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Updated November 2019
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Protein Info
Short Name:
ZFYVE26
Full Name:
Zinc finger FYVE domain-containing protein 26
Alias:
KIAA0321; spastizin; SPG15; ZFY26; zinc finger FYVE domain containing 26; zinc finger, FYVE domain containing 26
Type:
Unknown function
Mass (Da):
284640
Number AA:
UniProt ID:
Q68DK2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
F
G
K
E
E
A
A
S
Q
K
Q
L
F
G
F
Site 2
Y124
E
N
I
L
E
E
L
Y
E
T
L
T
Q
G
A
Site 3
T128
E
E
L
Y
E
T
L
T
Q
G
A
V
G
H
V
Site 4
S144
D
G
N
P
R
R
E
S
W
T
P
R
L
S
S
Site 5
T146
N
P
R
R
E
S
W
T
P
R
L
S
S
E
A
Site 6
S150
E
S
W
T
P
R
L
S
S
E
A
V
S
V
L
Site 7
S151
S
W
T
P
R
L
S
S
E
A
V
S
V
L
W
Site 8
S164
L
W
D
L
L
R
Q
S
P
Q
P
A
Q
A
L
Site 9
T182
L
L
E
E
D
D
G
T
G
L
C
H
W
P
L
Site 10
S209
R
A
L
Q
G
P
D
S
V
P
P
G
V
V
D
Site 11
T249
E
L
L
E
A
C
R
T
E
G
S
P
L
R
E
Site 12
S252
E
A
C
R
T
E
G
S
P
L
R
E
E
R
L
Site 13
S261
L
R
E
E
R
L
L
S
C
L
L
H
K
A
S
Site 14
S273
K
A
S
R
G
L
L
S
L
Y
G
H
T
Y
A
Site 15
Y275
S
R
G
L
L
S
L
Y
G
H
T
Y
A
E
K
Site 16
Y279
L
S
L
Y
G
H
T
Y
A
E
K
V
T
E
K
Site 17
T291
T
E
K
P
P
R
A
T
A
S
G
K
V
S
P
Site 18
S293
K
P
P
R
A
T
A
S
G
K
V
S
P
D
H
Site 19
S297
A
T
A
S
G
K
V
S
P
D
H
L
D
P
E
Site 20
S312
R
A
M
L
A
L
F
S
N
P
N
P
A
E
A
Site 21
Y324
A
E
A
W
K
V
A
Y
F
Y
C
L
S
N
N
Site 22
S379
L
G
W
T
H
C
Q
S
L
E
S
A
K
R
L
Site 23
S382
T
H
C
Q
S
L
E
S
A
K
R
L
L
Q
T
Site 24
T389
S
A
K
R
L
L
Q
T
L
H
R
T
Q
G
P
Site 25
Y434
I
P
K
R
D
L
L
Y
H
L
H
G
G
D
S
Site 26
S441
Y
H
L
H
G
G
D
S
H
S
V
L
Y
T
L
Site 27
S443
L
H
G
G
D
S
H
S
V
L
Y
T
L
H
H
Site 28
Y446
G
D
S
H
S
V
L
Y
T
L
H
H
L
T
N
Site 29
T447
D
S
H
S
V
L
Y
T
L
H
H
L
T
N
L
Site 30
T452
L
Y
T
L
H
H
L
T
N
L
P
A
L
R
E
Site 31
S490
A
P
V
P
E
H
L
S
Q
C
Q
N
L
T
L
Site 32
Y498
Q
C
Q
N
L
T
L
Y
Q
G
F
C
A
M
K
Site 33
S527
Q
C
Q
D
C
K
D
S
L
S
E
D
L
A
S
Site 34
S529
Q
D
C
K
D
S
L
S
E
D
L
A
S
A
T
Site 35
S534
S
L
S
E
D
L
A
S
A
T
E
P
A
N
D
Site 36
S542
A
T
E
P
A
N
D
S
L
S
S
P
G
A
A
Site 37
S544
E
P
A
N
D
S
L
S
S
P
G
A
A
N
L
Site 38
S545
P
A
N
D
S
L
S
S
P
G
A
A
N
L
F
Site 39
Y555
A
A
N
L
F
S
T
Y
L
A
R
C
Q
Q
Y
Site 40
Y562
Y
L
A
R
C
Q
Q
Y
L
C
S
I
P
D
S
Site 41
Y599
E
P
H
L
P
E
D
Y
A
E
D
D
D
I
E
Site 42
S609
D
D
D
I
E
G
K
S
P
S
G
L
R
S
P
Site 43
S611
D
I
E
G
K
S
P
S
G
L
R
S
P
S
E
Site 44
S615
K
S
P
S
G
L
R
S
P
S
E
S
P
Q
H
Site 45
S617
P
S
G
L
R
S
P
S
E
S
P
Q
H
I
A
Site 46
S619
G
L
R
S
P
S
E
S
P
Q
H
I
A
H
P
Site 47
S630
I
A
H
P
E
R
K
S
E
R
G
S
L
G
V
Site 48
S634
E
R
K
S
E
R
G
S
L
G
V
P
K
T
L
Site 49
Y643
G
V
P
K
T
L
A
Y
T
M
P
S
H
V
K
Site 50
S656
V
K
A
E
P
K
D
S
Y
P
G
P
H
R
H
Site 51
Y657
K
A
E
P
K
D
S
Y
P
G
P
H
R
H
S
Site 52
S664
Y
P
G
P
H
R
H
S
F
L
D
L
K
H
F
Site 53
S700
Q
E
Q
L
D
E
I
S
S
R
S
P
P
E
K
Site 54
S701
E
Q
L
D
E
I
S
S
R
S
P
P
E
K
P
Site 55
S703
L
D
E
I
S
S
R
S
P
P
E
K
P
K
Q
Site 56
S712
P
E
K
P
K
Q
E
S
Q
S
C
S
G
S
R
Site 57
S714
K
P
K
Q
E
S
Q
S
C
S
G
S
R
D
G
Site 58
S716
K
Q
E
S
Q
S
C
S
G
S
R
D
G
L
Q
Site 59
S718
E
S
Q
S
C
S
G
S
R
D
G
L
Q
S
R
Site 60
S724
G
S
R
D
G
L
Q
S
R
L
H
R
L
S
K
Site 61
S730
Q
S
R
L
H
R
L
S
K
V
V
S
E
A
Q
Site 62
S734
H
R
L
S
K
V
V
S
E
A
Q
W
R
H
K
Site 63
T744
Q
W
R
H
K
V
V
T
S
N
H
R
S
E
E
Site 64
S745
W
R
H
K
V
V
T
S
N
H
R
S
E
E
Q
Site 65
S749
V
V
T
S
N
H
R
S
E
E
Q
P
S
R
R
Site 66
S754
H
R
S
E
E
Q
P
S
R
R
Y
Q
P
A
T
Site 67
Y757
E
E
Q
P
S
R
R
Y
Q
P
A
T
R
H
P
Site 68
T761
S
R
R
Y
Q
P
A
T
R
H
P
S
L
R
R
Site 69
S765
Q
P
A
T
R
H
P
S
L
R
R
G
R
R
T
Site 70
T772
S
L
R
R
G
R
R
T
R
R
S
Q
A
D
G
Site 71
S775
R
G
R
R
T
R
R
S
Q
A
D
G
R
D
R
Site 72
S784
A
D
G
R
D
R
G
S
N
P
S
L
E
S
T
Site 73
S787
R
D
R
G
S
N
P
S
L
E
S
T
S
S
E
Site 74
S790
G
S
N
P
S
L
E
S
T
S
S
E
L
S
T
Site 75
T791
S
N
P
S
L
E
S
T
S
S
E
L
S
T
S
Site 76
S792
N
P
S
L
E
S
T
S
S
E
L
S
T
S
T
Site 77
S793
P
S
L
E
S
T
S
S
E
L
S
T
S
T
S
Site 78
S796
E
S
T
S
S
E
L
S
T
S
T
S
E
G
S
Site 79
T797
S
T
S
S
E
L
S
T
S
T
S
E
G
S
L
Site 80
S798
T
S
S
E
L
S
T
S
T
S
E
G
S
L
S
Site 81
T799
S
S
E
L
S
T
S
T
S
E
G
S
L
S
A
Site 82
S800
S
E
L
S
T
S
T
S
E
G
S
L
S
A
M
Site 83
S803
S
T
S
T
S
E
G
S
L
S
A
M
S
G
R
Site 84
S805
S
T
S
E
G
S
L
S
A
M
S
G
R
N
E
Site 85
S808
E
G
S
L
S
A
M
S
G
R
N
E
L
H
S
Site 86
S815
S
G
R
N
E
L
H
S
R
L
H
P
H
P
Q
Site 87
S823
R
L
H
P
H
P
Q
S
S
L
I
P
M
M
F
Site 88
S824
L
H
P
H
P
Q
S
S
L
I
P
M
M
F
S
Site 89
T855
E
A
H
Q
V
L
F
T
F
N
L
K
S
S
P
Site 90
S860
L
F
T
F
N
L
K
S
S
P
S
S
G
E
L
Site 91
S861
F
T
F
N
L
K
S
S
P
S
S
G
E
L
M
Site 92
S863
F
N
L
K
S
S
P
S
S
G
E
L
M
F
M
Site 93
S864
N
L
K
S
S
P
S
S
G
E
L
M
F
M
E
Site 94
Y873
E
L
M
F
M
E
R
Y
Q
E
V
I
Q
E
L
Site 95
S892
H
K
I
E
N
Q
N
S
D
A
G
S
S
T
I
Site 96
S896
N
Q
N
S
D
A
G
S
S
T
I
R
R
T
G
Site 97
S897
Q
N
S
D
A
G
S
S
T
I
R
R
T
G
S
Site 98
T898
N
S
D
A
G
S
S
T
I
R
R
T
G
S
G
Site 99
T902
G
S
S
T
I
R
R
T
G
S
G
R
S
T
L
Site 100
S904
S
T
I
R
R
T
G
S
G
R
S
T
L
Q
A
Site 101
T908
R
T
G
S
G
R
S
T
L
Q
A
I
G
S
A
Site 102
S936
T
D
K
L
L
N
T
S
G
D
P
I
P
M
L
Site 103
S1001
T
A
E
R
R
L
N
S
S
L
E
R
R
G
R
Site 104
S1002
A
E
R
R
L
N
S
S
L
E
R
R
G
R
R
Site 105
Y1036
Q
I
S
K
S
L
N
Y
L
L
M
S
A
S
Q
Site 106
S1040
S
L
N
Y
L
L
M
S
A
S
Q
T
K
S
E
Site 107
S1042
N
Y
L
L
M
S
A
S
Q
T
K
S
E
S
V
Site 108
T1044
L
L
M
S
A
S
Q
T
K
S
E
S
V
E
E
Site 109
S1046
M
S
A
S
Q
T
K
S
E
S
V
E
E
K
G
Site 110
S1048
A
S
Q
T
K
S
E
S
V
E
E
K
G
G
G
Site 111
S1060
G
G
G
P
P
R
C
S
I
T
E
L
L
Q
M
Site 112
S1079
L
S
E
D
C
V
A
S
H
T
T
L
S
Q
Q
Site 113
S1084
V
A
S
H
T
T
L
S
Q
Q
L
D
Q
V
L
Site 114
S1093
Q
L
D
Q
V
L
Q
S
L
R
E
A
L
E
L
Site 115
T1105
L
E
L
P
E
P
R
T
P
P
L
S
S
L
V
Site 116
S1109
E
P
R
T
P
P
L
S
S
L
V
E
Q
A
A
Site 117
T1142
Q
K
N
L
G
K
Q
T
P
S
G
S
R
Q
M
Site 118
S1144
N
L
G
K
Q
T
P
S
G
S
R
Q
M
D
Y
Site 119
S1146
G
K
Q
T
P
S
G
S
R
Q
M
D
Y
L
G
Site 120
Y1151
S
G
S
R
Q
M
D
Y
L
G
T
F
F
S
Y
Site 121
S1171
A
V
L
L
Q
S
L
S
S
E
P
D
H
V
E
Site 122
S1172
V
L
L
Q
S
L
S
S
E
P
D
H
V
E
V
Site 123
S1197
Q
S
S
S
Q
L
V
S
H
L
L
F
E
R
Q
Site 124
S1239
C
E
P
L
A
L
C
S
S
R
Q
S
Q
Q
T
Site 125
S1240
E
P
L
A
L
C
S
S
R
Q
S
Q
Q
T
S
Site 126
S1243
A
L
C
S
S
R
Q
S
Q
Q
T
S
S
L
L
Site 127
T1246
S
S
R
Q
S
Q
Q
T
S
S
L
L
T
R
L
Site 128
S1247
S
R
Q
S
Q
Q
T
S
S
L
L
T
R
L
G
Site 129
S1248
R
Q
S
Q
Q
T
S
S
L
L
T
R
L
G
T
Site 130
T1251
Q
Q
T
S
S
L
L
T
R
L
G
T
L
A
Q
Site 131
S1271
C
L
D
D
L
P
L
S
T
P
S
S
P
R
T
Site 132
T1272
L
D
D
L
P
L
S
T
P
S
S
P
R
T
T
Site 133
S1274
D
L
P
L
S
T
P
S
S
P
R
T
T
E
N
Site 134
S1275
L
P
L
S
T
P
S
S
P
R
T
T
E
N
P
Site 135
T1278
S
T
P
S
S
P
R
T
T
E
N
P
T
L
E
Site 136
T1279
T
P
S
S
P
R
T
T
E
N
P
T
L
E
R
Site 137
T1283
P
R
T
T
E
N
P
T
L
E
R
K
P
Y
S
Site 138
Y1289
P
T
L
E
R
K
P
Y
S
S
P
R
D
S
S
Site 139
S1290
T
L
E
R
K
P
Y
S
S
P
R
D
S
S
L
Site 140
S1291
L
E
R
K
P
Y
S
S
P
R
D
S
S
L
P
Site 141
S1295
P
Y
S
S
P
R
D
S
S
L
P
A
L
T
S
Site 142
S1296
Y
S
S
P
R
D
S
S
L
P
A
L
T
S
S
Site 143
S1330
A
S
P
R
L
K
V
S
K
P
S
L
S
W
K
Site 144
S1333
R
L
K
V
S
K
P
S
L
S
W
K
E
L
R
Site 145
S1335
K
V
S
K
P
S
L
S
W
K
E
L
R
G
R
Site 146
S1380
A
W
E
P
L
R
G
S
L
Q
Q
G
Q
S
L
Site 147
S1420
L
S
E
A
F
E
E
S
L
V
A
R
D
W
S
Site 148
S1427
S
L
V
A
R
D
W
S
R
A
L
Q
L
T
E
Site 149
T1433
W
S
R
A
L
Q
L
T
E
V
Y
G
R
D
V
Site 150
S1444
G
R
D
V
D
D
L
S
S
I
K
D
A
V
L
Site 151
S1445
R
D
V
D
D
L
S
S
I
K
D
A
V
L
S
Site 152
Y1464
Y
D
K
E
G
W
Q
Y
L
F
P
V
K
D
A
Site 153
Y1521
K
L
A
E
L
Q
V
Y
Q
K
I
L
G
L
Q
Site 154
Y1560
M
I
L
E
A
Q
E
Y
E
L
C
E
E
W
G
Site 155
Y1570
C
E
E
W
G
C
L
Y
P
I
P
R
E
H
L
Site 156
S1579
I
P
R
E
H
L
I
S
L
H
Q
K
H
L
L
Site 157
T1608
L
R
R
I
P
D
P
T
M
C
L
E
V
T
E
Site 158
T1622
E
Q
S
L
D
Q
H
T
S
L
A
T
S
H
F
Site 159
S1623
Q
S
L
D
Q
H
T
S
L
A
T
S
H
F
L
Site 160
S1627
Q
H
T
S
L
A
T
S
H
F
L
A
N
Y
L
Site 161
Y1633
T
S
H
F
L
A
N
Y
L
T
T
H
F
Y
G
Site 162
T1643
T
H
F
Y
G
Q
L
T
A
V
R
H
R
E
I
Site 163
T1662
V
G
S
K
I
L
L
T
L
P
E
Q
H
R
A
Site 164
S1670
L
P
E
Q
H
R
A
S
Y
S
H
L
S
S
N
Site 165
Y1671
P
E
Q
H
R
A
S
Y
S
H
L
S
S
N
P
Site 166
S1672
E
Q
H
R
A
S
Y
S
H
L
S
S
N
P
L
Site 167
S1675
R
A
S
Y
S
H
L
S
S
N
P
L
F
M
L
Site 168
S1676
A
S
Y
S
H
L
S
S
N
P
L
F
M
L
E
Site 169
S1719
F
T
M
D
E
V
D
S
L
L
S
R
Y
A
E
Site 170
Y1733
E
K
A
L
D
F
P
Y
P
Q
R
E
K
R
S
Site 171
S1742
Q
R
E
K
R
S
D
S
V
I
H
L
Q
E
I
Site 172
T1758
H
Q
A
A
D
P
E
T
L
P
R
S
P
S
A
Site 173
S1762
D
P
E
T
L
P
R
S
P
S
A
E
F
S
P
Site 174
S1764
E
T
L
P
R
S
P
S
A
E
F
S
P
A
A
Site 175
S1768
R
S
P
S
A
E
F
S
P
A
A
P
P
G
I
Site 176
S1776
P
A
A
P
P
G
I
S
S
I
H
S
P
S
L
Site 177
S1777
A
A
P
P
G
I
S
S
I
H
S
P
S
L
R
Site 178
S1780
P
G
I
S
S
I
H
S
P
S
L
R
E
R
S
Site 179
S1782
I
S
S
I
H
S
P
S
L
R
E
R
S
F
P
Site 180
S1787
S
P
S
L
R
E
R
S
F
P
P
T
Q
P
S
Site 181
T1791
R
E
R
S
F
P
P
T
Q
P
S
Q
E
F
V
Site 182
S1794
S
F
P
P
T
Q
P
S
Q
E
F
V
P
P
A
Site 183
T1802
Q
E
F
V
P
P
A
T
P
P
A
R
H
Q
W
Site 184
S1844
R
C
G
R
L
V
C
S
S
C
S
T
K
K
M
Site 185
Y1868
A
R
V
C
D
Q
C
Y
S
Y
C
N
K
D
V
Site 186
S1888
E
K
P
E
A
L
D
S
S
K
S
E
S
P
P
Site 187
S1889
K
P
E
A
L
D
S
S
K
S
E
S
P
P
Y
Site 188
S1891
E
A
L
D
S
S
K
S
E
S
P
P
Y
S
F
Site 189
S1893
L
D
S
S
K
S
E
S
P
P
Y
S
F
V
V
Site 190
Y1896
S
K
S
E
S
P
P
Y
S
F
V
V
R
V
P
Site 191
S1897
K
S
E
S
P
P
Y
S
F
V
V
R
V
P
K
Site 192
S1924
E
E
N
E
L
V
R
S
E
F
Y
Y
E
Q
A
Site 193
Y1928
L
V
R
S
E
F
Y
Y
E
Q
A
P
S
A
S
Site 194
S1962
I
E
H
C
C
R
L
S
K
G
L
T
N
P
E
Site 195
T1966
C
R
L
S
K
G
L
T
N
P
E
V
D
A
G
Site 196
S2025
A
A
Y
R
H
V
P
S
L
D
Q
I
L
Q
P
Site 197
Y2048
Q
L
L
E
A
E
Y
Y
Q
L
G
V
E
V
S
Site 198
S2055
Y
Q
L
G
V
E
V
S
T
K
T
G
L
D
T
Site 199
S2122
S
T
V
R
P
F
V
S
L
Q
D
D
D
Y
F
Site 200
Y2128
V
S
L
Q
D
D
D
Y
F
A
T
L
R
E
L
Site 201
T2131
Q
D
D
D
Y
F
A
T
L
R
E
L
E
A
T
Site 202
T2138
T
L
R
E
L
E
A
T
L
R
T
Q
S
L
S
Site 203
Y2159
G
K
I
M
N
N
T
Y
Y
Q
E
C
L
F
Y
Site 204
Y2160
K
I
M
N
N
T
Y
Y
Q
E
C
L
F
Y
L
Site 205
Y2166
Y
Y
Q
E
C
L
F
Y
L
H
N
Y
S
T
N
Site 206
S2198
L
H
L
L
N
K
E
S
P
P
E
V
F
I
E
Site 207
Y2212
E
G
I
F
Q
P
S
Y
K
S
G
K
L
H
T
Site 208
S2226
T
L
E
N
L
L
E
S
I
D
P
T
L
E
S
Site 209
T2230
L
L
E
S
I
D
P
T
L
E
S
W
G
K
Y
Site 210
S2233
S
I
D
P
T
L
E
S
W
G
K
Y
L
I
A
Site 211
Y2237
T
L
E
S
W
G
K
Y
L
I
A
A
C
Q
H
Site 212
Y2250
Q
H
L
Q
K
K
N
Y
Y
H
I
L
Y
E
L
Site 213
Y2255
K
N
Y
Y
H
I
L
Y
E
L
Q
Q
F
M
K
Site 214
S2281
F
F
S
H
K
A
K
S
Y
T
E
L
G
E
K
Site 215
S2290
T
E
L
G
E
K
L
S
W
L
L
K
A
K
D
Site 216
Y2302
A
K
D
H
L
K
I
Y
L
Q
E
T
S
R
S
Site 217
T2306
L
K
I
Y
L
Q
E
T
S
R
S
S
G
R
K
Site 218
S2310
L
Q
E
T
S
R
S
S
G
R
K
K
T
T
F
Site 219
T2315
R
S
S
G
R
K
K
T
T
F
F
R
K
K
M
Site 220
T2316
S
S
G
R
K
K
T
T
F
F
R
K
K
M
T
Site 221
S2349
R
F
L
H
R
C
E
S
A
G
T
S
Q
I
T
Site 222
S2353
R
C
E
S
A
G
T
S
Q
I
T
T
L
P
L
Site 223
Y2419
Q
L
V
E
K
E
K
Y
S
E
I
Q
Q
L
L
Site 224
S2430
Q
Q
L
L
K
C
V
S
E
S
G
M
A
A
K
Site 225
S2438
E
S
G
M
A
A
K
S
D
G
D
T
I
L
L
Site 226
Y2476
D
D
N
K
V
R
A
Y
L
I
C
C
K
L
R
Site 227
T2498
K
Q
E
H
S
R
A
T
A
L
V
Q
Q
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation