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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKRD25
Full Name:
KN motif and ankyrin repeat domain-containing protein 2
Alias:
Ankyrin repeat domain 25; ANR25; KANK2; KN motif and ankyrin repeat domain-containing protein 2: Ankyrin repeat domain-containing protein 25: SRC-1-interacting protein: SRC1-interacting protein: Matrix-remodeling-associated protein 3: KN motif and ankyrin repeat domain-containing protein 2: Ankyrin repeat domain-containing protein 25: SRC-1-interacting protein: SRC1-interacting protein: Matrix-remodeling-associated protein 3: KN motif and ankyrin repeat domain-containing protein 2: Ankyrin repeat domain-containing protein 25: SRC-1-interacting protein: SRC1-interacting protein: Matrix-remodeling-associated protein 3; Matrix-remodelling associated 3; MXRA3; SIP; SRC-1 interacting protein
Type:
Transcription regulation
Mass (Da):
91174
Number AA:
851
UniProt ID:
Q63ZY3
International Prot ID:
IPI00470559
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
V
P
A
P
F
P
G
T
P
G
P
A
S
P
P
Site 2
S19
P
G
T
P
G
P
A
S
P
P
A
F
P
A
K
Site 3
Y32
A
K
D
P
D
P
P
Y
S
V
E
T
P
Y
G
Site 4
S33
K
D
P
D
P
P
Y
S
V
E
T
P
Y
G
Y
Site 5
T36
D
P
P
Y
S
V
E
T
P
Y
G
Y
R
L
D
Site 6
Y38
P
Y
S
V
E
T
P
Y
G
Y
R
L
D
L
D
Site 7
Y49
L
D
L
D
F
L
K
Y
V
D
D
I
E
K
G
Site 8
T58
D
D
I
E
K
G
H
T
L
R
R
V
A
V
Q
Site 9
S71
V
Q
R
R
P
R
L
S
S
L
P
R
G
P
G
Site 10
S72
Q
R
R
P
R
L
S
S
L
P
R
G
P
G
S
Site 11
S79
S
L
P
R
G
P
G
S
W
W
T
S
T
E
S
Site 12
T82
R
G
P
G
S
W
W
T
S
T
E
S
L
C
S
Site 13
S83
G
P
G
S
W
W
T
S
T
E
S
L
C
S
N
Site 14
T84
P
G
S
W
W
T
S
T
E
S
L
C
S
N
A
Site 15
S86
S
W
W
T
S
T
E
S
L
C
S
N
A
S
G
Site 16
S89
T
S
T
E
S
L
C
S
N
A
S
G
D
S
R
Site 17
S92
E
S
L
C
S
N
A
S
G
D
S
R
H
S
A
Site 18
S95
C
S
N
A
S
G
D
S
R
H
S
A
Y
S
Y
Site 19
S98
A
S
G
D
S
R
H
S
A
Y
S
Y
C
G
R
Site 20
Y100
G
D
S
R
H
S
A
Y
S
Y
C
G
R
G
F
Site 21
S101
D
S
R
H
S
A
Y
S
Y
C
G
R
G
F
Y
Site 22
Y102
S
R
H
S
A
Y
S
Y
C
G
R
G
F
Y
P
Site 23
Y108
S
Y
C
G
R
G
F
Y
P
Q
Y
G
A
L
E
Site 24
Y111
G
R
G
F
Y
P
Q
Y
G
A
L
E
T
R
G
Site 25
T141
R
L
E
D
Q
A
A
T
P
T
G
L
G
S
L
Site 26
T143
E
D
Q
A
A
T
P
T
G
L
G
S
L
T
P
Site 27
S147
A
T
P
T
G
L
G
S
L
T
P
S
A
A
G
Site 28
T149
P
T
G
L
G
S
L
T
P
S
A
A
G
S
T
Site 29
S158
S
A
A
G
S
T
A
S
L
V
G
V
G
L
P
Site 30
T168
G
V
G
L
P
P
P
T
P
R
S
S
G
L
S
Site 31
S171
L
P
P
P
T
P
R
S
S
G
L
S
T
P
V
Site 32
S172
P
P
P
T
P
R
S
S
G
L
S
T
P
V
P
Site 33
S175
T
P
R
S
S
G
L
S
T
P
V
P
P
S
A
Site 34
T176
P
R
S
S
G
L
S
T
P
V
P
P
S
A
G
Site 35
S181
L
S
T
P
V
P
P
S
A
G
H
L
A
H
V
Site 36
S217
P
V
L
Q
V
K
L
S
V
L
Q
E
E
K
R
Site 37
T227
Q
E
E
K
R
Q
L
T
V
Q
L
K
S
Q
K
Site 38
S232
Q
L
T
V
Q
L
K
S
Q
K
F
L
G
H
P
Site 39
S246
P
T
A
G
R
G
R
S
E
L
C
L
D
L
P
Site 40
S266
P
V
A
L
E
T
R
S
V
G
T
W
V
R
E
Site 41
S323
Q
A
W
P
P
P
D
S
P
V
R
V
D
T
V
Site 42
T329
D
S
P
V
R
V
D
T
V
R
V
V
E
G
P
Site 43
S356
A
P
A
Q
R
A
Q
S
L
E
P
Y
G
T
G
Site 44
Y360
R
A
Q
S
L
E
P
Y
G
T
G
L
R
A
L
Site 45
T362
Q
S
L
E
P
Y
G
T
G
L
R
A
L
A
M
Site 46
S375
A
M
P
G
R
P
E
S
P
P
V
F
R
S
Q
Site 47
S381
E
S
P
P
V
F
R
S
Q
E
V
V
E
T
M
Site 48
T387
R
S
Q
E
V
V
E
T
M
C
P
V
P
A
A
Site 49
S406
V
H
M
V
K
K
I
S
I
T
E
R
S
C
D
Site 50
S425
L
P
E
V
P
A
E
S
S
S
S
P
P
G
S
Site 51
S426
P
E
V
P
A
E
S
S
S
S
P
P
G
S
E
Site 52
S427
E
V
P
A
E
S
S
S
S
P
P
G
S
E
V
Site 53
S428
V
P
A
E
S
S
S
S
P
P
G
S
E
V
A
Site 54
S432
S
S
S
S
P
P
G
S
E
V
A
S
L
T
Q
Site 55
S436
P
P
G
S
E
V
A
S
L
T
Q
P
E
K
S
Site 56
T438
G
S
E
V
A
S
L
T
Q
P
E
K
S
T
G
Site 57
S443
S
L
T
Q
P
E
K
S
T
G
R
V
P
T
Q
Site 58
T449
K
S
T
G
R
V
P
T
Q
E
P
T
H
R
E
Site 59
T458
E
P
T
H
R
E
P
T
R
Q
A
A
S
Q
E
Site 60
S463
E
P
T
R
Q
A
A
S
Q
E
S
E
E
A
G
Site 61
T472
E
S
E
E
A
G
G
T
G
G
P
P
A
G
V
Site 62
T493
K
E
E
V
A
D
P
T
A
H
R
R
S
L
Q
Site 63
S498
D
P
T
A
H
R
R
S
L
Q
F
V
G
V
N
Site 64
Y508
F
V
G
V
N
G
G
Y
E
S
S
S
E
D
S
Site 65
S510
G
V
N
G
G
Y
E
S
S
S
E
D
S
S
T
Site 66
S511
V
N
G
G
Y
E
S
S
S
E
D
S
S
T
A
Site 67
S512
N
G
G
Y
E
S
S
S
E
D
S
S
T
A
E
Site 68
S515
Y
E
S
S
S
E
D
S
S
T
A
E
N
I
S
Site 69
S516
E
S
S
S
E
D
S
S
T
A
E
N
I
S
D
Site 70
T517
S
S
S
E
D
S
S
T
A
E
N
I
S
D
N
Site 71
S522
S
S
T
A
E
N
I
S
D
N
D
S
T
E
N
Site 72
S526
E
N
I
S
D
N
D
S
T
E
N
E
A
P
E
Site 73
T527
N
I
S
D
N
D
S
T
E
N
E
A
P
E
P
Site 74
S540
E
P
R
E
R
V
P
S
V
A
E
A
P
Q
L
Site 75
T552
P
Q
L
R
P
A
G
T
A
A
A
K
T
S
R
Site 76
T557
A
G
T
A
A
A
K
T
S
R
Q
E
C
Q
L
Site 77
S565
S
R
Q
E
C
Q
L
S
R
E
S
Q
H
I
P
Site 78
S568
E
C
Q
L
S
R
E
S
Q
H
I
P
T
A
E
Site 79
T582
E
G
A
S
G
S
N
T
E
E
E
I
R
M
E
Site 80
S591
E
E
I
R
M
E
L
S
P
D
L
I
S
A
C
Site 81
T622
E
L
K
V
A
Y
T
T
V
L
Q
E
W
L
R
Site 82
S634
W
L
R
L
A
C
R
S
D
A
H
P
E
L
V
Site 83
T669
I
A
D
S
N
G
N
T
A
L
H
Y
S
V
S
Site 84
Y673
N
G
N
T
A
L
H
Y
S
V
S
H
A
N
F
Site 85
S674
G
N
T
A
L
H
Y
S
V
S
H
A
N
F
P
Site 86
Y702
D
K
Q
N
R
A
G
Y
S
P
I
M
L
T
A
Site 87
S703
K
Q
N
R
A
G
Y
S
P
I
M
L
T
A
L
Site 88
T715
T
A
L
A
T
L
K
T
Q
D
D
I
E
T
V
Site 89
T721
K
T
Q
D
D
I
E
T
V
L
Q
L
F
R
L
Site 90
S736
G
N
I
N
A
K
A
S
Q
A
G
Q
T
A
L
Site 91
S800
A
V
P
S
C
D
I
S
L
T
D
R
D
G
S
Site 92
T802
P
S
C
D
I
S
L
T
D
R
D
G
S
T
A
Site 93
S823
A
G
Q
S
E
I
A
S
M
L
Y
S
R
M
N
Site 94
Y826
S
E
I
A
S
M
L
Y
S
R
M
N
I
K
C
Site 95
S834
S
R
M
N
I
K
C
S
F
A
P
M
S
D
D
Site 96
S839
K
C
S
F
A
P
M
S
D
D
E
S
P
T
S
Site 97
S843
A
P
M
S
D
D
E
S
P
T
S
S
S
A
E
Site 98
S846
S
D
D
E
S
P
T
S
S
S
A
E
E
_
_
Site 99
S847
D
D
E
S
P
T
S
S
S
A
E
E
_
_
_
Site 100
S848
D
E
S
P
T
S
S
S
A
E
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation