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Updated November 2019
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Protein Info
Short Name:
C2orf16
Full Name:
Uncharacterized protein C2orf16
Alias:
CB016; LOC84226
Type:
Mass (Da):
224306
Number AA:
1984
UniProt ID:
Q68DN1
International Prot ID:
IPI00470912
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
A
Q
Q
Q
G
I
N
Y
Q
E
L
T
S
G
W
Site 2
S26
S
G
W
Q
D
V
K
S
M
M
L
V
P
E
P
Site 3
S39
E
P
T
R
K
F
P
S
G
P
L
L
T
S
V
Site 4
S45
P
S
G
P
L
L
T
S
V
R
F
S
N
L
S
Site 5
S49
L
L
T
S
V
R
F
S
N
L
S
P
E
S
Q
Site 6
S52
S
V
R
F
S
N
L
S
P
E
S
Q
Q
Q
D
Site 7
S62
S
Q
Q
Q
D
V
K
S
L
E
F
T
V
E
P
Site 8
T66
D
V
K
S
L
E
F
T
V
E
P
K
L
Q
S
Site 9
S80
S
V
K
H
V
K
L
S
S
V
S
L
Q
Q
T
Site 10
S90
S
L
Q
Q
T
I
K
S
V
E
L
A
P
G
S
Site 11
S97
S
V
E
L
A
P
G
S
L
P
Q
R
V
K
Y
Site 12
Y104
S
L
P
Q
R
V
K
Y
G
E
Q
T
P
R
T
Site 13
T108
R
V
K
Y
G
E
Q
T
P
R
T
N
Y
Q
I
Site 14
T111
Y
G
E
Q
T
P
R
T
N
Y
Q
I
M
E
S
Site 15
Y113
E
Q
T
P
R
T
N
Y
Q
I
M
E
S
S
E
Site 16
Y132
P
G
H
Q
F
A
K
Y
A
E
M
I
P
Q
P
Site 17
Y141
E
M
I
P
Q
P
K
Y
Q
I
P
K
S
A
N
Site 18
S146
P
K
Y
Q
I
P
K
S
A
N
L
I
S
I
P
Site 19
Y155
N
L
I
S
I
P
I
Y
H
A
T
E
S
S
E
Site 20
T158
S
I
P
I
Y
H
A
T
E
S
S
E
M
A
Q
Site 21
S178
G
I
D
T
V
E
K
S
V
G
L
T
P
K
L
Site 22
T182
V
E
K
S
V
G
L
T
P
K
L
T
G
R
A
Site 23
T186
V
G
L
T
P
K
L
T
G
R
A
K
E
S
L
Site 24
S192
L
T
G
R
A
K
E
S
L
G
M
L
L
Q
P
Site 25
T210
V
P
K
F
V
D
L
T
P
M
V
R
D
Q
G
Site 26
S218
P
M
V
R
D
Q
G
S
K
F
L
G
L
T
P
Site 27
T224
G
S
K
F
L
G
L
T
P
E
K
S
Y
Q
I
Site 28
S228
L
G
L
T
P
E
K
S
Y
Q
I
L
E
T
M
Site 29
S239
L
E
T
M
E
L
L
S
Q
S
R
P
R
V
K
Site 30
S241
T
M
E
L
L
S
Q
S
R
P
R
V
K
D
V
Site 31
Y252
V
K
D
V
G
E
L
Y
M
K
P
L
Q
Q
T
Site 32
T259
Y
M
K
P
L
Q
Q
T
V
E
Y
E
G
I
T
Site 33
Y262
P
L
Q
Q
T
V
E
Y
E
G
I
T
P
E
L
Site 34
T266
T
V
E
Y
E
G
I
T
P
E
L
K
H
Y
F
Site 35
Y272
I
T
P
E
L
K
H
Y
F
T
E
A
M
G
L
Site 36
T274
P
E
L
K
H
Y
F
T
E
A
M
G
L
T
A
Site 37
T294
A
N
E
F
F
G
M
T
P
K
P
T
S
Q
A
Site 38
S299
G
M
T
P
K
P
T
S
Q
A
T
G
F
A
E
Site 39
S308
A
T
G
F
A
E
R
S
P
R
L
C
P
Q
N
Site 40
S332
K
R
L
Q
G
E
E
S
V
V
L
I
P
K
S
Site 41
S346
S
L
H
H
V
P
D
S
A
S
G
M
T
P
G
Site 42
S348
H
H
V
P
D
S
A
S
G
M
T
P
G
L
G
Site 43
T351
P
D
S
A
S
G
M
T
P
G
L
G
H
R
V
Site 44
S361
L
G
H
R
V
P
E
S
V
E
L
T
S
K
S
Site 45
T365
V
P
E
S
V
E
L
T
S
K
S
G
V
Q
V
Site 46
S368
S
V
E
L
T
S
K
S
G
V
Q
V
E
K
T
Site 47
T375
S
G
V
Q
V
E
K
T
L
Q
L
T
P
K
P
Site 48
T379
V
E
K
T
L
Q
L
T
P
K
P
Q
H
H
V
Site 49
S388
K
P
Q
H
H
V
G
S
P
G
I
I
S
G
L
Site 50
S402
L
G
H
Q
V
P
E
S
V
N
L
T
C
K
Q
Site 51
S416
Q
W
L
Q
M
E
E
S
L
E
V
P
L
K
Q
Site 52
S425
E
V
P
L
K
Q
T
S
Q
V
I
G
H
E
E
Site 53
S433
Q
V
I
G
H
E
E
S
V
E
L
T
S
E
A
Site 54
T437
H
E
E
S
V
E
L
T
S
E
A
R
Q
H
R
Site 55
S447
A
R
Q
H
R
E
V
S
M
G
L
T
K
S
K
Site 56
T451
R
E
V
S
M
G
L
T
K
S
K
N
Q
S
M
Site 57
S453
V
S
M
G
L
T
K
S
K
N
Q
S
M
K
S
Site 58
S457
L
T
K
S
K
N
Q
S
M
K
S
P
G
T
T
Site 59
S460
S
K
N
Q
S
M
K
S
P
G
T
T
P
G
P
Site 60
T463
Q
S
M
K
S
P
G
T
T
P
G
P
L
G
R
Site 61
T464
S
M
K
S
P
G
T
T
P
G
P
L
G
R
I
Site 62
T486
P
E
P
L
D
Q
V
T
E
S
A
R
T
Q
L
Site 63
S488
P
L
D
Q
V
T
E
S
A
R
T
Q
L
Q
V
Site 64
S512
D
V
P
K
V
V
Q
S
V
K
V
T
P
G
P
Site 65
S526
P
P
F
Q
I
V
K
S
V
T
I
P
R
P
T
Site 66
T533
S
V
T
I
P
R
P
T
P
Q
M
V
E
Y
I
Site 67
Y539
P
T
P
Q
M
V
E
Y
I
E
L
T
P
K
L
Site 68
T543
M
V
E
Y
I
E
L
T
P
K
L
Q
Y
V
R
Site 69
Y548
E
L
T
P
K
L
Q
Y
V
R
P
S
E
H
H
Site 70
S552
K
L
Q
Y
V
R
P
S
E
H
H
T
G
P
C
Site 71
T556
V
R
P
S
E
H
H
T
G
P
C
L
Q
D
V
Site 72
S565
P
C
L
Q
D
V
K
S
T
K
L
I
T
K
P
Site 73
T579
P
K
H
Q
I
L
E
T
V
E
L
T
G
F
Q
Site 74
S603
P
S
L
Q
I
V
K
S
E
E
L
A
P
G
P
Site 75
S652
V
P
A
E
L
T
P
S
P
C
T
Q
V
K
S
Site 76
T655
E
L
T
P
S
P
C
T
Q
V
K
S
A
E
L
Site 77
S659
S
P
C
T
Q
V
K
S
A
E
L
T
S
P
Q
Site 78
T663
Q
V
K
S
A
E
L
T
S
P
Q
T
S
P
F
Site 79
S664
V
K
S
A
E
L
T
S
P
Q
T
S
P
F
E
Site 80
S668
E
L
T
S
P
Q
T
S
P
F
E
E
H
T
I
Site 81
S687
Q
G
L
Q
A
V
K
S
T
V
I
K
T
E
P
Site 82
T688
G
L
Q
A
V
K
S
T
V
I
K
T
E
P
P
Site 83
T692
G
L
Q
A
V
K
S
T
V
I
K
T
E
P
P
Site 84
S719
R
D
C
Q
K
L
T
S
E
E
L
Q
V
G
T
Site 85
S729
L
Q
V
G
T
D
F
S
R
F
L
Q
S
S
S
Site 86
S734
D
F
S
R
F
L
Q
S
S
S
T
T
L
I
S
Site 87
S735
F
S
R
F
L
Q
S
S
S
T
T
L
I
S
S
Site 88
S736
S
R
F
L
Q
S
S
S
T
T
L
I
S
S
S
Site 89
T737
R
F
L
Q
S
S
S
T
T
L
I
S
S
S
V
Site 90
T738
F
L
Q
S
S
S
T
T
L
I
S
S
S
V
R
Site 91
S741
S
S
S
T
T
L
I
S
S
S
V
R
T
A
S
Site 92
S742
S
S
T
T
L
I
S
S
S
V
R
T
A
S
E
Site 93
S743
S
T
T
L
I
S
S
S
V
R
T
A
S
E
L
Site 94
S748
S
S
S
V
R
T
A
S
E
L
G
G
L
W
D
Site 95
S756
E
L
G
G
L
W
D
S
G
I
Q
E
V
S
R
Site 96
Y781
I
L
Q
P
E
E
T
Y
I
D
P
T
M
I
Q
Site 97
T785
E
E
T
Y
I
D
P
T
M
I
Q
S
L
T
F
Site 98
S801
L
A
L
H
N
Q
S
S
D
K
T
A
N
I
V
Site 99
T804
H
N
Q
S
S
D
K
T
A
N
I
V
E
N
P
Site 100
S822
I
L
G
V
D
V
I
S
K
E
T
T
K
R
K
Site 101
T826
D
V
I
S
K
E
T
T
K
R
K
Q
M
E
E
Site 102
S837
Q
M
E
E
L
E
N
S
L
Q
R
H
L
P
Q
Site 103
S845
L
Q
R
H
L
P
Q
S
W
R
S
R
S
R
T
Site 104
S850
P
Q
S
W
R
S
R
S
R
T
F
Q
A
E
S
Site 105
T852
S
W
R
S
R
S
R
T
F
Q
A
E
S
G
V
Site 106
S866
V
Q
K
G
L
I
K
S
F
P
G
R
Q
H
N
Site 107
Y888
R
Q
R
L
P
R
K
Y
L
S
T
M
L
M
L
Site 108
S890
R
L
P
R
K
Y
L
S
T
M
L
M
L
G
N
Site 109
S909
T
M
E
R
K
L
C
S
Q
T
S
L
A
E
R
Site 110
S912
R
K
L
C
S
Q
T
S
L
A
E
R
A
T
A
Site 111
T918
T
S
L
A
E
R
A
T
A
D
T
C
Q
S
I
Site 112
T921
A
E
R
A
T
A
D
T
C
Q
S
I
Q
N
L
Site 113
S939
P
A
E
L
M
E
P
S
Q
S
L
P
E
K
G
Site 114
S941
E
L
M
E
P
S
Q
S
L
P
E
K
G
P
V
Site 115
S951
E
K
G
P
V
T
I
S
Q
P
S
V
V
K
N
Site 116
Y959
Q
P
S
V
V
K
N
Y
I
Q
R
H
T
F
Y
Site 117
T979
R
M
A
L
R
I
W
T
R
G
S
T
S
S
I
Site 118
S982
L
R
I
W
T
R
G
S
T
S
S
I
I
Q
Q
Site 119
T983
R
I
W
T
R
G
S
T
S
S
I
I
Q
Q
Y
Site 120
S985
W
T
R
G
S
T
S
S
I
I
Q
Q
Y
S
G
Site 121
S991
S
S
I
I
Q
Q
Y
S
G
T
R
V
R
I
K
Site 122
T1003
R
I
K
K
T
N
S
T
F
N
G
I
S
Q
E
Site 123
S1033
V
L
V
K
S
E
S
S
L
S
I
F
Y
D
R
Site 124
S1035
V
K
S
E
S
S
L
S
I
F
Y
D
R
E
D
Site 125
Y1038
E
S
S
L
S
I
F
Y
D
R
E
D
L
V
P
Site 126
S1049
D
L
V
P
M
E
E
S
E
D
S
Q
S
D
S
Site 127
S1052
P
M
E
E
S
E
D
S
Q
S
D
S
Q
T
R
Site 128
S1054
E
E
S
E
D
S
Q
S
D
S
Q
T
R
I
S
Site 129
S1056
S
E
D
S
Q
S
D
S
Q
T
R
I
S
E
S
Site 130
T1058
D
S
Q
S
D
S
Q
T
R
I
S
E
S
Q
H
Site 131
S1061
S
D
S
Q
T
R
I
S
E
S
Q
H
S
L
K
Site 132
S1063
S
Q
T
R
I
S
E
S
Q
H
S
L
K
P
N
Site 133
S1066
R
I
S
E
S
Q
H
S
L
K
P
N
Y
L
S
Site 134
Y1071
Q
H
S
L
K
P
N
Y
L
S
Q
A
K
T
D
Site 135
S1073
S
L
K
P
N
Y
L
S
Q
A
K
T
D
F
S
Site 136
T1077
N
Y
L
S
Q
A
K
T
D
F
S
E
Q
F
Q
Site 137
S1080
S
Q
A
K
T
D
F
S
E
Q
F
Q
L
L
E
Site 138
S1140
H
H
K
L
Q
T
T
S
G
P
Y
L
L
I
Y
Site 139
T1155
P
Q
L
H
L
V
R
T
P
E
G
H
G
E
V
Site 140
S1176
R
L
R
I
G
K
R
S
Q
I
S
K
Y
R
E
Site 141
S1179
I
G
K
R
S
Q
I
S
K
Y
R
E
R
D
R
Site 142
Y1181
K
R
S
Q
I
S
K
Y
R
E
R
D
R
P
V
Site 143
S1192
D
R
P
V
I
R
R
S
P
I
S
P
S
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S
H
L
S
P
L
E
R
S
R
C
Site 296
S1860
H
L
S
P
L
E
R
S
R
C
S
P
S
E
R
Site 297
S1863
P
L
E
R
S
R
C
S
P
S
E
R
R
G
H
Site 298
S1865
E
R
S
R
C
S
P
S
E
R
R
G
H
S
S
Site 299
S1871
P
S
E
R
R
G
H
S
S
S
G
K
T
C
H
Site 300
S1872
S
E
R
R
G
H
S
S
S
G
K
T
C
H
S
Site 301
S1873
E
R
R
G
H
S
S
S
G
K
T
C
H
S
P
Site 302
T1876
G
H
S
S
S
G
K
T
C
H
S
P
S
E
R
Site 303
S1879
S
S
G
K
T
C
H
S
P
S
E
R
S
H
R
Site 304
S1881
G
K
T
C
H
S
P
S
E
R
S
H
R
S
P
Site 305
S1884
C
H
S
P
S
E
R
S
H
R
S
P
S
G
M
Site 306
S1887
P
S
E
R
S
H
R
S
P
S
G
M
R
Q
G
Site 307
S1889
E
R
S
H
R
S
P
S
G
M
R
Q
G
R
T
Site 308
T1896
S
G
M
R
Q
G
R
T
S
E
R
S
H
R
S
Site 309
S1897
G
M
R
Q
G
R
T
S
E
R
S
H
R
S
S
Site 310
S1900
Q
G
R
T
S
E
R
S
H
R
S
S
C
E
R
Site 311
S1904
S
E
R
S
H
R
S
S
C
E
R
T
R
H
S
Site 312
T1908
H
R
S
S
C
E
R
T
R
H
S
P
S
E
M
Site 313
S1911
S
C
E
R
T
R
H
S
P
S
E
M
R
P
G
Site 314
S1913
E
R
T
R
H
S
P
S
E
M
R
P
G
R
P
Site 315
S1921
E
M
R
P
G
R
P
S
G
R
N
H
C
S
P
Site 316
S1927
P
S
G
R
N
H
C
S
P
S
E
R
S
R
R
Site 317
S1929
G
R
N
H
C
S
P
S
E
R
S
R
R
S
P
Site 318
S1932
H
C
S
P
S
E
R
S
R
R
S
P
L
K
E
Site 319
S1935
P
S
E
R
S
R
R
S
P
L
K
E
G
L
K
Site 320
Y1943
P
L
K
E
G
L
K
Y
S
F
P
G
E
R
P
Site 321
S1944
L
K
E
G
L
K
Y
S
F
P
G
E
R
P
S
Site 322
S1951
S
F
P
G
E
R
P
S
H
S
L
S
R
D
F
Site 323
S1953
P
G
E
R
P
S
H
S
L
S
R
D
F
K
N
Site 324
S1955
E
R
P
S
H
S
L
S
R
D
F
K
N
Q
T
Site 325
T1963
R
D
F
K
N
Q
T
T
L
L
G
T
T
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation