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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPRC1
Full Name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Alias:
PGC-1-related coactivator; PRC
Type:
Transcription, coactivator/corepressor
Mass (Da):
177544
Number AA:
1664
UniProt ID:
Q5VV67
International Prot ID:
IPI00419509
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
D
G
V
A
P
P
P
S
G
G
P
G
P
D
P
Site 2
S30
P
G
G
G
A
R
G
S
G
W
G
S
R
S
Q
Site 3
S34
A
R
G
S
G
W
G
S
R
S
Q
A
P
Y
G
Site 4
S36
G
S
G
W
G
S
R
S
Q
A
P
Y
G
T
L
Site 5
Y40
G
S
R
S
Q
A
P
Y
G
T
L
G
A
V
S
Site 6
T42
R
S
Q
A
P
Y
G
T
L
G
A
V
S
G
G
Site 7
S61
L
H
E
E
A
G
D
S
G
F
V
S
L
S
R
Site 8
S65
A
G
D
S
G
F
V
S
L
S
R
L
G
P
S
Site 9
S67
D
S
G
F
V
S
L
S
R
L
G
P
S
L
R
Site 10
S72
S
L
S
R
L
G
P
S
L
R
D
K
D
L
E
Site 11
T89
E
L
M
L
Q
D
E
T
L
L
G
T
M
Q
S
Site 12
S111
S
L
I
E
D
F
G
S
L
G
E
S
R
L
S
Site 13
S115
D
F
G
S
L
G
E
S
R
L
S
L
E
D
Q
Site 14
S118
S
L
G
E
S
R
L
S
L
E
D
Q
N
E
V
Site 15
S126
L
E
D
Q
N
E
V
S
L
L
T
A
L
T
E
Site 16
S140
E
I
L
D
N
A
D
S
E
N
L
S
P
F
D
Site 17
S144
N
A
D
S
E
N
L
S
P
F
D
S
I
P
D
Site 18
S148
E
N
L
S
P
F
D
S
I
P
D
S
E
L
L
Site 19
S152
P
F
D
S
I
P
D
S
E
L
L
V
S
P
R
Site 20
S157
P
D
S
E
L
L
V
S
P
R
E
G
S
S
L
Site 21
S162
L
V
S
P
R
E
G
S
S
L
H
K
L
L
T
Site 22
S163
V
S
P
R
E
G
S
S
L
H
K
L
L
T
L
Site 23
T169
S
S
L
H
K
L
L
T
L
S
R
T
P
P
E
Site 24
S171
L
H
K
L
L
T
L
S
R
T
P
P
E
R
D
Site 25
T173
K
L
L
T
L
S
R
T
P
P
E
R
D
L
I
Site 26
T181
P
P
E
R
D
L
I
T
P
V
D
P
L
G
P
Site 27
S189
P
V
D
P
L
G
P
S
T
G
S
S
R
G
S
Site 28
T190
V
D
P
L
G
P
S
T
G
S
S
R
G
S
G
Site 29
S192
P
L
G
P
S
T
G
S
S
R
G
S
G
V
E
Site 30
S193
L
G
P
S
T
G
S
S
R
G
S
G
V
E
M
Site 31
S196
S
T
G
S
S
R
G
S
G
V
E
M
S
L
P
Site 32
S201
R
G
S
G
V
E
M
S
L
P
D
P
S
W
D
Site 33
S206
E
M
S
L
P
D
P
S
W
D
F
S
P
P
S
Site 34
S210
P
D
P
S
W
D
F
S
P
P
S
F
L
E
T
Site 35
S213
S
W
D
F
S
P
P
S
F
L
E
T
S
S
P
Site 36
T217
S
P
P
S
F
L
E
T
S
S
P
K
L
P
S
Site 37
S218
P
P
S
F
L
E
T
S
S
P
K
L
P
S
W
Site 38
S219
P
S
F
L
E
T
S
S
P
K
L
P
S
W
R
Site 39
S224
T
S
S
P
K
L
P
S
W
R
P
P
R
S
R
Site 40
S230
P
S
W
R
P
P
R
S
R
P
R
W
G
Q
S
Site 41
S237
S
R
P
R
W
G
Q
S
P
P
P
Q
Q
R
S
Site 42
S244
S
P
P
P
Q
Q
R
S
D
G
E
E
E
E
E
Site 43
S254
E
E
E
E
E
V
A
S
F
S
G
Q
I
L
A
Site 44
S269
G
E
L
D
N
C
V
S
S
I
P
D
F
P
M
Site 45
T288
P
E
E
E
D
K
A
T
A
A
E
M
A
V
P
Site 46
S304
A
G
D
E
S
I
S
S
L
S
E
L
V
R
A
Site 47
S306
D
E
S
I
S
S
L
S
E
L
V
R
A
M
H
Site 48
T321
P
Y
C
L
P
N
L
T
H
L
A
S
L
E
D
Site 49
S325
P
N
L
T
H
L
A
S
L
E
D
E
L
Q
E
Site 50
T338
Q
E
Q
P
D
D
L
T
L
P
E
G
C
V
V
Site 51
S380
R
P
V
L
L
D
D
S
L
E
T
S
S
A
L
Site 52
S415
C
S
E
K
E
G
L
S
L
N
S
E
E
K
L
Site 53
S424
N
S
E
E
K
L
D
S
A
C
L
L
K
P
R
Site 54
S453
P
A
N
A
A
P
G
S
Q
R
A
R
K
G
R
Site 55
S464
R
K
G
R
K
K
K
S
K
E
Q
P
A
A
C
Site 56
Y475
P
A
A
C
V
E
G
Y
A
R
R
L
R
S
S
Site 57
S481
G
Y
A
R
R
L
R
S
S
S
R
G
Q
S
T
Site 58
S482
Y
A
R
R
L
R
S
S
S
R
G
Q
S
T
V
Site 59
S483
A
R
R
L
R
S
S
S
R
G
Q
S
T
V
G
Site 60
S487
R
S
S
S
R
G
Q
S
T
V
G
T
E
V
T
Site 61
T488
S
S
S
R
G
Q
S
T
V
G
T
E
V
T
S
Site 62
T491
R
G
Q
S
T
V
G
T
E
V
T
S
Q
V
D
Site 63
S495
T
V
G
T
E
V
T
S
Q
V
D
N
L
Q
K
Site 64
S536
A
A
A
L
E
N
S
S
P
K
N
L
E
R
S
Site 65
S543
S
P
K
N
L
E
R
S
A
G
Q
S
S
P
A
Site 66
S547
L
E
R
S
A
G
Q
S
S
P
A
K
E
G
P
Site 67
S548
E
R
S
A
G
Q
S
S
P
A
K
E
G
P
L
Site 68
Y558
K
E
G
P
L
D
L
Y
P
K
L
A
D
T
I
Site 69
T564
L
Y
P
K
L
A
D
T
I
Q
T
N
P
I
P
Site 70
T572
I
Q
T
N
P
I
P
T
H
L
S
L
V
D
S
Site 71
S575
N
P
I
P
T
H
L
S
L
V
D
S
A
Q
A
Site 72
S579
T
H
L
S
L
V
D
S
A
Q
A
S
P
M
P
Site 73
S589
A
S
P
M
P
V
D
S
V
E
A
D
P
T
A
Site 74
S619
V
D
L
A
S
T
S
S
E
L
V
E
P
L
P
Site 75
S688
V
D
P
V
L
V
K
S
R
P
T
D
P
R
R
Site 76
T691
V
L
V
K
S
R
P
T
D
P
R
R
G
A
V
Site 77
S699
D
P
R
R
G
A
V
S
S
A
L
G
G
S
A
Site 78
S700
P
R
R
G
A
V
S
S
A
L
G
G
S
A
P
Site 79
S715
Q
L
L
V
E
S
E
S
L
D
P
P
K
T
I
Site 80
T721
E
S
L
D
P
P
K
T
I
I
P
E
V
K
E
Site 81
S732
E
V
K
E
V
V
D
S
L
K
I
E
S
G
T
Site 82
S737
V
D
S
L
K
I
E
S
G
T
S
A
T
T
H
Site 83
S740
L
K
I
E
S
G
T
S
A
T
T
H
E
A
R
Site 84
S752
E
A
R
P
R
P
L
S
L
S
E
Y
R
R
R
Site 85
S754
R
P
R
P
L
S
L
S
E
Y
R
R
R
R
Q
Site 86
Y756
R
P
L
S
L
S
E
Y
R
R
R
R
Q
Q
R
Site 87
T767
R
Q
Q
R
Q
A
E
T
E
E
R
S
P
Q
P
Site 88
S771
Q
A
E
T
E
E
R
S
P
Q
P
P
T
G
K
Site 89
T776
E
R
S
P
Q
P
P
T
G
K
W
P
S
L
P
Site 90
S781
P
P
T
G
K
W
P
S
L
P
E
T
P
T
G
Site 91
T785
K
W
P
S
L
P
E
T
P
T
G
L
A
D
I
Site 92
S810
K
K
T
A
L
Q
R
S
P
E
T
P
L
E
I
Site 93
S825
C
L
V
P
V
G
P
S
P
A
S
P
S
P
E
Site 94
S828
P
V
G
P
S
P
A
S
P
S
P
E
P
P
V
Site 95
S830
G
P
S
P
A
S
P
S
P
E
P
P
V
S
K
Site 96
S836
P
S
P
E
P
P
V
S
K
P
V
A
S
S
P
Site 97
S842
V
S
K
P
V
A
S
S
P
T
E
Q
V
P
S
Site 98
S849
S
P
T
E
Q
V
P
S
Q
E
M
P
L
L
A
Site 99
S859
M
P
L
L
A
R
P
S
P
P
V
Q
S
V
S
Site 100
S864
R
P
S
P
P
V
Q
S
V
S
P
A
V
P
T
Site 101
S866
S
P
P
V
Q
S
V
S
P
A
V
P
T
P
P
Site 102
S891
G
G
L
G
M
P
P
S
L
P
P
P
P
L
Q
Site 103
S901
P
P
P
L
Q
P
P
S
L
P
L
S
M
G
P
Site 104
S905
Q
P
P
S
L
P
L
S
M
G
P
V
L
P
D
Site 105
T915
P
V
L
P
D
P
F
T
H
Y
A
P
L
P
S
Site 106
Y917
L
P
D
P
F
T
H
Y
A
P
L
P
S
W
P
Site 107
Y926
P
L
P
S
W
P
C
Y
P
H
V
S
P
S
G
Site 108
S932
C
Y
P
H
V
S
P
S
G
Y
P
C
L
P
P
Site 109
Y934
P
H
V
S
P
S
G
Y
P
C
L
P
P
P
P
Site 110
S960
Y
A
V
P
P
T
C
S
V
P
W
A
P
P
P
Site 111
S971
A
P
P
P
A
P
V
S
P
Y
S
S
T
C
T
Site 112
S974
P
A
P
V
S
P
Y
S
S
T
C
T
Y
G
P
Site 113
S975
A
P
V
S
P
Y
S
S
T
C
T
Y
G
P
L
Site 114
T976
P
V
S
P
Y
S
S
T
C
T
Y
G
P
L
G
Site 115
T978
S
P
Y
S
S
T
C
T
Y
G
P
L
G
W
G
Site 116
Y979
P
Y
S
S
T
C
T
Y
G
P
L
G
W
G
P
Site 117
S995
P
Q
H
A
P
F
W
S
T
V
P
P
P
P
L
Site 118
T996
Q
H
A
P
F
W
S
T
V
P
P
P
P
L
P
Site 119
S1006
P
P
P
L
P
P
A
S
I
G
R
A
V
P
Q
Site 120
T1021
P
K
M
E
S
R
G
T
P
A
G
P
P
E
N
Site 121
T1050
P
G
H
G
A
P
Q
T
E
P
T
K
V
E
V
Site 122
S1063
E
V
K
P
V
P
A
S
P
H
P
K
H
K
V
Site 123
S1071
P
H
P
K
H
K
V
S
A
L
V
Q
S
P
Q
Site 124
S1076
K
V
S
A
L
V
Q
S
P
Q
M
K
A
L
A
Site 125
S1097
V
T
V
E
E
P
A
S
E
R
L
K
P
E
T
Site 126
T1104
S
E
R
L
K
P
E
T
Q
E
T
R
P
R
E
Site 127
T1107
L
K
P
E
T
Q
E
T
R
P
R
E
K
P
P
Site 128
T1118
E
K
P
P
L
P
A
T
K
A
V
P
T
P
R
Site 129
T1123
P
A
T
K
A
V
P
T
P
R
Q
S
T
V
P
Site 130
S1127
A
V
P
T
P
R
Q
S
T
V
P
K
L
P
A
Site 131
T1128
V
P
T
P
R
Q
S
T
V
P
K
L
P
A
V
Site 132
S1144
P
A
R
L
R
K
L
S
F
L
P
T
P
R
T
Site 133
T1148
R
K
L
S
F
L
P
T
P
R
T
Q
G
S
E
Site 134
T1151
S
F
L
P
T
P
R
T
Q
G
S
E
D
V
V
Site 135
S1174
I
E
A
S
D
L
S
S
L
L
E
Q
F
E
K
Site 136
S1182
L
L
E
Q
F
E
K
S
E
A
K
K
E
C
P
Site 137
S1196
P
P
P
A
P
A
D
S
L
A
V
G
N
S
G
Site 138
S1202
D
S
L
A
V
G
N
S
G
G
V
D
I
P
Q
Site 139
T1229
L
A
N
V
A
G
L
T
P
P
A
T
P
P
H
Site 140
T1233
A
G
L
T
P
P
A
T
P
P
H
Q
L
W
K
Site 141
S1246
W
K
P
L
A
A
V
S
L
L
A
K
A
K
S
Site 142
S1253
S
L
L
A
K
A
K
S
P
K
S
T
A
Q
E
Site 143
S1256
A
K
A
K
S
P
K
S
T
A
Q
E
G
T
L
Site 144
T1257
K
A
K
S
P
K
S
T
A
Q
E
G
T
L
K
Site 145
T1262
K
S
T
A
Q
E
G
T
L
K
P
E
G
V
T
Site 146
S1287
Q
E
G
V
H
G
P
S
R
V
H
V
G
S
G
Site 147
S1293
P
S
R
V
H
V
G
S
G
D
H
D
Y
C
V
Site 148
Y1298
V
G
S
G
D
H
D
Y
C
V
R
S
R
T
P
Site 149
S1302
D
H
D
Y
C
V
R
S
R
T
P
P
K
K
M
Site 150
T1304
D
Y
C
V
R
S
R
T
P
P
K
K
M
P
A
Site 151
S1319
L
V
I
P
E
V
G
S
R
W
N
V
K
R
H
Site 152
T1330
V
K
R
H
Q
D
I
T
I
K
P
V
L
S
L
Site 153
S1350
P
P
P
C
I
A
A
S
R
E
P
L
D
H
R
Site 154
S1359
E
P
L
D
H
R
T
S
S
E
Q
A
D
P
S
Site 155
S1360
P
L
D
H
R
T
S
S
E
Q
A
D
P
S
A
Site 156
S1366
S
S
E
Q
A
D
P
S
A
P
C
L
A
P
S
Site 157
S1377
L
A
P
S
S
L
L
S
P
E
A
S
P
C
R
Site 158
S1381
S
L
L
S
P
E
A
S
P
C
R
N
D
M
N
Site 159
T1389
P
C
R
N
D
M
N
T
R
T
P
P
E
P
S
Site 160
T1391
R
N
D
M
N
T
R
T
P
P
E
P
S
A
K
Site 161
S1401
E
P
S
A
K
Q
R
S
M
R
C
Y
R
K
A
Site 162
Y1405
K
Q
R
S
M
R
C
Y
R
K
A
C
R
S
A
Site 163
S1411
C
Y
R
K
A
C
R
S
A
S
P
S
S
Q
G
Site 164
S1413
R
K
A
C
R
S
A
S
P
S
S
Q
G
W
Q
Site 165
S1415
A
C
R
S
A
S
P
S
S
Q
G
W
Q
G
R
Site 166
S1416
C
R
S
A
S
P
S
S
Q
G
W
Q
G
R
R
Site 167
S1427
Q
G
R
R
G
R
N
S
R
S
V
S
S
G
S
Site 168
S1429
R
R
G
R
N
S
R
S
V
S
S
G
S
N
R
Site 169
S1431
G
R
N
S
R
S
V
S
S
G
S
N
R
T
S
Site 170
S1432
R
N
S
R
S
V
S
S
G
S
N
R
T
S
E
Site 171
S1434
S
R
S
V
S
S
G
S
N
R
T
S
E
A
S
Site 172
T1437
V
S
S
G
S
N
R
T
S
E
A
S
S
S
S
Site 173
S1438
S
S
G
S
N
R
T
S
E
A
S
S
S
S
S
Site 174
S1441
S
N
R
T
S
E
A
S
S
S
S
S
S
S
S
Site 175
S1442
N
R
T
S
E
A
S
S
S
S
S
S
S
S
S
Site 176
S1443
R
T
S
E
A
S
S
S
S
S
S
S
S
S
S
Site 177
S1444
T
S
E
A
S
S
S
S
S
S
S
S
S
S
S
Site 178
S1445
S
E
A
S
S
S
S
S
S
S
S
S
S
S
R
Site 179
S1446
E
A
S
S
S
S
S
S
S
S
S
S
S
R
S
Site 180
S1447
A
S
S
S
S
S
S
S
S
S
S
S
R
S
R
Site 181
S1448
S
S
S
S
S
S
S
S
S
S
S
R
S
R
S
Site 182
S1449
S
S
S
S
S
S
S
S
S
S
R
S
R
S
R
Site 183
S1450
S
S
S
S
S
S
S
S
S
R
S
R
S
R
S
Site 184
S1451
S
S
S
S
S
S
S
S
R
S
R
S
R
S
L
Site 185
S1453
S
S
S
S
S
S
R
S
R
S
R
S
L
S
P
Site 186
S1455
S
S
S
S
R
S
R
S
R
S
L
S
P
P
H
Site 187
S1457
S
S
R
S
R
S
R
S
L
S
P
P
H
K
R
Site 188
S1459
R
S
R
S
R
S
L
S
P
P
H
K
R
W
R
Site 189
S1468
P
H
K
R
W
R
R
S
S
C
S
S
S
G
R
Site 190
S1469
H
K
R
W
R
R
S
S
C
S
S
S
G
R
S
Site 191
S1471
R
W
R
R
S
S
C
S
S
S
G
R
S
R
R
Site 192
S1472
W
R
R
S
S
C
S
S
S
G
R
S
R
R
C
Site 193
S1473
R
R
S
S
C
S
S
S
G
R
S
R
R
C
S
Site 194
S1476
S
C
S
S
S
G
R
S
R
R
C
S
S
S
S
Site 195
S1480
S
G
R
S
R
R
C
S
S
S
S
S
S
S
S
Site 196
S1481
G
R
S
R
R
C
S
S
S
S
S
S
S
S
S
Site 197
S1482
R
S
R
R
C
S
S
S
S
S
S
S
S
S
S
Site 198
S1483
S
R
R
C
S
S
S
S
S
S
S
S
S
S
S
Site 199
S1484
R
R
C
S
S
S
S
S
S
S
S
S
S
S
S
Site 200
S1485
R
C
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 201
S1486
C
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 202
S1487
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 203
S1493
S
S
S
S
S
S
S
S
S
S
S
S
S
S
R
Site 204
S1494
S
S
S
S
S
S
S
S
S
S
S
S
S
R
S
Site 205
S1495
S
S
S
S
S
S
S
S
S
S
S
S
R
S
R
Site 206
S1499
S
S
S
S
S
S
S
S
R
S
R
S
R
S
P
Site 207
S1501
S
S
S
S
S
S
R
S
R
S
R
S
P
S
P
Site 208
S1503
S
S
S
S
R
S
R
S
R
S
P
S
P
R
R
Site 209
S1505
S
S
R
S
R
S
R
S
P
S
P
R
R
R
S
Site 210
S1507
R
S
R
S
R
S
P
S
P
R
R
R
S
D
R
Site 211
S1512
S
P
S
P
R
R
R
S
D
R
R
R
R
Y
S
Site 212
Y1518
R
S
D
R
R
R
R
Y
S
S
Y
R
S
H
D
Site 213
S1519
S
D
R
R
R
R
Y
S
S
Y
R
S
H
D
H
Site 214
S1520
D
R
R
R
R
Y
S
S
Y
R
S
H
D
H
Y
Site 215
Y1521
R
R
R
R
Y
S
S
Y
R
S
H
D
H
Y
Q
Site 216
S1523
R
R
Y
S
S
Y
R
S
H
D
H
Y
Q
R
Q
Site 217
Y1527
S
Y
R
S
H
D
H
Y
Q
R
Q
R
V
L
Q
Site 218
T1555
G
K
I
P
G
R
M
T
R
S
E
L
K
Q
R
Site 219
S1564
S
E
L
K
Q
R
F
S
V
F
G
E
I
E
E
Site 220
Y1583
F
R
V
Q
G
D
N
Y
G
F
V
T
Y
R
Y
Site 221
T1587
G
D
N
Y
G
F
V
T
Y
R
Y
A
E
E
A
Site 222
Y1590
Y
G
F
V
T
Y
R
Y
A
E
E
A
F
A
A
Site 223
S1626
R
R
Q
F
C
K
R
S
Y
S
D
L
D
S
N
Site 224
Y1627
R
Q
F
C
K
R
S
Y
S
D
L
D
S
N
R
Site 225
S1628
Q
F
C
K
R
S
Y
S
D
L
D
S
N
R
E
Site 226
S1632
R
S
Y
S
D
L
D
S
N
R
E
D
F
D
P
Site 227
S1644
F
D
P
A
P
V
K
S
K
F
D
S
L
D
F
Site 228
S1648
P
V
K
S
K
F
D
S
L
D
F
D
T
L
L
Site 229
T1653
F
D
S
L
D
F
D
T
L
L
K
Q
A
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation