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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDCA2
Full Name:
Cell division cycle-associated protein 2
Alias:
Cell division cycle associated 2; FLJ25804; MGC129906; MGC129907; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo-Man
Type:
Phosphatase binding protein, for PPP1CC
Mass (Da):
112747
Number AA:
1024
UniProt ID:
Q69YH5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
S
K
D
K
P
P
E
T
K
E
S
A
M
N
N
Site 2
S15
K
P
P
E
T
K
E
S
A
M
N
N
A
G
G
Site 3
S25
N
N
A
G
G
N
A
S
F
I
L
G
T
G
K
Site 4
T35
L
G
T
G
K
I
V
T
P
Q
K
H
A
E
L
Site 5
T48
E
L
P
P
N
P
C
T
P
D
T
F
K
S
P
Site 6
T51
P
N
P
C
T
P
D
T
F
K
S
P
L
N
F
Site 7
S54
C
T
P
D
T
F
K
S
P
L
N
F
S
T
V
Site 8
T60
K
S
P
L
N
F
S
T
V
T
V
E
Q
L
G
Site 9
T69
T
V
E
Q
L
G
I
T
P
E
S
F
V
R
N
Site 10
S72
Q
L
G
I
T
P
E
S
F
V
R
N
S
A
G
Site 11
S77
P
E
S
F
V
R
N
S
A
G
K
S
S
S
Y
Site 12
S81
V
R
N
S
A
G
K
S
S
S
Y
L
K
K
C
Site 13
S83
N
S
A
G
K
S
S
S
Y
L
K
K
C
R
R
Site 14
S92
L
K
K
C
R
R
R
S
A
V
G
A
R
G
S
Site 15
S99
S
A
V
G
A
R
G
S
P
E
T
N
H
L
I
Site 16
T102
G
A
R
G
S
P
E
T
N
H
L
I
R
F
I
Site 17
S121
N
I
K
N
A
R
K
S
P
L
A
Q
D
S
P
Site 18
S127
K
S
P
L
A
Q
D
S
P
S
Q
G
S
P
A
Site 19
S129
P
L
A
Q
D
S
P
S
Q
G
S
P
A
L
Y
Site 20
S132
Q
D
S
P
S
Q
G
S
P
A
L
Y
R
N
V
Site 21
Y136
S
Q
G
S
P
A
L
Y
R
N
V
N
T
L
R
Site 22
T141
A
L
Y
R
N
V
N
T
L
R
E
R
I
S
A
Site 23
S147
N
T
L
R
E
R
I
S
A
F
Q
S
A
F
H
Site 24
S151
E
R
I
S
A
F
Q
S
A
F
H
S
I
K
E
Site 25
S155
A
F
Q
S
A
F
H
S
I
K
E
N
E
K
M
Site 26
S169
M
T
G
C
L
E
F
S
E
A
G
K
E
S
E
Site 27
T178
A
G
K
E
S
E
M
T
D
L
T
R
K
E
G
Site 28
T181
E
S
E
M
T
D
L
T
R
K
E
G
L
S
A
Site 29
S187
L
T
R
K
E
G
L
S
A
C
Q
Q
S
G
F
Site 30
S199
S
G
F
P
A
V
L
S
S
K
R
R
R
I
S
Site 31
S200
G
F
P
A
V
L
S
S
K
R
R
R
I
S
Y
Site 32
S206
S
S
K
R
R
R
I
S
Y
Q
R
D
S
D
E
Site 33
Y207
S
K
R
R
R
I
S
Y
Q
R
D
S
D
E
N
Site 34
S211
R
I
S
Y
Q
R
D
S
D
E
N
L
T
D
A
Site 35
T216
R
D
S
D
E
N
L
T
D
A
E
G
K
V
I
Site 36
S245
V
E
T
S
V
D
L
S
E
I
S
S
K
L
G
Site 37
S249
V
D
L
S
E
I
S
S
K
L
G
S
T
Q
S
Site 38
S253
E
I
S
S
K
L
G
S
T
Q
S
G
F
L
V
Site 39
T254
I
S
S
K
L
G
S
T
Q
S
G
F
L
V
E
Site 40
S256
S
K
L
G
S
T
Q
S
G
F
L
V
E
E
S
Site 41
S267
V
E
E
S
L
P
L
S
E
L
T
E
T
S
N
Site 42
T272
P
L
S
E
L
T
E
T
S
N
A
L
K
V
A
Site 43
S287
D
C
V
V
G
K
G
S
S
D
A
V
S
P
D
Site 44
S288
C
V
V
G
K
G
S
S
D
A
V
S
P
D
T
Site 45
S292
K
G
S
S
D
A
V
S
P
D
T
F
T
A
E
Site 46
T295
S
D
A
V
S
P
D
T
F
T
A
E
V
S
S
Site 47
T297
A
V
S
P
D
T
F
T
A
E
V
S
S
D
A
Site 48
S310
D
A
V
P
D
V
R
S
P
A
T
P
A
C
R
Site 49
T313
P
D
V
R
S
P
A
T
P
A
C
R
R
D
L
Site 50
T322
A
C
R
R
D
L
P
T
P
K
T
F
V
L
R
Site 51
T325
R
D
L
P
T
P
K
T
F
V
L
R
S
V
L
Site 52
S330
P
K
T
F
V
L
R
S
V
L
K
K
P
S
V
Site 53
S336
R
S
V
L
K
K
P
S
V
K
M
C
L
E
S
Site 54
Y352
Q
E
H
C
N
N
L
Y
D
D
D
G
T
H
P
Site 55
T357
N
L
Y
D
D
D
G
T
H
P
S
L
I
S
N
Site 56
S360
D
D
D
G
T
H
P
S
L
I
S
N
L
P
N
Site 57
S363
G
T
H
P
S
L
I
S
N
L
P
N
C
C
K
Site 58
T395
M
R
K
R
K
R
V
T
F
G
E
D
L
S
P
Site 59
S401
V
T
F
G
E
D
L
S
P
E
V
F
D
E
S
Site 60
S408
S
P
E
V
F
D
E
S
L
P
A
N
T
P
L
Site 61
T413
D
E
S
L
P
A
N
T
P
L
R
K
G
G
T
Site 62
T420
T
P
L
R
K
G
G
T
P
V
C
K
K
D
F
Site 63
S432
K
D
F
S
G
L
S
S
L
L
L
E
Q
S
P
Site 64
S438
S
S
L
L
L
E
Q
S
P
V
P
E
P
L
P
Site 65
S471
V
S
F
A
V
L
S
S
P
N
K
S
S
I
S
Site 66
S475
V
L
S
S
P
N
K
S
S
I
S
E
T
L
S
Site 67
S476
L
S
S
P
N
K
S
S
I
S
E
T
L
S
G
Site 68
S478
S
P
N
K
S
S
I
S
E
T
L
S
G
T
D
Site 69
T480
N
K
S
S
I
S
E
T
L
S
G
T
D
T
F
Site 70
S482
S
S
I
S
E
T
L
S
G
T
D
T
F
S
S
Site 71
T484
I
S
E
T
L
S
G
T
D
T
F
S
S
S
N
Site 72
T486
E
T
L
S
G
T
D
T
F
S
S
S
N
N
H
Site 73
S488
L
S
G
T
D
T
F
S
S
S
N
N
H
E
K
Site 74
S490
G
T
D
T
F
S
S
S
N
N
H
E
K
I
S
Site 75
S498
N
N
H
E
K
I
S
S
P
K
V
G
R
I
T
Site 76
T505
S
P
K
V
G
R
I
T
R
T
S
N
R
R
N
Site 77
S508
V
G
R
I
T
R
T
S
N
R
R
N
Q
L
V
Site 78
S516
N
R
R
N
Q
L
V
S
V
V
E
E
S
V
C
Site 79
S543
K
K
I
N
R
R
K
S
Q
E
T
K
C
T
K
Site 80
T546
N
R
R
K
S
Q
E
T
K
C
T
K
R
A
L
Site 81
T549
K
S
Q
E
T
K
C
T
K
R
A
L
P
K
K
Site 82
S557
K
R
A
L
P
K
K
S
Q
V
L
K
S
C
R
Site 83
S562
K
K
S
Q
V
L
K
S
C
R
K
K
K
G
K
Site 84
S573
K
K
G
K
G
K
K
S
V
Q
K
S
L
Y
G
Site 85
S577
G
K
K
S
V
Q
K
S
L
Y
G
E
R
D
I
Site 86
Y579
K
S
V
Q
K
S
L
Y
G
E
R
D
I
A
S
Site 87
S586
Y
G
E
R
D
I
A
S
K
K
P
L
L
S
P
Site 88
S592
A
S
K
K
P
L
L
S
P
I
P
E
L
P
E
Site 89
T604
L
P
E
V
P
E
M
T
P
S
I
P
S
I
R
Site 90
S606
E
V
P
E
M
T
P
S
I
P
S
I
R
R
L
Site 91
S609
E
M
T
P
S
I
P
S
I
R
R
L
G
S
G
Site 92
S615
P
S
I
R
R
L
G
S
G
Y
F
S
S
N
G
Site 93
Y617
I
R
R
L
G
S
G
Y
F
S
S
N
G
K
L
Site 94
S619
R
L
G
S
G
Y
F
S
S
N
G
K
L
E
E
Site 95
S620
L
G
S
G
Y
F
S
S
N
G
K
L
E
E
V
Site 96
T629
G
K
L
E
E
V
K
T
P
K
N
P
V
K
R
Site 97
Y655
M
H
Q
G
Y
D
K
Y
D
V
S
E
F
C
S
Site 98
S662
Y
D
V
S
E
F
C
S
Y
I
K
S
S
S
S
Site 99
Y663
D
V
S
E
F
C
S
Y
I
K
S
S
S
S
L
Site 100
S666
E
F
C
S
Y
I
K
S
S
S
S
L
G
N
A
Site 101
S669
S
Y
I
K
S
S
S
S
L
G
N
A
T
S
D
Site 102
S675
S
S
L
G
N
A
T
S
D
E
D
P
N
T
N
Site 103
T681
T
S
D
E
D
P
N
T
N
I
M
N
I
N
E
Site 104
S699
I
P
K
A
K
N
K
S
E
S
E
N
E
P
K
Site 105
T709
E
N
E
P
K
A
G
T
D
S
P
V
S
C
A
Site 106
S711
E
P
K
A
G
T
D
S
P
V
S
C
A
S
I
Site 107
S714
A
G
T
D
S
P
V
S
C
A
S
I
T
E
E
Site 108
T719
P
V
S
C
A
S
I
T
E
E
R
V
A
S
D
Site 109
S725
I
T
E
E
R
V
A
S
D
S
P
K
P
A
L
Site 110
S727
E
E
R
V
A
S
D
S
P
K
P
A
L
T
L
Site 111
T733
D
S
P
K
P
A
L
T
L
Q
Q
G
Q
E
F
Site 112
S757
L
C
Q
F
F
K
I
S
P
D
L
N
I
K
C
Site 113
S805
L
I
E
N
T
K
E
S
K
S
Q
S
E
D
L
Site 114
S807
E
N
T
K
E
S
K
S
Q
S
E
D
L
G
R
Site 115
S809
T
K
E
S
K
S
Q
S
E
D
L
G
R
K
P
Site 116
S819
L
G
R
K
P
M
E
S
S
S
V
V
S
C
R
Site 117
S820
G
R
K
P
M
E
S
S
S
V
V
S
C
R
D
Site 118
S821
R
K
P
M
E
S
S
S
V
V
S
C
R
D
R
Site 119
S824
M
E
S
S
S
V
V
S
C
R
D
R
K
D
R
Site 120
S834
D
R
K
D
R
R
R
S
M
C
Y
S
D
G
R
Site 121
Y837
D
R
R
R
S
M
C
Y
S
D
G
R
S
L
H
Site 122
S838
R
R
R
S
M
C
Y
S
D
G
R
S
L
H
L
Site 123
S842
M
C
Y
S
D
G
R
S
L
H
L
E
K
N
G
Site 124
T852
L
E
K
N
G
N
H
T
P
S
S
S
V
G
S
Site 125
S854
K
N
G
N
H
T
P
S
S
S
V
G
S
S
V
Site 126
S855
N
G
N
H
T
P
S
S
S
V
G
S
S
V
E
Site 127
S856
G
N
H
T
P
S
S
S
V
G
S
S
V
E
I
Site 128
S859
T
P
S
S
S
V
G
S
S
V
E
I
S
L
E
Site 129
S860
P
S
S
S
V
G
S
S
V
E
I
S
L
E
N
Site 130
S868
V
E
I
S
L
E
N
S
E
L
F
K
D
L
S
Site 131
S875
S
E
L
F
K
D
L
S
D
A
I
E
Q
T
F
Site 132
T881
L
S
D
A
I
E
Q
T
F
Q
R
R
N
S
E
Site 133
S887
Q
T
F
Q
R
R
N
S
E
T
K
V
R
R
S
Site 134
T889
F
Q
R
R
N
S
E
T
K
V
R
R
S
T
R
Site 135
S894
S
E
T
K
V
R
R
S
T
R
L
Q
K
D
L
Site 136
T895
E
T
K
V
R
R
S
T
R
L
Q
K
D
L
E
Site 137
S910
N
E
G
L
V
W
I
S
L
P
L
P
S
T
S
Site 138
S915
W
I
S
L
P
L
P
S
T
S
Q
K
A
K
R
Site 139
T916
I
S
L
P
L
P
S
T
S
Q
K
A
K
R
R
Site 140
S917
S
L
P
L
P
S
T
S
Q
K
A
K
R
R
T
Site 141
T924
S
Q
K
A
K
R
R
T
I
C
T
F
D
S
S
Site 142
T927
A
K
R
R
T
I
C
T
F
D
S
S
G
F
E
Site 143
S930
R
T
I
C
T
F
D
S
S
G
F
E
S
M
S
Site 144
S931
T
I
C
T
F
D
S
S
G
F
E
S
M
S
P
Site 145
S935
F
D
S
S
G
F
E
S
M
S
P
I
K
E
T
Site 146
S937
S
S
G
F
E
S
M
S
P
I
K
E
T
V
S
Site 147
T942
S
M
S
P
I
K
E
T
V
S
S
R
Q
K
P
Site 148
S944
S
P
I
K
E
T
V
S
S
R
Q
K
P
Q
M
Site 149
S945
P
I
K
E
T
V
S
S
R
Q
K
P
Q
M
A
Site 150
S956
P
Q
M
A
P
P
V
S
D
P
E
N
S
Q
G
Site 151
S961
P
V
S
D
P
E
N
S
Q
G
P
A
A
G
S
Site 152
S968
S
Q
G
P
A
A
G
S
S
D
E
P
G
K
R
Site 153
S969
Q
G
P
A
A
G
S
S
D
E
P
G
K
R
R
Site 154
S978
E
P
G
K
R
R
K
S
F
C
I
S
T
L
A
Site 155
S982
R
R
K
S
F
C
I
S
T
L
A
N
T
K
A
Site 156
T983
R
K
S
F
C
I
S
T
L
A
N
T
K
A
T
Site 157
S991
L
A
N
T
K
A
T
S
Q
F
K
G
Y
R
R
Site 158
Y996
A
T
S
Q
F
K
G
Y
R
R
R
S
S
L
N
Site 159
S1000
F
K
G
Y
R
R
R
S
S
L
N
G
K
G
E
Site 160
S1001
K
G
Y
R
R
R
S
S
L
N
G
K
G
E
S
Site 161
S1009
L
N
G
K
G
E
S
S
L
T
A
L
E
R
I
Site 162
T1011
G
K
G
E
S
S
L
T
A
L
E
R
I
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation