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Updated November 2019
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Protein Info
Short Name:
TTLL5
Full Name:
Tubulin polyglutamylase TTLL5
Alias:
EC 6.-.-.-; SRC1 and TIF2-associated modulatory protein; Tubulin polyglutamylase TTLL5
Type:
Ligase, Nuclear receptor co-regulator
Mass (Da):
143105
Number AA:
1277
UniProt ID:
Q6EMB2
International Prot ID:
IPI00456634
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005929
GO:0005932
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004835
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
M
A
R
D
L
E
E
T
A
S
S
S
E
D
E
Site 2
S14
R
D
L
E
E
T
A
S
S
S
E
D
E
E
V
Site 3
S15
D
L
E
E
T
A
S
S
S
E
D
E
E
V
I
Site 4
S16
L
E
E
T
A
S
S
S
E
D
E
E
V
I
S
Site 5
S23
S
E
D
E
E
V
I
S
Q
E
D
H
P
C
I
Site 6
Y67
G
E
R
Y
H
L
S
Y
K
I
V
R
T
D
S
Site 7
T72
L
S
Y
K
I
V
R
T
D
S
R
L
V
R
S
Site 8
S74
Y
K
I
V
R
T
D
S
R
L
V
R
S
I
L
Site 9
Y96
V
H
P
S
S
T
D
Y
N
L
M
W
T
G
S
Site 10
S114
P
F
L
L
R
T
L
S
E
A
Q
K
V
N
H
Site 11
S125
K
V
N
H
F
P
R
S
Y
E
L
T
R
K
D
Site 12
Y126
V
N
H
F
P
R
S
Y
E
L
T
R
K
D
R
Site 13
T129
F
P
R
S
Y
E
L
T
R
K
D
R
L
Y
K
Site 14
Y135
L
T
R
K
D
R
L
Y
K
N
I
I
R
M
Q
Site 15
S169
E
Y
A
E
F
C
N
S
Y
S
K
D
R
G
P
Site 16
Y170
Y
A
E
F
C
N
S
Y
S
K
D
R
G
P
W
Site 17
S184
W
I
V
K
P
V
A
S
S
R
G
R
G
V
Y
Site 18
Y191
S
S
R
G
R
G
V
Y
L
I
N
N
P
N
Q
Site 19
Y227
F
K
F
D
V
R
L
Y
V
L
V
T
S
Y
D
Site 20
Y233
L
Y
V
L
V
T
S
Y
D
P
L
V
I
Y
L
Site 21
Y239
S
Y
D
P
L
V
I
Y
L
Y
E
E
G
L
A
Site 22
Y241
D
P
L
V
I
Y
L
Y
E
E
G
L
A
R
F
Site 23
T250
E
G
L
A
R
F
A
T
V
R
Y
D
Q
G
A
Site 24
Y270
Q
F
M
H
L
T
N
Y
S
V
N
K
K
S
G
Site 25
S276
N
Y
S
V
N
K
K
S
G
D
Y
V
S
C
D
Site 26
Y279
V
N
K
K
S
G
D
Y
V
S
C
D
D
P
E
Site 27
S281
K
K
S
G
D
Y
V
S
C
D
D
P
E
V
E
Site 28
Y290
D
D
P
E
V
E
D
Y
G
N
K
W
S
M
S
Site 29
Y302
S
M
S
A
M
L
R
Y
L
K
Q
E
G
R
D
Site 30
T310
L
K
Q
E
G
R
D
T
T
A
L
M
A
H
V
Site 31
T311
K
Q
E
G
R
D
T
T
A
L
M
A
H
V
E
Site 32
S344
K
T
F
V
P
H
R
S
S
C
F
E
L
Y
G
Site 33
S345
T
F
V
P
H
R
S
S
C
F
E
L
Y
G
F
Site 34
S407
Q
D
P
A
Q
R
A
S
T
R
P
I
Y
P
T
Site 35
T408
D
P
A
Q
R
A
S
T
R
P
I
Y
P
T
F
Site 36
Y412
R
A
S
T
R
P
I
Y
P
T
F
E
S
S
R
Site 37
T414
S
T
R
P
I
Y
P
T
F
E
S
S
R
R
N
Site 38
S417
P
I
Y
P
T
F
E
S
S
R
R
N
P
F
Q
Site 39
S418
I
Y
P
T
F
E
S
S
R
R
N
P
F
Q
K
Site 40
S433
P
Q
R
C
R
P
L
S
A
S
D
A
E
M
K
Site 41
S435
R
C
R
P
L
S
A
S
D
A
E
M
K
N
L
Site 42
S445
E
M
K
N
L
V
G
S
A
R
E
K
G
P
G
Site 43
T491
R
I
F
P
T
S
E
T
W
E
I
Y
G
S
Y
Site 44
Y495
T
S
E
T
W
E
I
Y
G
S
Y
L
E
H
K
Site 45
S497
E
T
W
E
I
Y
G
S
Y
L
E
H
K
T
S
Site 46
Y498
T
W
E
I
Y
G
S
Y
L
E
H
K
T
S
M
Site 47
T519
R
L
F
Q
D
R
M
T
A
D
G
A
P
E
L
Site 48
S530
A
P
E
L
K
I
E
S
L
N
S
K
A
K
L
Site 49
Y542
A
K
L
H
A
A
L
Y
E
R
K
L
L
S
L
Site 50
S548
L
Y
E
R
K
L
L
S
L
E
V
R
K
R
R
Site 51
S558
V
R
K
R
R
R
R
S
S
R
L
R
A
M
R
Site 52
S559
R
K
R
R
R
R
S
S
R
L
R
A
M
R
P
Site 53
Y568
L
R
A
M
R
P
K
Y
P
V
I
T
Q
P
A
Site 54
T581
P
A
E
M
N
V
K
T
E
T
E
S
E
E
E
Site 55
S603
E
D
E
E
Q
E
A
S
Q
E
E
S
A
G
F
Site 56
S607
Q
E
A
S
Q
E
E
S
A
G
F
L
R
E
N
Site 57
Y618
L
R
E
N
Q
A
K
Y
T
P
S
L
T
A
L
Site 58
T619
R
E
N
Q
A
K
Y
T
P
S
L
T
A
L
V
Site 59
S621
N
Q
A
K
Y
T
P
S
L
T
A
L
V
E
N
Site 60
T629
L
T
A
L
V
E
N
T
P
K
E
N
S
M
K
Site 61
S695
Q
I
R
L
M
K
D
S
G
G
Q
T
F
S
A
Site 62
T699
M
K
D
S
G
G
Q
T
F
S
A
S
W
A
A
Site 63
S701
D
S
G
G
Q
T
F
S
A
S
W
A
A
K
E
Site 64
S703
G
G
Q
T
F
S
A
S
W
A
A
K
E
D
E
Site 65
S723
V
R
F
L
K
R
A
S
N
N
L
Q
H
S
L
Site 66
S729
A
S
N
N
L
Q
H
S
L
R
M
V
L
P
S
Site 67
Y759
L
G
D
F
I
I
V
Y
N
K
E
T
E
Q
M
Site 68
S796
Q
E
F
I
R
Q
A
S
E
A
E
L
E
E
V
Site 69
T805
A
E
L
E
E
V
L
T
F
Y
T
Q
K
N
K
Site 70
S813
F
Y
T
Q
K
N
K
S
A
S
V
F
L
G
T
Site 71
S815
T
Q
K
N
K
S
A
S
V
F
L
G
T
H
S
Site 72
T820
S
A
S
V
F
L
G
T
H
S
K
I
S
K
N
Site 73
S832
S
K
N
N
N
N
Y
S
D
S
G
A
K
G
D
Site 74
S834
N
N
N
N
Y
S
D
S
G
A
K
G
D
H
P
Site 75
S867
E
I
H
S
D
K
L
S
R
F
T
T
S
A
E
Site 76
T870
S
D
K
L
S
R
F
T
T
S
A
E
K
E
A
Site 77
T871
D
K
L
S
R
F
T
T
S
A
E
K
E
A
K
Site 78
Y881
E
K
E
A
K
L
V
Y
S
N
S
S
S
G
P
Site 79
S882
K
E
A
K
L
V
Y
S
N
S
S
S
G
P
T
Site 80
S884
A
K
L
V
Y
S
N
S
S
S
G
P
T
A
T
Site 81
S886
L
V
Y
S
N
S
S
S
G
P
T
A
T
L
Q
Site 82
T891
S
S
S
G
P
T
A
T
L
Q
K
I
P
N
T
Site 83
T898
T
L
Q
K
I
P
N
T
H
L
S
S
V
T
T
Site 84
S901
K
I
P
N
T
H
L
S
S
V
T
T
S
D
L
Site 85
S902
I
P
N
T
H
L
S
S
V
T
T
S
D
L
S
Site 86
T905
T
H
L
S
S
V
T
T
S
D
L
S
P
G
P
Site 87
S906
H
L
S
S
V
T
T
S
D
L
S
P
G
P
C
Site 88
S909
S
V
T
T
S
D
L
S
P
G
P
C
H
H
S
Site 89
S916
S
P
G
P
C
H
H
S
S
L
S
Q
I
P
S
Site 90
S917
P
G
P
C
H
H
S
S
L
S
Q
I
P
S
A
Site 91
S919
P
C
H
H
S
S
L
S
Q
I
P
S
A
I
P
Site 92
S923
S
S
L
S
Q
I
P
S
A
I
P
S
M
P
H
Site 93
S927
Q
I
P
S
A
I
P
S
M
P
H
Q
P
T
I
Site 94
S944
N
T
V
S
A
S
A
S
P
C
L
H
P
G
A
Site 95
S956
P
G
A
Q
N
I
P
S
P
T
G
L
P
R
C
Site 96
S965
T
G
L
P
R
C
R
S
G
S
H
T
I
G
P
Site 97
S967
L
P
R
C
R
S
G
S
H
T
I
G
P
F
S
Site 98
T969
R
C
R
S
G
S
H
T
I
G
P
F
S
S
F
Site 99
S974
S
H
T
I
G
P
F
S
S
F
Q
S
A
A
H
Site 100
S978
G
P
F
S
S
F
Q
S
A
A
H
I
Y
S
Q
Site 101
S984
Q
S
A
A
H
I
Y
S
Q
K
L
S
R
P
S
Site 102
S988
H
I
Y
S
Q
K
L
S
R
P
S
S
A
K
A
Site 103
S991
S
Q
K
L
S
R
P
S
S
A
K
A
G
S
C
Site 104
S992
Q
K
L
S
R
P
S
S
A
K
A
G
S
C
Y
Site 105
S997
P
S
S
A
K
A
G
S
C
Y
L
N
K
H
H
Site 106
Y999
S
A
K
A
G
S
C
Y
L
N
K
H
H
S
G
Site 107
S1018
Q
K
E
G
E
D
A
S
L
Y
S
K
R
Y
N
Site 108
Y1020
E
G
E
D
A
S
L
Y
S
K
R
Y
N
Q
S
Site 109
S1021
G
E
D
A
S
L
Y
S
K
R
Y
N
Q
S
M
Site 110
Y1045
E
K
Q
A
A
R
Q
Y
S
P
S
S
H
I
N
Site 111
S1046
K
Q
A
A
R
Q
Y
S
P
S
S
H
I
N
L
Site 112
S1048
A
A
R
Q
Y
S
P
S
S
H
I
N
L
L
T
Site 113
S1049
A
R
Q
Y
S
P
S
S
H
I
N
L
L
T
Q
Site 114
T1055
S
S
H
I
N
L
L
T
Q
Q
V
T
N
L
N
Site 115
S1072
T
G
I
I
N
R
S
S
A
S
A
P
P
T
L
Site 116
S1074
I
I
N
R
S
S
A
S
A
P
P
T
L
R
P
Site 117
T1078
S
S
A
S
A
P
P
T
L
R
P
I
I
S
P
Site 118
S1084
P
T
L
R
P
I
I
S
P
S
G
P
T
W
S
Site 119
S1086
L
R
P
I
I
S
P
S
G
P
T
W
S
T
Q
Site 120
S1091
S
P
S
G
P
T
W
S
T
Q
S
D
P
Q
A
Site 121
T1092
P
S
G
P
T
W
S
T
Q
S
D
P
Q
A
P
Site 122
S1094
G
P
T
W
S
T
Q
S
D
P
Q
A
P
E
N
Site 123
S1103
P
Q
A
P
E
N
H
S
S
S
P
G
S
R
S
Site 124
S1104
Q
A
P
E
N
H
S
S
S
P
G
S
R
S
L
Site 125
S1105
A
P
E
N
H
S
S
S
P
G
S
R
S
L
Q
Site 126
S1108
N
H
S
S
S
P
G
S
R
S
L
Q
T
G
G
Site 127
S1110
S
S
S
P
G
S
R
S
L
Q
T
G
G
F
A
Site 128
Y1127
G
E
V
E
N
N
V
Y
S
Q
A
T
G
V
V
Site 129
S1128
E
V
E
N
N
V
Y
S
Q
A
T
G
V
V
P
Site 130
Y1139
G
V
V
P
Q
H
K
Y
H
P
T
A
G
S
Y
Site 131
S1169
S
R
Q
L
L
D
Q
S
R
A
R
H
Q
A
I
Site 132
S1179
R
H
Q
A
I
F
G
S
Q
T
L
P
N
S
N
Site 133
T1181
Q
A
I
F
G
S
Q
T
L
P
N
S
N
L
W
Site 134
T1189
L
P
N
S
N
L
W
T
M
N
N
G
A
G
C
Site 135
S1199
N
G
A
G
C
R
I
S
S
A
T
A
S
G
Q
Site 136
S1200
G
A
G
C
R
I
S
S
A
T
A
S
G
Q
K
Site 137
T1202
G
C
R
I
S
S
A
T
A
S
G
Q
K
P
T
Site 138
S1204
R
I
S
S
A
T
A
S
G
Q
K
P
T
T
L
Site 139
T1210
A
S
G
Q
K
P
T
T
L
P
Q
K
V
V
P
Site 140
S1224
P
P
P
S
S
C
A
S
L
V
P
K
P
P
P
Site 141
T1241
E
Q
V
L
R
R
A
T
S
Q
K
A
S
K
G
Site 142
S1242
Q
V
L
R
R
A
T
S
Q
K
A
S
K
G
S
Site 143
S1246
R
A
T
S
Q
K
A
S
K
G
S
S
A
E
G
Site 144
S1250
Q
K
A
S
K
G
S
S
A
E
G
Q
L
N
G
Site 145
S1260
G
Q
L
N
G
L
Q
S
S
L
N
P
A
A
F
Site 146
S1273
A
F
V
P
I
T
S
S
T
D
P
A
H
T
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation