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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRHL2
Full Name:
Grainyhead-like protein 2 homolog
Alias:
Brother of mammalian grainyhead;Transcription factor CP2-like 3
Type:
Mass (Da):
Number AA:
UniProt ID:
Q6ISB3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
V
A
L
V
P
M
P
S
D
P
P
F
N
T
R
Site 2
T25
P
S
D
P
P
F
N
T
R
R
A
Y
T
S
E
Site 3
Y29
P
F
N
T
R
R
A
Y
T
S
E
D
E
A
W
Site 4
T30
F
N
T
R
R
A
Y
T
S
E
D
E
A
W
K
Site 5
S31
N
T
R
R
A
Y
T
S
E
D
E
A
W
K
S
Site 6
S38
S
E
D
E
A
W
K
S
Y
L
E
N
P
L
T
Site 7
T45
S
Y
L
E
N
P
L
T
A
A
T
K
A
M
M
Site 8
Y68
A
A
A
L
G
L
L
Y
D
Y
Y
K
V
P
R
Site 9
Y70
A
L
G
L
L
Y
D
Y
Y
K
V
P
R
D
K
Site 10
Y71
L
G
L
L
Y
D
Y
Y
K
V
P
R
D
K
R
Site 11
S81
P
R
D
K
R
L
L
S
V
S
K
A
S
D
S
Site 12
S83
D
K
R
L
L
S
V
S
K
A
S
D
S
Q
E
Site 13
S88
S
V
S
K
A
S
D
S
Q
E
D
Q
E
K
R
Site 14
T100
E
K
R
N
C
L
G
T
S
E
A
Q
S
N
L
Site 15
S101
K
R
N
C
L
G
T
S
E
A
Q
S
N
L
S
Site 16
S105
L
G
T
S
E
A
Q
S
N
L
S
G
G
E
N
Site 17
S134
N
Q
D
H
L
E
N
S
K
R
E
Q
Y
S
I
Site 18
Y139
E
N
S
K
R
E
Q
Y
S
I
S
F
P
E
S
Site 19
S140
N
S
K
R
E
Q
Y
S
I
S
F
P
E
S
S
Site 20
S142
K
R
E
Q
Y
S
I
S
F
P
E
S
S
A
I
Site 21
S146
Y
S
I
S
F
P
E
S
S
A
I
I
P
V
S
Site 22
Y174
F
M
A
P
P
V
H
Y
P
R
G
D
G
E
E
Site 23
T190
R
V
V
I
F
E
Q
T
Q
Y
D
V
P
S
L
Site 24
S196
Q
T
Q
Y
D
V
P
S
L
A
T
H
S
A
Y
Site 25
Y203
S
L
A
T
H
S
A
Y
L
K
D
D
Q
R
S
Site 26
S210
Y
L
K
D
D
Q
R
S
T
P
D
S
T
Y
S
Site 27
T211
L
K
D
D
Q
R
S
T
P
D
S
T
Y
S
E
Site 28
S214
D
Q
R
S
T
P
D
S
T
Y
S
E
S
F
K
Site 29
T215
Q
R
S
T
P
D
S
T
Y
S
E
S
F
K
D
Site 30
Y216
R
S
T
P
D
S
T
Y
S
E
S
F
K
D
A
Site 31
S217
S
T
P
D
S
T
Y
S
E
S
F
K
D
A
A
Site 32
S219
P
D
S
T
Y
S
E
S
F
K
D
A
A
T
E
Site 33
T225
E
S
F
K
D
A
A
T
E
K
F
R
S
A
S
Site 34
S230
A
A
T
E
K
F
R
S
A
S
V
G
A
E
E
Site 35
S232
T
E
K
F
R
S
A
S
V
G
A
E
E
Y
M
Site 36
Y238
A
S
V
G
A
E
E
Y
M
Y
D
Q
T
S
S
Site 37
Y240
V
G
A
E
E
Y
M
Y
D
Q
T
S
S
G
T
Site 38
T243
E
E
Y
M
Y
D
Q
T
S
S
G
T
F
Q
Y
Site 39
T247
Y
D
Q
T
S
S
G
T
F
Q
Y
T
L
E
A
Site 40
T251
S
S
G
T
F
Q
Y
T
L
E
A
T
K
S
L
Site 41
S257
Y
T
L
E
A
T
K
S
L
R
Q
K
Q
G
E
Site 42
T268
K
Q
G
E
G
P
M
T
Y
L
N
K
G
Q
F
Site 43
Y269
Q
G
E
G
P
M
T
Y
L
N
K
G
Q
F
Y
Site 44
T279
K
G
Q
F
Y
A
I
T
L
S
E
T
G
D
N
Site 45
S281
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Site 46
S294
K
C
F
R
H
P
I
S
K
V
R
S
V
V
M
Site 47
Y316
N
R
D
E
Q
L
K
Y
W
K
Y
W
H
S
R
Site 48
T326
Y
W
H
S
R
Q
H
T
A
K
Q
R
V
L
D
Site 49
Y337
R
V
L
D
I
A
D
Y
K
E
S
F
N
T
I
Site 50
T343
D
Y
K
E
S
F
N
T
I
G
N
I
E
E
I
Site 51
S375
F
I
T
V
N
C
L
S
T
D
F
S
S
Q
K
Site 52
T376
I
T
V
N
C
L
S
T
D
F
S
S
Q
K
G
Site 53
S379
N
C
L
S
T
D
F
S
S
Q
K
G
V
K
G
Site 54
S380
C
L
S
T
D
F
S
S
Q
K
G
V
K
G
L
Site 55
T395
P
L
M
I
Q
I
D
T
Y
S
Y
N
N
R
S
Site 56
Y396
L
M
I
Q
I
D
T
Y
S
Y
N
N
R
S
N
Site 57
Y398
I
Q
I
D
T
Y
S
Y
N
N
R
S
N
K
P
Site 58
S442
K
K
G
K
G
Q
A
S
Q
T
Q
C
N
S
S
Site 59
T444
G
K
G
Q
A
S
Q
T
Q
C
N
S
S
S
D
Site 60
S448
A
S
Q
T
Q
C
N
S
S
S
D
G
K
L
A
Site 61
S463
A
I
P
L
Q
K
K
S
D
I
T
Y
F
K
T
Site 62
T466
L
Q
K
K
S
D
I
T
Y
F
K
T
M
P
D
Site 63
Y467
Q
K
K
S
D
I
T
Y
F
K
T
M
P
D
L
Site 64
T470
S
D
I
T
Y
F
K
T
M
P
D
L
H
S
Q
Site 65
S476
K
T
M
P
D
L
H
S
Q
P
V
L
F
I
P
Site 66
Y497
L
Q
R
T
G
Q
V
Y
Y
N
T
D
D
E
R
Site 67
T535
K
Q
M
K
E
E
G
T
K
R
V
L
L
Y
V
Site 68
Y541
G
T
K
R
V
L
L
Y
V
R
K
E
T
D
D
Site 69
T546
L
L
Y
V
R
K
E
T
D
D
V
F
D
A
L
Site 70
S568
K
G
L
M
E
A
I
S
E
K
Y
G
L
P
V
Site 71
Y571
M
E
A
I
S
E
K
Y
G
L
P
V
E
K
I
Site 72
S585
I
A
K
L
Y
K
K
S
K
K
G
I
L
V
N
Site 73
T606
E
H
Y
S
N
E
D
T
F
I
L
N
M
E
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation