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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF425
Full Name:
Zinc finger protein 425
Alias:
ZN425
Type:
Unknown function
Mass (Da):
87721
Number AA:
752
UniProt ID:
Q6IV72
International Prot ID:
IPI00184520
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
T
F
D
D
V
A
L
Y
F
S
E
Q
E
W
E
Site 2
S19
D
D
V
A
L
Y
F
S
E
Q
E
W
E
I
L
Site 3
Y42
K
Q
E
M
K
T
N
Y
E
T
L
D
S
L
G
Site 4
S47
T
N
Y
E
T
L
D
S
L
G
Y
A
F
S
K
Site 5
Y50
E
T
L
D
S
L
G
Y
A
F
S
K
P
D
L
Site 6
S53
D
S
L
G
Y
A
F
S
K
P
D
L
I
T
W
Site 7
S70
Q
G
R
M
L
L
I
S
E
Q
G
C
L
D
K
Site 8
T78
E
Q
G
C
L
D
K
T
R
R
T
T
S
P
P
Site 9
T81
C
L
D
K
T
R
R
T
T
S
P
P
T
D
E
Site 10
T82
L
D
K
T
R
R
T
T
S
P
P
T
D
E
Q
Site 11
S83
D
K
T
R
R
T
T
S
P
P
T
D
E
Q
L
Site 12
T106
L
C
F
D
D
E
G
T
P
R
T
K
E
E
D
Site 13
S145
A
Q
T
A
T
F
Q
S
P
S
L
R
E
T
E
Site 14
S147
T
A
T
F
Q
S
P
S
L
R
E
T
E
I
L
Site 15
T151
Q
S
P
S
L
R
E
T
E
I
L
N
K
K
V
Site 16
S159
E
I
L
N
K
K
V
S
I
T
A
Y
D
P
D
Site 17
Y163
K
K
V
S
I
T
A
Y
D
P
D
K
K
D
L
Site 18
T177
L
R
H
K
P
R
E
T
P
G
R
L
E
I
P
Site 19
T185
P
G
R
L
E
I
P
T
G
P
R
C
Y
S
C
Site 20
Y190
I
P
T
G
P
R
C
Y
S
C
Y
V
C
R
K
Site 21
Y193
G
P
R
C
Y
S
C
Y
V
C
R
K
V
F
Q
Site 22
S211
D
L
L
K
H
K
R
S
H
S
K
S
Q
L
C
Site 23
S213
L
K
H
K
R
S
H
S
K
S
Q
L
C
R
Y
Site 24
S215
H
K
R
S
H
S
K
S
Q
L
C
R
Y
P
K
Site 25
Y220
S
K
S
Q
L
C
R
Y
P
K
Y
K
N
S
S
Site 26
Y223
Q
L
C
R
Y
P
K
Y
K
N
S
S
R
G
K
Site 27
S226
R
Y
P
K
Y
K
N
S
S
R
G
K
S
E
L
Site 28
S231
K
N
S
S
R
G
K
S
E
L
R
R
T
Q
R
Site 29
T236
G
K
S
E
L
R
R
T
Q
R
L
L
C
Q
K
Site 30
S254
Q
C
S
E
C
E
K
S
Y
F
L
K
G
S
L
Site 31
Y255
C
S
E
C
E
K
S
Y
F
L
K
G
S
L
V
Site 32
Y274
V
H
T
G
Q
R
P
Y
P
C
P
E
C
D
K
Site 33
T318
F
V
Q
Q
C
E
L
T
E
H
L
R
L
H
S
Site 34
S325
T
E
H
L
R
L
H
S
G
E
K
P
F
Q
C
Site 35
T350
R
G
M
K
V
H
L
T
Q
H
S
G
K
R
P
Site 36
S366
H
C
P
E
C
G
R
S
F
S
R
K
A
A
L
Site 37
S368
P
E
C
G
R
S
F
S
R
K
A
A
L
K
T
Site 38
T375
S
R
K
A
A
L
K
T
H
Q
R
T
H
S
E
Site 39
S381
K
T
H
Q
R
T
H
S
E
E
K
P
F
S
C
Site 40
S387
H
S
E
E
K
P
F
S
C
G
E
C
G
R
K
Site 41
Y397
E
C
G
R
K
F
I
Y
K
I
K
L
D
E
H
Site 42
T409
D
E
H
I
R
V
H
T
G
E
K
P
F
S
C
Site 43
S415
H
T
G
E
K
P
F
S
C
P
E
C
N
K
S
Site 44
S422
S
C
P
E
C
N
K
S
F
R
L
K
R
S
L
Site 45
S428
K
S
F
R
L
K
R
S
L
K
A
H
G
L
Q
Site 46
S465
R
A
H
Q
R
L
H
S
E
Q
K
P
F
P
C
Site 47
T480
A
E
C
G
K
R
F
T
R
P
S
K
L
A
C
Site 48
S483
G
K
R
F
T
R
P
S
K
L
A
C
H
T
R
Site 49
T506
P
C
G
E
C
K
K
T
F
S
Q
Q
S
R
L
Site 50
S508
G
E
C
K
K
T
F
S
Q
Q
S
R
L
T
Q
Site 51
T514
F
S
Q
Q
S
R
L
T
Q
H
L
K
V
H
T
Site 52
T522
Q
H
L
K
V
H
T
T
E
K
P
F
S
C
A
Site 53
S527
H
T
T
E
K
P
F
S
C
A
E
C
G
R
S
Site 54
S534
S
C
A
E
C
G
R
S
F
R
R
R
A
H
L
Site 55
T542
F
R
R
R
A
H
L
T
E
H
T
R
L
H
S
Site 56
S549
T
E
H
T
R
L
H
S
G
E
E
P
F
Q
C
Site 57
S564
P
E
C
D
K
S
F
S
W
K
A
S
M
K
F
Site 58
Y591
C
G
E
C
D
K
T
Y
T
H
Q
S
Q
L
T
Site 59
S595
D
K
T
Y
T
H
Q
S
Q
L
T
E
H
L
R
Site 60
S605
T
E
H
L
R
L
H
S
G
E
K
P
Y
Q
C
Site 61
Y610
L
H
S
G
E
K
P
Y
Q
C
P
E
C
E
K
Site 62
T618
Q
C
P
E
C
E
K
T
F
R
L
K
G
N
L
Site 63
S627
R
L
K
G
N
L
K
S
H
L
L
Q
H
S
G
Site 64
S633
K
S
H
L
L
Q
H
S
G
Q
K
P
F
S
C
Site 65
T654
F
T
Q
Q
Y
R
L
T
E
H
I
R
V
H
S
Site 66
S661
T
E
H
I
R
V
H
S
G
E
K
P
F
Q
C
Site 67
Y675
C
P
E
C
D
K
S
Y
C
I
R
G
S
L
K
Site 68
S680
K
S
Y
C
I
R
G
S
L
K
V
H
L
Y
K
Site 69
Y686
G
S
L
K
V
H
L
Y
K
H
S
G
E
R
P
Site 70
S708
K
G
F
L
Q
K
R
S
L
K
A
H
L
C
L
Site 71
S717
K
A
H
L
C
L
H
S
G
E
R
P
F
S
C
Site 72
S723
H
S
G
E
R
P
F
S
C
D
E
C
G
R
S
Site 73
S730
S
C
D
E
C
G
R
S
F
T
Y
V
G
A
L
Site 74
T732
D
E
C
G
R
S
F
T
Y
V
G
A
L
K
T
Site 75
Y733
E
C
G
R
S
F
T
Y
V
G
A
L
K
T
H
Site 76
T739
T
Y
V
G
A
L
K
T
H
I
A
V
H
A
K
Site 77
S751
H
A
K
E
K
P
S
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation