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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC66
Full Name:
Leucine-rich repeat-containing protein 66
Alias:
Type:
Mass (Da):
97778
Number AA:
880
UniProt ID:
Q68CR7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
M
T
N
A
S
R
K
S
N
I
L
F
N
S
E
Site 2
S78
F
F
R
V
L
L
Q
S
H
T
K
K
E
E
W
Site 3
S93
K
I
K
H
L
D
L
S
N
N
L
I
S
K
I
Site 4
S125
N
N
A
I
H
S
L
S
L
D
L
L
S
P
K
Site 5
S130
S
L
S
L
D
L
L
S
P
K
S
S
W
V
K
Site 6
S133
L
D
L
L
S
P
K
S
S
W
V
K
R
H
R
Site 7
S134
D
L
L
S
P
K
S
S
W
V
K
R
H
R
S
Site 8
S141
S
W
V
K
R
H
R
S
S
F
R
N
R
F
P
Site 9
S142
W
V
K
R
H
R
S
S
F
R
N
R
F
P
L
Site 10
S161
I
L
Q
R
N
K
L
S
D
T
P
K
G
L
W
Site 11
T163
Q
R
N
K
L
S
D
T
P
K
G
L
W
K
L
Site 12
S172
K
G
L
W
K
L
K
S
L
Q
S
L
D
L
S
Site 13
S175
W
K
L
K
S
L
Q
S
L
D
L
S
F
N
G
Site 14
T294
S
E
E
A
N
G
G
T
P
Q
S
R
I
S
R
Site 15
S297
A
N
G
G
T
P
Q
S
R
I
S
R
E
T
R
Site 16
S300
G
T
P
Q
S
R
I
S
R
E
T
R
L
P
P
Site 17
T303
Q
S
R
I
S
R
E
T
R
L
P
P
I
H
L
Site 18
S315
I
H
L
H
R
M
K
S
L
I
R
S
K
A
E
Site 19
S319
R
M
K
S
L
I
R
S
K
A
E
R
P
Q
G
Site 20
T330
R
P
Q
G
G
R
H
T
G
I
S
T
L
G
K
Site 21
S333
G
G
R
H
T
G
I
S
T
L
G
K
K
A
K
Site 22
S343
G
K
K
A
K
A
G
S
G
L
R
K
K
Q
R
Site 23
S355
K
Q
R
R
L
P
R
S
V
R
S
T
R
D
V
Site 24
S358
R
L
P
R
S
V
R
S
T
R
D
V
Q
A
A
Site 25
T359
L
P
R
S
V
R
S
T
R
D
V
Q
A
A
G
Site 26
Y400
L
G
A
F
T
R
P
Y
V
D
R
L
W
Q
K
Site 27
S411
L
W
Q
K
K
C
Q
S
K
S
P
G
L
D
N
Site 28
S413
Q
K
K
C
Q
S
K
S
P
G
L
D
N
A
Y
Site 29
Y420
S
P
G
L
D
N
A
Y
S
N
E
G
F
Y
D
Site 30
S421
P
G
L
D
N
A
Y
S
N
E
G
F
Y
D
D
Site 31
T435
D
M
E
A
A
G
H
T
P
H
P
E
T
H
L
Site 32
T440
G
H
T
P
H
P
E
T
H
L
R
Q
V
F
P
Site 33
Y452
V
F
P
H
L
S
L
Y
E
N
Q
T
P
F
W
Site 34
T456
L
S
L
Y
E
N
Q
T
P
F
W
V
T
Q
P
Site 35
T468
T
Q
P
H
P
H
A
T
V
I
P
D
R
T
L
Site 36
T474
A
T
V
I
P
D
R
T
L
G
R
S
R
K
D
Site 37
S478
P
D
R
T
L
G
R
S
R
K
D
P
G
S
S
Site 38
S484
R
S
R
K
D
P
G
S
S
Q
S
P
G
Q
C
Site 39
S485
S
R
K
D
P
G
S
S
Q
S
P
G
Q
C
G
Site 40
S487
K
D
P
G
S
S
Q
S
P
G
Q
C
G
D
N
Site 41
T495
P
G
Q
C
G
D
N
T
G
A
G
S
G
N
D
Site 42
S499
G
D
N
T
G
A
G
S
G
N
D
G
A
V
Y
Site 43
Y506
S
G
N
D
G
A
V
Y
S
I
L
Q
R
H
P
Site 44
S507
G
N
D
G
A
V
Y
S
I
L
Q
R
H
P
H
Site 45
Y539
D
I
L
G
E
W
T
Y
E
T
V
A
Q
E
E
Site 46
T541
L
G
E
W
T
Y
E
T
V
A
Q
E
E
P
L
Site 47
S549
V
A
Q
E
E
P
L
S
A
H
S
V
G
V
S
Site 48
S556
S
A
H
S
V
G
V
S
S
V
A
G
T
S
H
Site 49
S566
A
G
T
S
H
A
V
S
G
S
S
R
Y
D
S
Site 50
S568
T
S
H
A
V
S
G
S
S
R
Y
D
S
N
E
Site 51
S569
S
H
A
V
S
G
S
S
R
Y
D
S
N
E
L
Site 52
S573
S
G
S
S
R
Y
D
S
N
E
L
D
P
S
L
Site 53
S579
D
S
N
E
L
D
P
S
L
S
G
E
I
T
A
Site 54
S581
N
E
L
D
P
S
L
S
G
E
I
T
A
S
L
Site 55
T593
A
S
L
C
K
M
L
T
H
A
E
A
Q
R
T
Site 56
T600
T
H
A
E
A
Q
R
T
G
D
S
K
E
R
G
Site 57
S603
E
A
Q
R
T
G
D
S
K
E
R
G
G
T
E
Site 58
T609
D
S
K
E
R
G
G
T
E
Q
S
L
W
D
S
Site 59
S612
E
R
G
G
T
E
Q
S
L
W
D
S
Q
M
E
Site 60
S616
T
E
Q
S
L
W
D
S
Q
M
E
F
S
K
E
Site 61
S627
F
S
K
E
R
Q
V
S
S
S
I
D
L
L
S
Site 62
S628
S
K
E
R
Q
V
S
S
S
I
D
L
L
S
I
Site 63
S629
K
E
R
Q
V
S
S
S
I
D
L
L
S
I
Q
Site 64
S634
S
S
S
I
D
L
L
S
I
Q
Q
P
R
L
S
Site 65
S641
S
I
Q
Q
P
R
L
S
G
A
R
A
E
E
A
Site 66
S650
A
R
A
E
E
A
L
S
A
H
Y
S
E
V
P
Site 67
S654
E
A
L
S
A
H
Y
S
E
V
P
Y
G
D
P
Site 68
Y658
A
H
Y
S
E
V
P
Y
G
D
P
R
D
T
G
Site 69
T664
P
Y
G
D
P
R
D
T
G
P
S
V
F
P
P
Site 70
S667
D
P
R
D
T
G
P
S
V
F
P
P
R
W
D
Site 71
S675
V
F
P
P
R
W
D
S
G
L
D
V
T
P
A
Site 72
T680
W
D
S
G
L
D
V
T
P
A
N
K
E
P
V
Site 73
S690
N
K
E
P
V
Q
K
S
T
P
S
D
T
C
C
Site 74
T691
K
E
P
V
Q
K
S
T
P
S
D
T
C
C
E
Site 75
S693
P
V
Q
K
S
T
P
S
D
T
C
C
E
L
E
Site 76
T695
Q
K
S
T
P
S
D
T
C
C
E
L
E
S
D
Site 77
S701
D
T
C
C
E
L
E
S
D
C
D
S
D
E
G
Site 78
S705
E
L
E
S
D
C
D
S
D
E
G
S
L
F
T
Site 79
S709
D
C
D
S
D
E
G
S
L
F
T
L
S
S
I
Site 80
T712
S
D
E
G
S
L
F
T
L
S
S
I
S
S
E
Site 81
S714
E
G
S
L
F
T
L
S
S
I
S
S
E
S
A
Site 82
S715
G
S
L
F
T
L
S
S
I
S
S
E
S
A
R
Site 83
S717
L
F
T
L
S
S
I
S
S
E
S
A
R
S
K
Site 84
S718
F
T
L
S
S
I
S
S
E
S
A
R
S
K
T
Site 85
S720
L
S
S
I
S
S
E
S
A
R
S
K
T
E
E
Site 86
S723
I
S
S
E
S
A
R
S
K
T
E
E
A
V
P
Site 87
T725
S
E
S
A
R
S
K
T
E
E
A
V
P
D
E
Site 88
S734
E
A
V
P
D
E
E
S
L
Q
D
E
S
S
G
Site 89
S740
E
S
L
Q
D
E
S
S
G
A
S
K
D
N
V
Site 90
S743
Q
D
E
S
S
G
A
S
K
D
N
V
T
A
V
Site 91
T748
G
A
S
K
D
N
V
T
A
V
D
S
L
E
E
Site 92
S752
D
N
V
T
A
V
D
S
L
E
E
N
V
T
F
Site 93
T758
D
S
L
E
E
N
V
T
F
Q
T
I
P
G
K
Site 94
S779
P
F
E
K
P
L
I
S
A
P
D
S
G
M
Y
Site 95
S783
P
L
I
S
A
P
D
S
G
M
Y
K
T
H
L
Site 96
T788
P
D
S
G
M
Y
K
T
H
L
E
N
A
S
D
Site 97
S794
K
T
H
L
E
N
A
S
D
T
D
R
S
E
G
Site 98
T796
H
L
E
N
A
S
D
T
D
R
S
E
G
L
S
Site 99
S799
N
A
S
D
T
D
R
S
E
G
L
S
P
W
P
Site 100
S803
T
D
R
S
E
G
L
S
P
W
P
R
S
P
G
Site 101
S808
G
L
S
P
W
P
R
S
P
G
N
S
P
L
G
Site 102
S812
W
P
R
S
P
G
N
S
P
L
G
D
E
F
P
Site 103
Y824
E
F
P
G
M
F
T
Y
D
Y
D
T
A
L
Q
Site 104
Y826
P
G
M
F
T
Y
D
Y
D
T
A
L
Q
S
K
Site 105
T828
M
F
T
Y
D
Y
D
T
A
L
Q
S
K
A
A
Site 106
S840
K
A
A
E
W
H
C
S
L
R
D
L
E
F
S
Site 107
S847
S
L
R
D
L
E
F
S
N
V
D
V
L
Q
Q
Site 108
T855
N
V
D
V
L
Q
Q
T
P
P
C
S
A
E
V
Site 109
S859
L
Q
Q
T
P
P
C
S
A
E
V
P
S
D
P
Site 110
S864
P
C
S
A
E
V
P
S
D
P
D
K
A
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation