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Updated November 2019
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Protein Info
Short Name:
WDR78
Full Name:
WD repeat-containing protein 78
Alias:
Type:
Mass (Da):
94573
Number AA:
848
UniProt ID:
Q5VTH9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
P
G
K
H
S
G
A
S
A
R
A
A
N
G
G
Site 2
Y21
A
N
G
G
A
W
G
Y
R
D
F
R
G
G
Q
Site 3
T35
Q
K
K
G
W
C
T
T
P
Q
L
V
A
T
M
Site 4
S45
L
V
A
T
M
P
V
S
P
A
G
S
H
K
Q
Site 5
S49
M
P
V
S
P
A
G
S
H
K
Q
Q
N
F
G
Site 6
T61
N
F
G
L
N
N
A
T
Q
P
K
K
S
I
S
Site 7
S66
N
A
T
Q
P
K
K
S
I
S
F
F
A
T
M
Site 8
S68
T
Q
P
K
K
S
I
S
F
F
A
T
M
K
A
Site 9
S87
G
Y
T
G
A
N
Q
S
R
M
A
V
S
K
T
Site 10
T103
L
I
P
P
E
L
K
T
V
E
K
P
N
P
N
Site 11
T125
D
I
N
G
T
D
V
T
P
R
P
L
Y
H
P
Site 12
Y130
D
V
T
P
R
P
L
Y
H
P
D
P
L
T
G
Site 13
T136
L
Y
H
P
D
P
L
T
G
T
A
K
P
S
K
Site 14
T138
H
P
D
P
L
T
G
T
A
K
P
S
K
L
L
Site 15
S142
L
T
G
T
A
K
P
S
K
L
L
T
S
Q
E
Site 16
T146
A
K
P
S
K
L
L
T
S
Q
E
G
S
L
G
Site 17
S147
K
P
S
K
L
L
T
S
Q
E
G
S
L
G
S
Site 18
S151
L
L
T
S
Q
E
G
S
L
G
S
E
F
I
S
Site 19
S154
S
Q
E
G
S
L
G
S
E
F
I
S
S
Y
S
Site 20
S158
S
L
G
S
E
F
I
S
S
Y
S
L
Y
Q
N
Site 21
S159
L
G
S
E
F
I
S
S
Y
S
L
Y
Q
N
T
Site 22
S161
S
E
F
I
S
S
Y
S
L
Y
Q
N
T
I
N
Site 23
Y163
F
I
S
S
Y
S
L
Y
Q
N
T
I
N
P
S
Site 24
T166
S
Y
S
L
Y
Q
N
T
I
N
P
S
T
L
G
Site 25
T171
Q
N
T
I
N
P
S
T
L
G
Q
F
T
R
S
Site 26
T176
P
S
T
L
G
Q
F
T
R
S
V
L
G
S
S
Site 27
S182
F
T
R
S
V
L
G
S
S
T
V
S
K
S
S
Site 28
S183
T
R
S
V
L
G
S
S
T
V
S
K
S
S
V
Site 29
T184
R
S
V
L
G
S
S
T
V
S
K
S
S
V
S
Site 30
S188
G
S
S
T
V
S
K
S
S
V
S
A
S
E
S
Site 31
S189
S
S
T
V
S
K
S
S
V
S
A
S
E
S
I
Site 32
S191
T
V
S
K
S
S
V
S
A
S
E
S
I
A
E
Site 33
S193
S
K
S
S
V
S
A
S
E
S
I
A
E
D
L
Site 34
S195
S
S
V
S
A
S
E
S
I
A
E
D
L
E
E
Site 35
Y205
E
D
L
E
E
P
S
Y
K
R
E
R
L
T
S
Site 36
T211
S
Y
K
R
E
R
L
T
S
F
T
D
L
Q
V
Site 37
S212
Y
K
R
E
R
L
T
S
F
T
D
L
Q
V
I
Site 38
T214
R
E
R
L
T
S
F
T
D
L
Q
V
I
R
A
Site 39
T228
A
A
P
E
K
I
V
T
K
E
D
L
E
K
N
Site 40
T241
K
N
I
E
I
I
L
T
E
T
E
T
L
R
F
Site 41
S257
D
L
P
T
V
M
V
S
V
E
S
E
E
A
E
Site 42
Y286
N
R
L
G
N
D
L
Y
V
E
R
M
M
Q
T
Site 43
T293
Y
V
E
R
M
M
Q
T
F
N
G
A
P
K
N
Site 44
Y323
M
S
T
A
W
D
L
Y
D
S
Y
N
A
M
E
Site 45
Y326
A
W
D
L
Y
D
S
Y
N
A
M
E
L
V
S
Site 46
S339
V
S
L
S
V
K
Q
S
V
V
E
S
S
S
K
Site 47
S343
V
K
Q
S
V
V
E
S
S
S
K
A
N
V
L
Site 48
S345
Q
S
V
V
E
S
S
S
K
A
N
V
L
P
K
Site 49
S361
Q
D
Q
R
L
P
G
S
T
T
E
K
N
S
E
Site 50
T362
D
Q
R
L
P
G
S
T
T
E
K
N
S
E
T
Site 51
T363
Q
R
L
P
G
S
T
T
E
K
N
S
E
T
S
Site 52
S367
G
S
T
T
E
K
N
S
E
T
S
S
L
M
D
Site 53
S371
E
K
N
S
E
T
S
S
L
M
D
I
E
N
V
Site 54
S391
H
E
D
E
E
D
H
S
D
A
I
L
K
S
D
Site 55
S397
H
S
D
A
I
L
K
S
D
K
F
H
Q
D
L
Site 56
S477
A
N
L
E
R
L
W
S
F
S
C
D
L
T
K
Site 57
S479
L
E
R
L
W
S
F
S
C
D
L
T
K
G
L
Site 58
T483
W
S
F
S
C
D
L
T
K
G
L
N
V
S
S
Site 59
S490
T
K
G
L
N
V
S
S
L
A
W
N
K
T
N
Site 60
T496
S
S
L
A
W
N
K
T
N
P
D
L
L
A
V
Site 61
Y533
P
M
W
P
E
R
I
Y
Q
S
P
Y
G
V
T
Site 62
S535
W
P
E
R
I
Y
Q
S
P
Y
G
V
T
A
V
Site 63
Y564
H
N
G
T
I
A
I
Y
N
V
R
S
N
S
N
Site 64
S570
I
Y
N
V
R
S
N
S
N
V
P
V
L
D
S
Site 65
S577
S
N
V
P
V
L
D
S
S
E
S
P
Q
K
H
Site 66
S578
N
V
P
V
L
D
S
S
E
S
P
Q
K
H
L
Site 67
S580
P
V
L
D
S
S
E
S
P
Q
K
H
L
G
P
Site 68
T600
W
I
E
Q
D
R
G
T
T
G
D
G
K
R
E
Site 69
T601
I
E
Q
D
R
G
T
T
G
D
G
K
R
E
I
Site 70
S611
G
K
R
E
I
L
V
S
I
S
A
D
G
R
I
Site 71
S619
I
S
A
D
G
R
I
S
K
W
V
I
R
K
G
Site 72
Y630
I
R
K
G
L
D
C
Y
D
L
M
R
L
K
R
Site 73
T639
L
M
R
L
K
R
T
T
A
A
S
N
K
K
G
Site 74
S642
L
K
R
T
T
A
A
S
N
K
K
G
G
E
K
Site 75
S658
K
K
D
E
A
L
I
S
R
Q
A
P
G
M
C
Site 76
Y676
H
P
K
D
T
N
I
Y
L
A
G
T
E
E
G
Site 77
Y696
S
C
S
Y
N
E
Q
Y
L
D
T
Y
R
G
H
Site 78
T699
Y
N
E
Q
Y
L
D
T
Y
R
G
H
K
G
P
Site 79
Y700
N
E
Q
Y
L
D
T
Y
R
G
H
K
G
P
V
Site 80
Y708
R
G
H
K
G
P
V
Y
K
V
T
W
N
P
F
Site 81
S740
Q
Q
E
N
V
K
P
S
L
S
F
Y
P
A
T
Site 82
S742
E
N
V
K
P
S
L
S
F
Y
P
A
T
S
V
Site 83
Y819
S
D
G
Q
V
S
V
Y
E
L
R
N
M
P
T
Site 84
T826
Y
E
L
R
N
M
P
T
V
L
E
T
G
R
G
Site 85
T838
G
R
G
D
I
M
D
T
L
L
G
S
K
S
N
Site 86
S842
I
M
D
T
L
L
G
S
K
S
N
Q
S
A
_
Site 87
S844
D
T
L
L
G
S
K
S
N
Q
S
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation