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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMEK1
Full Name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Alias:
FLFL1; FLJ20707; KIAA2010; MSTP033; PP4R3A; PPP4R3A; SMEK 1, suppressor of mek1; Smk1; Smk-1
Type:
Membrane protein, integral, Motility/polarity/chemotaxis
Mass (Da):
95368
Number AA:
833
UniProt ID:
Q6IN85
International Prot ID:
IPI00217013
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
T
R
R
R
V
K
V
Y
T
L
N
E
D
R
Q
Site 2
T12
R
R
R
V
K
V
Y
T
L
N
E
D
R
Q
W
Site 3
T24
R
Q
W
D
D
R
G
T
G
H
V
S
S
G
Y
Site 4
S29
R
G
T
G
H
V
S
S
G
Y
V
E
R
L
K
Site 5
Y31
T
G
H
V
S
S
G
Y
V
E
R
L
K
G
M
Site 6
S39
V
E
R
L
K
G
M
S
L
L
V
R
A
E
S
Site 7
S46
S
L
L
V
R
A
E
S
D
G
S
L
L
L
E
Site 8
S49
V
R
A
E
S
D
G
S
L
L
L
E
S
K
I
Site 9
T60
E
S
K
I
N
P
N
T
A
Y
Q
K
Q
Q
D
Site 10
T68
A
Y
Q
K
Q
Q
D
T
L
I
V
W
S
E
A
Site 11
Y78
V
W
S
E
A
E
N
Y
D
L
A
L
S
F
Q
Site 12
S83
E
N
Y
D
L
A
L
S
F
Q
E
K
A
G
C
Site 13
S106
Q
V
Q
G
K
D
P
S
V
D
I
T
Q
D
L
Site 14
T110
K
D
P
S
V
D
I
T
Q
D
L
V
D
E
S
Site 15
S117
T
Q
D
L
V
D
E
S
E
E
E
R
F
D
D
Site 16
S126
E
E
R
F
D
D
M
S
S
P
G
L
E
L
P
Site 17
S127
E
R
F
D
D
M
S
S
P
G
L
E
L
P
S
Site 18
S134
S
P
G
L
E
L
P
S
C
E
L
S
R
L
E
Site 19
S138
E
L
P
S
C
E
L
S
R
L
E
E
I
A
E
Site 20
S153
L
V
A
S
S
L
P
S
P
L
R
R
E
K
L
Site 21
Y169
L
A
L
E
N
E
G
Y
I
K
K
L
L
E
L
Site 22
Y226
D
V
I
G
C
L
E
Y
D
P
A
L
S
Q
P
Site 23
S231
L
E
Y
D
P
A
L
S
Q
P
R
K
H
R
E
Site 24
S253
F
K
E
V
I
P
I
S
D
P
E
L
K
Q
K
Site 25
T264
L
K
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Site 26
Y269
H
Q
T
Y
R
V
Q
Y
I
Q
D
M
V
L
P
Site 27
T277
I
Q
D
M
V
L
P
T
P
S
V
F
E
E
N
Site 28
T312
Q
E
D
E
K
F
L
T
D
L
F
A
Q
L
T
Site 29
S342
L
K
E
F
C
A
F
S
Q
T
L
Q
P
Q
N
Site 30
T344
E
F
C
A
F
S
Q
T
L
Q
P
Q
N
R
D
Site 31
T356
N
R
D
A
F
F
K
T
L
S
N
M
G
I
L
Site 32
S386
S
A
A
T
D
I
F
S
Y
L
V
E
Y
N
P
Site 33
S411
A
Q
Q
N
D
D
V
S
K
K
L
T
E
Q
K
Site 34
T415
D
D
V
S
K
K
L
T
E
Q
K
I
T
S
K
Site 35
T420
K
L
T
E
Q
K
I
T
S
K
D
I
L
L
I
Site 36
T438
I
E
H
M
I
C
D
T
D
P
E
L
G
G
A
Site 37
S499
N
T
T
E
D
K
P
S
K
D
D
F
Q
T
A
Site 38
Y570
I
G
L
K
D
E
F
Y
N
R
Y
I
M
K
S
Site 39
Y573
K
D
E
F
Y
N
R
Y
I
M
K
S
F
L
F
Site 40
T617
V
E
D
I
K
S
L
T
A
H
V
I
E
N
Y
Site 41
Y633
K
A
L
E
D
V
D
Y
V
Q
T
F
K
G
L
Site 42
T636
E
D
V
D
Y
V
Q
T
F
K
G
L
K
L
R
Site 43
S658
Q
D
N
P
K
L
D
S
M
R
S
I
L
R
N
Site 44
S661
P
K
L
D
S
M
R
S
I
L
R
N
H
R
Y
Site 45
Y668
S
I
L
R
N
H
R
Y
R
R
D
A
R
T
L
Site 46
T674
R
Y
R
R
D
A
R
T
L
E
D
E
E
E
M
Site 47
T685
E
E
E
M
W
F
N
T
D
E
D
D
M
E
D
Site 48
S698
E
D
G
E
A
V
V
S
P
S
D
K
T
K
N
Site 49
S700
G
E
A
V
V
S
P
S
D
K
T
K
N
D
D
Site 50
T703
V
V
S
P
S
D
K
T
K
N
D
D
D
I
M
Site 51
S737
V
L
L
K
T
N
L
S
G
R
Q
S
P
S
F
Site 52
S741
T
N
L
S
G
R
Q
S
P
S
F
K
L
S
L
Site 53
S743
L
S
G
R
Q
S
P
S
F
K
L
S
L
S
S
Site 54
S747
Q
S
P
S
F
K
L
S
L
S
S
G
T
K
T
Site 55
S749
P
S
F
K
L
S
L
S
S
G
T
K
T
N
L
Site 56
T754
S
L
S
S
G
T
K
T
N
L
T
S
Q
S
S
Site 57
T757
S
G
T
K
T
N
L
T
S
Q
S
S
T
T
N
Site 58
S758
G
T
K
T
N
L
T
S
Q
S
S
T
T
N
L
Site 59
S760
K
T
N
L
T
S
Q
S
S
T
T
N
L
P
G
Site 60
S761
T
N
L
T
S
Q
S
S
T
T
N
L
P
G
S
Site 61
T762
N
L
T
S
Q
S
S
T
T
N
L
P
G
S
P
Site 62
T763
L
T
S
Q
S
S
T
T
N
L
P
G
S
P
G
Site 63
S768
S
T
T
N
L
P
G
S
P
G
S
P
G
S
P
Site 64
S771
N
L
P
G
S
P
G
S
P
G
S
P
G
S
P
Site 65
S774
G
S
P
G
S
P
G
S
P
G
S
P
G
S
P
Site 66
S777
G
S
P
G
S
P
G
S
P
G
S
P
G
S
V
Site 67
S780
G
S
P
G
S
P
G
S
P
G
S
V
P
K
N
Site 68
S783
G
S
P
G
S
P
G
S
V
P
K
N
T
S
Q
Site 69
S789
G
S
V
P
K
N
T
S
Q
T
A
A
I
T
T
Site 70
Y806
G
L
V
G
L
V
D
Y
P
D
D
D
E
D
D
Site 71
T822
E
D
E
D
K
E
D
T
L
P
L
S
K
K
A
Site 72
S826
K
E
D
T
L
P
L
S
K
K
A
K
F
D
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation