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Updated November 2019
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Protein Info
Short Name:
DUSP27
Full Name:
Inactive dual specificity phosphatase 27
Alias:
dual specificity phosphatase 27; DUS27
Type:
Mass (Da):
130180
Number AA:
UniProt ID:
Q5VZP5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008138
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
T
R
K
D
T
E
E
E
Q
V
V
P
Site 2
Y29
V
R
A
V
Q
A
H
Y
L
R
S
P
S
P
S
Site 3
S32
V
Q
A
H
Y
L
R
S
P
S
P
S
Q
Y
S
Site 4
S34
A
H
Y
L
R
S
P
S
P
S
Q
Y
S
M
V
Site 5
S36
Y
L
R
S
P
S
P
S
Q
Y
S
M
V
S
D
Site 6
Y38
R
S
P
S
P
S
Q
Y
S
M
V
S
D
A
E
Site 7
S39
S
P
S
P
S
Q
Y
S
M
V
S
D
A
E
T
Site 8
S42
P
S
Q
Y
S
M
V
S
D
A
E
T
E
S
I
Site 9
T46
S
M
V
S
D
A
E
T
E
S
I
F
M
E
P
Site 10
S48
V
S
D
A
E
T
E
S
I
F
M
E
P
I
H
Site 11
Y97
Q
L
L
V
E
D
L
Y
N
R
V
R
E
K
M
Site 12
T107
V
R
E
K
M
D
D
T
S
L
Y
N
T
P
C
Site 13
S108
R
E
K
M
D
D
T
S
L
Y
N
T
P
C
V
Site 14
Y110
K
M
D
D
T
S
L
Y
N
T
P
C
V
L
D
Site 15
T112
D
D
T
S
L
Y
N
T
P
C
V
L
D
L
Q
Site 16
S147
N
V
F
I
A
E
K
S
V
A
V
N
K
G
R
Site 17
Y173
A
A
H
G
T
G
V
Y
T
G
P
E
F
Y
T
Site 18
Y186
Y
T
G
L
E
I
Q
Y
L
G
V
E
V
D
D
Site 19
S200
D
F
P
E
V
D
I
S
Q
H
F
R
K
A
S
Site 20
S207
S
Q
H
F
R
K
A
S
E
F
L
D
E
A
L
Site 21
S225
R
G
K
V
L
V
S
S
E
M
G
I
S
R
S
Site 22
Y262
V
R
K
K
R
A
I
Y
P
N
E
G
F
L
K
Site 23
Y286
M
E
E
R
E
E
D
Y
G
R
E
G
G
S
A
Site 24
T301
E
A
E
E
G
E
G
T
G
S
M
L
G
A
R
Site 25
S303
E
E
G
E
G
T
G
S
M
L
G
A
R
V
H
Site 26
T313
G
A
R
V
H
A
L
T
V
E
E
E
D
D
S
Site 27
S320
T
V
E
E
E
D
D
S
A
S
H
L
S
G
S
Site 28
S322
E
E
E
D
D
S
A
S
H
L
S
G
S
S
L
Site 29
S325
D
D
S
A
S
H
L
S
G
S
S
L
G
K
A
Site 30
S328
A
S
H
L
S
G
S
S
L
G
K
A
T
Q
A
Site 31
T333
G
S
S
L
G
K
A
T
Q
A
S
K
P
L
T
Site 32
S336
L
G
K
A
T
Q
A
S
K
P
L
T
L
I
D
Site 33
T340
T
Q
A
S
K
P
L
T
L
I
D
E
E
E
E
Site 34
Y351
E
E
E
E
E
K
L
Y
E
Q
W
K
K
G
Q
Site 35
S362
K
K
G
Q
G
L
L
S
D
K
V
P
Q
D
G
Site 36
S374
Q
D
G
G
G
W
R
S
A
S
S
G
Q
G
G
Site 37
S376
G
G
G
W
R
S
A
S
S
G
Q
G
G
E
E
Site 38
S377
G
G
W
R
S
A
S
S
G
Q
G
G
E
E
L
Site 39
Y408
E
R
Y
Q
A
E
G
Y
R
R
W
G
R
E
E
Site 40
S421
E
E
E
K
E
E
E
S
D
A
G
S
S
V
G
Site 41
S425
E
E
E
S
D
A
G
S
S
V
G
R
R
R
R
Site 42
S426
E
E
S
D
A
G
S
S
V
G
R
R
R
R
T
Site 43
T433
S
V
G
R
R
R
R
T
L
S
E
S
S
A
W
Site 44
S435
G
R
R
R
R
T
L
S
E
S
S
A
W
E
S
Site 45
S437
R
R
R
T
L
S
E
S
S
A
W
E
S
V
S
Site 46
S438
R
R
T
L
S
E
S
S
A
W
E
S
V
S
S
Site 47
S442
S
E
S
S
A
W
E
S
V
S
S
H
D
I
W
Site 48
S444
S
S
A
W
E
S
V
S
S
H
D
I
W
V
L
Site 49
S445
S
A
W
E
S
V
S
S
H
D
I
W
V
L
K
Site 50
S470
G
R
R
R
R
A
D
S
M
S
S
E
S
T
W
Site 51
S472
R
R
R
A
D
S
M
S
S
E
S
T
W
D
A
Site 52
T476
D
S
M
S
S
E
S
T
W
D
A
W
N
E
R
Site 53
S492
L
E
I
E
K
E
A
S
R
R
Y
H
A
K
S
Site 54
Y495
E
K
E
A
S
R
R
Y
H
A
K
S
K
R
E
Site 55
S499
S
R
R
Y
H
A
K
S
K
R
E
E
A
A
D
Site 56
S508
R
E
E
A
A
D
R
S
S
E
A
G
S
R
V
Site 57
S509
E
E
A
A
D
R
S
S
E
A
G
S
R
V
R
Site 58
S513
D
R
S
S
E
A
G
S
R
V
R
E
D
D
E
Site 59
S522
V
R
E
D
D
E
D
S
V
G
S
E
A
S
S
Site 60
S525
D
D
E
D
S
V
G
S
E
A
S
S
F
Y
N
Site 61
S529
S
V
G
S
E
A
S
S
F
Y
N
F
C
S
R
Site 62
Y531
G
S
E
A
S
S
F
Y
N
F
C
S
R
N
K
Site 63
S535
S
S
F
Y
N
F
C
S
R
N
K
D
K
L
T
Site 64
T542
S
R
N
K
D
K
L
T
A
L
E
R
W
K
I
Site 65
S566
K
D
L
G
A
G
D
S
S
G
E
P
G
A
E
Site 66
S567
D
L
G
A
G
D
S
S
G
E
P
G
A
E
E
Site 67
S582
A
V
G
E
K
N
P
S
D
V
S
L
T
A
Y
Site 68
S585
E
K
N
P
S
D
V
S
L
T
A
Y
Q
A
W
Site 69
Y589
S
D
V
S
L
T
A
Y
Q
A
W
K
L
K
H
Site 70
S612
K
E
E
V
V
E
L
S
K
G
E
D
S
A
L
Site 71
T636
L
L
E
R
S
R
Q
T
L
E
E
S
Q
S
M
Site 72
S640
S
R
Q
T
L
E
E
S
Q
S
M
A
S
W
E
Site 73
S642
Q
T
L
E
E
S
Q
S
M
A
S
W
E
A
D
Site 74
S645
E
E
S
Q
S
M
A
S
W
E
A
D
S
S
T
Site 75
S650
M
A
S
W
E
A
D
S
S
T
A
S
G
S
I
Site 76
S651
A
S
W
E
A
D
S
S
T
A
S
G
S
I
P
Site 77
T652
S
W
E
A
D
S
S
T
A
S
G
S
I
P
L
Site 78
S654
E
A
D
S
S
T
A
S
G
S
I
P
L
S
A
Site 79
S656
D
S
S
T
A
S
G
S
I
P
L
S
A
F
W
Site 80
S668
A
F
W
S
A
D
P
S
V
S
A
D
G
D
T
Site 81
T675
S
V
S
A
D
G
D
T
T
S
V
L
S
T
Q
Site 82
T676
V
S
A
D
G
D
T
T
S
V
L
S
T
Q
S
Site 83
S677
S
A
D
G
D
T
T
S
V
L
S
T
Q
S
H
Site 84
S680
G
D
T
T
S
V
L
S
T
Q
S
H
R
S
H
Site 85
T681
D
T
T
S
V
L
S
T
Q
S
H
R
S
H
L
Site 86
S683
T
S
V
L
S
T
Q
S
H
R
S
H
L
S
Q
Site 87
S686
L
S
T
Q
S
H
R
S
H
L
S
Q
A
A
S
Site 88
S689
Q
S
H
R
S
H
L
S
Q
A
A
S
N
I
A
Site 89
S693
S
H
L
S
Q
A
A
S
N
I
A
G
C
S
T
Site 90
S699
A
S
N
I
A
G
C
S
T
S
N
P
T
T
P
Site 91
T700
S
N
I
A
G
C
S
T
S
N
P
T
T
P
L
Site 92
S701
N
I
A
G
C
S
T
S
N
P
T
T
P
L
P
Site 93
T705
C
S
T
S
N
P
T
T
P
L
P
N
L
P
V
Site 94
S746
Q
N
E
M
L
L
L
S
R
S
P
S
V
A
S
Site 95
S753
S
R
S
P
S
V
A
S
M
K
A
V
P
A
A
Site 96
S769
C
L
G
D
D
Q
V
S
M
L
S
G
H
S
S
Site 97
S772
D
D
Q
V
S
M
L
S
G
H
S
S
S
S
L
Site 98
S787
G
G
C
L
L
P
Q
S
Q
A
R
P
S
S
D
Site 99
S792
P
Q
S
Q
A
R
P
S
S
D
M
Q
S
V
L
Site 100
S793
Q
S
Q
A
R
P
S
S
D
M
Q
S
V
L
S
Site 101
S797
R
P
S
S
D
M
Q
S
V
L
S
C
N
T
T
Site 102
S800
S
D
M
Q
S
V
L
S
C
N
T
T
L
S
S
Site 103
T804
S
V
L
S
C
N
T
T
L
S
S
P
A
E
S
Site 104
S806
L
S
C
N
T
T
L
S
S
P
A
E
S
C
R
Site 105
S807
S
C
N
T
T
L
S
S
P
A
E
S
C
R
S
Site 106
S811
T
L
S
S
P
A
E
S
C
R
S
K
V
R
G
Site 107
S814
S
P
A
E
S
C
R
S
K
V
R
G
T
S
K
Site 108
T819
C
R
S
K
V
R
G
T
S
K
P
I
F
S
L
Site 109
S820
R
S
K
V
R
G
T
S
K
P
I
F
S
L
F
Site 110
S852
M
E
L
R
E
K
M
S
E
Y
K
M
E
K
L
Site 111
S861
Y
K
M
E
K
L
A
S
D
N
K
R
S
S
L
Site 112
S867
A
S
D
N
K
R
S
S
L
F
K
K
K
K
V
Site 113
T889
V
G
D
G
D
E
D
T
D
S
A
I
G
S
F
Site 114
S891
D
G
D
E
D
T
D
S
A
I
G
S
F
R
Y
Site 115
S895
D
T
D
S
A
I
G
S
F
R
Y
S
S
R
S
Site 116
Y898
S
A
I
G
S
F
R
Y
S
S
R
S
N
S
Q
Site 117
S899
A
I
G
S
F
R
Y
S
S
R
S
N
S
Q
K
Site 118
S900
I
G
S
F
R
Y
S
S
R
S
N
S
Q
K
P
Site 119
S902
S
F
R
Y
S
S
R
S
N
S
Q
K
P
E
T
Site 120
S904
R
Y
S
S
R
S
N
S
Q
K
P
E
T
D
T
Site 121
T909
S
N
S
Q
K
P
E
T
D
T
C
S
S
L
A
Site 122
T911
S
Q
K
P
E
T
D
T
C
S
S
L
A
V
C
Site 123
S913
K
P
E
T
D
T
C
S
S
L
A
V
C
D
H
Site 124
S914
P
E
T
D
T
C
S
S
L
A
V
C
D
H
Y
Site 125
Y921
S
L
A
V
C
D
H
Y
A
S
G
S
R
V
G
Site 126
S923
A
V
C
D
H
Y
A
S
G
S
R
V
G
K
E
Site 127
S934
V
G
K
E
M
D
S
S
I
N
K
W
L
S
G
Site 128
S940
S
S
I
N
K
W
L
S
G
L
R
T
E
E
K
Site 129
T944
K
W
L
S
G
L
R
T
E
E
K
P
P
F
Q
Site 130
S952
E
E
K
P
P
F
Q
S
D
W
S
G
S
S
R
Site 131
S955
P
P
F
Q
S
D
W
S
G
S
S
R
G
K
Y
Site 132
S957
F
Q
S
D
W
S
G
S
S
R
G
K
Y
T
R
Site 133
Y962
S
G
S
S
R
G
K
Y
T
R
S
S
L
L
R
Site 134
S966
R
G
K
Y
T
R
S
S
L
L
R
E
T
E
S
Site 135
T971
R
S
S
L
L
R
E
T
E
S
K
S
S
S
Y
Site 136
S973
S
L
L
R
E
T
E
S
K
S
S
S
Y
K
F
Site 137
S975
L
R
E
T
E
S
K
S
S
S
Y
K
F
S
K
Site 138
S976
R
E
T
E
S
K
S
S
S
Y
K
F
S
K
S
Site 139
S977
E
T
E
S
K
S
S
S
Y
K
F
S
K
S
Q
Site 140
S981
K
S
S
S
Y
K
F
S
K
S
Q
S
E
E
Q
Site 141
S983
S
S
Y
K
F
S
K
S
Q
S
E
E
Q
D
T
Site 142
S985
Y
K
F
S
K
S
Q
S
E
E
Q
D
T
S
S
Site 143
T990
S
Q
S
E
E
Q
D
T
S
S
Y
H
E
A
N
Site 144
S991
Q
S
E
E
Q
D
T
S
S
Y
H
E
A
N
G
Site 145
S992
S
E
E
Q
D
T
S
S
Y
H
E
A
N
G
N
Site 146
Y993
E
E
Q
D
T
S
S
Y
H
E
A
N
G
N
S
Site 147
S1000
Y
H
E
A
N
G
N
S
V
R
S
T
S
R
F
Site 148
S1003
A
N
G
N
S
V
R
S
T
S
R
F
S
S
S
Site 149
T1004
N
G
N
S
V
R
S
T
S
R
F
S
S
S
S
Site 150
S1005
G
N
S
V
R
S
T
S
R
F
S
S
S
S
T
Site 151
S1008
V
R
S
T
S
R
F
S
S
S
S
T
R
E
G
Site 152
S1009
R
S
T
S
R
F
S
S
S
S
T
R
E
G
R
Site 153
S1010
S
T
S
R
F
S
S
S
S
T
R
E
G
R
E
Site 154
S1011
T
S
R
F
S
S
S
S
T
R
E
G
R
E
M
Site 155
T1012
S
R
F
S
S
S
S
T
R
E
G
R
E
M
H
Site 156
S1022
G
R
E
M
H
K
F
S
R
S
T
Y
N
E
T
Site 157
S1024
E
M
H
K
F
S
R
S
T
Y
N
E
T
S
S
Site 158
T1025
M
H
K
F
S
R
S
T
Y
N
E
T
S
S
S
Site 159
Y1026
H
K
F
S
R
S
T
Y
N
E
T
S
S
S
R
Site 160
S1030
R
S
T
Y
N
E
T
S
S
S
R
E
E
S
P
Site 161
S1031
S
T
Y
N
E
T
S
S
S
R
E
E
S
P
E
Site 162
S1032
T
Y
N
E
T
S
S
S
R
E
E
S
P
E
P
Site 163
S1036
T
S
S
S
R
E
E
S
P
E
P
Y
F
F
R
Site 164
Y1040
R
E
E
S
P
E
P
Y
F
F
R
R
T
P
E
Site 165
T1045
E
P
Y
F
F
R
R
T
P
E
S
S
E
R
E
Site 166
S1048
F
F
R
R
T
P
E
S
S
E
R
E
E
S
P
Site 167
S1049
F
R
R
T
P
E
S
S
E
R
E
E
S
P
E
Site 168
S1054
E
S
S
E
R
E
E
S
P
E
P
Q
R
P
N
Site 169
S1075
W
E
D
V
E
E
S
S
K
S
D
F
S
E
F
Site 170
S1077
D
V
E
E
S
S
K
S
D
F
S
E
F
G
A
Site 171
S1080
E
S
S
K
S
D
F
S
E
F
G
A
K
R
K
Site 172
T1089
F
G
A
K
R
K
F
T
Q
S
F
M
R
S
E
Site 173
S1091
A
K
R
K
F
T
Q
S
F
M
R
S
E
E
E
Site 174
S1095
F
T
Q
S
F
M
R
S
E
E
E
G
E
K
E
Site 175
T1104
E
E
G
E
K
E
R
T
E
N
R
E
E
G
R
Site 176
S1114
R
E
E
G
R
F
A
S
G
R
R
S
Q
Y
R
Site 177
S1118
R
F
A
S
G
R
R
S
Q
Y
R
R
S
T
D
Site 178
Y1120
A
S
G
R
R
S
Q
Y
R
R
S
T
D
R
E
Site 179
S1123
R
R
S
Q
Y
R
R
S
T
D
R
E
E
E
E
Site 180
T1124
R
S
Q
Y
R
R
S
T
D
R
E
E
E
E
E
Site 181
T1150
R
R
Q
E
E
T
R
T
K
L
Q
K
R
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation