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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FMN1
Full Name:
Formin-1
Alias:
DKFZP686C2281; FLJ45135; FMN; Formin (limb deformity); Formin 1; LD; Limb deformity protein; Limb deformity protein homolog; MGC125288; MGC125289
Type:
Adhesion; DNA binding protein
Mass (Da):
157546
Number AA:
1419
UniProt ID:
Q68DA7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005912
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
K
G
E
V
R
G
F
S
Y
K
G
T
V
T
L
Site 2
T37
R
G
F
S
Y
K
G
T
V
T
L
D
R
S
N
Site 3
T39
F
S
Y
K
G
T
V
T
L
D
R
S
N
K
G
Site 4
Y51
N
K
G
F
H
N
C
Y
Q
V
R
E
E
A
D
Site 5
S61
R
E
E
A
D
I
I
S
L
S
Q
E
P
D
E
Site 6
S63
E
A
D
I
I
S
L
S
Q
E
P
D
E
H
P
Site 7
T78
G
D
I
F
F
K
Q
T
P
T
K
D
I
L
T
Site 8
T85
T
P
T
K
D
I
L
T
E
L
Y
K
L
T
T
Site 9
T92
T
E
L
Y
K
L
T
T
E
R
E
R
L
L
T
Site 10
T99
T
E
R
E
R
L
L
T
N
L
L
S
S
D
H
Site 11
S123
E
G
K
L
Q
E
L
S
V
S
L
A
P
E
D
Site 12
S125
K
L
Q
E
L
S
V
S
L
A
P
E
D
D
C
Site 13
T153
G
P
L
N
K
R
S
T
H
G
N
K
K
P
R
Site 14
S162
G
N
K
K
P
R
R
S
S
G
R
R
E
S
F
Site 15
S163
N
K
K
P
R
R
S
S
G
R
R
E
S
F
G
Site 16
S168
R
S
S
G
R
R
E
S
F
G
A
L
P
Q
K
Site 17
T177
G
A
L
P
Q
K
R
T
K
R
K
G
R
G
G
Site 18
S187
K
G
R
G
G
R
E
S
A
P
L
M
G
K
D
Site 19
S198
M
G
K
D
K
I
C
S
S
H
S
L
P
L
S
Site 20
S199
G
K
D
K
I
C
S
S
H
S
L
P
L
S
R
Site 21
S201
D
K
I
C
S
S
H
S
L
P
L
S
R
T
R
Site 22
S205
S
S
H
S
L
P
L
S
R
T
R
P
N
L
W
Site 23
S229
P
N
G
A
L
A
C
S
L
Q
R
R
E
S
C
Site 24
S235
C
S
L
Q
R
R
E
S
C
P
P
D
I
P
K
Site 25
T243
C
P
P
D
I
P
K
T
P
D
T
D
L
G
F
Site 26
T246
D
I
P
K
T
P
D
T
D
L
G
F
G
S
F
Site 27
S252
D
T
D
L
G
F
G
S
F
E
T
A
F
K
D
Site 28
S272
E
V
L
P
P
D
C
S
S
T
E
A
G
G
D
Site 29
S273
V
L
P
P
D
C
S
S
T
E
A
G
G
D
G
Site 30
S286
D
G
I
R
R
P
P
S
G
L
E
H
Q
Q
T
Site 31
T293
S
G
L
E
H
Q
Q
T
G
L
S
E
S
H
Q
Site 32
S296
E
H
Q
Q
T
G
L
S
E
S
H
Q
D
P
E
Site 33
S298
Q
Q
T
G
L
S
E
S
H
Q
D
P
E
K
H
Site 34
S327
T
C
K
Q
K
P
V
S
K
V
V
A
K
V
Q
Site 35
S338
A
K
V
Q
D
L
S
S
Q
V
Q
R
V
V
K
Site 36
S383
A
E
A
G
A
H
G
S
R
R
Q
G
K
E
R
Site 37
S395
K
E
R
Q
G
D
R
S
S
Q
S
P
A
G
E
Site 38
S396
E
R
Q
G
D
R
S
S
Q
S
P
A
G
E
T
Site 39
S398
Q
G
D
R
S
S
Q
S
P
A
G
E
T
A
S
Site 40
T403
S
Q
S
P
A
G
E
T
A
S
I
S
S
V
S
Site 41
S405
S
P
A
G
E
T
A
S
I
S
S
V
S
A
S
Site 42
S407
A
G
E
T
A
S
I
S
S
V
S
A
S
A
E
Site 43
S408
G
E
T
A
S
I
S
S
V
S
A
S
A
E
G
Site 44
S412
S
I
S
S
V
S
A
S
A
E
G
A
V
N
K
Site 45
T445
R
L
G
F
P
V
H
T
S
V
P
H
T
R
P
Site 46
S446
L
G
F
P
V
H
T
S
V
P
H
T
R
P
E
Site 47
T450
V
H
T
S
V
P
H
T
R
P
E
T
R
N
K
Site 48
T454
V
P
H
T
R
P
E
T
R
N
K
R
R
A
G
Site 49
S482
P
H
K
V
G
P
D
S
S
Q
P
R
G
D
K
Site 50
S483
H
K
V
G
P
D
S
S
Q
P
R
G
D
K
K
Site 51
S493
R
G
D
K
K
K
P
S
P
P
A
P
A
A
L
Site 52
S507
L
G
K
V
F
N
N
S
A
S
Q
S
S
T
H
Site 53
S509
K
V
F
N
N
S
A
S
Q
S
S
T
H
K
Q
Site 54
S511
F
N
N
S
A
S
Q
S
S
T
H
K
Q
T
S
Site 55
T513
N
S
A
S
Q
S
S
T
H
K
Q
T
S
P
V
Site 56
T517
Q
S
S
T
H
K
Q
T
S
P
V
P
S
P
L
Site 57
S518
S
S
T
H
K
Q
T
S
P
V
P
S
P
L
S
Site 58
S522
K
Q
T
S
P
V
P
S
P
L
S
P
R
L
P
Site 59
S525
S
P
V
P
S
P
L
S
P
R
L
P
S
P
Q
Site 60
S530
P
L
S
P
R
L
P
S
P
Q
Q
H
H
R
I
Site 61
S554
R
E
A
A
L
N
D
S
P
C
R
K
S
R
V
Site 62
S559
N
D
S
P
C
R
K
S
R
V
F
S
G
C
V
Site 63
S563
C
R
K
S
R
V
F
S
G
C
V
S
A
D
T
Site 64
S567
R
V
F
S
G
C
V
S
A
D
T
L
E
P
P
Site 65
T570
S
G
C
V
S
A
D
T
L
E
P
P
S
S
A
Site 66
S575
A
D
T
L
E
P
P
S
S
A
K
V
T
E
T
Site 67
S576
D
T
L
E
P
P
S
S
A
K
V
T
E
T
K
Site 68
T580
P
P
S
S
A
K
V
T
E
T
K
G
A
S
P
Site 69
T582
S
S
A
K
V
T
E
T
K
G
A
S
P
A
F
Site 70
S586
V
T
E
T
K
G
A
S
P
A
F
L
R
A
G
Site 71
T602
P
R
L
V
P
G
E
T
L
E
K
S
L
G
P
Site 72
S606
P
G
E
T
L
E
K
S
L
G
P
G
K
T
T
Site 73
T612
K
S
L
G
P
G
K
T
T
A
E
P
Q
H
Q
Site 74
S620
T
A
E
P
Q
H
Q
S
P
P
G
I
S
S
E
Site 75
S625
H
Q
S
P
P
G
I
S
S
E
G
F
P
W
D
Site 76
S626
Q
S
P
P
G
I
S
S
E
G
F
P
W
D
G
Site 77
T638
W
D
G
F
N
E
Q
T
P
K
D
L
P
N
R
Site 78
S671
L
H
E
E
R
E
K
S
N
R
S
E
L
Y
L
Site 79
Y677
K
S
N
R
S
E
L
Y
L
D
L
H
P
D
H
Site 80
S685
L
D
L
H
P
D
H
S
L
T
E
Q
D
D
R
Site 81
T693
L
T
E
Q
D
D
R
T
P
G
R
L
Q
A
V
Site 82
T706
A
V
W
P
P
P
K
T
K
D
T
E
E
K
V
Site 83
T709
P
P
P
K
T
K
D
T
E
E
K
V
G
L
K
Site 84
Y717
E
E
K
V
G
L
K
Y
T
E
A
E
Y
Q
A
Site 85
Y722
L
K
Y
T
E
A
E
Y
Q
A
A
I
L
H
L
Site 86
T759
R
G
E
H
A
M
I
T
A
R
L
E
E
T
I
Site 87
T791
R
K
D
V
C
I
S
T
D
D
D
C
P
P
K
Site 88
T811
C
V
Q
T
D
R
E
T
F
L
K
P
C
E
S
Site 89
S818
T
F
L
K
P
C
E
S
E
S
K
T
T
R
S
Site 90
S820
L
K
P
C
E
S
E
S
K
T
T
R
S
N
Q
Site 91
T822
P
C
E
S
E
S
K
T
T
R
S
N
Q
L
V
Site 92
S836
V
P
K
K
L
N
I
S
S
L
S
Q
L
S
P
Site 93
S837
P
K
K
L
N
I
S
S
L
S
Q
L
S
P
P
Site 94
S839
K
L
N
I
S
S
L
S
Q
L
S
P
P
N
D
Site 95
S842
I
S
S
L
S
Q
L
S
P
P
N
D
H
K
D
Site 96
S874
A
L
P
P
P
P
A
S
I
P
P
P
P
P
L
Site 97
S883
P
P
P
P
P
L
P
S
G
L
G
S
L
S
P
Site 98
S889
P
S
G
L
G
S
L
S
P
A
P
P
M
P
P
Site 99
S898
A
P
P
M
P
P
V
S
A
G
P
P
L
P
P
Site 100
S917
P
P
P
L
P
P
P
S
S
A
G
P
P
P
P
Site 101
S918
P
P
L
P
P
P
S
S
A
G
P
P
P
P
P
Site 102
S933
P
P
P
P
L
P
N
S
P
A
P
P
N
P
G
Site 103
S965
G
L
F
F
G
L
G
S
S
S
S
Q
C
P
R
Site 104
S966
L
F
F
G
L
G
S
S
S
S
Q
C
P
R
K
Site 105
S968
F
G
L
G
S
S
S
S
Q
C
P
R
K
P
A
Site 106
S979
R
K
P
A
I
E
P
S
C
P
M
K
P
L
Y
Site 107
Y986
S
C
P
M
K
P
L
Y
W
T
R
I
Q
I
S
Site 108
S996
R
I
Q
I
S
D
R
S
Q
N
A
T
P
T
L
Site 109
T1000
S
D
R
S
Q
N
A
T
P
T
L
W
D
S
L
Site 110
T1002
R
S
Q
N
A
T
P
T
L
W
D
S
L
E
E
Site 111
S1006
A
T
P
T
L
W
D
S
L
E
E
P
D
I
R
Site 112
S1016
E
P
D
I
R
D
P
S
E
F
E
Y
L
F
S
Site 113
Y1020
R
D
P
S
E
F
E
Y
L
F
S
K
D
T
T
Site 114
S1023
S
E
F
E
Y
L
F
S
K
D
T
T
Q
Q
K
Site 115
T1027
Y
L
F
S
K
D
T
T
Q
Q
K
K
K
P
L
Site 116
S1035
Q
Q
K
K
K
P
L
S
E
T
Y
E
K
K
N
Site 117
T1058
L
D
G
K
R
S
Q
T
V
G
I
L
I
S
S
Site 118
Y1094
L
E
T
L
A
A
L
Y
E
N
R
A
Q
E
D
Site 119
Y1109
E
L
V
K
I
R
K
Y
Y
E
T
S
K
E
E
Site 120
Y1110
L
V
K
I
R
K
Y
Y
E
T
S
K
E
E
E
Site 121
T1112
K
I
R
K
Y
Y
E
T
S
K
E
E
E
L
K
Site 122
S1113
I
R
K
Y
Y
E
T
S
K
E
E
E
L
K
L
Site 123
Y1190
L
I
L
A
F
G
N
Y
M
N
G
G
N
R
T
Site 124
Y1204
T
R
G
Q
A
D
G
Y
S
L
E
I
L
P
K
Site 125
S1205
R
G
Q
A
D
G
Y
S
L
E
I
L
P
K
L
Site 126
S1217
P
K
L
K
D
V
K
S
R
D
N
G
I
N
L
Site 127
Y1231
L
V
D
Y
V
V
K
Y
Y
L
R
Y
Y
D
Q
Site 128
Y1232
V
D
Y
V
V
K
Y
Y
L
R
Y
Y
D
Q
E
Site 129
Y1236
V
K
Y
Y
L
R
Y
Y
D
Q
E
A
G
T
E
Site 130
S1245
Q
E
A
G
T
E
K
S
V
F
P
L
P
E
P
Site 131
S1259
P
Q
D
F
F
L
A
S
Q
V
K
F
E
D
L
Site 132
S1280
L
K
R
Q
L
E
A
S
E
K
Q
M
V
V
V
Site 133
S1291
M
V
V
V
C
K
E
S
P
K
E
Y
L
Q
P
Site 134
Y1295
C
K
E
S
P
K
E
Y
L
Q
P
F
K
D
K
Site 135
S1327
H
L
E
N
A
Q
K
S
F
E
T
T
V
R
Y
Site 136
T1331
A
Q
K
S
F
E
T
T
V
R
Y
F
G
M
K
Site 137
Y1334
S
F
E
T
T
V
R
Y
F
G
M
K
P
K
S
Site 138
S1341
Y
F
G
M
K
P
K
S
G
E
K
E
I
T
P
Site 139
T1347
K
S
G
E
K
E
I
T
P
S
Y
V
F
M
V
Site 140
Y1350
E
K
E
I
T
P
S
Y
V
F
M
V
W
Y
E
Site 141
T1364
E
F
C
S
D
F
K
T
I
W
K
R
E
S
K
Site 142
S1370
K
T
I
W
K
R
E
S
K
N
I
S
K
E
R
Site 143
S1374
K
R
E
S
K
N
I
S
K
E
R
L
K
M
A
Site 144
S1384
R
L
K
M
A
Q
E
S
V
S
K
L
T
S
E
Site 145
S1386
K
M
A
Q
E
S
V
S
K
L
T
S
E
K
K
Site 146
S1390
E
S
V
S
K
L
T
S
E
K
K
V
E
T
K
Site 147
S1404
K
K
I
N
P
T
A
S
L
K
E
R
L
R
Q
Site 148
S1415
R
L
R
Q
K
E
A
S
V
T
T
N
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation