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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEATR6
Full Name:
HEAT repeat-containing protein 6
Alias:
ABC1; Amplified in breast cancer 1; Amplified in breast cancer protein 1; FLJ22087; HEAT repeat containing 6
Type:
Oncoprotein
Mass (Da):
128781
Number AA:
1181
UniProt ID:
Q6AI08
International Prot ID:
IPI00464999
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Q
V
V
G
S
W
P
S
V
Q
P
R
E
A
P
Site 2
S45
C
A
L
R
P
D
D
S
S
S
A
R
T
E
I
Site 3
S46
A
L
R
P
D
D
S
S
S
A
R
T
E
I
H
Site 4
S47
L
R
P
D
D
S
S
S
A
R
T
E
I
H
L
Site 5
T50
D
D
S
S
S
A
R
T
E
I
H
L
L
F
D
Site 6
S61
L
L
F
D
Q
L
I
S
E
N
Y
S
E
G
S
Site 7
Y64
D
Q
L
I
S
E
N
Y
S
E
G
S
G
V
A
Site 8
S65
Q
L
I
S
E
N
Y
S
E
G
S
G
V
A
P
Site 9
S95
L
N
Q
N
H
L
V
S
K
V
S
Q
L
I
H
Site 10
Y157
N
G
S
K
C
Q
K
Y
L
P
E
L
L
G
N
Site 11
S172
T
G
L
L
M
K
L
S
D
L
A
Q
S
D
P
Site 12
S220
A
F
L
T
I
L
Q
S
P
K
S
S
D
M
D
Site 13
S223
T
I
L
Q
S
P
K
S
S
D
M
D
D
I
T
Site 14
S224
I
L
Q
S
P
K
S
S
D
M
D
D
I
T
F
Site 15
S244
N
A
L
K
G
I
Q
S
L
L
N
G
G
R
M
Site 16
T254
N
G
G
R
M
K
L
T
Q
T
D
E
L
G
A
Site 17
T288
M
P
T
V
L
Y
P
T
P
L
P
Q
Y
D
G
Site 18
Y293
Y
P
T
P
L
P
Q
Y
D
G
R
T
P
I
K
Site 19
T297
L
P
Q
Y
D
G
R
T
P
I
K
P
Q
Q
S
Site 20
S304
T
P
I
K
P
Q
Q
S
E
S
S
A
S
R
P
Site 21
S306
I
K
P
Q
Q
S
E
S
S
A
S
R
P
T
L
Site 22
S307
K
P
Q
Q
S
E
S
S
A
S
R
P
T
L
N
Site 23
S309
Q
Q
S
E
S
S
A
S
R
P
T
L
N
K
K
Site 24
T312
E
S
S
A
S
R
P
T
L
N
K
K
K
K
S
Site 25
S336
G
E
E
E
E
K
E
S
S
G
E
I
E
A
A
Site 26
S337
E
E
E
E
K
E
S
S
G
E
I
E
A
A
P
Site 27
T348
E
A
A
P
V
T
G
T
G
R
V
N
L
H
E
Site 28
T358
V
N
L
H
E
G
N
T
W
C
P
S
S
L
G
Site 29
S362
E
G
N
T
W
C
P
S
S
L
G
V
Q
S
L
Site 30
S363
G
N
T
W
C
P
S
S
L
G
V
Q
S
L
P
Site 31
S368
P
S
S
L
G
V
Q
S
L
P
L
D
G
S
G
Site 32
S374
Q
S
L
P
L
D
G
S
G
A
A
E
K
D
G
Site 33
S383
A
A
E
K
D
G
V
S
S
S
F
S
S
S
S
Site 34
S384
A
E
K
D
G
V
S
S
S
F
S
S
S
S
W
Site 35
S385
E
K
D
G
V
S
S
S
F
S
S
S
S
W
K
Site 36
S387
D
G
V
S
S
S
F
S
S
S
S
W
K
R
V
Site 37
S388
G
V
S
S
S
F
S
S
S
S
W
K
R
V
S
Site 38
S389
V
S
S
S
F
S
S
S
S
W
K
R
V
S
S
Site 39
S390
S
S
S
F
S
S
S
S
W
K
R
V
S
S
S
Site 40
S395
S
S
S
W
K
R
V
S
S
S
E
S
D
F
S
Site 41
S396
S
S
W
K
R
V
S
S
S
E
S
D
F
S
D
Site 42
S397
S
W
K
R
V
S
S
S
E
S
D
F
S
D
A
Site 43
S399
K
R
V
S
S
S
E
S
D
F
S
D
A
E
G
Site 44
S402
S
S
S
E
S
D
F
S
D
A
E
G
G
M
Q
Site 45
S410
D
A
E
G
G
M
Q
S
K
M
R
S
Y
Q
A
Site 46
S414
G
M
Q
S
K
M
R
S
Y
Q
A
K
V
R
Q
Site 47
Y415
M
Q
S
K
M
R
S
Y
Q
A
K
V
R
Q
G
Site 48
Y440
S
I
E
K
K
V
L
Y
G
Y
W
S
A
F
I
Site 49
Y442
E
K
K
V
L
Y
G
Y
W
S
A
F
I
P
D
Site 50
T450
W
S
A
F
I
P
D
T
P
E
L
G
S
P
Q
Site 51
S455
P
D
T
P
E
L
G
S
P
Q
S
V
S
L
M
Site 52
T465
S
V
S
L
M
T
L
T
L
K
D
P
S
P
K
Site 53
S470
T
L
T
L
K
D
P
S
P
K
T
R
A
C
A
Site 54
T473
L
K
D
P
S
P
K
T
R
A
C
A
L
Q
V
Site 55
S493
E
G
S
K
Q
F
L
S
V
A
E
D
T
S
D
Site 56
T506
S
D
H
R
R
A
F
T
P
F
S
V
M
I
A
Site 57
S548
K
C
L
A
N
L
V
S
N
A
P
Y
D
R
L
Site 58
Y552
N
L
V
S
N
A
P
Y
D
R
L
K
L
S
L
Site 59
S558
P
Y
D
R
L
K
L
S
L
L
T
K
V
W
N
Site 60
Y570
V
W
N
Q
I
K
P
Y
I
R
H
K
D
V
N
Site 61
S608
L
L
L
Q
Q
P
C
S
S
G
L
G
N
S
N
Site 62
S614
C
S
S
G
L
G
N
S
N
S
A
T
P
H
L
Site 63
S616
S
G
L
G
N
S
N
S
A
T
P
H
L
S
P
Site 64
T618
L
G
N
S
N
S
A
T
P
H
L
S
P
P
D
Site 65
S622
N
S
A
T
P
H
L
S
P
P
D
W
W
K
K
Site 66
S635
K
K
A
P
A
G
P
S
L
E
E
T
S
V
S
Site 67
T639
A
G
P
S
L
E
E
T
S
V
S
S
P
K
G
Site 68
S640
G
P
S
L
E
E
T
S
V
S
S
P
K
G
S
Site 69
S642
S
L
E
E
T
S
V
S
S
P
K
G
S
S
E
Site 70
S643
L
E
E
T
S
V
S
S
P
K
G
S
S
E
P
Site 71
S647
S
V
S
S
P
K
G
S
S
E
P
C
W
L
I
Site 72
S648
V
S
S
P
K
G
S
S
E
P
C
W
L
I
R
Site 73
S659
W
L
I
R
L
C
I
S
I
V
V
L
P
K
E
Site 74
S668
V
V
L
P
K
E
D
S
C
S
G
S
D
A
G
Site 75
S670
L
P
K
E
D
S
C
S
G
S
D
A
G
S
A
Site 76
S672
K
E
D
S
C
S
G
S
D
A
G
S
A
A
G
Site 77
S676
C
S
G
S
D
A
G
S
A
A
G
S
T
Y
E
Site 78
S680
D
A
G
S
A
A
G
S
T
Y
E
P
S
P
M
Site 79
T681
A
G
S
A
A
G
S
T
Y
E
P
S
P
M
R
Site 80
Y682
G
S
A
A
G
S
T
Y
E
P
S
P
M
R
L
Site 81
S685
A
G
S
T
Y
E
P
S
P
M
R
L
E
A
L
Site 82
S727
C
M
G
E
A
D
P
S
I
Q
L
H
G
A
K
Site 83
T741
K
L
L
E
E
L
G
T
G
L
I
Q
Q
Y
K
Site 84
Y747
G
T
G
L
I
Q
Q
Y
K
P
D
S
T
A
A
Site 85
S751
I
Q
Q
Y
K
P
D
S
T
A
A
P
D
Q
R
Site 86
T752
Q
Q
Y
K
P
D
S
T
A
A
P
D
Q
R
A
Site 87
S783
L
P
R
A
L
Q
N
S
E
H
P
T
L
Q
A
Site 88
T787
L
Q
N
S
E
H
P
T
L
Q
A
S
A
C
D
Site 89
S791
E
H
P
T
L
Q
A
S
A
C
D
A
L
S
S
Site 90
S805
S
I
L
P
E
A
F
S
N
L
P
N
D
R
Q
Site 91
S869
L
M
S
L
E
D
K
S
L
N
V
R
A
K
A
Site 92
T893
T
L
I
V
N
M
E
T
P
D
P
S
F
Q
E
Site 93
S897
N
M
E
T
P
D
P
S
F
Q
E
E
F
S
G
Site 94
S913
L
L
L
K
M
L
R
S
A
I
E
A
S
K
D
Site 95
S926
K
D
K
D
K
V
K
S
N
A
V
R
A
L
G
Site 96
S942
L
L
H
F
L
Q
P
S
H
I
E
K
P
T
F
Site 97
T948
P
S
H
I
E
K
P
T
F
A
E
I
I
E
E
Site 98
S962
E
S
I
Q
A
L
I
S
T
V
L
T
E
A
A
Site 99
T963
S
I
Q
A
L
I
S
T
V
L
T
E
A
A
M
Site 100
S998
L
G
T
A
P
W
T
S
Q
A
Y
N
A
L
T
Site 101
T1005
S
Q
A
Y
N
A
L
T
S
V
V
T
S
C
K
Site 102
S1006
Q
A
Y
N
A
L
T
S
V
V
T
S
C
K
N
Site 103
S1025
I
R
S
A
A
A
L
S
V
P
G
K
R
E
Q
Site 104
Y1033
V
P
G
K
R
E
Q
Y
G
S
V
D
Q
Y
A
Site 105
S1035
G
K
R
E
Q
Y
G
S
V
D
Q
Y
A
R
I
Site 106
Y1039
Q
Y
G
S
V
D
Q
Y
A
R
I
W
N
A
L
Site 107
T1094
D
L
P
C
M
K
E
T
L
E
L
S
G
N
M
Site 108
S1098
M
K
E
T
L
E
L
S
G
N
M
V
Q
S
Y
Site 109
Y1105
S
G
N
M
V
Q
S
Y
I
L
Q
F
L
K
S
Site 110
S1112
Y
I
L
Q
F
L
K
S
G
A
E
G
D
D
T
Site 111
T1119
S
G
A
E
G
D
D
T
G
A
P
H
S
P
Q
Site 112
S1124
D
D
T
G
A
P
H
S
P
Q
E
R
D
Q
M
Site 113
S1141
M
A
L
K
H
M
G
S
I
Q
A
P
T
G
D
Site 114
T1149
I
Q
A
P
T
G
D
T
A
R
R
A
I
M
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation