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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLFN12L
Full Name:
Schlafen family member 12-like
Alias:
Schlafen 5; SLFN5
Type:
Unknown function
Mass (Da):
62476
Number AA:
549
UniProt ID:
Q6IEE8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
E
G
L
A
A
H
G
T
R
R
A
G
K
W
K
Site 2
T21
R
A
G
K
W
K
R
T
Q
V
P
L
L
G
E
Site 3
T72
V
L
N
V
G
R
V
T
L
G
E
N
N
R
K
Site 4
Y118
A
E
V
E
N
K
G
Y
S
Y
K
K
D
G
I
Site 5
S119
E
V
E
N
K
G
Y
S
Y
K
K
D
G
I
G
Site 6
Y152
D
F
M
Q
N
G
N
Y
F
H
I
F
V
K
S
Site 7
S161
H
I
F
V
K
S
W
S
L
E
T
S
G
P
Q
Site 8
S165
K
S
W
S
L
E
T
S
G
P
Q
I
A
T
L
Site 9
T171
T
S
G
P
Q
I
A
T
L
S
S
S
L
Y
K
Site 10
S173
G
P
Q
I
A
T
L
S
S
S
L
Y
K
R
D
Site 11
S175
Q
I
A
T
L
S
S
S
L
Y
K
R
D
V
T
Site 12
Y177
A
T
L
S
S
S
L
Y
K
R
D
V
T
S
A
Site 13
T182
S
L
Y
K
R
D
V
T
S
A
K
V
M
N
A
Site 14
Y207
E
K
T
G
G
R
A
Y
L
R
P
E
F
P
A
Site 15
Y242
F
N
R
T
E
L
G
Y
K
E
K
L
T
F
T
Site 16
T247
L
G
Y
K
E
K
L
T
F
T
E
S
T
H
V
Site 17
S251
E
K
L
T
F
T
E
S
T
H
V
E
I
K
N
Site 18
T269
E
K
L
L
Q
R
I
T
E
I
L
P
Q
Y
V
Site 19
S277
E
I
L
P
Q
Y
V
S
A
F
A
N
T
D
G
Site 20
S305
I
G
F
K
A
E
K
S
Y
S
T
K
L
E
E
Site 21
S307
F
K
A
E
K
S
Y
S
T
K
L
E
E
V
T
Site 22
Y343
L
C
K
F
L
G
V
Y
D
K
G
R
L
C
G
Site 23
Y351
D
K
G
R
L
C
G
Y
V
Y
A
L
R
V
E
Site 24
S371
V
F
A
K
K
P
D
S
W
H
V
K
D
N
R
Site 25
T383
D
N
R
V
K
Q
L
T
E
K
E
W
I
Q
F
Site 26
S403
P
V
C
E
E
L
P
S
P
A
S
T
S
S
P
Site 27
S406
E
E
L
P
S
P
A
S
T
S
S
P
V
S
Q
Site 28
T407
E
L
P
S
P
A
S
T
S
S
P
V
S
Q
S
Site 29
S408
L
P
S
P
A
S
T
S
S
P
V
S
Q
S
Y
Site 30
S409
P
S
P
A
S
T
S
S
P
V
S
Q
S
Y
P
Site 31
S412
A
S
T
S
S
P
V
S
Q
S
Y
P
L
R
E
Site 32
S414
T
S
S
P
V
S
Q
S
Y
P
L
R
E
Y
I
Site 33
Y415
S
S
P
V
S
Q
S
Y
P
L
R
E
Y
I
N
Site 34
Y420
Q
S
Y
P
L
R
E
Y
I
N
F
K
I
Q
P
Site 35
Y430
F
K
I
Q
P
L
R
Y
H
L
P
G
L
S
E
Site 36
T440
P
G
L
S
E
K
I
T
C
A
P
K
T
F
C
Site 37
T445
K
I
T
C
A
P
K
T
F
C
R
N
L
F
S
Site 38
S452
T
F
C
R
N
L
F
S
Q
H
E
G
L
K
Q
Site 39
S472
M
G
S
V
N
K
G
S
L
I
F
S
R
S
W
Site 40
S476
N
K
G
S
L
I
F
S
R
S
W
S
L
D
L
Site 41
T508
D
K
P
P
V
L
Y
T
F
H
M
V
Q
D
E
Site 42
Y520
Q
D
E
E
F
K
D
Y
S
T
Q
T
A
Q
T
Site 43
T522
E
E
F
K
D
Y
S
T
Q
T
A
Q
T
L
K
Site 44
Y538
K
L
A
K
I
G
G
Y
T
K
K
V
C
V
M
Site 45
S552
M
T
K
I
F
Y
L
S
P
E
G
K
T
S
C
Site 46
S558
L
S
P
E
G
K
T
S
C
Q
Y
D
L
N
S
Site 47
Y561
E
G
K
T
S
C
Q
Y
D
L
N
S
Q
V
I
Site 48
S565
S
C
Q
Y
D
L
N
S
Q
V
I
Y
P
E
S
Site 49
Y569
D
L
N
S
Q
V
I
Y
P
E
S
Y
Y
W
T
Site 50
S589
K
D
L
E
K
A
L
S
N
I
L
P
K
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation