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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMPD2
Full Name:
FERM and PDZ domain-containing protein 2
Alias:
PDZ domain-containing protein 5C
Type:
Mass (Da):
144250
Number AA:
1309
UniProt ID:
Q68DX3
International Prot ID:
IPI00783413
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
G
M
S
L
S
S
V
T
L
A
S
A
L
Q
V
Site 2
S19
L
S
S
V
T
L
A
S
A
L
Q
V
R
G
E
Site 3
S29
Q
V
R
G
E
A
L
S
E
E
E
I
W
S
L
Site 4
S52
L
E
D
L
R
N
D
S
S
D
Y
V
V
C
P
Site 5
S53
E
D
L
R
N
D
S
S
D
Y
V
V
C
P
W
Site 6
Y55
L
R
N
D
S
S
D
Y
V
V
C
P
W
S
A
Site 7
S71
L
S
A
A
G
S
L
S
F
Q
G
R
V
S
H
Site 8
S94
P
E
L
L
Q
G
Q
S
E
D
E
Q
P
D
A
Site 9
S102
E
D
E
Q
P
D
A
S
Q
M
H
V
Y
S
L
Site 10
T139
P
L
H
S
I
L
L
T
M
C
E
D
Q
P
H
Site 11
T150
D
Q
P
H
R
R
C
T
L
Q
S
V
L
E
A
Site 12
S153
H
R
R
C
T
L
Q
S
V
L
E
A
C
R
V
Site 13
S166
R
V
H
E
K
E
V
S
V
Y
P
A
P
A
G
Site 14
Y168
H
E
K
E
V
S
V
Y
P
A
P
A
G
L
H
Site 15
S198
E
K
R
V
V
E
E
S
S
S
V
Q
Q
N
R
Site 16
S200
R
V
V
E
E
S
S
S
V
Q
Q
N
R
S
Y
Site 17
Y207
S
V
Q
Q
N
R
S
Y
L
L
R
K
R
L
R
Site 18
T216
L
R
K
R
L
R
G
T
S
S
E
S
P
A
A
Site 19
S217
R
K
R
L
R
G
T
S
S
E
S
P
A
A
Q
Site 20
S218
K
R
L
R
G
T
S
S
E
S
P
A
A
Q
A
Site 21
S220
L
R
G
T
S
S
E
S
P
A
A
Q
A
P
E
Site 22
S235
C
L
H
P
C
R
V
S
E
R
S
T
E
T
Q
Site 23
S238
P
C
R
V
S
E
R
S
T
E
T
Q
S
S
P
Site 24
T239
C
R
V
S
E
R
S
T
E
T
Q
S
S
P
E
Site 25
S244
R
S
T
E
T
Q
S
S
P
E
P
H
W
S
T
Site 26
T251
S
P
E
P
H
W
S
T
L
T
H
S
H
C
S
Site 27
T253
E
P
H
W
S
T
L
T
H
S
H
C
S
L
L
Site 28
S280
Q
Q
A
G
R
R
L
S
S
G
S
V
H
S
A
Site 29
S281
Q
A
G
R
R
L
S
S
G
S
V
H
S
A
A
Site 30
S283
G
R
R
L
S
S
G
S
V
H
S
A
A
D
S
Site 31
S286
L
S
S
G
S
V
H
S
A
A
D
S
S
W
P
Site 32
S290
S
V
H
S
A
A
D
S
S
W
P
T
T
P
S
Site 33
S291
V
H
S
A
A
D
S
S
W
P
T
T
P
S
Q
Site 34
T294
A
A
D
S
S
W
P
T
T
P
S
Q
R
G
F
Site 35
T295
A
D
S
S
W
P
T
T
P
S
Q
R
G
F
L
Site 36
S297
S
S
W
P
T
T
P
S
Q
R
G
F
L
Q
R
Site 37
S306
R
G
F
L
Q
R
R
S
K
F
S
R
P
E
F
Site 38
S309
L
Q
R
R
S
K
F
S
R
P
E
F
I
L
L
Site 39
S329
M
T
L
H
L
P
G
S
V
V
T
K
K
G
K
Site 40
S398
K
E
F
F
F
L
D
S
E
T
R
L
C
K
I
Site 41
T421
P
Q
K
T
S
M
N
T
F
T
L
F
L
R
I
Site 42
S441
H
Y
G
L
L
Q
H
S
L
T
R
H
Q
F
Y
Site 43
T443
G
L
L
Q
H
S
L
T
R
H
Q
F
Y
L
Q
Site 44
Y461
D
I
L
E
E
R
L
Y
C
N
E
E
I
L
L
Site 45
Y482
L
Q
A
E
F
G
N
Y
P
K
E
Q
V
E
S
Site 46
Y492
E
Q
V
E
S
K
P
Y
F
H
V
E
D
Y
I
Site 47
Y498
P
Y
F
H
V
E
D
Y
I
P
A
S
L
I
E
Site 48
S523
V
S
E
M
H
R
L
S
S
A
L
W
G
E
D
Site 49
S524
S
E
M
H
R
L
S
S
A
L
W
G
E
D
A
Site 50
T539
E
L
K
F
L
R
V
T
Q
Q
L
P
E
Y
G
Site 51
S554
V
L
V
H
Q
V
F
S
E
K
R
R
P
E
E
Site 52
Y575
C
A
K
G
V
I
V
Y
E
V
K
N
N
S
R
Site 53
T593
L
R
F
Q
W
R
E
T
G
K
I
S
T
Y
Q
Site 54
Y599
E
T
G
K
I
S
T
Y
Q
E
K
F
T
I
T
Site 55
T604
S
T
Y
Q
E
K
F
T
I
T
S
S
V
T
G
Site 56
T606
Y
Q
E
K
F
T
I
T
S
S
V
T
G
K
K
Site 57
S607
Q
E
K
F
T
I
T
S
S
V
T
G
K
K
H
Site 58
S608
E
K
F
T
I
T
S
S
V
T
G
K
K
H
T
Site 59
T610
F
T
I
T
S
S
V
T
G
K
K
H
T
F
V
Site 60
T615
S
V
T
G
K
K
H
T
F
V
T
D
S
A
K
Site 61
T618
G
K
K
H
T
F
V
T
D
S
A
K
T
G
K
Site 62
Y626
D
S
A
K
T
G
K
Y
L
L
D
L
C
S
A
Site 63
S643
G
F
N
A
Q
M
G
S
G
Q
P
S
H
V
L
Site 64
S647
Q
M
G
S
G
Q
P
S
H
V
L
F
D
H
D
Site 65
S663
F
V
Q
M
A
N
L
S
P
A
H
Q
A
R
S
Site 66
S682
W
I
Q
R
L
S
C
S
E
N
E
L
F
V
S
Site 67
S689
S
E
N
E
L
F
V
S
R
L
Q
G
A
A
G
Site 68
S700
G
A
A
G
G
L
L
S
T
S
M
D
N
F
N
Site 69
S702
A
G
G
L
L
S
T
S
M
D
N
F
N
V
D
Site 70
S711
D
N
F
N
V
D
G
S
K
E
A
G
A
E
G
Site 71
S722
G
A
E
G
I
G
R
S
P
C
T
G
R
E
Q
Site 72
T725
G
I
G
R
S
P
C
T
G
R
E
Q
L
K
S
Site 73
S732
T
G
R
E
Q
L
K
S
A
C
V
I
Q
K
P
Site 74
T741
C
V
I
Q
K
P
M
T
W
D
S
L
S
G
P
Site 75
S744
Q
K
P
M
T
W
D
S
L
S
G
P
P
V
Q
Site 76
S746
P
M
T
W
D
S
L
S
G
P
P
V
Q
S
M
Site 77
S752
L
S
G
P
P
V
Q
S
M
H
A
G
S
K
N
Site 78
S764
S
K
N
N
R
R
K
S
F
I
A
E
P
G
R
Site 79
T777
G
R
E
I
V
R
V
T
L
K
R
D
P
H
R
Site 80
S796
V
I
N
E
G
E
Y
S
G
Q
A
D
P
G
I
Site 81
T819
G
P
A
E
K
A
K
T
I
K
P
G
G
Q
T
Site 82
S849
A
V
R
M
I
Q
N
S
P
D
N
I
E
L
I
Site 83
S858
D
N
I
E
L
I
I
S
Q
S
K
G
V
G
G
Site 84
S860
I
E
L
I
I
S
Q
S
K
G
V
G
G
N
N
Site 85
S874
N
P
D
E
E
K
N
S
T
A
N
S
G
V
S
Site 86
T875
P
D
E
E
K
N
S
T
A
N
S
G
V
S
S
Site 87
S878
E
K
N
S
T
A
N
S
G
V
S
S
T
D
I
Site 88
S881
S
T
A
N
S
G
V
S
S
T
D
I
L
S
F
Site 89
S893
L
S
F
G
Y
Q
G
S
L
L
S
H
T
Q
D
Site 90
S896
G
Y
Q
G
S
L
L
S
H
T
Q
D
Q
D
R
Site 91
T905
T
Q
D
Q
D
R
N
T
E
E
L
D
M
A
G
Site 92
S925
P
R
L
R
H
Q
L
S
F
L
P
L
K
G
A
Site 93
S934
L
P
L
K
G
A
G
S
S
C
P
P
S
P
P
Site 94
S935
P
L
K
G
A
G
S
S
C
P
P
S
P
P
E
Site 95
S939
A
G
S
S
C
P
P
S
P
P
E
I
S
A
G
Site 96
S944
P
P
S
P
P
E
I
S
A
G
E
I
Y
F
V
Site 97
T959
E
L
V
K
E
D
G
T
L
G
F
S
V
T
G
Site 98
S963
E
D
G
T
L
G
F
S
V
T
G
G
I
N
T
Site 99
S1038
L
E
R
R
V
P
R
S
T
Q
Q
C
P
S
A
Site 100
T1039
E
R
R
V
P
R
S
T
Q
Q
C
P
S
A
N
Site 101
S1044
R
S
T
Q
Q
C
P
S
A
N
D
S
M
G
D
Site 102
S1048
Q
C
P
S
A
N
D
S
M
G
D
E
R
T
A
Site 103
S1067
T
A
L
P
G
R
P
S
S
C
V
S
V
T
D
Site 104
S1068
A
L
P
G
R
P
S
S
C
V
S
V
T
D
G
Site 105
S1071
G
R
P
S
S
C
V
S
V
T
D
G
P
K
F
Site 106
T1073
P
S
S
C
V
S
V
T
D
G
P
K
F
E
V
Site 107
S1092
N
A
N
G
L
G
F
S
F
V
Q
M
E
K
E
Site 108
S1100
F
V
Q
M
E
K
E
S
C
S
H
L
K
S
D
Site 109
S1106
E
S
C
S
H
L
K
S
D
L
V
R
I
K
R
Site 110
T1140
L
A
V
N
G
R
S
T
E
G
L
I
F
Q
E
Site 111
T1180
E
L
E
Q
E
W
Q
T
P
E
L
S
A
D
K
Site 112
S1184
E
W
Q
T
P
E
L
S
A
D
K
E
F
T
R
Site 113
T1193
D
K
E
F
T
R
A
T
C
T
D
S
C
T
S
Site 114
T1195
E
F
T
R
A
T
C
T
D
S
C
T
S
P
I
Site 115
S1197
T
R
A
T
C
T
D
S
C
T
S
P
I
L
D
Site 116
S1200
T
C
T
D
S
C
T
S
P
I
L
D
Q
E
D
Site 117
S1208
P
I
L
D
Q
E
D
S
W
R
D
S
A
S
P
Site 118
S1212
Q
E
D
S
W
R
D
S
A
S
P
D
A
G
E
Site 119
S1214
D
S
W
R
D
S
A
S
P
D
A
G
E
G
L
Site 120
S1227
G
L
G
L
R
P
E
S
S
Q
K
A
I
R
E
Site 121
S1228
L
G
L
R
P
E
S
S
Q
K
A
I
R
E
A
Site 122
S1248
R
E
R
P
W
A
S
S
L
T
H
S
P
E
S
Site 123
T1250
R
P
W
A
S
S
L
T
H
S
P
E
S
H
P
Site 124
S1252
W
A
S
S
L
T
H
S
P
E
S
H
P
H
L
Site 125
S1255
S
L
T
H
S
P
E
S
H
P
H
L
C
K
L
Site 126
S1269
L
H
Q
E
R
D
E
S
T
L
A
T
S
L
E
Site 127
T1270
H
Q
E
R
D
E
S
T
L
A
T
S
L
E
K
Site 128
Y1295
D
I
M
R
L
G
R
Y
S
F
S
S
P
L
T
Site 129
S1296
I
M
R
L
G
R
Y
S
F
S
S
P
L
T
R
Site 130
S1298
R
L
G
R
Y
S
F
S
S
P
L
T
R
L
S
Site 131
S1299
L
G
R
Y
S
F
S
S
P
L
T
R
L
S
T
Site 132
T1302
Y
S
F
S
S
P
L
T
R
L
S
T
D
I
F
Site 133
S1305
S
S
P
L
T
R
L
S
T
D
I
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation