KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LRRC8E
Full Name:
Leucine-rich repeat-containing protein 8E
Alias:
Type:
Mass (Da):
90247
Number AA:
796
UniProt ID:
Q6NSJ5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S65
H
E
L
Q
E
N
L
S
E
A
P
C
Q
Q
L
Site 2
Y114
Y
E
T
A
L
H
W
Y
T
K
Y
F
P
Y
L
Site 3
T142
F
W
F
K
F
P
G
T
S
S
K
I
E
H
F
Site 4
S144
F
K
F
P
G
T
S
S
K
I
E
H
F
I
S
Site 5
T162
K
C
F
D
S
P
W
T
T
R
A
L
S
E
V
Site 6
T163
C
F
D
S
P
W
T
T
R
A
L
S
E
V
S
Site 7
S167
P
W
T
T
R
A
L
S
E
V
S
G
E
N
Q
Site 8
Y252
V
E
E
G
D
I
L
Y
T
M
Y
I
R
Q
T
Site 9
Y296
E
T
S
E
V
T
G
Y
A
S
F
C
C
N
H
Site 10
Y342
F
H
R
P
L
K
E
Y
S
F
R
S
V
R
E
Site 11
S343
H
R
P
L
K
E
Y
S
F
R
S
V
R
E
E
Site 12
S346
L
K
E
Y
S
F
R
S
V
R
E
E
T
G
M
Site 13
T351
F
R
S
V
R
E
E
T
G
M
G
D
I
P
D
Site 14
Y373
M
L
H
L
I
D
Q
Y
D
S
L
Y
S
K
R
Site 15
S375
H
L
I
D
Q
Y
D
S
L
Y
S
K
R
F
A
Site 16
Y377
I
D
Q
Y
D
S
L
Y
S
K
R
F
A
V
F
Site 17
S378
D
Q
Y
D
S
L
Y
S
K
R
F
A
V
F
L
Site 18
S386
K
R
F
A
V
F
L
S
E
V
S
E
S
R
L
Site 19
S391
F
L
S
E
V
S
E
S
R
L
K
Q
L
N
L
Site 20
T403
L
N
L
N
H
E
W
T
P
E
K
L
R
Q
K
Site 21
S437
P
D
T
V
F
E
L
S
E
V
E
S
L
R
L
Site 22
S470
Q
E
L
S
L
L
H
S
P
A
R
L
P
F
S
Site 23
T527
Q
E
L
A
R
A
A
T
L
E
S
L
R
E
L
Site 24
S530
A
R
A
A
T
L
E
S
L
R
E
L
K
Q
L
Site 25
S541
L
K
Q
L
K
V
L
S
L
R
S
N
A
G
K
Site 26
S552
N
A
G
K
V
P
A
S
V
T
D
V
A
G
H
Site 27
S564
A
G
H
L
Q
R
L
S
L
H
N
D
G
A
R
Site 28
S619
L
K
D
N
H
L
R
S
I
E
E
I
L
S
F
Site 29
S625
R
S
I
E
E
I
L
S
F
Q
H
C
R
K
L
Site 30
Y644
L
W
H
N
Q
I
A
Y
V
P
E
H
V
R
K
Site 31
S654
E
H
V
R
K
L
R
S
L
E
Q
L
Y
L
S
Site 32
Y659
L
R
S
L
E
Q
L
Y
L
S
Y
N
K
L
E
Site 33
S661
S
L
E
Q
L
Y
L
S
Y
N
K
L
E
T
L
Site 34
T667
L
S
Y
N
K
L
E
T
L
P
S
Q
L
G
L
Site 35
S670
N
K
L
E
T
L
P
S
Q
L
G
L
C
S
G
Site 36
S690
V
S
H
N
G
L
H
S
L
P
P
E
V
G
L
Site 37
S735
L
L
G
D
N
Q
L
S
Q
L
S
P
H
V
G
Site 38
S738
D
N
Q
L
S
Q
L
S
P
H
V
G
A
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation