KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CRYBG3
Full Name:
Beta/gamma crystallin domain-containing protein 3
Alias:
Type:
Mass (Da):
116197
Number AA:
1022
UniProt ID:
Q68DQ2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
P
D
F
Q
P
G
D
T
T
V
R
L
D
K
R
Site 2
T10
D
F
Q
P
G
D
T
T
V
R
L
D
K
R
M
Site 3
S18
V
R
L
D
K
R
M
S
L
T
A
I
Y
D
K
Site 4
Y23
R
M
S
L
T
A
I
Y
D
K
R
R
E
T
D
Site 5
T29
I
Y
D
K
R
R
E
T
D
Y
S
D
K
G
Y
Site 6
Y31
D
K
R
R
E
T
D
Y
S
D
K
G
Y
N
L
Site 7
S32
K
R
R
E
T
D
Y
S
D
K
G
Y
N
L
A
Site 8
Y36
T
D
Y
S
D
K
G
Y
N
L
A
F
V
S
Q
Site 9
S42
G
Y
N
L
A
F
V
S
Q
D
E
Q
E
N
S
Site 10
S49
S
Q
D
E
Q
E
N
S
S
F
T
I
L
Y
E
Site 11
S50
Q
D
E
Q
E
N
S
S
F
T
I
L
Y
E
E
Site 12
Y55
N
S
S
F
T
I
L
Y
E
E
P
L
Q
E
E
Site 13
Y65
P
L
Q
E
E
D
K
Y
A
S
A
E
A
R
Q
Site 14
T73
A
S
A
E
A
R
Q
T
Q
S
V
L
F
H
D
Site 15
S75
A
E
A
R
Q
T
Q
S
V
L
F
H
D
T
S
Site 16
T81
Q
S
V
L
F
H
D
T
S
A
D
S
M
P
V
Site 17
S85
F
H
D
T
S
A
D
S
M
P
V
L
A
C
E
Site 18
S94
P
V
L
A
C
E
R
S
E
S
R
T
D
L
V
Site 19
S96
L
A
C
E
R
S
E
S
R
T
D
L
V
H
H
Site 20
T98
C
E
R
S
E
S
R
T
D
L
V
H
H
F
E
Site 21
T113
K
G
T
K
L
G
E
T
F
D
S
D
S
S
E
Site 22
S116
K
L
G
E
T
F
D
S
D
S
S
E
M
F
L
Site 23
S118
G
E
T
F
D
S
D
S
S
E
M
F
L
S
V
Site 24
S124
D
S
S
E
M
F
L
S
V
E
A
K
R
Y
K
Site 25
Y133
E
A
K
R
Y
K
I
Y
P
L
A
L
S
P
I
Site 26
S138
K
I
Y
P
L
A
L
S
P
I
Y
E
D
D
S
Site 27
Y141
P
L
A
L
S
P
I
Y
E
D
D
S
S
Q
E
Site 28
S145
S
P
I
Y
E
D
D
S
S
Q
E
D
I
L
S
Site 29
S146
P
I
Y
E
D
D
S
S
Q
E
D
I
L
S
S
Site 30
S152
S
S
Q
E
D
I
L
S
S
E
V
S
P
G
H
Site 31
S153
S
Q
E
D
I
L
S
S
E
V
S
P
G
H
H
Site 32
S156
D
I
L
S
S
E
V
S
P
G
H
H
G
P
R
Site 33
S165
G
H
H
G
P
R
K
S
R
D
S
E
N
Q
S
Site 34
S168
G
P
R
K
S
R
D
S
E
N
Q
S
S
S
V
Site 35
S172
S
R
D
S
E
N
Q
S
S
S
V
L
S
L
L
Site 36
S173
R
D
S
E
N
Q
S
S
S
V
L
S
L
L
Q
Site 37
S174
D
S
E
N
Q
S
S
S
V
L
S
L
L
Q
S
Site 38
S177
N
Q
S
S
S
V
L
S
L
L
Q
S
V
S
E
Site 39
S183
L
S
L
L
Q
S
V
S
E
R
L
K
M
N
F
Site 40
S219
K
G
D
L
R
A
G
S
G
E
R
V
T
F
Q
Site 41
T224
A
G
S
G
E
R
V
T
F
Q
L
P
D
P
S
Site 42
S231
T
F
Q
L
P
D
P
S
I
T
F
Y
P
D
D
Site 43
T233
Q
L
P
D
P
S
I
T
F
Y
P
D
D
Q
E
Site 44
Y235
P
D
P
S
I
T
F
Y
P
D
D
Q
E
S
V
Site 45
S241
F
Y
P
D
D
Q
E
S
V
G
I
S
K
N
S
Site 46
S245
D
Q
E
S
V
G
I
S
K
N
S
Y
V
M
P
Site 47
Y249
V
G
I
S
K
N
S
Y
V
M
P
N
E
P
T
Site 48
S258
M
P
N
E
P
T
T
S
N
L
Q
V
G
L
W
Site 49
T269
V
G
L
W
P
E
K
T
S
F
L
Q
K
S
D
Site 50
S270
G
L
W
P
E
K
T
S
F
L
Q
K
S
D
L
Site 51
S275
K
T
S
F
L
Q
K
S
D
L
T
S
K
L
H
Site 52
T278
F
L
Q
K
S
D
L
T
S
K
L
H
S
S
L
Site 53
S279
L
Q
K
S
D
L
T
S
K
L
H
S
S
L
K
Site 54
S283
D
L
T
S
K
L
H
S
S
L
K
S
A
Y
H
Site 55
S284
L
T
S
K
L
H
S
S
L
K
S
A
Y
H
Q
Site 56
S287
K
L
H
S
S
L
K
S
A
Y
H
Q
Y
L
Q
Site 57
Y292
L
K
S
A
Y
H
Q
Y
L
Q
T
S
Q
S
H
Site 58
S296
Y
H
Q
Y
L
Q
T
S
Q
S
H
S
S
E
K
Site 59
S298
Q
Y
L
Q
T
S
Q
S
H
S
S
E
K
G
A
Site 60
S300
L
Q
T
S
Q
S
H
S
S
E
K
G
A
R
F
Site 61
S316
G
I
F
Q
E
P
V
S
K
Y
F
R
V
Q
D
Site 62
Y318
F
Q
E
P
V
S
K
Y
F
R
V
Q
D
S
P
Site 63
S324
K
Y
F
R
V
Q
D
S
P
G
R
L
S
P
F
Site 64
S329
Q
D
S
P
G
R
L
S
P
F
I
E
N
V
D
Site 65
T339
I
E
N
V
D
K
Q
T
L
R
C
N
P
R
P
Site 66
Y352
R
P
G
K
M
V
I
Y
D
L
H
E
S
T
Y
Site 67
Y364
S
T
Y
K
Q
E
V
Y
C
N
I
P
D
A
T
Site 68
Y391
V
R
G
C
W
I
L
Y
E
K
P
H
F
R
G
Site 69
S430
Q
R
N
F
I
L
G
S
L
K
R
V
L
K
D
Site 70
S439
K
R
V
L
K
D
C
S
I
P
E
I
E
L
F
Site 71
Y457
D
P
A
C
C
P
V
Y
I
Q
R
A
V
P
N
Site 72
S471
N
L
E
E
L
N
I
S
K
S
V
S
F
T
V
Site 73
S473
E
E
L
N
I
S
K
S
V
S
F
T
V
K
S
Site 74
Y486
K
S
G
V
W
L
A
Y
P
D
I
N
F
K
G
Site 75
T496
I
N
F
K
G
Q
A
T
V
L
E
E
D
H
G
Site 76
T509
H
G
L
F
E
I
S
T
A
E
M
K
S
L
H
Site 77
S514
I
S
T
A
E
M
K
S
L
H
P
L
Q
M
G
Site 78
Y536
M
N
L
K
V
I
I
Y
E
K
P
H
F
H
G
Site 79
S554
E
F
S
E
H
I
D
S
V
P
N
F
L
K
N
Site 80
Y581
I
G
G
V
W
V
A
Y
E
K
E
H
F
K
G
Site 81
S601
E
E
G
D
F
E
D
S
N
A
C
G
A
L
S
Site 82
S625
Q
A
N
F
I
E
S
S
V
T
L
F
E
S
D
Site 83
T627
N
F
I
E
S
S
V
T
L
F
E
S
D
L
E
Site 84
S631
S
S
V
T
L
F
E
S
D
L
E
S
G
K
F
Site 85
S635
L
F
E
S
D
L
E
S
G
K
F
I
D
I
T
Site 86
T642
S
G
K
F
I
D
I
T
N
Q
E
I
S
D
L
Site 87
S647
D
I
T
N
Q
E
I
S
D
L
E
E
I
G
F
Site 88
S656
L
E
E
I
G
F
G
S
K
T
R
S
I
H
V
Site 89
T658
E
I
G
F
G
S
K
T
R
S
I
H
V
K
S
Site 90
S660
G
F
G
S
K
T
R
S
I
H
V
K
S
G
V
Site 91
Y671
K
S
G
V
W
V
A
Y
Q
Q
K
F
F
C
G
Site 92
Y681
K
F
F
C
G
E
Q
Y
I
L
E
K
G
K
Y
Site 93
Y688
Y
I
L
E
K
G
K
Y
K
C
F
F
D
W
G
Site 94
S703
G
S
N
N
I
I
M
S
I
R
P
I
Q
L
E
Site 95
S725
P
H
L
L
K
A
F
S
K
P
G
F
Q
G
E
Site 96
T737
Q
G
E
C
I
D
F
T
E
E
T
S
D
L
T
Site 97
S741
I
D
F
T
E
E
T
S
D
L
T
S
L
M
P
Site 98
T744
T
E
E
T
S
D
L
T
S
L
M
P
C
S
F
Site 99
S745
E
E
T
S
D
L
T
S
L
M
P
C
S
F
K
Site 100
S789
T
S
C
G
C
P
A
S
K
V
K
S
L
K
P
Site 101
S793
C
P
A
S
K
V
K
S
L
K
P
I
D
Y
V
Site 102
Y799
K
S
L
K
P
I
D
Y
V
F
E
E
P
S
I
Site 103
S827
H
L
E
E
A
V
N
S
V
L
N
K
D
L
H
Site 104
Y836
L
N
K
D
L
H
F
Y
T
Q
S
V
W
V
K
Site 105
T837
N
K
D
L
H
F
Y
T
Q
S
V
W
V
K
S
Site 106
T878
T
A
F
S
R
W
K
T
I
G
S
L
R
P
M
Site 107
S881
S
R
W
K
T
I
G
S
L
R
P
M
K
Q
P
Site 108
Y891
P
M
K
Q
P
A
V
Y
I
R
I
K
N
R
A
Site 109
Y902
K
N
R
A
Q
G
E
Y
L
T
V
T
G
S
L
Site 110
T904
R
A
Q
G
E
Y
L
T
V
T
G
S
L
A
D
Site 111
S908
E
Y
L
T
V
T
G
S
L
A
D
T
R
A
T
Site 112
S920
R
A
T
S
V
C
I
S
P
Y
S
G
K
N
T
Site 113
Y931
G
K
N
T
Q
I
W
Y
Y
C
R
G
L
F
K
Site 114
Y932
K
N
T
Q
I
W
Y
Y
C
R
G
L
F
K
S
Site 115
S939
Y
C
R
G
L
F
K
S
K
A
S
D
T
C
L
Site 116
T944
F
K
S
K
A
S
D
T
C
L
D
V
I
G
G
Site 117
T979
W
R
L
N
K
N
G
T
I
S
S
Y
L
S
D
Site 118
S981
L
N
K
N
G
T
I
S
S
Y
L
S
D
Q
L
Site 119
S982
N
K
N
G
T
I
S
S
Y
L
S
D
Q
L
V
Site 120
Y983
K
N
G
T
I
S
S
Y
L
S
D
Q
L
V
L
Site 121
T1014
Q
P
L
E
G
E
E
T
Q
K
W
D
I
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation