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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF16
Full Name:
Rho guanine nucleotide exchange factor 16
Alias:
ARHGG; GEF16; NBR; putative neuroblastoma protein; Rho guanine exchange factor (GEF) 16
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
80105
Number AA:
709
UniProt ID:
Q5VV41
International Prot ID:
IPI00550506
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005085
GO:0005088
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
Q
R
H
S
D
S
S
L
E
E
K
Site 2
S8
M
A
Q
R
H
S
D
S
S
L
E
E
K
L
L
Site 3
S9
A
Q
R
H
S
D
S
S
L
E
E
K
L
L
G
Site 4
S21
L
L
G
H
R
F
H
S
E
L
R
L
D
A
G
Site 5
S33
D
A
G
G
N
P
A
S
G
L
P
M
V
R
G
Site 6
S41
G
L
P
M
V
R
G
S
P
R
V
R
D
D
A
Site 7
S97
P
K
S
L
A
V
A
S
K
A
K
T
P
A
R
Site 8
T101
A
V
A
S
K
A
K
T
P
A
R
H
Q
S
F
Site 9
S107
K
T
P
A
R
H
Q
S
F
G
A
A
V
L
S
Site 10
S114
S
F
G
A
A
V
L
S
R
E
A
A
R
R
D
Site 11
S129
P
K
L
L
P
A
P
S
F
S
L
D
D
M
D
Site 12
S153
R
R
N
L
R
N
Q
S
Y
R
A
A
M
K
G
Site 13
Y154
R
N
L
R
N
Q
S
Y
R
A
A
M
K
G
L
Site 14
S174
Q
G
D
A
I
Q
L
S
P
K
L
Q
A
L
A
Site 15
S185
Q
A
L
A
E
E
P
S
Q
P
H
T
R
S
P
Site 16
T189
E
E
P
S
Q
P
H
T
R
S
P
A
K
N
K
Site 17
S191
P
S
Q
P
H
T
R
S
P
A
K
N
K
K
T
Site 18
T198
S
P
A
K
N
K
K
T
L
G
R
K
R
G
H
Site 19
S208
R
K
R
G
H
K
G
S
F
K
D
D
P
Q
L
Site 20
Y216
F
K
D
D
P
Q
L
Y
Q
E
I
Q
E
R
G
Site 21
T226
I
Q
E
R
G
L
N
T
S
Q
E
S
D
D
D
Site 22
S227
Q
E
R
G
L
N
T
S
Q
E
S
D
D
D
I
Site 23
S230
G
L
N
T
S
Q
E
S
D
D
D
I
L
D
E
Site 24
S238
D
D
D
I
L
D
E
S
S
S
P
E
G
T
Q
Site 25
S239
D
D
I
L
D
E
S
S
S
P
E
G
T
Q
K
Site 26
S240
D
I
L
D
E
S
S
S
P
E
G
T
Q
K
V
Site 27
T244
E
S
S
S
P
E
G
T
Q
K
V
D
A
T
I
Site 28
T250
G
T
Q
K
V
D
A
T
I
V
V
K
S
Y
R
Site 29
S255
D
A
T
I
V
V
K
S
Y
R
P
A
Q
V
T
Site 30
T262
S
Y
R
P
A
Q
V
T
W
S
Q
L
P
E
V
Site 31
S264
R
P
A
Q
V
T
W
S
Q
L
P
E
V
V
E
Site 32
S279
L
G
I
L
D
Q
L
S
T
E
E
R
K
R
Q
Site 33
T280
G
I
L
D
Q
L
S
T
E
E
R
K
R
Q
E
Site 34
T294
E
A
M
F
E
I
L
T
S
E
F
S
Y
Q
H
Site 35
S295
A
M
F
E
I
L
T
S
E
F
S
Y
Q
H
S
Site 36
S298
E
I
L
T
S
E
F
S
Y
Q
H
S
L
S
I
Site 37
S302
S
E
F
S
Y
Q
H
S
L
S
I
L
V
E
E
Site 38
T319
Q
S
K
E
L
R
A
T
V
T
Q
M
E
H
H
Site 39
T321
K
E
L
R
A
T
V
T
Q
M
E
H
H
H
L
Site 40
Y374
A
E
K
H
F
H
P
Y
I
A
Y
C
S
N
E
Site 41
Y383
A
Y
C
S
N
E
V
Y
Q
Q
R
T
L
Q
K
Site 42
S393
R
T
L
Q
K
L
I
S
S
N
A
A
F
R
E
Site 43
S394
T
L
Q
K
L
I
S
S
N
A
A
F
R
E
A
Site 44
T441
M
D
T
L
C
L
K
T
Q
G
H
S
E
R
Y
Site 45
S445
C
L
K
T
Q
G
H
S
E
R
Y
K
A
A
S
Site 46
S452
S
E
R
Y
K
A
A
S
R
A
L
K
A
I
S
Site 47
Y479
M
E
R
M
E
Q
M
Y
T
L
H
T
Q
L
D
Site 48
T483
E
Q
M
Y
T
L
H
T
Q
L
D
F
S
K
V
Site 49
S488
L
H
T
Q
L
D
F
S
K
V
K
S
L
P
L
Site 50
T525
R
K
I
A
S
R
P
T
C
Y
L
F
L
F
N
Site 51
Y546
K
K
K
S
E
E
S
Y
M
V
Q
D
Y
A
Q
Site 52
Y551
E
S
Y
M
V
Q
D
Y
A
Q
M
N
H
I
Q
Site 53
S565
Q
V
E
K
I
E
P
S
E
L
P
L
P
G
G
Site 54
S576
L
P
G
G
G
N
R
S
S
S
V
P
H
P
F
Site 55
S577
P
G
G
G
N
R
S
S
S
V
P
H
P
F
Q
Site 56
S578
G
G
G
N
R
S
S
S
V
P
H
P
F
Q
V
Site 57
T586
V
P
H
P
F
Q
V
T
L
L
R
N
S
E
G
Site 58
S591
Q
V
T
L
L
R
N
S
E
G
R
Q
E
Q
L
Site 59
S601
R
Q
E
Q
L
L
L
S
S
D
S
A
S
D
R
Site 60
S602
Q
E
Q
L
L
L
S
S
D
S
A
S
D
R
A
Site 61
S604
Q
L
L
L
S
S
D
S
A
S
D
R
A
R
W
Site 62
S606
L
L
S
S
D
S
A
S
D
R
A
R
W
I
V
Site 63
Y667
Q
Q
E
D
G
W
L
Y
G
E
R
L
R
D
G
Site 64
T676
E
R
L
R
D
G
E
T
G
W
F
P
E
D
F
Site 65
T688
E
D
F
A
R
F
I
T
S
R
V
A
V
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation