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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN13
Full Name:
Calpain-13
Alias:
Calpain 13; CAN13; FLJ23523
Type:
EC 3.4.22.-; Protease
Mass (Da):
76700
Number AA:
UniProt ID:
Q6MZZ7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Q
E
P
S
V
E
T
S
I
I
K
F
K
D
Q
Site 2
T23
F
K
D
Q
D
F
T
T
L
R
D
H
C
L
S
Site 3
S30
T
L
R
D
H
C
L
S
M
G
R
T
F
K
D
Site 4
T34
H
C
L
S
M
G
R
T
F
K
D
E
T
F
P
Site 5
T39
G
R
T
F
K
D
E
T
F
P
A
A
D
S
S
Site 6
S46
T
F
P
A
A
D
S
S
I
G
Q
K
L
L
Q
Site 7
S58
L
L
Q
E
K
R
L
S
N
V
I
W
K
R
P
Site 8
T103
L
A
A
L
G
S
L
T
Q
N
P
Q
Y
R
Q
Site 9
Y108
S
L
T
Q
N
P
Q
Y
R
Q
K
I
L
M
V
Site 10
S117
Q
K
I
L
M
V
Q
S
F
S
H
Q
Y
A
G
Site 11
S179
A
Y
A
K
L
L
G
S
Y
S
D
L
H
Y
G
Site 12
Y185
G
S
Y
S
D
L
H
Y
G
F
L
E
D
A
L
Site 13
S208
T
N
I
H
L
H
S
S
P
V
D
L
V
K
A
Site 14
T230
G
S
L
I
T
C
A
T
P
S
G
P
T
D
T
Site 15
Y261
T
G
A
E
Q
I
Q
Y
R
R
G
W
E
E
I
Site 16
S287
A
E
W
R
G
R
W
S
D
G
S
Q
E
W
E
Site 17
S290
R
G
R
W
S
D
G
S
Q
E
W
E
E
T
C
Site 18
T296
G
S
Q
E
W
E
E
T
C
D
P
R
K
S
Q
Site 19
S302
E
T
C
D
P
R
K
S
Q
L
H
K
K
R
E
Site 20
S415
F
Q
V
I
L
A
G
S
Q
R
F
R
E
K
F
Site 21
S428
K
F
P
P
V
F
F
S
S
F
R
N
T
V
Q
Site 22
S429
F
P
P
V
F
F
S
S
F
R
N
T
V
Q
S
Site 23
T433
F
F
S
S
F
R
N
T
V
Q
S
S
N
N
K
Site 24
S436
S
F
R
N
T
V
Q
S
S
N
N
K
F
R
R
Site 25
T446
N
K
F
R
R
N
F
T
M
T
Y
H
L
S
P
Site 26
T448
F
R
R
N
F
T
M
T
Y
H
L
S
P
G
N
Site 27
Y449
R
R
N
F
T
M
T
Y
H
L
S
P
G
N
Y
Site 28
Y456
Y
H
L
S
P
G
N
Y
V
V
V
A
Q
T
R
Site 29
T462
N
Y
V
V
V
A
Q
T
R
R
K
S
A
E
F
Site 30
S466
V
A
Q
T
R
R
K
S
A
E
F
L
L
R
I
Site 31
S480
I
F
L
K
M
P
D
S
D
R
H
L
S
S
H
Site 32
S485
P
D
S
D
R
H
L
S
S
H
F
N
L
R
M
Site 33
S486
D
S
D
R
H
L
S
S
H
F
N
L
R
M
K
Site 34
S495
F
N
L
R
M
K
G
S
P
S
E
H
G
S
Q
Site 35
S497
L
R
M
K
G
S
P
S
E
H
G
S
Q
Q
S
Site 36
S501
G
S
P
S
E
H
G
S
Q
Q
S
I
F
N
R
Site 37
S504
S
E
H
G
S
Q
Q
S
I
F
N
R
Y
A
Q
Site 38
Y509
Q
Q
S
I
F
N
R
Y
A
Q
Q
R
L
D
I
Site 39
T519
Q
R
L
D
I
D
A
T
Q
L
Q
G
L
L
N
Site 40
S539
G
P
P
G
D
M
F
S
L
D
E
C
R
S
L
Site 41
Y573
L
W
K
R
L
V
H
Y
Q
H
V
F
Q
K
V
Site 42
T616
R
E
L
L
H
L
V
T
L
R
Y
S
D
S
V
Site 43
S620
H
L
V
T
L
R
Y
S
D
S
V
G
R
V
S
Site 44
S622
V
T
L
R
Y
S
D
S
V
G
R
V
S
F
P
Site 45
T644
R
L
E
A
M
A
K
T
F
R
N
L
S
K
D
Site 46
S649
A
K
T
F
R
N
L
S
K
D
G
K
G
L
Y
Site 47
Y656
S
K
D
G
K
G
L
Y
L
T
E
M
E
W
M
Site 48
T658
D
G
K
G
L
Y
L
T
E
M
E
W
M
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation