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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF518A
Full Name:
Zinc finger protein 518A
Alias:
DKFZp781O2147; KIAA0335; MGC125707; MGC125710; Z518A; Zinc finger protein 518; ZNF518
Type:
Transcription regulation
Mass (Da):
166782
Number AA:
1483
UniProt ID:
Q6AHZ1
International Prot ID:
IPI00307665
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
F
C
D
E
K
Q
T
T
L
K
K
D
Y
D
V
Site 2
Y21
Q
T
T
L
K
K
D
Y
D
V
K
N
E
I
V
Site 3
S31
K
N
E
I
V
D
R
S
A
P
K
P
K
I
S
Site 4
S38
S
A
P
K
P
K
I
S
G
S
I
H
Y
A
L
Site 5
S40
P
K
P
K
I
S
G
S
I
H
Y
A
L
K
N
Site 6
Y70
L
K
H
E
V
D
K
Y
R
K
L
F
Q
S
K
Site 7
S76
K
Y
R
K
L
F
Q
S
K
Q
Q
T
A
R
K
Site 8
T80
L
F
Q
S
K
Q
Q
T
A
R
K
S
I
S
I
Site 9
S84
K
Q
Q
T
A
R
K
S
I
S
I
K
T
V
S
Site 10
T89
R
K
S
I
S
I
K
T
V
S
C
V
E
E
C
Site 11
T97
V
S
C
V
E
E
C
T
L
L
H
K
S
E
R
Site 12
S102
E
C
T
L
L
H
K
S
E
R
A
E
E
E
G
Site 13
T128
C
L
K
C
R
D
N
T
R
Y
S
P
N
D
L
Site 14
Y130
K
C
R
D
N
T
R
Y
S
P
N
D
L
Q
K
Site 15
S131
C
R
D
N
T
R
Y
S
P
N
D
L
Q
K
H
Site 16
T171
V
F
K
Q
H
R
R
T
H
R
S
T
L
V
K
Site 17
S174
Q
H
R
R
T
H
R
S
T
L
V
K
C
D
I
Site 18
T175
H
R
R
T
H
R
S
T
L
V
K
C
D
I
C
Site 19
T189
C
N
N
E
S
V
Y
T
L
L
N
L
T
K
H
Site 20
T221
F
S
T
Q
D
V
G
T
F
V
Q
H
I
H
R
Site 21
Y234
H
R
H
N
E
I
H
Y
K
C
G
K
C
H
H
Site 22
T259
H
L
H
I
H
S
G
T
F
P
F
T
C
Q
Y
Site 23
Y266
T
F
P
F
T
C
Q
Y
C
S
Y
G
A
T
R
Site 24
T272
Q
Y
C
S
Y
G
A
T
R
R
E
H
L
V
R
Site 25
Y290
T
L
H
K
E
H
L
Y
A
K
E
K
L
E
K
Site 26
Y300
E
K
L
E
K
D
K
Y
E
K
R
M
A
K
T
Site 27
S308
E
K
R
M
A
K
T
S
A
G
L
K
L
I
L
Site 28
Y318
L
K
L
I
L
K
R
Y
K
I
G
A
S
R
K
Site 29
T326
K
I
G
A
S
R
K
T
F
W
K
R
K
K
I
Site 30
S335
W
K
R
K
K
I
N
S
G
S
D
R
S
I
E
Site 31
S337
R
K
K
I
N
S
G
S
D
R
S
I
E
K
N
Site 32
S340
I
N
S
G
S
D
R
S
I
E
K
N
T
Q
V
Site 33
T354
V
L
K
K
M
N
K
T
Q
T
K
S
E
D
Q
Site 34
S358
M
N
K
T
Q
T
K
S
E
D
Q
S
H
V
V
Site 35
S362
Q
T
K
S
E
D
Q
S
H
V
V
Q
E
H
L
Site 36
S370
H
V
V
Q
E
H
L
S
E
E
K
D
E
R
L
Site 37
S388
N
N
D
K
A
P
E
S
E
S
E
K
P
T
P
Site 38
S390
D
K
A
P
E
S
E
S
E
K
P
T
P
L
S
Site 39
T394
E
S
E
S
E
K
P
T
P
L
S
T
G
Q
G
Site 40
S397
S
E
K
P
T
P
L
S
T
G
Q
G
N
R
A
Site 41
S437
K
N
N
K
L
A
V
S
P
N
Y
N
A
T
F
Site 42
S469
P
I
K
Q
N
V
C
S
P
G
S
Q
S
G
A
Site 43
S472
Q
N
V
C
S
P
G
S
Q
S
G
A
A
K
D
Site 44
T481
S
G
A
A
K
D
G
T
A
N
L
Q
P
Q
T
Site 45
T491
L
Q
P
Q
T
L
D
T
N
G
F
L
T
G
V
Site 46
T505
V
T
T
E
L
N
D
T
V
Y
M
K
A
A
T
Site 47
Y507
T
E
L
N
D
T
V
Y
M
K
A
A
T
P
F
Site 48
T512
T
V
Y
M
K
A
A
T
P
F
S
C
S
S
S
Site 49
S519
T
P
F
S
C
S
S
S
I
L
S
G
K
A
S
Site 50
S522
S
C
S
S
S
I
L
S
G
K
A
S
S
E
K
Site 51
S526
S
I
L
S
G
K
A
S
S
E
K
E
M
T
L
Site 52
T532
A
S
S
E
K
E
M
T
L
I
S
Q
R
N
N
Site 53
S535
E
K
E
M
T
L
I
S
Q
R
N
N
M
L
Q
Site 54
Y546
N
M
L
Q
T
M
D
Y
E
K
S
V
S
S
L
Site 55
S549
Q
T
M
D
Y
E
K
S
V
S
S
L
S
A
T
Site 56
S551
M
D
Y
E
K
S
V
S
S
L
S
A
T
S
E
Site 57
S552
D
Y
E
K
S
V
S
S
L
S
A
T
S
E
L
Site 58
S554
E
K
S
V
S
S
L
S
A
T
S
E
L
V
T
Site 59
T567
V
T
A
S
V
N
L
T
T
K
F
E
T
R
D
Site 60
T584
D
F
W
G
N
H
L
T
Q
S
H
P
E
V
L
Site 61
S586
W
G
N
H
L
T
Q
S
H
P
E
V
L
G
T
Site 62
T593
S
H
P
E
V
L
G
T
T
I
K
S
P
D
K
Site 63
S632
C
E
L
P
V
E
S
S
N
Q
G
S
L
P
F
Site 64
S636
V
E
S
S
N
Q
G
S
L
P
F
H
N
Y
S
Site 65
Y642
G
S
L
P
F
H
N
Y
S
K
V
N
N
S
N
Site 66
S643
S
L
P
F
H
N
Y
S
K
V
N
N
S
N
K
Site 67
S648
N
Y
S
K
V
N
N
S
N
K
R
R
R
F
S
Site 68
S655
S
N
K
R
R
R
F
S
G
T
A
V
Y
E
N
Site 69
T657
K
R
R
R
F
S
G
T
A
V
Y
E
N
P
Q
Site 70
Y660
R
F
S
G
T
A
V
Y
E
N
P
Q
R
E
S
Site 71
S667
Y
E
N
P
Q
R
E
S
S
S
S
K
T
V
V
Site 72
S668
E
N
P
Q
R
E
S
S
S
S
K
T
V
V
Q
Site 73
S670
P
Q
R
E
S
S
S
S
K
T
V
V
Q
Q
P
Site 74
T672
R
E
S
S
S
S
K
T
V
V
Q
Q
P
I
S
Site 75
S681
V
Q
Q
P
I
S
E
S
F
L
S
L
V
R
Q
Site 76
S684
P
I
S
E
S
F
L
S
L
V
R
Q
E
S
S
Site 77
S690
L
S
L
V
R
Q
E
S
S
K
P
D
S
L
L
Site 78
S691
S
L
V
R
Q
E
S
S
K
P
D
S
L
L
A
Site 79
S695
Q
E
S
S
K
P
D
S
L
L
A
S
I
S
L
Site 80
S699
K
P
D
S
L
L
A
S
I
S
L
L
N
D
K
Site 81
S701
D
S
L
L
A
S
I
S
L
L
N
D
K
D
G
Site 82
T709
L
L
N
D
K
D
G
T
L
K
A
K
S
E
I
Site 83
S714
D
G
T
L
K
A
K
S
E
I
E
E
Q
Y
V
Site 84
Y720
K
S
E
I
E
E
Q
Y
V
L
E
K
G
Q
N
Site 85
Y734
N
I
D
G
Q
N
L
Y
S
N
E
N
Q
N
L
Site 86
S754
K
S
K
W
E
D
F
S
N
V
D
S
P
M
M
Site 87
S758
E
D
F
S
N
V
D
S
P
M
M
P
R
I
T
Site 88
S766
P
M
M
P
R
I
T
S
V
F
S
L
Q
S
Q
Site 89
S769
P
R
I
T
S
V
F
S
L
Q
S
Q
Q
A
S
Site 90
S772
T
S
V
F
S
L
Q
S
Q
Q
A
S
E
F
L
Site 91
S776
S
L
Q
S
Q
Q
A
S
E
F
L
P
P
E
V
Site 92
S801
K
P
D
V
K
Q
D
S
S
N
T
P
N
K
G
Site 93
S802
P
D
V
K
Q
D
S
S
N
T
P
N
K
G
L
Site 94
T804
V
K
Q
D
S
S
N
T
P
N
K
G
L
P
L
Site 95
S816
L
P
L
H
C
D
Q
S
F
Q
K
H
E
R
E
Site 96
S830
E
G
K
I
V
E
S
S
K
D
F
K
V
Q
G
Site 97
S866
F
G
K
E
K
Q
V
S
S
I
P
Q
D
V
R
Site 98
S867
G
K
E
K
Q
V
S
S
I
P
Q
D
V
R
D
Site 99
S875
I
P
Q
D
V
R
D
S
E
K
M
P
R
I
S
Site 100
S882
S
E
K
M
P
R
I
S
G
F
G
T
L
L
K
Site 101
T886
P
R
I
S
G
F
G
T
L
L
K
T
Q
S
D
Site 102
S892
G
T
L
L
K
T
Q
S
D
A
I
I
T
Q
Q
Site 103
T897
T
Q
S
D
A
I
I
T
Q
Q
L
V
K
D
K
Site 104
T908
V
K
D
K
L
R
A
T
T
Q
N
L
G
S
F
Site 105
T909
K
D
K
L
R
A
T
T
Q
N
L
G
S
F
Y
Site 106
S914
A
T
T
Q
N
L
G
S
F
Y
M
Q
S
P
L
Site 107
S919
L
G
S
F
Y
M
Q
S
P
L
L
N
S
E
Q
Site 108
S924
M
Q
S
P
L
L
N
S
E
Q
K
K
T
I
I
Site 109
T929
L
N
S
E
Q
K
K
T
I
I
V
Q
T
S
K
Site 110
S969
N
S
Q
G
I
P
A
S
L
F
V
N
K
K
P
Site 111
T981
K
K
P
G
M
V
L
T
L
N
N
G
K
L
E
Site 112
S991
N
G
K
L
E
G
V
S
A
V
K
T
E
G
A
Site 113
T995
E
G
V
S
A
V
K
T
E
G
A
P
A
R
G
Site 114
T1003
E
G
A
P
A
R
G
T
V
T
K
E
P
C
K
Site 115
T1011
V
T
K
E
P
C
K
T
P
I
L
K
V
E
P
Site 116
T1024
E
P
N
N
N
C
L
T
P
G
L
C
S
S
I
Site 117
S1036
S
S
I
G
S
C
L
S
M
K
S
S
S
E
N
Site 118
S1039
G
S
C
L
S
M
K
S
S
S
E
N
T
L
P
Site 119
S1040
S
C
L
S
M
K
S
S
S
E
N
T
L
P
L
Site 120
S1041
C
L
S
M
K
S
S
S
E
N
T
L
P
L
K
Site 121
T1044
M
K
S
S
S
E
N
T
L
P
L
K
G
P
Y
Site 122
T1056
G
P
Y
I
L
K
P
T
S
S
V
K
A
V
L
Site 123
S1057
P
Y
I
L
K
P
T
S
S
V
K
A
V
L
I
Site 124
S1058
Y
I
L
K
P
T
S
S
V
K
A
V
L
I
P
Site 125
S1069
V
L
I
P
N
M
L
S
E
Q
Q
S
T
K
L
Site 126
S1073
N
M
L
S
E
Q
Q
S
T
K
L
N
I
S
D
Site 127
S1079
Q
S
T
K
L
N
I
S
D
S
V
K
Q
Q
N
Site 128
S1081
T
K
L
N
I
S
D
S
V
K
Q
Q
N
E
I
Site 129
Y1095
I
F
P
K
P
P
L
Y
T
F
L
P
D
G
K
Site 130
T1096
F
P
K
P
P
L
Y
T
F
L
P
D
G
K
Q
Site 131
Y1128
K
L
V
Q
N
S
T
Y
Q
N
I
Q
P
K
K
Site 132
T1139
Q
P
K
K
P
E
G
T
P
Q
R
I
L
L
K
Site 133
S1161
V
T
A
A
N
N
L
S
V
S
N
S
A
S
S
Site 134
S1163
A
A
N
N
L
S
V
S
N
S
A
S
S
L
Q
Site 135
S1165
N
N
L
S
V
S
N
S
A
S
S
L
Q
K
D
Site 136
S1167
L
S
V
S
N
S
A
S
S
L
Q
K
D
N
V
Site 137
S1168
S
V
S
N
S
A
S
S
L
Q
K
D
N
V
P
Site 138
S1176
L
Q
K
D
N
V
P
S
N
Q
I
I
G
G
E
Site 139
S1189
G
E
Q
K
E
P
E
S
R
D
A
L
P
F
L
Site 140
S1217
S
T
A
T
C
P
E
S
S
E
E
P
I
C
V
Site 141
S1218
T
A
T
C
P
E
S
S
E
E
P
I
C
V
S
Site 142
S1225
S
E
E
P
I
C
V
S
D
C
S
E
S
R
V
Site 143
T1237
S
R
V
L
R
C
K
T
N
C
R
I
E
R
N
Site 144
T1250
R
N
F
N
R
K
K
T
S
K
K
I
F
S
K
Site 145
S1251
N
F
N
R
K
K
T
S
K
K
I
F
S
K
T
Site 146
T1258
S
K
K
I
F
S
K
T
K
T
H
G
S
K
D
Site 147
T1260
K
I
F
S
K
T
K
T
H
G
S
K
D
S
E
Site 148
S1263
S
K
T
K
T
H
G
S
K
D
S
E
T
A
F
Site 149
S1266
K
T
H
G
S
K
D
S
E
T
A
F
V
S
R
Site 150
T1268
H
G
S
K
D
S
E
T
A
F
V
S
R
N
R
Site 151
S1284
C
K
R
K
C
R
D
S
Y
Q
E
P
P
R
R
Site 152
Y1285
K
R
K
C
R
D
S
Y
Q
E
P
P
R
R
K
Site 153
T1294
E
P
P
R
R
K
A
T
L
H
R
K
C
K
E
Site 154
T1311
K
P
E
D
V
R
E
T
F
G
F
S
R
P
R
Site 155
S1315
V
R
E
T
F
G
F
S
R
P
R
L
S
K
D
Site 156
S1320
G
F
S
R
P
R
L
S
K
D
S
I
R
T
L
Site 157
S1323
R
P
R
L
S
K
D
S
I
R
T
L
R
L
F
Site 158
T1326
L
S
K
D
S
I
R
T
L
R
L
F
P
F
S
Site 159
S1378
N
G
H
V
L
K
V
S
L
S
K
R
T
I
N
Site 160
Y1393
A
L
L
K
P
V
C
Y
N
P
P
K
T
T
Y
Site 161
T1398
V
C
Y
N
P
P
K
T
T
Y
D
D
F
S
K
Site 162
Y1400
Y
N
P
P
K
T
T
Y
D
D
F
S
K
R
H
Site 163
S1404
K
T
T
Y
D
D
F
S
K
R
H
K
T
F
K
Site 164
T1409
D
F
S
K
R
H
K
T
F
K
P
V
S
S
V
Site 165
S1414
H
K
T
F
K
P
V
S
S
V
K
E
R
F
V
Site 166
T1425
E
R
F
V
L
K
L
T
L
K
K
T
S
K
N
Site 167
T1429
L
K
L
T
L
K
K
T
S
K
N
N
Y
Q
I
Site 168
Y1434
K
K
T
S
K
N
N
Y
Q
I
V
K
T
T
S
Site 169
S1441
Y
Q
I
V
K
T
T
S
E
N
I
L
K
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation