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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CEP135
Full Name:
Centrosomal protein of 135 kDa
Alias:
Centrosomal protein 135kDa; Centrosomal protein 4; Cep135; CEP4; CP135; FLJ13621; KIAA0635
Type:
Uncharacterized protein, centrosome-associated
Mass (Da):
133504
Number AA:
1140
UniProt ID:
Q66GS9
International Prot ID:
IPI00550987
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005814
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007099
GO:0010457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
T
T
A
V
E
R
K
Y
I
N
I
R
K
R
L
Site 2
T24
D
Q
L
G
Y
R
Q
T
L
T
V
E
C
L
P
Site 3
T26
L
G
Y
R
Q
T
L
T
V
E
C
L
P
L
V
Site 4
S38
P
L
V
E
K
L
F
S
D
L
V
H
T
T
E
Site 5
S46
D
L
V
H
T
T
E
S
L
R
Q
S
K
L
S
Site 6
S50
T
T
E
S
L
R
Q
S
K
L
S
A
V
K
A
Site 7
S53
S
L
R
Q
S
K
L
S
A
V
K
A
E
K
E
Site 8
S79
K
L
E
N
A
R
L
S
R
E
N
N
E
L
Y
Site 9
Y86
S
R
E
N
N
E
L
Y
L
E
L
M
K
L
R
Site 10
S96
L
M
K
L
R
E
H
S
D
Q
H
V
K
E
L
Site 11
S106
H
V
K
E
L
K
T
S
L
K
K
C
A
R
E
Site 12
T114
L
K
K
C
A
R
E
T
A
D
L
K
F
L
N
Site 13
Y124
L
K
F
L
N
N
Q
Y
A
H
K
L
K
L
L
Site 14
S135
L
K
L
L
E
K
E
S
K
A
K
N
E
R
I
Site 15
T156
N
L
H
A
V
V
Q
T
P
G
G
K
K
R
S
Site 16
S163
T
P
G
G
K
K
R
S
I
A
F
R
R
Q
R
Site 17
S180
I
D
E
P
V
P
P
S
E
V
S
S
Y
P
V
Site 18
S183
P
V
P
P
S
E
V
S
S
Y
P
V
P
Q
P
Site 19
S184
V
P
P
S
E
V
S
S
Y
P
V
P
Q
P
D
Site 20
Y185
P
P
S
E
V
S
S
Y
P
V
P
Q
P
D
D
Site 21
Y194
V
P
Q
P
D
D
P
Y
I
A
D
L
L
Q
V
Site 22
S225
E
K
L
A
M
M
E
S
G
V
R
D
Y
S
K
Site 23
Y230
M
E
S
G
V
R
D
Y
S
K
Q
I
E
L
R
Site 24
S231
E
S
G
V
R
D
Y
S
K
Q
I
E
L
R
E
Site 25
S245
E
R
E
I
E
R
L
S
V
A
L
D
G
G
R
Site 26
S253
V
A
L
D
G
G
R
S
P
D
V
L
S
L
E
Site 27
S258
G
R
S
P
D
V
L
S
L
E
S
R
N
K
T
Site 28
T265
S
L
E
S
R
N
K
T
N
E
K
L
I
A
H
Site 29
T297
R
I
R
E
L
M
E
T
K
E
T
V
T
S
E
Site 30
T300
E
L
M
E
T
K
E
T
V
T
S
E
V
V
N
Site 31
S303
E
T
K
E
T
V
T
S
E
V
V
N
L
S
N
Site 32
S309
T
S
E
V
V
N
L
S
N
K
N
E
K
L
C
Site 33
T320
E
K
L
C
Q
E
L
T
E
I
D
Q
L
A
Q
Site 34
T339
H
K
E
E
L
L
E
T
A
D
K
E
L
G
E
Site 35
S356
K
E
I
K
R
K
L
S
E
M
Q
D
L
E
E
Site 36
S383
Q
K
E
K
E
R
L
S
D
E
L
L
V
K
S
Site 37
S390
S
D
E
L
L
V
K
S
D
L
E
T
V
V
H
Site 38
T394
L
V
K
S
D
L
E
T
V
V
H
Q
L
E
Q
Site 39
S407
E
Q
E
K
Q
R
L
S
K
K
V
E
S
F
A
Site 40
S412
R
L
S
K
K
V
E
S
F
A
V
T
E
R
Q
Site 41
T416
K
V
E
S
F
A
V
T
E
R
Q
L
T
L
E
Site 42
T421
A
V
T
E
R
Q
L
T
L
E
V
E
R
M
R
Site 43
S439
G
I
K
R
R
D
R
S
P
S
R
L
D
T
F
Site 44
S441
K
R
R
D
R
S
P
S
R
L
D
T
F
L
K
Site 45
T445
R
S
P
S
R
L
D
T
F
L
K
G
I
E
E
Site 46
Y456
G
I
E
E
E
R
D
Y
Y
K
K
E
L
E
R
Site 47
Y457
I
E
E
E
R
D
Y
Y
K
K
E
L
E
R
L
Site 48
S472
Q
H
I
I
Q
R
R
S
C
S
T
S
Y
S
A
Site 49
S474
I
I
Q
R
R
S
C
S
T
S
Y
S
A
R
E
Site 50
S476
Q
R
R
S
C
S
T
S
Y
S
A
R
E
K
S
Site 51
S478
R
S
C
S
T
S
Y
S
A
R
E
K
S
S
I
Site 52
S483
S
Y
S
A
R
E
K
S
S
I
F
R
T
P
E
Site 53
S484
Y
S
A
R
E
K
S
S
I
F
R
T
P
E
K
Site 54
T488
E
K
S
S
I
F
R
T
P
E
K
G
D
Y
N
Site 55
Y494
R
T
P
E
K
G
D
Y
N
S
E
I
H
Q
I
Site 56
S496
P
E
K
G
D
Y
N
S
E
I
H
Q
I
T
R
Site 57
Y518
M
L
E
R
F
E
K
Y
M
E
D
I
Q
S
N
Site 58
S524
K
Y
M
E
D
I
Q
S
N
V
K
L
L
T
A
Site 59
T530
Q
S
N
V
K
L
L
T
A
E
R
D
K
L
S
Site 60
S537
T
A
E
R
D
K
L
S
V
L
Y
N
E
A
Q
Site 61
S554
L
S
A
L
R
K
E
S
T
Q
T
T
A
P
H
Site 62
T555
S
A
L
R
K
E
S
T
Q
T
T
A
P
H
N
Site 63
T557
L
R
K
E
S
T
Q
T
T
A
P
H
N
I
V
Site 64
T558
R
K
E
S
T
Q
T
T
A
P
H
N
I
V
S
Site 65
S565
T
A
P
H
N
I
V
S
L
M
E
K
E
K
E
Site 66
S576
K
E
K
E
L
A
L
S
D
L
R
R
I
M
A
Site 67
S599
L
E
H
I
E
E
V
S
L
F
G
K
S
E
L
Site 68
T609
G
K
S
E
L
E
K
T
I
E
H
L
T
C
V
Site 69
Y625
H
Q
L
E
S
E
K
Y
E
L
K
S
K
V
L
Site 70
S629
S
E
K
Y
E
L
K
S
K
V
L
I
M
K
E
Site 71
T637
K
V
L
I
M
K
E
T
I
E
S
L
E
N
K
Site 72
S640
I
M
K
E
T
I
E
S
L
E
N
K
L
K
V
Site 73
S660
S
H
V
A
G
D
S
S
H
Q
K
T
E
V
N
Site 74
T664
G
D
S
S
H
Q
K
T
E
V
N
S
L
R
I
Site 75
S668
H
Q
K
T
E
V
N
S
L
R
I
V
N
E
Q
Site 76
S679
V
N
E
Q
L
Q
R
S
V
D
D
Y
Q
H
R
Site 77
Y683
L
Q
R
S
V
D
D
Y
Q
H
R
L
S
I
K
Site 78
S688
D
D
Y
Q
H
R
L
S
I
K
R
G
E
L
E
Site 79
S696
I
K
R
G
E
L
E
S
A
Q
A
Q
I
K
I
Site 80
S717
E
L
N
L
K
M
T
S
Q
D
E
E
A
H
V
Site 81
T742
E
K
D
F
L
Q
E
T
V
D
E
K
T
E
K
Site 82
S772
A
Q
M
K
I
M
I
S
E
C
E
S
S
V
N
Site 83
S776
I
M
I
S
E
C
E
S
S
V
N
Q
L
K
E
Site 84
S777
M
I
S
E
C
E
S
S
V
N
Q
L
K
E
T
Site 85
T784
S
V
N
Q
L
K
E
T
L
V
N
R
D
R
E
Site 86
S794
N
R
D
R
E
I
N
S
L
R
R
Q
L
D
A
Site 87
S812
E
L
D
E
V
G
R
S
R
E
I
A
F
K
E
Site 88
T829
R
L
Q
D
D
L
A
T
M
A
R
E
N
Q
E
Site 89
S853
Q
E
K
E
E
M
K
S
R
V
H
K
Y
I
T
Site 90
Y858
M
K
S
R
V
H
K
Y
I
T
E
V
S
R
W
Site 91
S867
T
E
V
S
R
W
E
S
L
M
A
A
K
E
K
Site 92
S905
H
Q
A
E
G
E
S
S
S
V
R
L
E
L
L
Site 93
S906
Q
A
E
G
E
S
S
S
V
R
L
E
L
L
S
Site 94
S913
S
V
R
L
E
L
L
S
I
D
T
E
R
R
H
Site 95
T916
L
E
L
L
S
I
D
T
E
R
R
H
L
R
E
Site 96
Y942
H
I
N
A
H
H
A
Y
E
S
Q
I
S
S
M
Site 97
S944
N
A
H
H
A
Y
E
S
Q
I
S
S
M
A
K
Site 98
S948
A
Y
E
S
Q
I
S
S
M
A
K
A
M
S
R
Site 99
S954
S
S
M
A
K
A
M
S
R
L
E
E
E
L
R
Site 100
S975
A
T
V
L
N
D
L
S
S
L
R
E
L
C
I
Site 101
S976
T
V
L
N
D
L
S
S
L
R
E
L
C
I
K
Site 102
S986
E
L
C
I
K
L
D
S
G
K
D
I
M
T
Q
Site 103
T992
D
S
G
K
D
I
M
T
Q
Q
L
N
S
K
N
Site 104
S997
I
M
T
Q
Q
L
N
S
K
N
L
E
F
E
R
Site 105
S1014
V
E
L
E
N
V
K
S
E
S
D
L
L
K
K
Site 106
S1024
D
L
L
K
K
Q
L
S
N
E
R
H
T
V
K
Site 107
T1029
Q
L
S
N
E
R
H
T
V
K
N
L
E
S
L
Site 108
T1039
N
L
E
S
L
L
A
T
N
R
D
K
E
F
H
Site 109
S1047
N
R
D
K
E
F
H
S
H
L
T
S
H
E
K
Site 110
S1051
E
F
H
S
H
L
T
S
H
E
K
D
T
E
I
Site 111
T1066
Q
L
L
K
E
K
L
T
L
S
E
S
K
L
T
Site 112
S1068
L
K
E
K
L
T
L
S
E
S
K
L
T
S
Q
Site 113
S1070
E
K
L
T
L
S
E
S
K
L
T
S
Q
S
R
Site 114
T1073
T
L
S
E
S
K
L
T
S
Q
S
R
E
N
T
Site 115
S1074
L
S
E
S
K
L
T
S
Q
S
R
E
N
T
M
Site 116
T1080
T
S
Q
S
R
E
N
T
M
L
R
A
K
V
A
Site 117
Y1093
V
A
Q
L
Q
T
D
Y
D
A
L
K
R
Q
I
Site 118
S1101
D
A
L
K
R
Q
I
S
T
E
R
Y
E
R
E
Site 119
Y1105
R
Q
I
S
T
E
R
Y
E
R
E
R
A
I
Q
Site 120
T1121
M
R
R
H
G
L
A
T
P
P
L
S
S
T
L
Site 121
S1125
G
L
A
T
P
P
L
S
S
T
L
R
S
P
S
Site 122
S1126
L
A
T
P
P
L
S
S
T
L
R
S
P
S
H
Site 123
T1127
A
T
P
P
L
S
S
T
L
R
S
P
S
H
S
Site 124
S1130
P
L
S
S
T
L
R
S
P
S
H
S
P
E
H
Site 125
S1132
S
S
T
L
R
S
P
S
H
S
P
E
H
R
N
Site 126
S1134
T
L
R
S
P
S
H
S
P
E
H
R
N
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation