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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYDE2
Full Name:
Rho GTPase-activating protein SYDE2
Alias:
FLJ13815; synapse defective 1, Rho GTPase, 2
Type:
Mass (Da):
124950
Number AA:
UniProt ID:
Q5VT97
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005100
PhosphoSite+
KinaseNET
Biological Process:
GO:0032862
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
P
S
C
S
R
S
L
E
S
L
R
Site 2
S8
M
R
P
S
C
S
R
S
L
E
S
L
R
V
G
Site 3
S11
S
C
S
R
S
L
E
S
L
R
V
G
A
K
P
Site 4
S52
G
G
R
M
D
G
W
S
G
D
R
A
R
A
A
Site 5
T62
R
A
R
A
A
A
P
T
G
L
Q
P
P
G
C
Site 6
S76
C
K
D
H
G
C
S
S
G
S
P
F
R
D
P
Site 7
S78
D
H
G
C
S
S
G
S
P
F
R
D
P
A
G
Site 8
S86
P
F
R
D
P
A
G
S
S
V
I
R
S
G
K
Site 9
S87
F
R
D
P
A
G
S
S
V
I
R
S
G
K
G
Site 10
S91
A
G
S
S
V
I
R
S
G
K
G
D
R
Q
E
Site 11
S101
G
D
R
Q
E
G
P
S
F
L
R
P
P
A
V
Site 12
T109
F
L
R
P
P
A
V
T
V
K
K
L
Q
K
W
Site 13
Y118
K
K
L
Q
K
W
M
Y
K
G
R
L
L
S
L
Site 14
S124
M
Y
K
G
R
L
L
S
L
G
M
K
G
R
A
Site 15
T134
M
K
G
R
A
R
G
T
A
P
K
V
T
G
T
Site 16
T141
T
A
P
K
V
T
G
T
Q
A
A
S
P
N
V
Site 17
S160
V
R
E
N
R
V
L
S
V
P
P
D
Q
R
I
Site 18
T168
V
P
P
D
Q
R
I
T
L
T
D
L
F
E
N
Site 19
T170
P
D
Q
R
I
T
L
T
D
L
F
E
N
A
Y
Site 20
Y177
T
D
L
F
E
N
A
Y
G
S
S
M
K
G
R
Site 21
S203
R
G
H
K
P
L
N
S
I
T
V
S
K
K
R
Site 22
T205
H
K
P
L
N
S
I
T
V
S
K
K
R
N
W
Site 23
S207
P
L
N
S
I
T
V
S
K
K
R
N
W
L
Y
Site 24
Y214
S
K
K
R
N
W
L
Y
Q
S
T
L
R
P
L
Site 25
S216
K
R
N
W
L
Y
Q
S
T
L
R
P
L
N
L
Site 26
T217
R
N
W
L
Y
Q
S
T
L
R
P
L
N
L
E
Site 27
S234
N
K
K
C
Q
D
R
S
H
L
S
I
S
P
V
Site 28
S237
C
Q
D
R
S
H
L
S
I
S
P
V
S
L
P
Site 29
S239
D
R
S
H
L
S
I
S
P
V
S
L
P
K
H
Site 30
S242
H
L
S
I
S
P
V
S
L
P
K
H
Q
L
S
Site 31
S249
S
L
P
K
H
Q
L
S
Q
S
F
L
K
S
S
Site 32
S251
P
K
H
Q
L
S
Q
S
F
L
K
S
S
K
E
Site 33
S255
L
S
Q
S
F
L
K
S
S
K
E
Y
C
T
Y
Site 34
S256
S
Q
S
F
L
K
S
S
K
E
Y
C
T
Y
V
Site 35
Y259
F
L
K
S
S
K
E
Y
C
T
Y
V
V
C
N
Site 36
Y262
S
S
K
E
Y
C
T
Y
V
V
C
N
A
T
N
Site 37
S271
V
C
N
A
T
N
S
S
L
S
K
N
C
A
L
Site 38
S306
E
D
D
D
L
G
I
S
S
A
L
S
F
G
E
Site 39
S307
D
D
D
L
G
I
S
S
A
L
S
F
G
E
A
Site 40
S332
N
L
S
M
L
S
G
S
D
L
M
K
A
E
R
Site 41
T341
L
M
K
A
E
R
H
T
E
D
S
L
C
S
S
Site 42
S344
A
E
R
H
T
E
D
S
L
C
S
S
E
H
A
Site 43
S348
T
E
D
S
L
C
S
S
E
H
A
G
D
I
Q
Site 44
T356
E
H
A
G
D
I
Q
T
T
R
S
N
G
M
N
Site 45
Y377
S
T
E
F
V
Q
Q
Y
K
Q
K
L
G
H
K
Site 46
T385
K
Q
K
L
G
H
K
T
Q
E
G
I
M
V
E
Site 47
S394
E
G
I
M
V
E
D
S
P
M
L
K
S
P
F
Site 48
S399
E
D
S
P
M
L
K
S
P
F
A
G
S
G
I
Site 49
S421
E
L
G
I
M
E
P
S
S
P
N
P
S
P
V
Site 50
S422
L
G
I
M
E
P
S
S
P
N
P
S
P
V
K
Site 51
S426
E
P
S
S
P
N
P
S
P
V
K
K
G
S
S
Site 52
S433
S
P
V
K
K
G
S
S
I
N
W
S
L
P
D
Site 53
S437
K
G
S
S
I
N
W
S
L
P
D
K
I
K
S
Site 54
S444
S
L
P
D
K
I
K
S
P
R
T
V
R
K
L
Site 55
T447
D
K
I
K
S
P
R
T
V
R
K
L
S
M
K
Site 56
S452
P
R
T
V
R
K
L
S
M
K
M
K
K
L
P
Site 57
S466
P
E
F
S
R
K
L
S
V
K
G
T
L
N
Y
Site 58
T470
R
K
L
S
V
K
G
T
L
N
Y
I
N
S
P
Site 59
S476
G
T
L
N
Y
I
N
S
P
D
N
T
P
S
L
Site 60
T480
Y
I
N
S
P
D
N
T
P
S
L
S
K
Y
N
Site 61
S482
N
S
P
D
N
T
P
S
L
S
K
Y
N
C
R
Site 62
S484
P
D
N
T
P
S
L
S
K
Y
N
C
R
E
V
Site 63
Y486
N
T
P
S
L
S
K
Y
N
C
R
E
V
H
H
Site 64
T494
N
C
R
E
V
H
H
T
D
I
L
P
S
G
N
Site 65
T503
I
L
P
S
G
N
T
T
T
A
A
K
R
N
V
Site 66
T518
I
S
R
Y
H
L
D
T
S
V
S
S
Q
Q
S
Site 67
S519
S
R
Y
H
L
D
T
S
V
S
S
Q
Q
S
Y
Site 68
S521
Y
H
L
D
T
S
V
S
S
Q
Q
S
Y
Q
K
Site 69
S525
T
S
V
S
S
Q
Q
S
Y
Q
K
K
N
S
M
Site 70
Y526
S
V
S
S
Q
Q
S
Y
Q
K
K
N
S
M
S
Site 71
S531
Q
S
Y
Q
K
K
N
S
M
S
S
K
Y
S
C
Site 72
S533
Y
Q
K
K
N
S
M
S
S
K
Y
S
C
K
G
Site 73
S534
Q
K
K
N
S
M
S
S
K
Y
S
C
K
G
G
Site 74
Y536
K
N
S
M
S
S
K
Y
S
C
K
G
G
Y
L
Site 75
S537
N
S
M
S
S
K
Y
S
C
K
G
G
Y
L
S
Site 76
Y542
K
Y
S
C
K
G
G
Y
L
S
D
G
D
S
P
Site 77
S544
S
C
K
G
G
Y
L
S
D
G
D
S
P
E
L
Site 78
S548
G
Y
L
S
D
G
D
S
P
E
L
T
T
K
A
Site 79
T552
D
G
D
S
P
E
L
T
T
K
A
S
K
H
G
Site 80
S556
P
E
L
T
T
K
A
S
K
H
G
S
E
N
K
Site 81
S560
T
K
A
S
K
H
G
S
E
N
K
F
G
K
G
Site 82
S572
G
K
G
K
E
I
I
S
N
S
C
S
K
N
E
Site 83
S574
G
K
E
I
I
S
N
S
C
S
K
N
E
I
D
Site 84
S576
E
I
I
S
N
S
C
S
K
N
E
I
D
I
D
Site 85
Y588
D
I
D
A
F
R
H
Y
S
F
S
D
Q
P
K
Site 86
S589
I
D
A
F
R
H
Y
S
F
S
D
Q
P
K
C
Site 87
S591
A
F
R
H
Y
S
F
S
D
Q
P
K
C
S
Q
Site 88
S597
F
S
D
Q
P
K
C
S
Q
Y
I
S
G
L
M
Site 89
Y599
D
Q
P
K
C
S
Q
Y
I
S
G
L
M
S
V
Site 90
Y609
G
L
M
S
V
H
F
Y
G
A
E
D
L
K
P
Site 91
S621
L
K
P
P
R
I
D
S
K
D
V
F
C
A
I
Site 92
T653
T
F
L
D
M
D
H
T
F
N
I
E
I
E
N
Site 93
S670
H
L
K
L
V
V
F
S
W
E
P
T
P
R
K
Site 94
T674
V
V
F
S
W
E
P
T
P
R
K
N
R
V
C
Site 95
S795
R
E
A
F
E
R
D
S
K
A
V
G
L
C
E
Site 96
Y818
I
T
G
V
L
K
D
Y
L
R
E
L
P
S
P
Site 97
S824
D
Y
L
R
E
L
P
S
P
L
I
T
K
Q
L
Site 98
S842
V
L
D
A
M
A
K
S
P
L
K
M
S
S
N
Site 99
Y860
N
D
P
G
D
S
K
Y
T
V
D
L
L
D
C
Site 100
T861
D
P
G
D
S
K
Y
T
V
D
L
L
D
C
L
Site 101
S888
D
H
L
K
L
V
A
S
Y
H
E
V
N
K
M
Site 102
S910
C
F
G
P
V
L
L
S
Q
R
Q
E
P
S
T
Site 103
T917
S
Q
R
Q
E
P
S
T
H
N
N
R
V
F
T
Site 104
T924
T
H
N
N
R
V
F
T
D
S
E
E
L
A
S
Site 105
S926
N
N
R
V
F
T
D
S
E
E
L
A
S
A
L
Site 106
T955
L
W
P
V
Q
R
L
T
V
K
K
S
T
D
N
Site 107
S959
Q
R
L
T
V
K
K
S
T
D
N
L
F
P
E
Site 108
S970
L
F
P
E
Q
K
S
S
L
N
Y
L
R
Q
K
Site 109
Y973
E
Q
K
S
S
L
N
Y
L
R
Q
K
K
E
R
Site 110
S987
R
P
H
M
L
N
L
S
G
T
D
S
S
G
V
Site 111
T989
H
M
L
N
L
S
G
T
D
S
S
G
V
L
R
Site 112
S991
L
N
L
S
G
T
D
S
S
G
V
L
R
P
R
Site 113
S1004
P
R
Q
N
R
L
D
S
P
L
S
N
R
Y
A
Site 114
S1007
N
R
L
D
S
P
L
S
N
R
Y
A
G
D
W
Site 115
Y1021
W
S
S
C
G
E
N
Y
F
L
N
T
K
E
N
Site 116
Y1034
E
N
L
N
D
V
D
Y
D
D
V
P
S
E
D
Site 117
S1039
V
D
Y
D
D
V
P
S
E
D
R
K
I
G
E
Site 118
S1049
R
K
I
G
E
N
Y
S
K
M
D
G
P
E
V
Site 119
T1078
Q
T
Y
L
T
M
Q
T
V
E
S
T
V
D
R
Site 120
T1098
D
L
Q
E
S
I
D
T
L
I
G
N
L
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation