R
L
R
P
R
Q
Site 16
S183
V
L
C
E
K
C
K
S
T
L
S
P
P
E
A
Site 17
T184
L
C
E
K
C
K
S
T
L
S
P
P
E
A
S
Site 18
S186
E
K
C
K
S
T
L
S
P
P
E
A
S
P
G
Site 19
S191
T
L
S
P
P
E
A
S
P
G
P
P
A
A
P
Site 20
S206
R
A
R
R
R
L
G
S
G
P
D
R
E
L
R
Site 21
T228
G
E
P
T
A
A
A
T
A
R
R
S
K
R
E
Site 22
S232
A
A
A
T
A
R
R
S
K
R
E
R
R
E
E
Site 23
S250
P
A
E
Q
V
P
R
S
P
V
I
K
I
S
Y
Site 24
S256
R
S
P
V
I
K
I
S
Y
S
T
P
Q
G
K
Site 25
Y257
S
P
V
I
K
I
S
Y
S
T
P
Q
G
K
G
Site 26
S258
P
V
I
K
I
S
Y
S
T
P
Q
G
K
G
E
Site 27
T259
V
I
K
I
S
Y
S
T
P
Q
G
K
G
E
V
Site 28
S271
G
E
V
V
K
I
P
S
R
V
H
G
S
L
E
Site 29
S276
I
P
S
R
V
H
G
S
L
E
P
F
R
P
Q
Site 30
S291
Q
A
P
Q
D
D
G
S
Q
D
P
E
V
L
D
Site 31
S301
P
E
V
L
D
R
E
S
R
D
R
P
S
C
A
Site 32
S306
R
E
S
R
D
R
P
S
C
A
P
S
A
S
I
Site 33
S310
D
R
P
S
C
A
P
S
A
S
I
P
K
L
K
Site 34
S312
P
S
C
A
P
S
A
S
I
P
K
L
K
L
T
Site 35
T319
S
I
P
K
L
K
L
T
R
P
V
P
A
G
A
Site 36
S343
K
P
H
R
L
G
D
S
E
H
E
P
V
Y
R
Site 37
Y349
D
S
E
H
E
P
V
Y
R
A
E
L
V
G
E
Site 38
Y360
L
V
G
E
L
N
G
Y
L
R
D
S
S
P
A
Site 39
S364
L
N
G
Y
L
R
D
S
S
P
A
P
C
A
D
Site 40
S365
N
G
Y
L
R
D
S
S
P
A
P
C
A
D
G
Site 41
S381
A
G
G
L
A
D
L
S
S
G
S
S
G
E
D
Site 42
S382
G
G
L
A
D
L
S
S
G
S
S
G
E
D
D
Site 43
S385
A
D
L
S
S
G
S
S
G
E
D
D
D
F
K
Site 44
S393
G
E
D
D
D
F
K
S
C
P
Q
G
P
Q
G
Site 45
S419
E
G
R
A
D
C
A
S
E
S
A
C
S
S
D
Site 46
S421
R
A
D
C
A
S
E
S
A
C
S
S
D
S
L
Site 47
S424
C
A
S
E
S
A
C
S
S
D
S
L
D
E
A
Site 48
S425
A
S
E
S
A
C
S
S
D
S
L
D
E
A
R
Site 49
S427
E
S
A
C
S
S
D
S
L
D
E
A
R
S
S
Site 50
S433
D
S
L
D
E
A
R
S
S
G
S
E
G
T
P
Site 51
S434
S
L
D
E
A
R
S
S
G
S
E
G
T
P
A
Site 52
T439
R
S
S
G
S
E
G
T
P
A
D
T
G
D
L
Site 53
T443
S
E
G
T
P
A
D
T
G
D
L
S
P
G
H
Site 54
S447
P
A
D
T
G
D
L
S
P
G
H
G
A
S
A
Site 55
S453
L
S
P
G
H
G
A
S
A
P
S
V
S
R
E
Site 56
S456
G
H
G
A
S
A
P
S
V
S
R
E
A
R
Q
Site 57
T464
V
S
R
E
A
R
Q
T
V
P
P
L
T
V
R
Site 58
T469
R
Q
T
V
P
P
L
T
V
R
L
H
T
Q
S
Site 59
S476
T
V
R
L
H
T
Q
S
V
S
E
C
I
T
E
Site 60
S478
R
L
H
T
Q
S
V
S
E
C
I
T
E
D
G
Site 61
T482
Q
S
V
S
E
C
I
T
E
D
G
R
T
V
A
Site 62
S512
P
A
R
V
L
D
I
S
L
G
Q
K
E
D
G
Site 63
S522
Q
K
E
D
G
E
P
S
W
R
E
A
K
V
S
Site 64
S529
S
W
R
E
A
K
V
S
W
F
G
S
P
T
T
Site 65
T536
S
W
F
G
S
P
T
T
S
F
L
S
I
S
K
Site 66
S542
T
T
S
F
L
S
I
S
K
L
S
P
F
S
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation