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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDR25
Full Name:
WD repeat-containing protein 25
Alias:
MGC4645; WD repeat domain 25
Type:
Mass (Da):
60160
Number AA:
UniProt ID:
Q64LD2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
L
M
A
S
L
V
A
Y
D
D
S
D
S
E
A
Site 2
S18
S
L
V
A
Y
D
D
S
D
S
E
A
E
T
E
Site 3
S20
V
A
Y
D
D
S
D
S
E
A
E
T
E
H
A
Site 4
T24
D
S
D
S
E
A
E
T
E
H
A
G
S
F
N
Site 5
S29
A
E
T
E
H
A
G
S
F
N
A
T
G
Q
Q
Site 6
S40
T
G
Q
Q
K
D
T
S
G
V
A
R
P
P
G
Site 7
S52
P
P
G
Q
D
F
A
S
G
T
L
D
V
P
K
Site 8
T54
G
Q
D
F
A
S
G
T
L
D
V
P
K
A
G
Site 9
T65
P
K
A
G
A
Q
P
T
K
H
G
S
C
E
D
Site 10
S69
A
Q
P
T
K
H
G
S
C
E
D
P
G
G
Y
Site 11
Y76
S
C
E
D
P
G
G
Y
R
L
P
L
A
Q
L
Site 12
S86
P
L
A
Q
L
G
R
S
D
W
G
S
C
P
S
Site 13
S90
L
G
R
S
D
W
G
S
C
P
S
Q
R
L
Q
Site 14
S93
S
D
W
G
S
C
P
S
Q
R
L
Q
W
P
G
Site 15
T106
P
G
K
E
P
Q
V
T
F
P
I
K
E
P
S
Site 16
S113
T
F
P
I
K
E
P
S
C
S
S
L
W
T
S
Site 17
S115
P
I
K
E
P
S
C
S
S
L
W
T
S
H
V
Site 18
S116
I
K
E
P
S
C
S
S
L
W
T
S
H
V
P
Site 19
T119
P
S
C
S
S
L
W
T
S
H
V
P
A
S
H
Site 20
S120
S
C
S
S
L
W
T
S
H
V
P
A
S
H
M
Site 21
S140
R
F
K
Q
V
K
L
S
R
N
F
P
K
S
S
Site 22
S146
L
S
R
N
F
P
K
S
S
F
H
A
Q
S
E
Site 23
S147
S
R
N
F
P
K
S
S
F
H
A
Q
S
E
S
Site 24
S152
K
S
S
F
H
A
Q
S
E
S
E
T
V
G
K
Site 25
S154
S
F
H
A
Q
S
E
S
E
T
V
G
K
N
G
Site 26
T156
H
A
Q
S
E
S
E
T
V
G
K
N
G
S
S
Site 27
S163
T
V
G
K
N
G
S
S
F
Q
K
K
K
C
E
Site 28
Y176
C
E
D
C
V
V
P
Y
T
P
R
R
L
R
Q
Site 29
T177
E
D
C
V
V
P
Y
T
P
R
R
L
R
Q
R
Site 30
S188
L
R
Q
R
Q
A
L
S
T
E
T
G
K
G
K
Site 31
T189
R
Q
R
Q
A
L
S
T
E
T
G
K
G
K
D
Site 32
Y212
G
R
A
P
A
P
L
Y
V
G
P
G
V
S
E
Site 33
Y224
V
S
E
F
I
Q
P
Y
L
N
S
H
Y
K
E
Site 34
T233
N
S
H
Y
K
E
T
T
V
P
R
K
V
L
F
Site 35
S266
S
K
S
H
M
L
L
S
T
S
M
D
K
T
F
Site 36
S268
S
H
M
L
L
S
T
S
M
D
K
T
F
K
V
Site 37
T272
L
S
T
S
M
D
K
T
F
K
V
W
N
A
V
Site 38
Y288
S
G
H
C
L
Q
T
Y
S
L
H
T
E
A
V
Site 39
S289
G
H
C
L
Q
T
Y
S
L
H
T
E
A
V
R
Site 40
T323
L
H
L
T
D
L
E
T
G
T
Q
L
F
S
G
Site 41
T325
L
T
D
L
E
T
G
T
Q
L
F
S
G
R
S
Site 42
S329
E
T
G
T
Q
L
F
S
G
R
S
D
F
R
I
Site 43
S332
T
Q
L
F
S
G
R
S
D
F
R
I
T
T
L
Site 44
T337
G
R
S
D
F
R
I
T
T
L
K
F
H
P
K
Site 45
T338
R
S
D
F
R
I
T
T
L
K
F
H
P
K
D
Site 46
T365
M
K
A
W
D
I
R
T
G
K
V
M
R
S
Y
Site 47
S371
R
T
G
K
V
M
R
S
Y
K
A
T
I
Q
Q
Site 48
Y372
T
G
K
V
M
R
S
Y
K
A
T
I
Q
Q
T
Site 49
T375
V
M
R
S
Y
K
A
T
I
Q
Q
T
L
D
I
Site 50
S389
I
L
F
L
R
E
G
S
E
F
L
S
S
T
D
Site 51
S393
R
E
G
S
E
F
L
S
S
T
D
A
S
T
R
Site 52
S394
E
G
S
E
F
L
S
S
T
D
A
S
T
R
D
Site 53
T395
G
S
E
F
L
S
S
T
D
A
S
T
R
D
S
Site 54
S398
F
L
S
S
T
D
A
S
T
R
D
S
A
D
R
Site 55
S402
T
D
A
S
T
R
D
S
A
D
R
T
I
I
A
Site 56
T406
T
R
D
S
A
D
R
T
I
I
A
W
D
F
R
Site 57
T414
I
I
A
W
D
F
R
T
S
A
K
I
S
N
Q
Site 58
S419
F
R
T
S
A
K
I
S
N
Q
I
F
H
E
R
Site 59
T428
Q
I
F
H
E
R
F
T
C
P
S
L
A
L
H
Site 60
S431
H
E
R
F
T
C
P
S
L
A
L
H
P
R
E
Site 61
Y459
L
F
S
T
V
W
P
Y
R
M
S
R
R
R
R
Site 62
Y467
R
M
S
R
R
R
R
Y
E
G
H
K
V
E
G
Site 63
Y475
E
G
H
K
V
E
G
Y
S
V
G
C
E
C
S
Site 64
S476
G
H
K
V
E
G
Y
S
V
G
C
E
C
S
P
Site 65
S482
Y
S
V
G
C
E
C
S
P
G
G
D
L
L
V
Site 66
Y500
A
D
G
R
V
L
M
Y
S
F
R
T
A
S
R
Site 67
S501
D
G
R
V
L
M
Y
S
F
R
T
A
S
R
A
Site 68
S506
M
Y
S
F
R
T
A
S
R
A
C
T
L
Q
G
Site 69
T510
R
T
A
S
R
A
C
T
L
Q
G
H
T
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation