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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYSM1
Full Name:
Histone H2A deubiquitinase MYSM1
Alias:
Myb-like, SWIRM and MPN domain-containing protein 1
Type:
Mass (Da):
95014
Number AA:
828
UniProt ID:
Q5VVJ2
International Prot ID:
IPI00044725
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
A
A
G
A
Q
P
G
S
G
E
N
T
A
S
V
Site 2
T28
Q
P
G
S
G
E
N
T
A
S
V
L
Q
K
D
Site 3
S30
G
S
G
E
N
T
A
S
V
L
Q
K
D
H
Y
Site 4
Y37
S
V
L
Q
K
D
H
Y
L
D
S
S
W
R
T
Site 5
S40
Q
K
D
H
Y
L
D
S
S
W
R
T
E
N
G
Site 6
S41
K
D
H
Y
L
D
S
S
W
R
T
E
N
G
L
Site 7
T44
Y
L
D
S
S
W
R
T
E
N
G
L
I
P
W
Site 8
T52
E
N
G
L
I
P
W
T
L
D
N
T
I
S
E
Site 9
T56
I
P
W
T
L
D
N
T
I
S
E
E
N
R
A
Site 10
Y74
K
M
L
L
E
E
E
Y
Y
L
S
K
K
S
Q
Site 11
Y75
M
L
L
E
E
E
Y
Y
L
S
K
K
S
Q
P
Site 12
S77
L
E
E
E
Y
Y
L
S
K
K
S
Q
P
E
K
Site 13
S80
E
Y
Y
L
S
K
K
S
Q
P
E
K
V
W
L
Site 14
Y96
Q
K
E
D
D
K
K
Y
M
K
S
L
Q
K
T
Site 15
S99
D
D
K
K
Y
M
K
S
L
Q
K
T
A
K
I
Site 16
T103
Y
M
K
S
L
Q
K
T
A
K
I
M
V
H
S
Site 17
S110
T
A
K
I
M
V
H
S
P
T
K
P
A
S
Y
Site 18
T112
K
I
M
V
H
S
P
T
K
P
A
S
Y
S
V
Site 19
S116
H
S
P
T
K
P
A
S
Y
S
V
K
W
T
I
Site 20
S118
P
T
K
P
A
S
Y
S
V
K
W
T
I
E
E
Site 21
T122
A
S
Y
S
V
K
W
T
I
E
E
K
E
L
F
Site 22
T141
A
K
F
G
R
R
W
T
K
I
S
K
L
I
G
Site 23
S144
G
R
R
W
T
K
I
S
K
L
I
G
S
R
T
Site 24
S149
K
I
S
K
L
I
G
S
R
T
V
L
Q
V
K
Site 25
T151
S
K
L
I
G
S
R
T
V
L
Q
V
K
S
Y
Site 26
S157
R
T
V
L
Q
V
K
S
Y
A
R
Q
Y
F
K
Site 27
Y158
T
V
L
Q
V
K
S
Y
A
R
Q
Y
F
K
N
Site 28
Y162
V
K
S
Y
A
R
Q
Y
F
K
N
K
V
K
C
Site 29
T175
K
C
G
L
D
K
E
T
P
N
Q
K
T
G
H
Site 30
T193
V
K
N
E
D
K
G
T
K
A
W
T
P
S
C
Site 31
T197
D
K
G
T
K
A
W
T
P
S
C
L
R
G
R
Site 32
S199
G
T
K
A
W
T
P
S
C
L
R
G
R
A
D
Site 33
S218
A
V
K
I
E
K
L
S
D
D
E
E
V
D
I
Site 34
T226
D
D
E
E
V
D
I
T
D
E
V
D
E
L
S
Site 35
S233
T
D
E
V
D
E
L
S
S
Q
T
P
Q
K
N
Site 36
S234
D
E
V
D
E
L
S
S
Q
T
P
Q
K
N
S
Site 37
T236
V
D
E
L
S
S
Q
T
P
Q
K
N
S
S
S
Site 38
S241
S
Q
T
P
Q
K
N
S
S
S
D
L
L
L
D
Site 39
S252
L
L
L
D
F
P
N
S
K
M
H
E
T
N
Q
Site 40
S265
N
Q
G
E
F
I
T
S
D
S
Q
E
A
L
F
Site 41
S267
G
E
F
I
T
S
D
S
Q
E
A
L
F
S
K
Site 42
S273
D
S
Q
E
A
L
F
S
K
S
S
R
G
C
L
Site 43
S275
Q
E
A
L
F
S
K
S
S
R
G
C
L
Q
N
Site 44
T288
Q
N
E
K
Q
D
E
T
L
S
S
S
E
I
T
Site 45
S290
E
K
Q
D
E
T
L
S
S
S
E
I
T
L
W
Site 46
S291
K
Q
D
E
T
L
S
S
S
E
I
T
L
W
T
Site 47
S292
Q
D
E
T
L
S
S
S
E
I
T
L
W
T
E
Site 48
T295
T
L
S
S
S
E
I
T
L
W
T
E
K
Q
S
Site 49
T298
S
S
E
I
T
L
W
T
E
K
Q
S
N
G
D
Site 50
S308
Q
S
N
G
D
K
K
S
I
E
L
N
D
Q
K
Site 51
S340
V
D
A
R
Q
L
P
S
P
E
P
C
E
I
Q
Site 52
S366
S
C
Q
M
V
E
E
S
H
E
E
E
E
L
K
Site 53
T405
F
E
G
R
Q
A
K
T
P
E
R
Y
L
K
I
Site 54
Y409
Q
A
K
T
P
E
R
Y
L
K
I
R
N
Y
I
Site 55
Y415
R
Y
L
K
I
R
N
Y
I
L
D
Q
W
E
I
Site 56
Y427
W
E
I
C
K
P
K
Y
L
N
K
T
S
V
R
Site 57
T431
K
P
K
Y
L
N
K
T
S
V
R
P
G
L
K
Site 58
S432
P
K
Y
L
N
K
T
S
V
R
P
G
L
K
N
Site 59
Y468
F
G
C
E
Q
A
V
Y
N
R
P
Q
T
V
D
Site 60
T473
A
V
Y
N
R
P
Q
T
V
D
K
V
R
I
R
Site 61
S497
Q
L
A
Q
R
L
Q
S
M
R
T
R
R
R
R
Site 62
T500
Q
R
L
Q
S
M
R
T
R
R
R
R
V
R
D
Site 63
T522
A
K
D
L
E
G
Q
T
F
E
H
L
S
A
E
Site 64
S527
G
Q
T
F
E
H
L
S
A
E
E
L
A
K
R
Site 65
S545
E
K
G
R
P
V
K
S
L
K
V
P
R
P
T
Site 66
T552
S
L
K
V
P
R
P
T
K
S
S
F
D
P
F
Site 67
S554
K
V
P
R
P
T
K
S
S
F
D
P
F
Q
L
Site 68
S555
V
P
R
P
T
K
S
S
F
D
P
F
Q
L
I
Site 69
S568
L
I
P
C
N
F
F
S
E
E
K
Q
E
P
F
Site 70
S607
G
L
L
G
G
R
Y
S
E
V
D
K
V
V
E
Site 71
S636
Q
C
E
M
D
P
V
S
Q
T
Q
A
S
E
T
Site 72
T643
S
Q
T
Q
A
S
E
T
L
A
V
R
G
F
S
Site 73
Y655
G
F
S
V
I
G
W
Y
H
S
H
P
A
F
D
Site 74
S666
P
A
F
D
P
N
P
S
L
R
D
I
D
T
Q
Site 75
T672
P
S
L
R
D
I
D
T
Q
A
K
Y
Q
S
Y
Site 76
Y676
D
I
D
T
Q
A
K
Y
Q
S
Y
F
S
R
G
Site 77
S678
D
T
Q
A
K
Y
Q
S
Y
F
S
R
G
G
A
Site 78
Y679
T
Q
A
K
Y
Q
S
Y
F
S
R
G
G
A
K
Site 79
Y695
I
G
M
I
V
S
P
Y
N
R
N
N
P
L
P
Site 80
S716
L
V
I
S
E
E
I
S
P
D
G
S
Y
R
L
Site 81
S720
E
E
I
S
P
D
G
S
Y
R
L
P
Y
K
F
Site 82
Y721
E
I
S
P
D
G
S
Y
R
L
P
Y
K
F
E
Site 83
Y725
D
G
S
Y
R
L
P
Y
K
F
E
V
Q
Q
M
Site 84
Y752
T
R
W
I
I
E
K
Y
R
L
S
H
S
S
V
Site 85
S755
I
I
E
K
Y
R
L
S
H
S
S
V
P
M
D
Site 86
S757
E
K
Y
R
L
S
H
S
S
V
P
M
D
K
I
Site 87
S758
K
Y
R
L
S
H
S
S
V
P
M
D
K
I
F
Site 88
S769
D
K
I
F
R
R
D
S
D
L
T
C
L
Q
K
Site 89
T772
F
R
R
D
S
D
L
T
C
L
Q
K
L
L
E
Site 90
T784
L
L
E
C
M
R
K
T
L
S
K
V
T
N
C
Site 91
S807
E
I
E
N
L
F
L
S
N
Y
K
S
N
Q
E
Site 92
Y809
E
N
L
F
L
S
N
Y
K
S
N
Q
E
N
G
Site 93
S811
L
F
L
S
N
Y
K
S
N
Q
E
N
G
V
T
Site 94
T818
S
N
Q
E
N
G
V
T
E
E
N
C
T
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation