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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA2018
Full Name:
Basic helix-loop-helix domain-containing protein KIAA2018
Alias:
K06A9.1-like; K2018; LOC205717
Type:
Mass (Da):
241153
Number AA:
2242
UniProt ID:
Q68DE3
International Prot ID:
IPI00217002
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005509
GO:0004571
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
P
E
M
T
E
N
E
T
P
T
K
K
Q
H
R
Site 2
T22
H
R
K
K
N
R
E
T
H
N
A
V
E
R
H
Site 3
S48
I
G
E
L
I
P
C
S
P
A
L
K
Q
S
K
Site 4
Y65
I
L
D
Q
A
F
K
Y
I
T
E
L
K
R
Q
Site 5
Y106
I
Q
K
E
N
G
R
Y
I
E
L
L
K
A
N
Site 6
Y118
K
A
N
D
I
C
L
Y
D
D
P
T
I
H
W
Site 7
S151
Q
K
K
I
I
V
Y
S
N
G
N
Q
P
G
G
Site 8
Y202
P
V
S
I
S
G
V
Y
P
S
E
N
K
P
W
Site 9
S204
S
I
S
G
V
Y
P
S
E
N
K
P
W
H
Q
Site 10
S242
S
I
L
E
L
P
T
S
E
S
E
S
N
V
L
Site 11
S244
L
E
L
P
T
S
E
S
E
S
N
V
L
G
A
Site 12
S246
L
P
T
S
E
S
E
S
N
V
L
G
A
T
S
Site 13
S260
S
G
S
L
I
A
V
S
I
E
S
E
P
H
Q
Site 14
S263
L
I
A
V
S
I
E
S
E
P
H
Q
H
H
S
Site 15
S280
T
C
L
N
D
Q
N
S
S
E
N
K
N
G
Q
Site 16
T297
P
K
V
L
K
K
M
T
P
C
V
T
N
I
P
Site 17
T301
K
K
M
T
P
C
V
T
N
I
P
H
S
S
S
Site 18
S306
C
V
T
N
I
P
H
S
S
S
A
T
A
T
K
Site 19
S308
T
N
I
P
H
S
S
S
A
T
A
T
K
V
H
Site 20
T310
I
P
H
S
S
S
A
T
A
T
K
V
H
H
G
Site 21
T312
H
S
S
S
A
T
A
T
K
V
H
H
G
N
K
Site 22
S323
H
G
N
K
S
C
L
S
I
Q
D
F
G
G
D
Site 23
S345
S
V
T
T
T
V
C
S
Q
P
P
R
T
A
G
Site 24
T350
V
C
S
Q
P
P
R
T
A
G
D
S
S
P
M
Site 25
S354
P
P
R
T
A
G
D
S
S
P
M
S
I
S
K
Site 26
S355
P
R
T
A
G
D
S
S
P
M
S
I
S
K
S
Site 27
S358
A
G
D
S
S
P
M
S
I
S
K
S
A
D
L
Site 28
S360
D
S
S
P
M
S
I
S
K
S
A
D
L
T
S
Site 29
S362
S
P
M
S
I
S
K
S
A
D
L
T
S
T
A
Site 30
T388
K
A
T
I
P
I
S
T
L
S
G
N
P
L
D
Site 31
S390
T
I
P
I
S
T
L
S
G
N
P
L
D
N
G
Site 32
T399
N
P
L
D
N
G
W
T
L
S
C
S
L
P
S
Site 33
S401
L
D
N
G
W
T
L
S
C
S
L
P
S
S
S
Site 34
S403
N
G
W
T
L
S
C
S
L
P
S
S
S
V
S
Site 35
S406
T
L
S
C
S
L
P
S
S
S
V
S
T
S
D
Site 36
S408
S
C
S
L
P
S
S
S
V
S
T
S
D
L
K
Site 37
S410
S
L
P
S
S
S
V
S
T
S
D
L
K
N
I
Site 38
S412
P
S
S
S
V
S
T
S
D
L
K
N
I
N
S
Site 39
S419
S
D
L
K
N
I
N
S
L
T
R
I
S
S
A
Site 40
T421
L
K
N
I
N
S
L
T
R
I
S
S
A
G
N
Site 41
S424
I
N
S
L
T
R
I
S
S
A
G
N
T
Q
T
Site 42
S425
N
S
L
T
R
I
S
S
A
G
N
T
Q
T
T
Site 43
T429
R
I
S
S
A
G
N
T
Q
T
T
W
T
T
L
Site 44
S447
G
N
T
I
Q
P
L
S
Q
T
P
S
S
A
V
Site 45
T449
T
I
Q
P
L
S
Q
T
P
S
S
A
V
T
P
Site 46
S451
Q
P
L
S
Q
T
P
S
S
A
V
T
P
V
L
Site 47
S452
P
L
S
Q
T
P
S
S
A
V
T
P
V
L
N
Site 48
T455
Q
T
P
S
S
A
V
T
P
V
L
N
E
S
G
Site 49
S461
V
T
P
V
L
N
E
S
G
T
S
P
T
T
S
Site 50
T463
P
V
L
N
E
S
G
T
S
P
T
T
S
N
H
Site 51
S464
V
L
N
E
S
G
T
S
P
T
T
S
N
H
S
Site 52
T467
E
S
G
T
S
P
T
T
S
N
H
S
R
Y
V
Site 53
S468
S
G
T
S
P
T
T
S
N
H
S
R
Y
V
A
Site 54
Y473
T
T
S
N
H
S
R
Y
V
A
T
D
I
N
L
Site 55
S483
T
D
I
N
L
N
N
S
F
P
A
D
G
Q
P
Site 56
S517
I
A
Q
P
Q
V
K
S
Q
P
P
K
N
I
L
Site 57
S541
Q
M
A
Q
P
V
G
S
A
V
N
S
A
P
T
Site 58
S545
P
V
G
S
A
V
N
S
A
P
T
N
Q
N
V
Site 59
T561
I
L
Q
P
P
S
T
T
P
C
P
T
V
M
R
Site 60
T565
P
S
T
T
P
C
P
T
V
M
R
A
E
V
S
Site 61
S601
L
P
A
P
P
P
G
S
V
R
L
P
I
N
G
Site 62
T611
L
P
I
N
G
A
N
T
V
I
G
S
N
N
S
Site 63
S618
T
V
I
G
S
N
N
S
V
Q
N
V
P
T
P
Site 64
T624
N
S
V
Q
N
V
P
T
P
Q
T
F
G
G
K
Site 65
T627
Q
N
V
P
T
P
Q
T
F
G
G
K
H
L
V
Site 66
S641
V
H
I
L
P
R
P
S
S
L
S
A
S
N
S
Site 67
S642
H
I
L
P
R
P
S
S
L
S
A
S
N
S
T
Site 68
S644
L
P
R
P
S
S
L
S
A
S
N
S
T
Q
T
Site 69
S646
R
P
S
S
L
S
A
S
N
S
T
Q
T
F
S
Site 70
S648
S
S
L
S
A
S
N
S
T
Q
T
F
S
V
T
Site 71
T651
S
A
S
N
S
T
Q
T
F
S
V
T
M
S
N
Site 72
S653
S
N
S
T
Q
T
F
S
V
T
M
S
N
Q
Q
Site 73
T655
S
T
Q
T
F
S
V
T
M
S
N
Q
Q
P
Q
Site 74
S657
Q
T
F
S
V
T
M
S
N
Q
Q
P
Q
T
I
Site 75
T663
M
S
N
Q
Q
P
Q
T
I
S
L
N
G
Q
L
Site 76
S665
N
Q
Q
P
Q
T
I
S
L
N
G
Q
L
F
A
Site 77
S678
F
A
L
Q
P
V
M
S
S
S
G
T
T
N
Q
Site 78
S680
L
Q
P
V
M
S
S
S
G
T
T
N
Q
T
P
Site 79
T682
P
V
M
S
S
S
G
T
T
N
Q
T
P
M
Q
Site 80
T686
S
S
G
T
T
N
Q
T
P
M
Q
I
I
Q
P
Site 81
T701
T
T
S
E
D
P
N
T
N
V
A
L
N
T
F
Site 82
S713
N
T
F
G
A
L
A
S
L
N
Q
S
I
S
Q
Site 83
S717
A
L
A
S
L
N
Q
S
I
S
Q
M
A
G
Q
Site 84
S719
A
S
L
N
Q
S
I
S
Q
M
A
G
Q
S
C
Site 85
S730
G
Q
S
C
V
Q
L
S
I
S
Q
P
A
N
S
Site 86
S732
S
C
V
Q
L
S
I
S
Q
P
A
N
S
Q
T
Site 87
S737
S
I
S
Q
P
A
N
S
Q
T
A
A
N
S
Q
Site 88
T739
S
Q
P
A
N
S
Q
T
A
A
N
S
Q
T
T
Site 89
S743
N
S
Q
T
A
A
N
S
Q
T
T
T
A
N
C
Site 90
T747
A
A
N
S
Q
T
T
T
A
N
C
V
S
L
T
Site 91
T762
T
T
A
A
P
P
V
T
T
D
S
S
A
T
L
Site 92
S765
A
P
P
V
T
T
D
S
S
A
T
L
A
S
T
Site 93
S766
P
P
V
T
T
D
S
S
A
T
L
A
S
T
Y
Site 94
S771
D
S
S
A
T
L
A
S
T
Y
N
L
V
S
T
Site 95
T772
S
S
A
T
L
A
S
T
Y
N
L
V
S
T
S
Site 96
Y773
S
A
T
L
A
S
T
Y
N
L
V
S
T
S
S
Site 97
S777
A
S
T
Y
N
L
V
S
T
S
S
M
N
T
V
Site 98
S792
A
C
L
P
N
M
K
S
K
R
L
N
K
K
P
Site 99
S810
K
H
L
A
A
N
K
S
A
C
P
L
N
S
V
Site 100
S816
K
S
A
C
P
L
N
S
V
R
D
V
S
K
L
Site 101
S821
L
N
S
V
R
D
V
S
K
L
D
C
P
N
T
Site 102
T828
S
K
L
D
C
P
N
T
E
G
S
A
E
P
P
Site 103
S860
V
S
Q
A
N
S
V
S
V
P
A
S
H
S
L
Site 104
S871
S
H
S
L
G
V
L
S
S
E
S
L
I
P
E
Site 105
S872
H
S
L
G
V
L
S
S
E
S
L
I
P
E
S
Site 106
S879
S
E
S
L
I
P
E
S
V
S
K
S
K
S
A
Site 107
S881
S
L
I
P
E
S
V
S
K
S
K
S
A
E
K
Site 108
S883
I
P
E
S
V
S
K
S
K
S
A
E
K
S
S
Site 109
S885
E
S
V
S
K
S
K
S
A
E
K
S
S
P
P
Site 110
S889
K
S
K
S
A
E
K
S
S
P
P
S
Q
E
S
Site 111
S890
S
K
S
A
E
K
S
S
P
P
S
Q
E
S
V
Site 112
S893
A
E
K
S
S
P
P
S
Q
E
S
V
T
S
E
Site 113
S896
S
S
P
P
S
Q
E
S
V
T
S
E
H
F
A
Site 114
S899
P
S
Q
E
S
V
T
S
E
H
F
A
M
A
A
Site 115
S909
F
A
M
A
A
A
K
S
K
D
S
T
P
N
L
Site 116
T913
A
A
K
S
K
D
S
T
P
N
L
Q
Q
E
T
Site 117
S921
P
N
L
Q
Q
E
T
S
Q
D
K
P
P
S
S
Site 118
S927
T
S
Q
D
K
P
P
S
S
L
A
L
S
D
A
Site 119
S928
S
Q
D
K
P
P
S
S
L
A
L
S
D
A
A
Site 120
S932
P
P
S
S
L
A
L
S
D
A
A
K
P
C
A
Site 121
S956
S
D
P
H
I
L
V
S
Q
V
P
G
L
S
S
Site 122
S962
V
S
Q
V
P
G
L
S
S
T
T
S
T
T
S
Site 123
S963
S
Q
V
P
G
L
S
S
T
T
S
T
T
S
T
Site 124
T964
Q
V
P
G
L
S
S
T
T
S
T
T
S
T
D
Site 125
S966
P
G
L
S
S
T
T
S
T
T
S
T
D
C
V
Site 126
T967
G
L
S
S
T
T
S
T
T
S
T
D
C
V
S
Site 127
S969
S
S
T
T
S
T
T
S
T
D
C
V
S
E
V
Site 128
T970
S
T
T
S
T
T
S
T
D
C
V
S
E
V
E
Site 129
S989
P
C
R
V
E
Q
D
S
S
D
T
M
Q
T
T
Site 130
S990
C
R
V
E
Q
D
S
S
D
T
M
Q
T
T
G
Site 131
S1009
Q
G
L
T
T
L
L
S
D
L
A
K
K
K
N
Site 132
S1020
K
K
K
N
P
Q
K
S
S
L
S
D
Q
M
D
Site 133
S1021
K
K
N
P
Q
K
S
S
L
S
D
Q
M
D
H
Site 134
S1032
Q
M
D
H
P
D
F
S
S
E
N
P
K
I
V
Site 135
S1033
M
D
H
P
D
F
S
S
E
N
P
K
I
V
D
Site 136
S1041
E
N
P
K
I
V
D
S
S
V
N
L
H
P
K
Site 137
S1042
N
P
K
I
V
D
S
S
V
N
L
H
P
K
Q
Site 138
S1077
D
Q
E
V
I
N
G
S
L
I
N
G
R
Q
A
Site 139
S1086
I
N
G
R
Q
A
D
S
P
M
S
T
S
S
G
Site 140
S1089
R
Q
A
D
S
P
M
S
T
S
S
G
S
S
R
Site 141
T1090
Q
A
D
S
P
M
S
T
S
S
G
S
S
R
S
Site 142
S1091
A
D
S
P
M
S
T
S
S
G
S
S
R
S
F
Site 143
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S
K
I
R
Q
P
Site 295
S1995
R
Q
P
E
R
N
R
S
G
N
Q
R
Q
S
T
Site 296
S2001
R
S
G
N
Q
R
Q
S
T
V
F
D
P
S
L
Site 297
T2002
S
G
N
Q
R
Q
S
T
V
F
D
P
S
L
P
Site 298
S2007
Q
S
T
V
F
D
P
S
L
P
H
L
P
L
S
Site 299
S2018
L
P
L
S
T
G
G
S
M
I
L
G
R
Q
Q
Site 300
T2028
L
G
R
Q
Q
P
A
T
E
K
R
G
S
I
V
Site 301
S2033
P
A
T
E
K
R
G
S
I
V
R
F
M
P
D
Site 302
S2041
I
V
R
F
M
P
D
S
P
Q
V
P
N
D
N
Site 303
S2049
P
Q
V
P
N
D
N
S
G
P
D
Q
H
T
L
Site 304
T2055
N
S
G
P
D
Q
H
T
L
S
Q
N
F
G
F
Site 305
S2057
G
P
D
Q
H
T
L
S
Q
N
F
G
F
S
F
Site 306
S2079
P
P
I
N
A
N
A
S
F
I
P
Q
V
T
Q
Site 307
S2088
I
P
Q
V
T
Q
P
S
A
T
R
T
P
A
L
Site 308
T2092
T
Q
P
S
A
T
R
T
P
A
L
I
P
V
D
Site 309
T2103
I
P
V
D
P
Q
N
T
L
P
S
F
Y
P
P
Site 310
S2106
D
P
Q
N
T
L
P
S
F
Y
P
P
Y
S
P
Site 311
Y2108
Q
N
T
L
P
S
F
Y
P
P
Y
S
P
A
H
Site 312
Y2111
L
P
S
F
Y
P
P
Y
S
P
A
H
P
T
L
Site 313
S2112
P
S
F
Y
P
P
Y
S
P
A
H
P
T
L
S
Site 314
T2117
P
Y
S
P
A
H
P
T
L
S
N
D
I
S
I
Site 315
S2119
S
P
A
H
P
T
L
S
N
D
I
S
I
P
Y
Site 316
S2123
P
T
L
S
N
D
I
S
I
P
Y
F
P
N
Q
Site 317
Y2126
S
N
D
I
S
I
P
Y
F
P
N
Q
M
F
S
Site 318
S2133
Y
F
P
N
Q
M
F
S
N
P
S
T
E
K
V
Site 319
S2136
N
Q
M
F
S
N
P
S
T
E
K
V
N
S
G
Site 320
T2137
Q
M
F
S
N
P
S
T
E
K
V
N
S
G
S
Site 321
S2142
P
S
T
E
K
V
N
S
G
S
L
N
N
R
F
Site 322
S2144
T
E
K
V
N
S
G
S
L
N
N
R
F
G
S
Site 323
S2151
S
L
N
N
R
F
G
S
I
L
S
P
P
R
P
Site 324
S2154
N
R
F
G
S
I
L
S
P
P
R
P
V
G
F
Site 325
S2213
P
L
L
T
I
A
N
S
S
A
S
D
S
S
K
Site 326
S2214
L
L
T
I
A
N
S
S
A
S
D
S
S
K
Q
Site 327
S2216
T
I
A
N
S
S
A
S
D
S
S
K
Q
S
S
Site 328
S2218
A
N
S
S
A
S
D
S
S
K
Q
S
S
N
R
Site 329
S2219
N
S
S
A
S
D
S
S
K
Q
S
S
N
R
P
Site 330
S2222
A
S
D
S
S
K
Q
S
S
N
R
P
A
H
N
Site 331
S2223
S
D
S
S
K
Q
S
S
N
R
P
A
H
N
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation