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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC9A4
Full Name:
Sodium/hydrogen exchanger 4
Alias:
DKFZp313b031; Nhe4; Sl9a4; Slc9a4; Solute carrier family 9 (sodium/hydrogen exchanger), member 4
Type:
Apical plasma membrane, Plasma membrane, Basolateral plasma membrane, Integral membrane protein
Mass (Da):
89816
Number AA:
798
UniProt ID:
Q6AI14
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0015385
PhosphoSite+
KinaseNET
Biological Process:
GO:0006885
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
L
E
C
S
E
A
S
S
D
L
N
E
S
A
N
Site 2
S33
A
S
S
D
L
N
E
S
A
N
S
T
A
Q
Y
Site 3
S36
D
L
N
E
S
A
N
S
T
A
Q
Y
A
S
N
Site 4
T37
L
N
E
S
A
N
S
T
A
Q
Y
A
S
N
A
Site 5
Y40
S
A
N
S
T
A
Q
Y
A
S
N
A
W
F
A
Site 6
S50
N
A
W
F
A
A
A
S
S
E
P
E
E
G
I
Site 7
S51
A
W
F
A
A
A
S
S
E
P
E
E
G
I
S
Site 8
S58
S
E
P
E
E
G
I
S
V
F
E
L
D
Y
D
Site 9
S121
I
F
G
T
D
H
K
S
P
P
V
M
D
S
S
Site 10
Y338
C
A
V
T
M
K
K
Y
V
E
E
N
V
S
Q
Site 11
S344
K
Y
V
E
E
N
V
S
Q
T
S
Y
T
T
I
Site 12
Y348
E
N
V
S
Q
T
S
Y
T
T
I
K
Y
F
M
Site 13
Y353
T
S
Y
T
T
I
K
Y
F
M
K
M
L
S
S
Site 14
T413
Y
I
S
N
Q
F
R
T
F
P
F
S
I
K
D
Site 15
Y426
K
D
Q
C
I
I
F
Y
S
G
A
R
G
A
G
Site 16
T463
T
L
V
V
I
Y
F
T
V
F
I
Q
G
I
T
Site 17
Y477
T
V
G
P
L
V
R
Y
L
D
V
K
K
T
N
Site 18
T483
R
Y
L
D
V
K
K
T
N
K
K
E
S
I
N
Site 19
S488
K
K
T
N
K
K
E
S
I
N
E
E
L
H
I
Site 20
Y528
F
K
K
F
D
H
R
Y
L
R
K
I
L
I
R
Site 21
S541
I
R
K
N
L
P
K
S
S
I
V
S
L
Y
K
Site 22
S545
L
P
K
S
S
I
V
S
L
Y
K
K
L
E
M
Site 23
Y547
K
S
S
I
V
S
L
Y
K
K
L
E
M
K
Q
Site 24
T567
E
T
G
I
L
S
S
T
A
F
S
I
P
H
Q
Site 25
S570
I
L
S
S
T
A
F
S
I
P
H
Q
A
Q
R
Site 26
S585
I
Q
G
I
K
R
L
S
P
E
D
V
E
S
I
Site 27
S591
L
S
P
E
D
V
E
S
I
R
D
I
L
T
S
Site 28
T597
E
S
I
R
D
I
L
T
S
N
M
Y
Q
V
R
Site 29
S598
S
I
R
D
I
L
T
S
N
M
Y
Q
V
R
Q
Site 30
Y601
D
I
L
T
S
N
M
Y
Q
V
R
Q
R
T
L
Site 31
T607
M
Y
Q
V
R
Q
R
T
L
S
Y
N
K
Y
N
Site 32
S609
Q
V
R
Q
R
T
L
S
Y
N
K
Y
N
L
K
Site 33
Y613
R
T
L
S
Y
N
K
Y
N
L
K
P
Q
T
S
Site 34
T634
I
L
I
R
R
Q
N
T
L
R
E
S
M
R
K
Site 35
S638
R
Q
N
T
L
R
E
S
M
R
K
G
H
S
L
Site 36
S644
E
S
M
R
K
G
H
S
L
P
W
G
K
P
A
Site 37
Y658
A
G
T
K
N
I
R
Y
L
S
Y
P
Y
G
N
Site 38
S660
T
K
N
I
R
Y
L
S
Y
P
Y
G
N
P
Q
Site 39
Y661
K
N
I
R
Y
L
S
Y
P
Y
G
N
P
Q
S
Site 40
Y663
I
R
Y
L
S
Y
P
Y
G
N
P
Q
S
A
G
Site 41
S668
Y
P
Y
G
N
P
Q
S
A
G
R
D
T
R
A
Site 42
T673
P
Q
S
A
G
R
D
T
R
A
A
G
F
S
D
Site 43
S679
D
T
R
A
A
G
F
S
D
D
D
S
S
D
P
Site 44
S683
A
G
F
S
D
D
D
S
S
D
P
G
S
P
S
Site 45
S684
G
F
S
D
D
D
S
S
D
P
G
S
P
S
I
Site 46
S688
D
D
S
S
D
P
G
S
P
S
I
T
F
S
A
Site 47
S690
S
S
D
P
G
S
P
S
I
T
F
S
A
C
S
Site 48
T692
D
P
G
S
P
S
I
T
F
S
A
C
S
R
I
Site 49
S694
G
S
P
S
I
T
F
S
A
C
S
R
I
G
S
Site 50
S697
S
I
T
F
S
A
C
S
R
I
G
S
L
Q
K
Site 51
S701
S
A
C
S
R
I
G
S
L
Q
K
Q
E
A
Q
Site 52
S715
Q
E
I
I
P
M
K
S
L
H
R
G
R
K
A
Site 53
S724
H
R
G
R
K
A
F
S
F
G
Y
Q
R
N
T
Site 54
Y727
R
K
A
F
S
F
G
Y
Q
R
N
T
S
Q
E
Site 55
T731
S
F
G
Y
Q
R
N
T
S
Q
E
E
Y
L
G
Site 56
S732
F
G
Y
Q
R
N
T
S
Q
E
E
Y
L
G
G
Site 57
Y736
R
N
T
S
Q
E
E
Y
L
G
G
V
R
R
V
Site 58
S760
A
V
D
E
E
G
E
S
G
G
E
S
E
G
K
Site 59
S764
E
G
E
S
G
G
E
S
E
G
K
A
S
L
V
Site 60
S769
G
E
S
E
G
K
A
S
L
V
E
V
R
S
R
Site 61
S775
A
S
L
V
E
V
R
S
R
W
T
A
D
H
G
Site 62
T778
V
E
V
R
S
R
W
T
A
D
H
G
H
S
R
Site 63
S790
H
S
R
D
H
H
R
S
H
S
P
L
L
Q
K
Site 64
S792
R
D
H
H
R
S
H
S
P
L
L
Q
K
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation