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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL10
Full Name:
Kelch-like protein 10
Alias:
Type:
Mass (Da):
68942
Number AA:
608
UniProt ID:
Q6JEL2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
M
E
S
A
A
A
S
T
R
F
H
Q
P
H
Site 2
Y80
N
N
T
E
K
K
V
Y
N
I
P
G
I
S
P
Site 3
Y96
M
M
K
L
I
I
E
Y
A
Y
T
R
T
V
P
Site 4
Y98
K
L
I
I
E
Y
A
Y
T
R
T
V
P
I
T
Site 5
T101
I
E
Y
A
Y
T
R
T
V
P
I
T
P
D
N
Site 6
T105
Y
T
R
T
V
P
I
T
P
D
N
V
E
K
L
Site 7
Y150
G
I
C
K
F
T
D
Y
Y
Y
C
P
E
L
R
Site 8
Y151
I
C
K
F
T
D
Y
Y
Y
C
P
E
L
R
Q
Site 9
Y152
C
K
F
T
D
Y
Y
Y
C
P
E
L
R
Q
K
Site 10
Y161
P
E
L
R
Q
K
A
Y
M
F
I
L
H
N
F
Site 11
S212
E
A
I
L
K
W
I
S
H
D
P
Q
N
R
K
Site 12
S223
Q
N
R
K
Q
H
I
S
I
L
L
P
K
V
R
Site 13
Y248
N
N
V
K
M
N
D
Y
V
K
D
S
E
E
C
Site 14
S277
N
M
N
G
P
S
N
S
D
F
T
N
P
L
T
Site 15
T284
S
D
F
T
N
P
L
T
R
P
R
L
P
Y
A
Site 16
S303
I
G
G
W
S
G
G
S
P
T
N
A
I
E
A
Site 17
Y311
P
T
N
A
I
E
A
Y
D
A
R
A
D
R
W
Site 18
T322
A
D
R
W
V
N
V
T
C
E
E
E
S
P
R
Site 19
S327
N
V
T
C
E
E
E
S
P
R
A
Y
H
G
A
Site 20
Y331
E
E
E
S
P
R
A
Y
H
G
A
A
Y
L
K
Site 21
Y336
R
A
Y
H
G
A
A
Y
L
K
G
Y
V
Y
I
Site 22
Y352
G
G
F
D
S
V
D
Y
F
N
S
V
K
R
F
Site 23
S355
D
S
V
D
Y
F
N
S
V
K
R
F
D
P
V
Site 24
S380
H
S
R
R
C
Y
V
S
V
T
V
L
G
N
F
Site 25
Y397
A
M
G
G
F
D
G
Y
V
R
L
N
T
A
E
Site 26
T402
D
G
Y
V
R
L
N
T
A
E
R
Y
E
P
E
Site 27
T410
A
E
R
Y
E
P
E
T
N
Q
W
T
L
I
A
Site 28
S424
A
P
M
H
E
Q
R
S
D
A
S
A
T
T
L
Site 29
T449
N
G
N
E
C
L
F
T
A
E
V
Y
N
T
E
Site 30
T461
N
T
E
S
N
Q
W
T
V
I
A
P
M
R
S
Site 31
S471
A
P
M
R
S
R
R
S
G
I
G
V
I
A
Y
Site 32
S496
D
G
A
N
R
L
R
S
A
E
A
Y
S
P
V
Site 33
Y500
R
L
R
S
A
E
A
Y
S
P
V
A
N
T
W
Site 34
S501
L
R
S
A
E
A
Y
S
P
V
A
N
T
W
R
Site 35
T506
A
Y
S
P
V
A
N
T
W
R
T
I
P
T
M
Site 36
S518
P
T
M
F
N
P
R
S
N
F
G
I
E
V
V
Site 37
Y547
T
T
F
N
V
E
C
Y
D
E
K
T
D
E
W
Site 38
Y555
D
E
K
T
D
E
W
Y
D
A
H
D
M
S
I
Site 39
Y563
D
A
H
D
M
S
I
Y
R
S
A
L
S
C
C
Site 40
Y599
A
L
R
D
E
V
K
Y
S
A
S
T
S
T
L
Site 41
S600
L
R
D
E
V
K
Y
S
A
S
T
S
T
L
P
Site 42
S602
D
E
V
K
Y
S
A
S
T
S
T
L
P
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation